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The all-around cohesive OVD

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Z-HYALIN plus - ZEISS premium cohesive OVD

Z-HYALIN plus – The all-around cohesive OVD

This high-viscosity OVDs is designed to meet all expectations for every type of cataract surgery.

  • Ease of use in any case
  • Flexibility of a high volume syringe (1.0 ml)
  • Good endothelium protection
  • Highly effective in space creation
  • Optimal chamber retention
  • Good capsular bag inflation
  • Fast and easy removal

Z-HYALIN plus – “Engineered for simplicity”


Z-HYALIN® plus – one viscosity to meet all expectations

Z-HYALIN plus cohesive OVD consists of a 1.5% solution of sodium hyaluronate derived from bacterial fermentation (nothing of animal origin) that has a high molecular weight and a high viscosity. The 1.0 ml volume of high viscosity cohesive OVD offers high flexibility of use.

ZEISS standard cohesive OVD



Bacterial Fermentation


Sodium Hyaluronate (NaHA)


1.5% NaHA


1.0 ml


7.2 - 7.6


300 - 360 mOsmol/kg

Molecular weight1

2,900,000 Da

Pseudoplasticity index


Zero-shear viscosity

Avg. 250,000 mPa.s

Cannula 27 G
Storage 2 - 8 °C
Packaging Single box or Multipack
1 single box of Z-HYALIN plus contains: 1 x syringe, 1 x 27G cannula,
1 multipack of Z-HYALIN plus contains: 10 x syringes, 10 x 27G cannulae


Engineered for simplicity – a concept that meets surgeons’ demands

Z-HYALIN® plus is the most versatile single viscosity OVD designed for every surgical need.


Dr. Fulvio BERGAMINI, MD Head of Ophthalmology Dpt, Istituto Auxologico di Milano, Italy

“I am a long time user of Z-HYALIN plus (Ophthalin plus) and I have never been disappointed. It‘s a very good all-around OVD.”


Dr. Till WERNER, MD Worms, Germany

“Like many ophthalmic surgeons the first OVD I got to know was Healon. Just a short time ago I have worked with Z-HYALIN plus for the first time and I am very comfortable with the good rheological behavior of this cohesive OVD. It is a biofermentative hyaluronic acid, produced without using any animal tissue. Its cohesive behavior maintains space perfectly for the relevant steps of cataract surgery and still provides good results for the phacoemulsification.“


Dr. Graeme MACINTOSH, MD Cheltenham Hospital, Gloucester, United Kingdom

“An ideal OVD should be biocompatible with ocular tissues, should create and maintain space during intraocular surgical manipulation and should protect the corneal endothelium. It should be easy to remove from the anterior chamber at the end of surgery and should have little effect on post operative IOP. Z-HYALIN plus offers me all these benefits and the peace of mind that goes with it!”

Dr. Alessandro GALAN

Dr. Alessandro GALAN, MD Direttore Unità Operativa Complessa Ospedale S. Antonio, Padova, Italy

“I tried a new viscoelastic, Z-HYALIN plus, in my daily surgery and I appreciated its quality and features fitting perfectly with my needs. It’s the ideal OVD for routine cataract surgery.”

Dr. Erfan KHADEM

Dr. Erfan KHADEM, MD Lead consultant. Care UK, Southampton, United Kingdom

“I have been using Z-HYALIN plus (Ophthalin plus) since 1996. I have no regrets and have experienced no problems. When I have moved departments, I have actively looked for this OVD. Z-HYALIN plus has all of the benefits and properties of Healon GV / Standard Healon. It offers great value for money with syringe containing 1 ml and not 0.85 ml. It’s my absolute preference for cataract surgery.”

Dr. Danielle DEIDIER

Dr. Danielle DEIDIER, MD Saint Vincent Clinic, Toulon, France

“Z-HYALIN plus is my choice for routine cataract surgery. By increasing the pseudoplasticity index and the zero-shear viscosity, Z-HYALIN plus allows very good creation and maintaining of volumes. Thus, it makes the surgery easier and, more important, avoids over complicating it. It protects intraocular tissues: endothelium and posterior capsule. Z-HYALIN plus, as a cohesive OVD, is easy to remove completely from the eye. It’s easy to use. It offers all the qualities of dispersive OVDs without having their drawbacks.”


“Z-HYALIN plus is also my favorite choice for MICS. Z-HYALIN plus fulfills all the specific requirements of the surgery through microincision: below 2 mm in C-MICS, below 1.3 mm in B-MICS, so surgery is in a closed environment. Z-HYALIN plus can be injected through a very thin cannula. During capsulorrhexis it offers excellent ease of maneuvers. The flap is not pushed against the anterior capsule offering more control and safety (a risk with the dispersive OVDs). During hydrodissection phase, there is no risk of capsular breakage due to over-pressure, because the viscoelastic can easily flow out through the micro-incisions (a risk with the dispersive OVDs). It’s the same during injection of the IOL, there is no risk of overpressure.”

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Z-HYALIN plus Testimonials

User testimonials

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The all-around cohesive OVD.

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  • 1 The molecular weight is calculated from average intrinsic viscosity according to the Mark–Houwink relationship.

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