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Creating vision with a SMILE. ZEISS ReLEx SMILE
innovationMADE BY ZEISS


  • Product Information
    ReLEx – Laser vision correction beyond LASIK

    ReLEx SMILE from ZEISS

    The first minimally invasive, flapless SMILE solution

    ReLEx® SMILE from ZEISS is the first and, until now, only solution for performing small incision lenticule extraction, or SMILE for short. ZEISS is the only company to provide a way for treating patients with this minimally invasive, flapless procedure. Now it is time: Move up to the 3rd generation of laser vision correction – with ZEISS ReLEx SMILE.

    Minimally invasive, flapless surgery

    Note: This diagram is based on an optical zone of 6.5 mm.

    Minimally invasive, flapless surgery
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    Explore the advantages of ReLEx SMILE from ZEISS

    Minimally invasive, flapless surgery – With ReLEx SMILE, a lenticule and a small incision of 2 – 4 mm is created inside the intact cornea, enabling an
    80 % smaller side-cut as compared to a LASIK flap. Furthermore, 30 % less cap cut is needed.

    First SMILE solution
    – With ReLEx SMILE, ZEISS is at the forefront of the
    3rd generation of laser vision correction, a procedure that is redefining refractive laser surgery as we know it.

    ZEISS technology – High precision and quality, experience in optics and refractive surgery, ease of use and seamless integration are what ZEISS technology stands for.

    ReLEx SMILE indication range for myopia and astigmatism:

    • Sphere: -0.50 to -10.00 D
    • Cylinder: 0 to 5.00 D
    • Spherical equivalent: -0.50 to -12.50 D
  • Treatment Steps

    Refractive correction with ReLEx SMILE from ZEISS

    Whereas LASIK procedures involve cutting a flap, folding it back and removing the corneal tissue through point-by-point ablation using an excimer laser,
    ZEISS ReLEx® SMILE utilizes the high-precision femtosecond laser VisuMax® from ZEISS to create a lenticule inside the cornea and access incision in a single treatment step.

    SMILE with VisuMax

    SMILE with VisuMax

    A refractive lenticule and small incision are created inside the intact cornea – all in one step.

    SMILE with VisuMax

    The lenticule is removed through the incision with only minimal disruption to the corneal biomechanics.

    SMILE with VisuMax

    Removing the lenticule changes the shape of the cornea, thereby achieving the desired refractive correction.

    Find out more about all three Generations
    of Laser Vision Correction – SMILE, LASIK and PRK!

  • Benefits

    SMILE combines the advantages of PRK and LASIK. With ReLEx® SMILE from ZEISS, minimally invasive, flapless surgery is possible for the very first time. It is the only SMILE product available on the market.


    Relex 2x doctor using relex

    ReLEx SMILE enables to perform the flapless SMILE procedure. Because there is no flap, there are also no flap-related complications. ReLEx SMILE reduces the incidence of infections and epithelial ingrowth while expediting epithelial healing.


    Up to 80 % smaller side-cut
    Femto-LASIK requires a side-cut of roughly 20 mm. With ZEISS ReLEx SMILE,
    a small incision of 2 – 4 mm is sufficient.


    Up to 30 % smaller cap incision area
    The lamellar incision area is roughly 1/3 smaller compared to Femto-LASIK.


    Greater integrity of the upper corneal layers
    With SMILE, the majority of the upper corneal layers remains intact. This offers the potential for more biomechanical preservation and stability.


    Less incidence of dry eye
    Requiring only a small incision rather than a flap, there are fewer transected nerves. Consequently, a significantly reduced incidence of dry eye is likely to be correlated.


    Relex 2x relex

    With ZEISS ReLEx SMILE, the entire procedure is performed with the groundbreaking femtosecond laser technology of the VisuMax®. As a result, there is no need for complex nomograms or fluence tests.


    Accuracy and dependability every time
    ZEISS ReLEx SMILE embodies precision, predictability, reproducibility and perfection. Using the VisuMax, it creates a precalculated lenticule and incision with utmost accuracy and dependability.


    In a way, it could be called one-stop refractive surgery. With
    ZEISS ReLEx SMILE, the entire correction is performed as a single-step: on one laser, with one treatment plan and one laser process.


    Lenticule and access in one
    What also makes it a single-step solution is that the lenticule inside the intact cornea as well as the access incision are created in one treatment step.


    Enhanced patient experience
    Incorporating superior ZEISS technology, ZEISS ReLEx SMILE enhances the treatment experience for patients with the outstanding cutting precision, exceptional speed and gentle treatment approach of the ZEISS VisuMax.

  • Clinical Data

    ReLEx SMILE – clinical results


    ReLEx smile - clinical results


    The clinical study reports on the results of the ReLEx® SMILE procedure for the correction of myopia and astigmatism (3 month results).1

    Background and method

    • 269 eyes were analyzed and evaluated in three study centers.
    • All the eyes had a BCVA of 20/20 or better before the operation.


    • Consistent results with outstanding predictability
    • Very close to target refraction
    • Valid across entire range of correction, from low to high-level myopia


    • 85 % of all patients with a preoperative best-corrected visual acuity of 20/20 or higher achieved uncorrected visual acuity of 20/20 or higher after surgery.


    • Impressive stability of the refractive correction (MR SEQ)


    • 100 % of all patients achieved target refraction within the typical "satisfaction zone" (± 1 D)
    • 97 % of all patients achieved target refraction with a precision of ± 0.5 D
  • Media Library

    Welcome to our download area.


    Broadening the vision of success

    Page(s): 6
    Filesize: 3,677 kB

    ReLEx SMILE from ZEISS

    The first minimally invasive SMILE solution

    Page(s): 4
    Filesize: 6,784 kB

    VisuMax from ZEISS

    Defining the pulse rate in refractive surgery

    Page(s): 6
    Filesize: 7,123 kB

    Video Downloads

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    ReLEx SMILE Trailer

    Type of file: mp4
    Filesize: 43.4 MB


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    ReLEx SMILE with VisuMax

    Type of file: mp4
    Filesize: 7.3 MB


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    SMILE in clinical usage – Prof. Reinstein

    Type of file: mp4
    Filesize: 107.6 MB


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    ReLEx SMILE minimally invasive surgery - Prof. Reinstein

    Type of file: mp4
    Filesize: 62.5 MB


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    Video ReLEx SMILE - Rupal Shah, MD

    Type of file: mp4
    Filesize: 28.3 MB


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    ReLEx SandArt Video

    Type of file: mp4
    Filesize: 40.9 MB


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    AAO 2012 - J. A. Ramirez-Miranda, MD

    ReLEx smile: Refractive Correction Without Flap

    Type of file: mp4
    Filesize: 25.2 MB


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    AAO 2012 - J. Dishler, MD

    Initial U.S. Clinical Trial Results: New ReLEx smile Procedure for Spherical Myopia Correction

    Type of file: mp4
    Filesize: 19.6 MB


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  • 1 Jesper Hjortdal (Aarhus Universitetshospital und Kommunehospital, Denmark), Rupal Shah (New Vision Laser Centers, India), Osama Ibrahim (Roayah Vision Center Alexandria, Egypt), Controlled Multicenter Study, data on file, 2011
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