IORT in the OR
innovationMADE BY ZEISS

Tailoring IORT to the needs of your patient.

This is the moment we work for.

innovationMADE BY ZEISS
innovationMADE BY ZEISS

Expanding your radiotherapy environment with targeted effectivness.


Learn more

innovationMADE BY ZEISS

Intraoperative Radiation Therapy (IORT)

Intraoperative radiation therapy (IORT) from ZEISS enables a targeted, risk-adapted and interdisciplinary treatment of tumors. By using low energy x-rays intraoperative radiation can be given with a high dose, precisely into the tumor or directly after resection to the tumor bed.

Radiation with INTRABEAM® enables an individual treatment minimizing collateral tissue damage and a shorter duration of the radiation therapy compared to external beam radiation therapy (EBRT). This can also reduce associated side effects and enhances treatment comfort for the patient – a key element in increased quality of life.1




Breast Cancer

Radiation therapy is an important element of the breast-conserving treatment for the mamma carcinoma. With intraoperative radiation therapy, radiation is given with a spherical applicator targeted to the area where the risk of recurrence is highest, directly into the tumor bed right after tumor resection. The effectiveness of the TARGIT method is confirmed by the TARGIT-A study and is already used in many breast cancer centers worldwide.1


Spinal Metastases

Kypho-IORT, a combination of intraoperative radiation and Kyphoplasty, enables the sterilization of the metastasis, offering immediate stabilization with pain reduction and at the same time avoiding damage to the healthy spinal cord. The combined procedure of Kypho-IORT offers immediate structural stabilization and provides local control of the tumor growth.2


Skin Cancer

The versatility of the INTRABEAM® is also displayed in the treatment of skin cancer with electronic brachytherapy. For the treatment of non-melanoma skin cancer, kilovoltage irradiation is an important therapeutic option which is also suitable for patients with a high operative risk.3


Gastrointestinal Tumors

A complete resection of gastrointestinal tumors is sometimes not possible for many patients. By using intraoperative radiation with the INTRABEAM®, the local control of recurrent colorectal tumors and advanced local tumors can be improved.4


Head and Neck Tumors

In general, for IORT no differences in postoperative complications compared to EBRT have been found.5 This is a result of different factors: first, due to the precise and targeted delivery of radiation directly and only to the target volume, and second, with IORT from ZEISS the normal tissue and sensitive structures in the head and neck area can be spared.






As third device generation of IORT from ZEISS, the new INTRABEAM 600 is the first fully integrated and connected treatment platform for IORT addressing multiple clinical needs in one solution.



The second device generation of IORT from ZEISS is the INTRABEAM System*, which is the only intraoperative radiation device used for the Phase III randomized trial "TARGIT-A" with more than 12 years of clinical study expertise.



In each IORT the best possible irradiation of the tumor or the tumor bed respectively the irradiation of non-melanoma skin tumors using electronic brachytherapy has to be ensured. Hence, ZEISS offers multiple applicators which ensure, depending on the type, size and shape of the tumor, an adapted dose distribution to the target tissue.



Training & Service

TARGIT Academy

For INTRABEAM® users, the TARGIT Academy offers a practical first hand training course including an intensive hands-on training which is conducted on a peer-to-peer basis from experts for experts in the field of IORT/ electronic brachytherapy. Due to the fact that the learning curve increases immediately the TARGIT Academy is equally suitable for all users.



The COMPLETE Service for the INTRABEAM® is an individual service package consisting of specialized service units according to customer requests, a straightforward device loaner concept and regular on-site inspections. With this concept an exact performance of the radiation therapy can be ensured at the customer site.


* The ZEISS INTRABEAM System consists of: INTRABEAM PRS 500 with XRS 4, INTRABEAM Cart and NC32 INTRABEAM Floor Stand

  • 1 Vaidya, J. S., Wenz, F., Bulsara, M., Tobias, J. S., Joseph, D. J., Keshtgar, M., … Baum, M. (2014). Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. The Lancet, 383(9917), 603–613.
  • 2 Wenz, F., Schneider, F., Neumaier, C., Kraus-Tiefenbacher, U., Reis, T., Schmidt, R., & Obertacke, U. (2010). Kypho-IORT - a novel approach of intraoperative radiotherapy during kyphoplasty for vertebral metastases. Radiation Oncology, 5(1), 11.
  • 3 Cognetta, A. B., Howard, B. M., Heaton, H. P., Stoddard, E. R., Hong, H. G., & Green, W. H. (2012). Superficial x-ray in the treatment of basal and squamous cell carcinomas: a viable option in select patients. Journal of the American Academy of Dermatology, 67(6), 1235–41.
  • 4 Algur, E., Mahadevan, A., & Deibel, C. (2005). Interstitial photon radiosurgery system for re-current and locally advanced rectal cancer: a retrospective review of 24 patients. ASCO Gastrointestinal Cancers Symposium, Jan 27–29, Hollywood, Florida, USA, Abstract No 208.
  • 5 Rutkowski, T., Wygoda, A., Hutnik, M., Składowski, K., Wydmański, J., Maciejewski, A., … Maciejewski, B. (2010). Intraoperative Radiotherapy (IORT) with Low-Energy Photons as a Boost in Patients with Early-Stage Oral Cancer with the Indications for Postoperative Radiotherapy. Strahlentherapie Und Onkologie, 186(9), 496–501.
We use cookies on this site. Cookies are small text files that are stored on your computer by websites. Cookies are widely used and help to optimize the pages that you view. By using this site, you agree to their use. more