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| ConforCor 3 from Carl Zeiss |
| Working in a world of single molecules | Downloads and Links | ||
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Deutsche Version
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| Jena, 21.11.2005. The new ConfoCor 3 from Carl Zeiss is much more than an imaging device. In combination with an LSM 510 or LSM 510 META Laser Scanning Microscope it permits high-resolution image acquisition and sensitive fluctuation analysis. The ConfoCor 3 detection module provides new insights into dynamic cell processes through quantitative analysis of the concentration, position, interaction and mobility of molecules. The combination of fast detectors and online data analysis allows the temporal resolution of ultra-fast dynamic processes. The requirements of maximum sensitivity and time resolution can be balanced with the greatest possible flexibility by choosing avalanche photodiodes or gallium arsenide-phosphide detectors. After imaging a cell, one or several measurement positions can be selected, which are precisely located by the scanning mirrors; the system then delivers all parameters of interest in real time. The new experimental capabilities provided by the ConfoCor 3 take effect in the investigation of molecule distribution in cells, diffusion processes by fluorescence correlation spectroscopy, and protein complex formations, in the detection of common movements and the quantification of receptor ligand interactions. Control and analysis software The basic software controls the detection module and allows convenient analysis of single measurements or software-controlled multi-measurements. Auto- and cross-correlation are calculated in real time, i.e. at the same time as the current measurement. And there is always the choice of using the raw data for individual analysis. The system’s automated ease of use takes the time-consuming effort out of data analysis. Sophisticated options The options include advanced software modules that incorporate the most common methods (free diffusion, anomalous diffusion and flow), provide for user-defined models, allow for global and interactive fitting with the possibility of defining start values and boundaries, and make photon counting histograms possible. Modular design The flexible design of the ConfoCor 3 enables the system to be adapted to specific needs. Perfect interplay between the ConfoCor 3 and the  The fully automated ConfoCor 3 from Carl Zeiss sets new standards in fluorescence fluctuation analysis, even at a single-molecule level. Gudrun Vogel Carl Zeiss Jena GmbH Press Officer Microscopes and Systems, Optical Systems and Components Phone: +49 3641 64-2770 Fax: +49 3641 64-2941 E-Mail: g.vogel@zeiss.de Dr. Klaus Weisshart Phone: +49 3641 64-2268 Fax: +49 3641 64-3144 E-Mail: micro@zeiss.de Number: J44/05 MI Number of Words: 398 Number of Signs: 3114 |
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