NEURO-SPINE SURGERY

Surgical management of spinal intramedullary tumors

  • Clinical challenges
  • Case example
  • Peer Insights

Surgery of intraspinal tumors

The surgical management of intramedullary spinal cord tumors (IMSCT) remains a major clinical challenge for neurosurgeons. IMSCTs arise from the spinal cord itself, leading to invasion and destruction of gray and white matter1. They account for 2 – 4% of all primary central nervous system tumors (CNS tumors) and 20 – 30% of all spinal cord tumors2. The most prevalent types of intramedullary spine cord tumors are gliomas such as astrocytomas and ependymomas, as well as hemangioblastomas1.

The surgical resection of intramedullary tumors aims at maximizing the extent of tumor resection while minimizing damage to the spinal cord parenchyma to preserve neurological function. Therefore, surgeons are faced with the challenge of finding and inspecting the interface between tumor and spinal cord3. Gross total resection (GTR) of the tumor may become especially difficult in astrocytoma cases, where the infiltrative nature of the tumor leads to a poorly defined resection plane1,3.

Clinical challenges

  • Opening and access

    Opening and access

    Multi-level laminectomy and dura opening under magnification

  • Tumor margins

    Tumor margins

    Identification of tumor margins to increase extent of resection

  • Gross total resection

    Gross total resection

    Efficient use of additional visualization modalities such as intraoperative fluorescence to achieve GTR while preserving the spinal cord

Yu-Mi Ryang, MD

Intraoperative fluorescence is really helpful in the resection of the tumor, especially if you have problems in finding the resection plane between the spinal cord and the tumor.

Yu-Mi Ryang, MD Head of Department Neurosurgery and Center for Spine Therapy, Helios Klinikum Berlin-Buch, Germany

Resecting intramedullary spinal tumors

Exemplary case presented by Yu-Mi Ryang, MD
  • Laminectomy

    Laminectomy

    Laminectomy after midline linear skin incision and subperiosteal muscle dissection

  • Dura opening

    Dura opening

    Midline dura incision and dura sutures

  • Spinal cord incision

    Spinal cord incision

    Midline spinal cord incision between the posterior columns

  • Tumor resection

    Tumor resection

    Tumor resection under intraoperative fluorescence

  • Closing

    Closing

    Closing with pial and dura sutures

Advanced Visualization Systems from ZEISS

Maximizing extent of resection while preserving neurological function remains a major challenge in complex tumor cases, such as when resecting intramedullary spinal cord tumors. Visualization systems from ZEISS support neurosurgeons to gain greater certainty in their workflow by offering innovative visualization modalities for inspecting delicate anatomical structures. With the microscope integrated YELLOW 560 from ZEISS, fluorescence-stained structures are highlighted, while non-stained tissue is visualized in its natural-like color.4


  • 1

    M Das J, Hoang S, Mesfin FB. Intramedullary Spinal Cord Tumors. [Updated 2021 May 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK442031/

  • 2

    Khalid, S., Kelly, R., Carlton, A., Wu, R., Peta, A., Melville, P., Maasarani, S., Meyer, H., & Adogwa, O. (2019). Adult intradural intramedullary astrocytomas: a multicenter analysis. Journal of spine surgery (Hong Kong), 5(1), 19–30. https://doi.org/10.21037/jss.2018.12.06

  • 3

    Takami, T., Naito, K., Yamagata, T., & Ohata, K. (2015). Surgical management of spinal intramedullary tumors: radical and safe strategy for benign tumors. Neurologia medico-chirurgica, 55(4), 317–327. https://doi.org/10.2176/nmc.ra.2014-0344

  • 4

    Please use the fluorescent agent as per the approval status for the application in your country.

  • 5

    Stage image courtesy of Dr. Aaron Cohen-Gadol, MD, Director, Department of Neurosurgery, Indiana University, Indianapolis, USA

  • 6

    Images are courtesy of Yu-Mi Ryang, MD, Head of Department Neurosurgery and Center for Spine Therapy, Helios Klinikum Berlin-Buch, Germany