Implementation of confocal endomicroscopy in brain surgery

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Dr. Simon Johannes Leierseder

Carl Zeiss Meditec AG


Implementation of confocal endomicroscopy in brain surgery

For enhancing intraoperative decision-making during surgical procedures, fluorescence-based imaging techniques are emerging as valuable tools. Particularly in the field of neurosurgery this method is becoming increasingly adopted in order to highlight vascular structures and tumors1. Typically, these methods are aimed at macroscopic visualization of fluorescent areas and rely on surgical microscopes which are equipped with appropriate filters and light sources. For confocal endomicroscopy (CEM)2 this principle has been refined to visualize the microstructure of tissue at high magnification. It delivers images in real time and in vivo, i.e. without the need to extract tissue. This document addresses the following topics:

  • Basics of confocal endomicroscopy
  • Summary of published and unpublished experience
  • Interpretation of confocal images

Sample pages from the whitepaper3

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