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Compendium

Publications presenting the usage of intraoperative radiotherapy (IORT) for oncological treatments

Focusing on indications, medical physics, radiobiology, technology aspects, quality of life as well as guidelines & recommendations

FEB 01, 2022 · 2 MIN READ
Compiled by

ZEISS Medical Technology

SUMMARY

List of articles about IORT as part of radiation oncology treatments

In this literature compendium ZEISS presents various clinical articles on IORT for various oncological indications but also focusing on specific relevant aspects, such as: medical physics, radiobiology, technology aspects, quality of life, cosmesis, guidelines, recommendations or health technology assessments (HTA) in English and German. The aim is to provide further information and share knowledge.

Each publication is based on the author´s own professional opinion or on their study results. It does not necessarily reflect the opinion of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or intended purpose of our medical devices. Therefore, suitability of clinical application for each publication should be carefully assessed by the concerned physician.

Oncological Indications

  • Year
    Title
    Link
    Journal
    Authors
    2021 Nov
    Intraoperative Radiotherapy in Brain Malignancies: Indications and Outcomes in Primary and Metastatic Brain Tumors
    Frontiers in oncology
    Cifarelli CP, Jacobson GM
    2021 Oct
    Dosimetric Comparison of Upfront Boosting With Stereotactic Radiosurgery Versus Intraoperative Radiotherapy for Glioblastoma
    Frontiers in oncology
    Sarria GR, Smalec Z, Muedder T, Holz JA, Scafa D, Koch D, Garbe S, Schneider M, Hamed M, Vatter H, Herrlinger U, Giordano FA, Schmeel LC
    2021 Aug
    Intraoperative radiotherapy with low-energy x-rays after neurosurgical resection of brain metastases- an Augsburg University Medical Center experience
    Strahlentherapie und Onkologie
    Kahl KH, Balagiannis N, Höck M, Schill S, Roushan Z, Shiban E, Müller H, Grossert U, Konietzko I, Sommer B, Maurer CJ, Berlis A, Heidecke V, Janzen T, Stüben G
    2021 Mar
    Dose homogeneity analysis of adjuvant radiation treatment in surgically resected brain metastases: Comparison of IORT, SRS and IMRT indices
    Brachytherapy
    Dahshan BA, Weir JS, Bice RP, Renz P, Cifarelli DT, Poplawski L, Hack J, Vargo JA, Cifarelli CP
    2020 Feb
    Current approaches to the management of brain metastases
    Clinical Oncology
    Suh JH, Kotecha R, Chao ST, Ahluwalia MS, Sahgal A, Chang EL
    2019 Oct
    Intraoperative radiotherapy (IORT) for surgically resected brain metastases: outcome analysis of an international cooperative study
    Journal of Neuro-Oncology
    Cifarelli CP, Brehmer S, Vargo JA, Hack JD, Kahl KH, Sarria-Vargas G, Giordano FA
    2019 Sep
    Intraoperative Radiotherapy for Glioblastoma: An International Pooled Analysis
    International Journal of Radiation Oncology, Biology & Physics
    Sarria GR, Sperk E, Xiaodi H, Sarria G, Wenz F, Brehmer S, Fu B, Min S, Zhang H, Qin S, Qiu, X, Abo-Madyan Y, Hänggi D, Martinez DA, Cabrera C, Giordano FA
    2019 May
    Intraoperative radiotherapy (IORT) for surgically resected brain metastases: Local control and dosimetric analysis.
    Journal of Global Oncology
    Cifarelli CP, Vargo JA, Hack JD, Renz PB, Poplawski L, Jacobson GM, Kahl KH, Brehmer S, Sarria G, Giordano FA
    2019 Jan
    Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Treatment of Adults With Metastatic Brain Tumors: Executive Summary
    Neurosurgery
    Olson JJ, Kalkanis SN, Ryken TC
    2018 Aug
    Feasibility of dose escalation using intraoperative radiotherapy following resection of large brain metastases compared to post-operative stereotactic radiosurgery
    Journal of Neuro-Oncology
    Vargo JA, Sparks KM, Singh R, Jacobson GM, Hack JD, Cifarelli CP
    2018 Apr
    Combined stereotactic biopsy and stepping-source interstitial irradiation of glioblastoma multiforme
    Journal of Neurosurgical Sciences
    Brehmer S, Guthier CV, Clausen S, Schneider F, Schulte DM, Benker M, Bludau F, Glatting G, Marx A, Schmiedek P, Hesser J, Wenz F, Giordano FA
    2018 Mar
    Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma (INTRAGO): An Open-Label, Dose-Escalation Phase I/II Trial
    Neurosurgery
    Giordano FA, Brehmer S, Mürle B, Welzel G, Sperk E, Keller A, Abo-Madyan Y, Scherzinger E, Clausen S, Schneider F, Herskind C, Glas M, Seiz-Rosenhagen M, Groden C, Hänggi D, Schmiedek P, Emami B, Souhami L, Petrecca K, Wenz F
    2016 Oct
    Initial Results of a Phase 1/2 Trial on Intraoperative Radiation Therapy (IORT) in Newly Diagnosed Glioblastoma Multiforme (INTRAGO)
    International Journal of Radiation Oncology, Biology & Physics
    Giordano FA, Brehmer S, Muerle B, Welzel G, Sperk E, Schneider F, Clausen S, Schmiedek P, Groden C, Hänggi D, Abo-Madyan Y, Wenz F
    2016 Jan
    Rationale for intraoperative radiotherapy in glioblastoma
    Journal of Neurosurgical Sciences
    Giordano FA, Wenz F, Petrecca K
    2015 Apr
    Intraoperative radiotherapy to treat newly diagnosed solitary brain metastasis: initial experience and long-term outcomes
    Journal of Neurosurgery
    Weil RJ, Mavinkurve GG, Chao ST, Vogelbaum MA, Suh JH, Kolar M, Toms SA
    2014 Sep
    INTRAOPERATIVE RADIOTHERAPY WITH INTRABEAM IN PRIMARY BRAIN TUMORS AFTER RESECTION: PRELIMINARY REPORTS OF 26 CASES
    Neuro-Oncology
    Han X, Fu B, Wu M, Zhang H, Li D, Zhang J, Sun D, Sun S
    2014 Feb
    Intraoperative radiotherapy (IORT)—a resurrected option for treating glioblastoma?
    Translational Cancer Research
    Giordano FA, Abo-Madyan Y, Brehmer S, Herskind C, Sperk E, Schneider F, Clausen S, Welzel G, Schmiedek P, Wenz F
    2006 Apr
    Phase I study of intraoperative radiotherapy with photon radiosurgery system in children with recurrent brain tumors: Preliminary report of first dose level (10 Gy)
    International Journal of Radiation Oncology, Biology & Physics
    Kalapurakal JA, Goldman S, Stellpflug W, Curran J, Sathiaseelan V, Marymont MH, Tomita T 
  • Year
    Title
    Link
    Journal
    Authors
    2021 Jan
    Kyphoplasty and intra-operative radiotheray, combination of kyphoplasty and intra-operative radiation for spinal metastases: technical feasibility of a novel approach
    International Orthopaedics
    Schmidt R, Wenz F, Reis T, Janik K, Bludau F, Obertacke U
    2019 May
    Combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful vertebral metastases - a randomized phase III study
    BMC Cancer
    Bludau F, Welzel G, Reis T, Abo-Madyan Y, Sperk E, Schneider F, Clausen S, Ruder AM, Obertacke U, Ghaly MM, Wenz F, Giordano FA
    2018 May
    Phase I/II trial of combined kyphoplasty and intraoperative radiotherapy in spinal metastases
    The Spine Journal
    Bludau F, Welzel G, Reis T, Schneider F, Sperk E, Neumaier C, Ehmann M, Clausen S, Obertacke U, Wenz F, Giordano FA
    2017 Aug
    Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases
    Scientific Reports
    Mohme M, Riethdorf S, Dreimann M, Werner S, Maire CL, Joosse SA, Bludau F, Mueller V, Neves RPL, Stoecklein NH, Lamszus K, Westphal M, Pantel K, Wikman H, Eicker SO
    2015 Sep
    Kyphoplastie kombiniert mit intraoperativer Radiotherapie (Kypho-IORT)
    Der Radiologe
    Bludau F, Reis T, Schneider F, Clausen S, Wenz F, Obertacke U
    2014 Jan
    Kypho-IORT: the first French treatment
    Translational Cancer Research
    Miglierini P, Dam-Hieu P, Key S
    2013 Jul
    Kyphoplastie in Kombination mit intraoperativer Radiotherapie
    Der Orthopäde
    Kayser R, Ender SA, Asse E, Wilhelm E, Adler F, Schmidt R, Wenz F, Obertacke U, Bludau F
  • Year
    Title
    Link
    Journal
    Authors
    2022 Jan
    Intraoperative Radiotherapy for Breast Cancer in Elderly Women
    Clinical Breast Cancer
    Guillerm SO, Bourstyn E, Itti R, Cahen-Doidy L, Quéro L, Labidi M, Marchand E, Lorphelin H, Giacchetti S, Cuvier C, Espié M, Teixeira L, Hennequin C
    2021 Jun
    Hypofractionated whole breast irradiation after IORT treatment is safe in patients receiving adjuvant chemotherpy
    Clinical and Translational Oncology
    Burgos-Burgos J, Vega V, Macias-Verde D, Gómez V, Travieso-Aja M, Travieso J, Vicente E, Murias C, Santana C, Ospina J, Lara PC
    2021 May
    New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer
    British Journal of Cancer
    Vaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Douek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams NR, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Corica T, Lundgren S, Holmes DR, Vinante L, Bozza F, Pazos M, Le Blanc-Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Joseph DJ, Tobias JS
    2021 Apr
    Intraoperative radiotherapy booster as part of breast-conservation therpy for breast cancer: a single-institution retrospective analysis
    Strahlentherapie und Onkologie
    Stoian R, Erbes T, Zamboglou C, Scholber J, Galney M, Sachpazidis I, Haehl E, Spohn SK, Verma V, Krug D, Rühle A, Juhasz-Böss I, Grosu AL, Nicolay NH, Sprave T
    2021 Apr
    Comparison of IORT (Radical and Boost Dose) and EBRT in Terms of Disease-Free Survival and Overall Survival according Demographic, Pathologic, and Biological Factors in Patients with Breast Cancer
    International Journal of Oncology
    Hashemi S, Javadi S, Akbari ME, Mirzaei H, Mahdavi SR
    2021 Mar
    Patients Older 65 Years With Early Breast Cancer Prefer Intraoperative Radiation as a Locoregional Treatment Choice
    Annals of Surgical Oncology
    Tang A, Cohan CM, Beattie G, Cureton EL, Svahn JD, Lyon LL, Kelly JF, Shim VC
    2021 Feb
    Assessment of Thyroid Lobe Dose in Breast Cancer Intraoperative Radiotherapy
    Journal of Biomedical Physics and Engineering
    Farkhani RR, Gholamhosseinian H, Anvari K, Forghani MN
    2021 Feb
    Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment
    British Journal of Cancer
    Vaidya JS, Bulsara M, Baum M, Tobias JS on behalf of TARGIT-A trial authors
    2021 Jan
    Intraoperative radiotherapy for breast cancer: powerful evidence to change practice
    Clinical Oncology
    Vaidya JS, Bulsara M, Baum M, Alvarado M, Bernstein M, Massarut S, Saunders C, Sperk E, Wenz F, Tobias JS, TARGIT-A investigators
    2021 Jul
    TARGIT-IORT during lumpectomy for breast cancer- better for patients than other PBI approaches
    Full Text
    International Journal of Radiation Oncology, Biology & Physics
    Vaidya JS, Bulsara M, Sperk E, Massarut S, Douek M, Alvarado M, Pigorsch S, Holmes D, Bernstein M, Saunders C, Flyger H, Joseph D, Wenz F, Tobias JS, TARGIT-A investigators
    2021 Feb
    Intraoperative radiotherapy in early breast cancer: observational comparison with whole breast radiotherapy
    Cirugía Espanola
    Guillén JRO, Almudi EH, Osorio GM, Carreras RI, Gómez JAF, Gómez IV, Mur CG, Franco MCC
    2020 Aug
    Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial
    The BMJ
    Vaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Douek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams NR, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Corica T, Lundgren S, Holmes DR, Vinante L, Bozza F, Pazos M, Le Blanc-Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Joseph DJ, Tobias JS, TARGIT-A trial authors
    2020 Mar
    The actual benefit of intraoperative radiation therapy using 50 kV x-rays in early breast cancer: A retrospective study of 676 patients
    The Breast Journal
    Tallet A, Racadot S, Boher J.-M, Cohen M, Barrou J, Houvenaeghel G, Gutowski M, Delmond L, Lemanski C
    2019 Sep
    First per Protocol Analysis of the Prospective Phase II Study of Intraoperative Radiotherapy (IORT) in Elderly Patients with Small Breast Cancer: Targit E(lderly)
    International Journal of Radiation Oncology, Biology & Physics
    Sperk E
    2017 Dec
    Intraoperative Radiotherapy for Breast Cancer
    Frontiers in Oncology
    Harris EER, Small W
    2017 Sep
    Targeted Intraoperative Radiotherapy Tumour Bed Boost during Breast-Conserving Surgery after Neoadjuvant Chemotherapy - a Subgroup Analysis of Hormone Receptor-Positive HER2-Negative Breast Cancer
    Breast Care
    Kolberg H-C, Lövey G, Akpolat-Basci L, Stephanou M, Fasching P, Untch M, Hoffmann O, Bulsara M, Vaidya J, Liedtke C
    2017 Aug
    Keynote Address at the American Society of Breast Surgeons 18th Annual Meeting
    Annals of Surgical Oncology
    Wenz F
    2017 Feb
    Early complications after intraoperative radiotherapy revisited
    Journal of Surgical Oncology
    Holmes DR
    2017 Jan
    Intraoperative radiotherapy (IORT) as boost in breast cancer
    Radiation Oncology
    Sedlmayer F, Reitsamer R, Wenz F, Sperk E, Fussl C, Kaiser J, Ziegler I, Zehentmayr F, Deutschmann H, Kopp P, Fastner G
    2016 Nov
    Targeted intraoperative radiotherapy tumour bed boost during breast-conserving surgery after neoadjuvant chemotherapy
    Strahlentherapie und Onkologie
    Kolberg H-C, Loevey G, Akpolat-Basci L, Stephanou M, Fasching PA, Untch M, Liedtke C, Bulsara M, Vaidya JS
    2016 Oct
    Reduced Mortality With Partial-Breast Irradiation for Early Breast Cancer: A Meta-Analysis of Randomized Trials
    International Journal of Radiation Oncology, Biology & Physics
    Vaidya JS, Bulsara M, Wenz F, Coombs N, Singer J, Ebbs S, Massarut S, Saunders C, Douek M, Williams NR, Joseph DJ, Tobias JS, Baum M
    2015 Nov
    Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the Breast
    The Breast Journal
    Rivera R, Banks A, Casillas-Lopez A, Rashtian A, Lewinsky B, Sheth P, Hovannesian-Larsen L, Brousseau D, Holmes DR
    2015 Jul
    Pride, Prejudice, or Science: Attitudes Towards the Results of the TARGIT-A Trial of Targeted Intraoperative Radiation Therapy for Breast Cancer
    International Journal of Radiation Oncology, Biology & Physics
    Vaidya JS, Bulsara M, Wenz F, Joseph D, Saunders C, Massarut S, Flyger HL, Eiermann W, Alvarado M, Esserman L, Falzon M, Brew-Graves C, Potyka I, Tobias JS, Baum M
    2015 Feb
    Intraoperative Radiotherapy of the Breast for Early-Stage Breast Cancer: Ready for Primetime
    The Breast Journal
    Holmes DR
    2014 Dec
    Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences
    International Journal of Breast Cancer
    Malter W, Kirn V, Richters L, Fridrich C, Markiefka B, Bongartz R, Semrau R, Mallmann P, Kraemer S
    2014 Jul
    A cohort analysis to identify eligible patients for intraoperative radiotherapy (IORT) of early breast cancer
    Radiation Oncology
    Sperk E, Astor D, Keller A, Welzel G, Gerhardt A, Tuschy B, Sütterlin M, Wenz F
    2014 Feb
    Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial
    The Lancet
    Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M, Flyger HL, Massarut S, Alvarado M, Saunders C, Eiermann W, Metaxas M, Sperk E, Sütterlin M, Brown D, Esserman L, Roncadin M, Thompson A, Dewar JA, Holtveg HMR, Pigorsch S, Falzon M, Harris E, Matthews A, Brew-Graves C, Potyka I, Corica T, Williams NR, Baum M
    2013 Jun
    Cost-Effectiveness Analysis of Intraoperative Radiation Therapy for Early-Stage Breast Cancer
    Annals of Surgical Oncology
    Alvarado MD, Mohan AJ, Esserman LJ, Park CC, Harrison BL, Howe RJ, Thorsen C Ozanne EM
    2012 Jul
    Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT A
    Breast Cancer Research and Treatment
    Sperk E, Welzel G, Keller A, Kraus-Tiefenbacher U, Gerhardt A, Sütterlin M, Wenz F
    2011 May
    Targeted Intraoperative Radiotherapy for Breast Cancer in Patients in Whom External Beam Radiation Is Not Possible
    International Journal of Radiation Oncology, Biology & Physics
    Keshtgar MRS, Vaidya JS, Tobias JS, Wenz F, Joseph D, Stacey C, Metaxas MG, Keller A, Corica T, Williams NR, Baum M
  • Title
    Title
    Link
    Journal
    Authors
    2021 Dec
    Dosimetric Comparison of Intraoperative Radiotherapy and SRS for Liver Metastases
    Frontiers in Oncology
    Scafa D, Muedder T, Holz JA, Koch D, Nour Y, Garbe S, Gonzalez-Carmona MA, Feldmann G, Vilz TO, Köksal M, Giordano FA, Schmeel LC, Sarria GR
    2021 Apr
    The role of intraoperative radiotherapy in advanced rectal cancer: a meta- analysis
    Colorectal Disease
    Fahy MR, Kelly ME, Foley MP, Nugent TS, Shields CJ, Winter DC
    2020 Aug
    INTRABEAM intraoperative radiotherapy combined with portal vein infusion chemotherapy for treating hepatocelular carcinoma with portal vein tumor thrombus
    BMC Surgery
    Song X, He Y, Liang H, Han M, Shao Z
    2020 Jun
    Low-kilovolt x-ray intraoperative radiotherapy for pT3 locally advanced colon cancer: a single-institution retrospective analysis
    World Journal of Surgical Oncology
    Ma L, Qiang J, Yin H, Lin L, Jiao Y, Ma C, Li X, Dong L, Cui J, Wei D, Sharma AM, Schwartz DL, Gu W, Chen H
    2020 Apr
    Intraoperative Strahlentherapie in der Abdominalchirurgie- eigene Erfahrungen
    Der Chirurg
    Joechle K, Gkika E, Grosu AL, Hopt UT, Neeff HP, Fichtner-Feigl S, Lang SA
    2020 Feb
    Short-term outcomes of laparoscopic intersphincteric resection with intraoperative radiotherapy using low-energy X-rays for primary locally advanced low rectal cancer: a single center experience
    World Journal of Surgical Oncology
    Xue W, Wang S, Zhao Z, Li Y, Shang A, Li D, Yang J, Wang T, Wang M
    2020 Jan
    Intraoperative radiotherapy as an immediate adjuvant treatment of rectal cancer due to limited access to external-beam radiotherapy
    Radiation Oncology
    Potemin S, Kübler J, Uvarov I, Wenz F, Giordano F
    2019 Mar
    A phase II study of intraoperative radiotherapy using a low-energy x-ray source for resectable pancreatic cancer: a study protocol
    BMC Surgery
    Kim JW, Cho Y, Kim HS, Choi WH, Park JS, Lee IJ
    2016 May
    The Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal Cancer
    Radiation Oncology
    Susko M, Lee J, Salama J, Thomas S, Uronis H, Hsu D, Migaly J, Willett C, Czito B, Palta M
    2016 Mar
    Intraoperative radiotherapy with low energy photons in recurrent colorectal cancer: a single centre retrospective study
    Contemporary Oncology
    Skórzewska M, Mielko J, Kurylcio A, Romanek J, Polkowski WP
    2015 Apr
    Intraoperative radiotherapy in locally-advanced and recurrent rectal cancer: retrospective review of 68 cases
    Translational Cancer Research
    Potemin S, Uvarov I, Vasilenko I
    2013 Nov
    Intraoperative Radiotherapy with Low-Energy Photons in Rectal Cancer Recurrence
    Targeted Intraoperative Radiotherapy in Oncology (Book)
    Polkowski WP, Skórzewska M
    2012 Jul
    Intraoperative radiation therapy with the photon radiosurgery system in locally advanced and recurrent rectal cancer: retrospective review of the Cleveland clinic experience
    Radiation Oncology
    Guo S, Reddy CA, Kolar M, Woody N, Mahadevan A, Deibel F, Dietz DW, Remzi FH, Suh JH
  • Year
    Title
    Link
    Journal
    Authors
    2016 Dec
    Intraoperative radiation therapy (IORT) in head and neck cancer: A systematic review
    Medicine
    Kyrgias G, Hajiioannou J, Tolia M, Kouloulias V, Lachanas V, Skoulakis C, Skarlatos I, Rapidis A, Bizakis I
    2016 Apr
    Intra-operative radiation therapy (IORT) in recurrent head and neck cancer
    Oral Oncology
    De Felice F, Musio D, Tombolini V
    2015 Apr
    Intraoperative radiotherapy (IORT) in the treatment of head and neck cancer
    Translational Cancer Research
    Münter MW, Köppen U, Ramuscak A, Sittel C, Wegner N
    2013 Dec
    Current advances in radiotherapy of head and neck malignancies
    Full Text
    Journal of International Oral Health
    Roopashri G, Baig M
  • Year
    Title
    Link
    Journal
    Authors
    2019 Sep
    Intraoperative Radiotherapy with Low Energy x-Rays for Primary and Recurrent Soft-Tissue Sarcoma
    International Journal of Radiation Oncology, Biology & Physics
    Sarria, G. R., Petrova, V., Abo-Madyan, Y., Wenz, F., Hohenberger, P., Sperk, E., & Giordano, F. A.
    2012 Dec
    Superficial x-ray in the treatment of basal and squamous cell carcinomas: A viable option in select patients
    Journal of the American Academy of Dermatology
    Cognetta AB, Howard BM, Heaton HP, Stoddard ER, Hong HG, Green W H
    2012 Mar
    Radiation Therapy and Skin Cancer
    Modern Practices in Radiation Therapy
    Tward JD, Anker CJ. Gaffney DK, Bowen G
    2003 May
    Use of Low-Energy X-Rays in the Treatment of Superficial Nonmelanomatous Skin Cancers
    Cancer Investigation
    Bodner WR, Hilaris BS, Alagheband M, Safai B, Mastoras CA, Saraf S

Medical Physics, Translational Research & Technology

  • Year
    Title
    Link
    Journal
    Authors
    2021 Dec
    Gold-nanoparticle-enriched breast tissue in breast cancer treatment using the INTRABEAM system: a Monte Carlo study
    Radiation and Environmental Biophysics
    Tegaw EM, Geraily G, Gholami S, Shojaei M, Tadesse GF
    2021 Nov
    Monte Carlo calculation of the TG-43 dosimetry parameters for the INTRABEAM source with spherical applicators
    Physics in Medicine & Biology
    Alvarez DSA, Watson P, Popovic M, Heng VJ, Evans M, Seuntjens J
    2021 Mar
    Patient-Specific Quality Assurance Using a 3D-Printed Chest Phantom for Intraoperative Radiotherapy in Breast Cancer
    Frontiers in Oncology
    Choi Y, Lee IJ, Park K, Park KR, Cho Y, Kim JW, Lee H
    2021 Feb
    A Comparison between Electron Gamma Shower, National Research Council/Easy Particle Propagation (EgSnrc/Epp) and Monte Carlo N-Particle Transport Code (MCNP) in Simulation of the INTRABEAM System with Spherical Applicators
    Journal of Biomedical Physics and Engineering
    Tegaw EM, Geraily GH, Etesami SM, Gholami S, Ghanbari H, Farzin M, Tadesse GF, Shojaei M
    2021 Jan
    Effective energy assessment during breast cancer intraoperative radiotherapy by low-energy X-rays: A Monte Carlo study
    Radiation and Environmental Biophysics
    Shamsabadi R, Baghani HR, Mowlavi AA, Azadegan B
    2020 Apr
    Dose-rate considerations for the INTRABEAM electronic brachytherapy system: Report from the American association of physicists in medicine task group no. 292
    Medical Physics
    Culberson WS, Davis SD, Gwe‐Ya Kim G, Lowenstein JR, Ouhib Z, Popovic M, Waldron TJ, Safigholi H, Simiele SJ, Rivard MJ
    2020 Feb
    Dosimetric evaluation of incorporating the revised V4.0 calibration protocol for breast intraoperative radiotherapy with the INTRABEAM system
    Journal of Applied Clinical Medical Physics
    Shaikh MY, Burmeister J, Scott R, Kumaraswamy LK, Nalichowski A, Joiner MC
    2018 Mar
    Intraoperative Radiotherapy With INTRABEAM: Technical and Dosimetric Considerations
    Frontiers in Oncology
    Sethi A, Emami B, Small W, Thomas TO
    2015 May
    Dosimetric characterization of INTRABEAM® miniature accelerator flat and surface applicators for dermatologic applications
    Medica Physica
    Goubert M, Parent L
    2014 Sep
    Radiation protection for an intraoperative X-ray source compared to C-arm fluoroscopyStrahlenschutz einer Röntgenquelle zur intraoperativen Strahlentherapie im Vergleich mit C-Bogen-Durchleuchtung
    Zeitschrift für Medizinische Physik
    Schneider F, Clausen S, Jahnke A, Steil V, Bludau F, Sütterlin M, Obertacke U, Wenz F
    2014 Jan
    Radiation protection for an intra-operative X-ray devicer an intra-operative X-ray device
    The British Journal of Radiology
    Eaton DJ, Gonzalez R, Duck S, Keshtgar M
    2014 Jan
    A novel approach for superficial intraoperative radiotherapy (IORT) using a 50 kV X-ray source: a technical and case report
    Journal of Applied Clinical Medical Physics
    Schneider F, Clausen S, Thölking J, Wenz F, Abo-Madyan Y
    2012 Oct
    Quality assurance and independent dosimetry for an intraoperative x-ray device
    Medical Physics
    Eaton DJ
    2011 Nov
    Development of a Novel Method for Intraoperative Radiotherapy During Kyphoplasty for Spinal Metastases (Kypho-IORT)
    International Journal of Radiation Oncology, Biology & Physics
    Schneider F, Greineck F, Clausen S, Mai S, Obertacke U, Reis T, Wenz F
  • Year
    Title
    Link
    Journal
    Authors
    2021 Jan
    Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer
    Journal of Radiation Research
    Linares-Galiana I, Berenguer-Frances MA, Cañas-Cortés R, Pujol-Canadell M,Comas-Antón S,Martínez E, Laplana M, Pérez-Montero H, Pla-Farnós MJ, Navarro-Martin A,Nuñez M ,Both B, Guedea F 
    2021 Apr
    Wound Fluid from Breast Cancer Patients Undergoing Intraoperative Radiotherapy Exhibits an Altered Cytokine Profile and Impairs Mesenchymal Stromal Cell Function
    Cancers (Basel)
    Wuhrer A , Uhlig S ,Tuschy B,Berlit S ,Sperk E , Bieback K, Sütterlin M
    2020 Aug
    Cardiac serum marker alterations after intraoperative radiotherapy with low-energy x-rays in early breast cancer as an indicator of possible cardiac toxicity
    Strahlentherapie und Onkologie
    Stefanovic S, Berlit S, Sperk E, Wenz F, Weiß C, Trinkmann F, Sütterlin M, Tuschy B
    2020 Feb
    Intraoperative radiotherapy for breast cancer treatment efficiently targets the tumor bed preventing breast adipose stromal cell outgrowth
    Strahlentherapie und Onkologie
    Uhlig S, Wuhrer A, Berlit S, Tuschy B, Sütterlin M, Bieback K
    2020 Feb
    Surgical Wound Fluids from Patients with Breast Cancer Reveal Similarities in the Biological Response Induced by Intraoperative Radiation Therapy and the Radiation-Induced Bystander Effect—Transcriptomic Approach
    International Journal of Molecular Sciences
    Kulcenty K, Piotrowski I, Rucinski M, Wroblewska JP, Jopek K, Murawa D, Suchorska WM
    2017 Jan
    Biology of high single doses of IORT: RBE, 5 R’s, and other biological aspects
    Radiation Oncology
    Herskind C, Ma L, Liu Q, Zhang B, Schneider F, Veldwijk MR, Wenz F
    2015 Apr
    Tissue inhomogeneity corrections in low-kV intra-operative radiotherapy (IORT)
    Translational Cancer Research
    Sethi A, Chinsky B, Gros S, Diak A
    2015 Apr
    Beyond the linear quadratic model: intraoperative radiotherapy and normal tissue tolerance
    Translational Cancer Research
    Emami B, Woloschak G, Small W
    2014 Feb
    Radiobiological aspects of intraoperative tumour-bed irradiation with low-energy X-rays (LEX-IORT)
    Translational Cancer Research
    Herskind C, Wenz F
    2014 Feb
    Cell and molecular response to IORT treatment
    International Journal of Radiation Oncology, Biology & Physics
    Minafra L, Bravatà V
    2014 Feb
    Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects
    Translational Cancer Research
    Sologuren I, Rodríguez-gallego C, Lara PC
    2013 Sep
    Mitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell line
    Journal of Neuro-Oncology
    Wang M, Maier P, Wenz F, Giordano FA, Herskind C
    2013 Mar
    Mitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell line
    International Journal of Radiation Oncology, Biology & Physics
    Liu Q, Schneider F, Ma L, Wenz F, Herskind C
    2008 Dec
    Sphere of Equivalence - A Novel Target Volume Concept for Intraoperative Radiotherapy Using Low-Energy X Rays
    International Journal of Radiation Oncology, Biology & Physics
    Herskind C, Griebel J, Kraus-Tiefenbacher U, Wenz F
    2008 Mar
    Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding
    Clinical Cancer Research
    Belletti B, Vaidya JS, D’Andrea S, Entschladen F, Roncadin M, Lovat F, Berton S, Perin T, Candiani E, Reccanello S, Veronesi A, Canzonieri V, Trovò MG, Zaenker KS, Colombatti A, Baldassarre G, Massarut S
  • Year
    Title
    Link
    Journal
    Authors
    2015 Apr
    Electronic brachytherapy—current status and future directions
    The British Journal of Radiology
    Eaton DJ

Quality of Life & Cosmesis

  • Year
    Title
    Link
    Journal
    Authors
    2019 Jan
    Patient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignment
    European Journal of Cancer Care
    Corica T, Saunders CM, Bulsara MK, Taylor M, Joseph DJ, Nowak AK
    2017 Jul
    Intraoperative radiotherapy: Patient selection, management, and follow-up
    Journal of Surgical Oncology
    Holmes DR, Zimmerman R
    2016 Sep
    Cosmesis and Breast-Related Quality of Life Outcomes After Intraoperative Radiation Therapy for Early Breast Cancer: A Substudy of the TARGIT-A Trial
    International Journal of Radiation Oncology, Biology & Physics
    Corica T, Nowak AK, Saunders CM, Bulsara M, Taylor M, Vaidya JS, Baum M, Joseph DJ
    2016 May
    Environmental and social benefits of the targeted intraoperative radiotherapy for breast cancer: data from UK TARGIT-A trial centres and two UK NHS hospitals offering TARGIT IORT
    The BMJ
    Coombs NJ, Coombs JM, Vaidya UJ, Singer J, Bulsara M, Tobias JS, Wenz F, Joseph DJ, Brown DA, Rainsbury R, Davidson T, Adamson DJA, Massarut S, Morgan D, Potyka I, Corica T, Falzon M, Williams N, Baum M, Vaidya JS
    2014 Feb
    Comparison of mammographic findings after intraoperative radiotherapy or external beam whole breast radiotherapy
    European Journal of Surgical Oncology
    Elsberger B, Romsauerova A, Vinnicombe S, Whelehan P, Brown DC, Dewar JA, Thompson AM, Evans, A
    2013 Nov
    Patient preferences regarding intraoperative versus external beam radiotherapy following breast-conserving surgery
    Breast Cancer Research and Treatment
    Alvarado MD, Conolly J, Park C, Sakata T, Mohan AJ, Harrison BL, Hayes M, Esserman LJ, Ozanne EM
    2013 Mar
    Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer
    The New England Journal of Medicine
    Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, Correa C, Cutter D, Gagliardi G, Gigante B, Jensen M-B, Nisbet A, Peto R, Rahimi K, Taylor C, Hall P
    2013 Jan
    Radiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from the randomized phase III trial TARGIT-A
    Radiation Oncology
    Welzel G, Boch A, Sperk E, Hofmann F, Kraus-Tiefenbacher U, Gerhardt A, Wenz F
    2012 Feb
    Persistent pain after targeted intraoperative radiotherapy (TARGIT) or external breast radiotherapy for breast cancer: A randomized trial
    The Breast
    Andersen KG, Gärtner R, Kroman N, Flyger H, Kehlet H
  • Year
    Title
    Link
    Journal
    Authors
    2018 Apr
    Cosmetic outcome as rated by patients, doctors, nurses and BCCT.core software assessed over 5 years in a subset of patients in the TARGIT-A Trial
    Radiation Oncology
    Corica T, Nowak AK, Saunders CM, Bulsara MK, Taylor M, Williams NR, Keshtgar M, Joseph DJ, Vaidya JS
    2017 Dec
    Aesthetic outcome after breast conserving surgery and either intraoperative radiotherapy or whole breast external beam radiotherapy for early breast cancer: objective assessment of patients in a randomized controlled trial in Lublin, Poland
    Full Text
    European Journal of Gynaecological Oncology
    Williams N, Kurylcio A, Jankiewicz M, Romanek J, Polkowski W, Michalopoulos N, Keshtgar M
    2014 Feb
    Oncoplastic breast reconstruction after IORT
    Translational Cancer Research
    Malter W, Kirn V, Mallmann P, Kraemer S
    2013 Jul
    Objective assessment of cosmetic outcome after targeted intraoperative radiotherapy in breast cancer: results from a randomised controlled trial
    Breast Cancer Research and Treatment
    Keshtgar MRS, Williams NR, Bulsara M, Saunders C, Flyger H, Cardoso JS, Corica T, Bentzon N, Michalopoulos NV, Joseph DJ

Guidelines, Recommendations & HTAs

  • Year
    Title
    Link
    Journal
    Authors
    2021 Sep
    Intraoperative Radiation Therapy (IORT)
    AETNA
    AETNA
    2020
    NCCN Guidelines
    NCCN
    NCCN
    2020
    Leitlinienprogramm Onkologie: S3-Leitlinie Früherkennung, Diagnose, Therapie und Nachsorge des Mammakarzinoms
    Leitlinienprogramm Onkologie
    Leitlinienprogramm Onkologie
    2019 Aug
    Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    Annals of Oncology
    Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S, Senkus E
    2018 Jun
    Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline
    Practical Radiation Oncology
    Smith BD, Bellon JR, Blitzblau R, Freedman G, Haffty B, Hahn C, Halberg F, Hoffman K, Horst K, Moran J, Patton C, Perlmutter J, Warren L, Whelan T, Wright JL, Jagsi R
    2018 Jan
    Intrabeam radiotherapy system for adjuvant treatment of early breast cancer Technology appraisal guidance [TA501]
    NICE
    NICE
    2016 Jan
    ESTRO-ACROP guideline “target delineation of glioblastomas”
    Radiotherapy and Oncology
    Niyazi M, Brada M, Chalmers AJ, Combs SE, Erridge SC, Fiorentino A, Grosu AL, Lagerwaard FJ, Minniti G, Mirimanoff R-O, Ricardi U, Short SC, Weber DC, Belka C
    2012 Sep
    Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline
    Practical Radiation Oncology
    Tsao MN, Rades D, Wirth A, Lo SS, Danielson BL, Gaspar LE, Sperduto PW, Vogelbaum MA, Radawski JD, Wang JZ, Gillin MT, Mohideen N, Hahn CA, Chang EL
  • Year
    Title
    Link
    Journal
    Authors
    2010 Mar
    Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: Recommendations of the Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group based on clinical evidence (2009)
    Radiotherapy and Oncology
    Polgár C, Van Limbergen E, Pötter R, Kovács G, Polo A, Lyczek J, Hildebrandt G, Niehoff P, Guinot JL, Guedea F, Johansson B, Ott OJ, Major T, Strnad V
  • Year
    Title
    Link
    Journal
    Authors
    2016 Sep
    An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial)
    Health Technology Assessment 
    Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Saunders C, Brew-Graves C, Potyka I, Morris S, Vaidya HJ, Williams NR, Baum M
    2015 Sep
    The INTRABEAM® Photon Radiotherapy System for the adjuvant treatment of early breast cancer: a systematic review and economic evaluation
    HTA
    Health Technology Assessment 
    Picot J, Copley V, Colquitt JL, Kalita N, Hartwell D, Bryant J

Miscellaneous

  • Year
    Title
    Link Text
    Journal
    Authors
    2020 Sep
    Adjuvant electronic brachytherapy for endometrical carcinoma: A 4-year outcomes report
    Brachytherapy
    Sarria GR, Sperk E, Wenz F, Schneider F, Abo-Madyan Y, Giordano FA, Ehmann M
    2020 Jul
    Safety and efficacy of INTRABEAM intraoperative radiotherapy for invasive thymoma
    Medicine
    Cui T, Dai J, Li J, Qian J, Li G, Sun J

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