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| * all images with kind permission of the authors |
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ALZHEIMERS 4D
Representation of 4-dimensional in vivo multiphoton recording of the biodistribution kinetics of the fluorescent biomarker PIB in the brain of a transgenic mouse model for Alzheimer's disease. Three distinct time points are shown here simultaneously as projections of their respective 3D volumes. Blue pseudocolor corresponds to the dye visible in the volume immediately after IV injection, green 5min later, and red at t=20min. PIB enters the brain, is rapidly cleared from circulation, and targets vascular and parenchymal amyloid deposits with high specificity, making it a suitable in vivo biomarker.
Brian J. Bacskai
Massachusetts General Hospital
USA
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