IORT in the OR
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Tailoring IORT to the needs of your patient.

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innovationMADE BY ZEISS

December 03 - 04, 2016 in Bangkok, Thailand

1st ZEISS INTRABEAM System APAC User Meeting

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Intraoperative Radiation Therapy (IORT)

The intraoperative radiation therapy (IORT) with the INTRABEAM System from ZEISS* enables a targeted, risk-adapted and interdisciplinary treatment of tumors. By using low energy x-rays the intraoperative radiation can be given with a high dose, local and precisely into the tumor or directly after resection to the tumor bed.

The radiation with the ZEISS INTRABEAM System enables an individual treatment minimizing collateral tissue damage and a shorter duration of the radiation therapy compared to EBRT. This can also reduce associated side effects and enhances the treatment comfort for the patient – a key element in increased quality of life.1




Breast Cancer

The  radiation therapy is an important element of the breast-conserving treatment for the mamma carcinoma. With intraoperative radiation therapy, radiation is given with a spherical applicator targeted to the area where the risk of recurrence is highest, directly into the tumor bed right after the tumor resection. The effectiveness of the TARGIT method is confirmed by the TARGIT-A study and is already used in numerous breast cancer centers worldwide.1


Spinal Metastases

The Kypho-IORT, a combination of intraoperative radiation and Kyphoplasty, enables the sterilization of the metastasis, offering immediate stabilization with pain reduction and at the same time avoiding damage to the healthy spinal cord. The combined procedure of Kypho-IORT offers immediate structural stabilization and provides local control of the tumor growth.2


Skin Cancer

The versatility of the ZEISS INTRABEAM System is also displayed in the treatment of skin cancer with electronic brachytherapy. For the treatment of non-melanoma skin cancer, kilovoltage irradiation is an important therapeutic option which is also suitable for patients with a high operative risk.3


Gastrointestinal Tumors

A complete resection of gastrointestinal tumors is sometimes not possible for many patients. By using intraoperative radiation with the INTRABEAM System from ZEISS, the local control of recurrent colorectal tumors and advanced local tumors can be improved.4


Head and Neck Tumors

In general, for IORT no differences in postoperative complications compared to EBRT have been found.5 This is a result of different factors: first, due to the precise and targeted delivery of radiation directly and only to the target volume, and second, with IORT from ZEISS the normal tissue and sensitive structures in the head and neck area can be spared.






The INTRABEAM® System from ZEISS offers decisive advantages for the intraoperative radiation therapy as well as for the electronic brachytherapy treatment. A targeted, local and highly effective therapy combined with an increased quality of life and treatment comfort for the patient.



In each IORT the best possible irradiation of the tumor or the tumor bed respectively the irradiation of non-melanoma skin tumors using electronic brachytherapy has to be ensured. Hence, ZEISS offers multiple applicators which ensure, depending on the type, size and shape of the tumor, an adapted dose distribution to the target tissue.



Training & Service

TARGIT Academy

The TARGIT Academy offers the user of a ZEISS INTRABEAM System a holistically first hand training course including an intensive hands-on training which is conducted on a peer-to-peer basis from experts for experts in the field of IORT/ electronic brachytherapy. Because the learning curve increases immediately the TARGIT Academy is equally suitable for all users.



The COMPLETE Service for the INTRABEAM System from ZEISS is an individual service package consisting of specialized service units according to customer requests, a straightforward device loaner concept and regular on-site inspections. With this concept an exact performance of the radiation therapy can be ensured at the customer site.


* The ZEISS INTRABEAM System consists of: INTRABEAM PRS 500 with XRS 4, INTRABEAM Cart and NC32 INTRABEAM Floor Stand

  • 1 Vaidya, J. S., Wenz, F., Bulsara, M., Tobias, J. S., Joseph, D. J., Keshtgar, M., … Baum, M. (2014). Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. The Lancet, 383(9917), 603–613.
  • 2 Wenz, F., Schneider, F., Neumaier, C., Kraus-Tiefenbacher, U., Reis, T., Schmidt, R., & Obertacke, U. (2010). Kypho-IORT - a novel approach of intraoperative radiotherapy during kyphoplasty for vertebral metastases. Radiation Oncology, 5(1), 11.
  • 3 Cognetta, A. B., Howard, B. M., Heaton, H. P., Stoddard, E. R., Hong, H. G., & Green, W. H. (2012). Superficial x-ray in the treatment of basal and squamous cell carcinomas: a viable option in select patients. Journal of the American Academy of Dermatology, 67(6), 1235–41.
  • 4 Algur, E., Mahadevan, A., & Deibel, C. (2005). Interstitial photon radiosurgery system for re-current and locally advanced rectal cancer: a retrospective review of 24 patients. ASCO Gastrointestinal Cancers Symposium, Jan 27–29, Hollywood, Florida, USA, Abstract No 208.
  • 5 Rutkowski, T., Wygoda, A., Hutnik, M., Składowski, K., Wydmański, J., Maciejewski, A., … Maciejewski, B. (2010). Intraoperative Radiotherapy (IORT) with Low-Energy Photons as a Boost in Patients with Early-Stage Oral Cancer with the Indications for Postoperative Radiotherapy. Strahlentherapie Und Onkologie, 186(9), 496–501.
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