Compendium
Publications presenting the usage of intraoperative radiotherapy (IORT) for oncological treatments
Focusing on indications, medical physics, radiobiology, technology aspects, quality of life as well as guidelines & recommendations
FEB 01, 2022
· 2 MIN READ
Compiled by
ZEISS Medical Technology
SUMMARY
List of articles about IORT as part of radiation oncology treatments
In this literature compendium ZEISS presents various clinical articles on IORT for various oncological indications but also focusing on specific relevant aspects, such as: medical physics, radiobiology, technology aspects, quality of life, cosmesis, guidelines, recommendations or health technology assessments (HTA) in English and German. The aim is to provide further information and share knowledge.
Each publication is based on the author´s own professional opinion or on their study results. It does not necessarily reflect the opinion of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or intended purpose of our medical devices. Therefore, suitability of clinical application for each publication should be carefully assessed by the concerned physician.
Oncological Indications
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YearTitleLinkJournalAuthors2021 NovIntraoperative Radiotherapy in Brain Malignancies: Indications and Outcomes in Primary and Metastatic Brain TumorsFrontiers in oncologyCifarelli CP, Jacobson GM2021 OctDosimetric Comparison of Upfront Boosting With Stereotactic Radiosurgery Versus Intraoperative Radiotherapy for GlioblastomaFrontiers in oncologySarria GR, Smalec Z, Muedder T, Holz JA, Scafa D, Koch D, Garbe S, Schneider M, Hamed M, Vatter H, Herrlinger U, Giordano FA, Schmeel LC2021 AugIntraoperative radiotherapy with low-energy x-rays after neurosurgical resection of brain metastases- an Augsburg University Medical Center experienceStrahlentherapie und OnkologieKahl KH, Balagiannis N, Höck M, Schill S, Roushan Z, Shiban E, Müller H, Grossert U, Konietzko I, Sommer B, Maurer CJ, Berlis A, Heidecke V, Janzen T, Stüben G2021 MarDose homogeneity analysis of adjuvant radiation treatment in surgically resected brain metastases: Comparison of IORT, SRS and IMRT indicesBrachytherapyDahshan BA, Weir JS, Bice RP, Renz P, Cifarelli DT, Poplawski L, Hack J, Vargo JA, Cifarelli CP2020 FebCurrent approaches to the management of brain metastasesClinical OncologySuh JH, Kotecha R, Chao ST, Ahluwalia MS, Sahgal A, Chang EL2019 OctIntraoperative radiotherapy (IORT) for surgically resected brain metastases: outcome analysis of an international cooperative studyJournal of Neuro-OncologyCifarelli CP, Brehmer S, Vargo JA, Hack JD, Kahl KH, Sarria-Vargas G, Giordano FA2019 SepIntraoperative Radiotherapy for Glioblastoma: An International Pooled AnalysisInternational Journal of Radiation Oncology, Biology & PhysicsSarria GR, Sperk E, Xiaodi H, Sarria G, Wenz F, Brehmer S, Fu B, Min S, Zhang H, Qin S, Qiu, X, Abo-Madyan Y, Hänggi D, Martinez DA, Cabrera C, Giordano FA2019 MayIntraoperative radiotherapy (IORT) for surgically resected brain metastases: Local control and dosimetric analysis.Journal of Global OncologyCifarelli CP, Vargo JA, Hack JD, Renz PB, Poplawski L, Jacobson GM, Kahl KH, Brehmer S, Sarria G, Giordano FA2019 JanCongress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Treatment of Adults With Metastatic Brain Tumors: Executive SummaryNeurosurgeryOlson JJ, Kalkanis SN, Ryken TC2018 AugFeasibility of dose escalation using intraoperative radiotherapy following resection of large brain metastases compared to post-operative stereotactic radiosurgeryJournal of Neuro-OncologyVargo JA, Sparks KM, Singh R, Jacobson GM, Hack JD, Cifarelli CP2018 AprCombined stereotactic biopsy and stepping-source interstitial irradiation of glioblastoma multiformeJournal of Neurosurgical SciencesBrehmer S, Guthier CV, Clausen S, Schneider F, Schulte DM, Benker M, Bludau F, Glatting G, Marx A, Schmiedek P, Hesser J, Wenz F, Giordano FA2018 MarIntraoperative Radiotherapy in Newly Diagnosed Glioblastoma (INTRAGO): An Open-Label, Dose-Escalation Phase I/II TrialNeurosurgeryGiordano FA, Brehmer S, Mürle B, Welzel G, Sperk E, Keller A, Abo-Madyan Y, Scherzinger E, Clausen S, Schneider F, Herskind C, Glas M, Seiz-Rosenhagen M, Groden C, Hänggi D, Schmiedek P, Emami B, Souhami L, Petrecca K, Wenz F2016 OctInitial Results of a Phase 1/2 Trial on Intraoperative Radiation Therapy (IORT) in Newly Diagnosed Glioblastoma Multiforme (INTRAGO)International Journal of Radiation Oncology, Biology & PhysicsGiordano FA, Brehmer S, Muerle B, Welzel G, Sperk E, Schneider F, Clausen S, Schmiedek P, Groden C, Hänggi D, Abo-Madyan Y, Wenz F2016 JanRationale for intraoperative radiotherapy in glioblastomaJournal of Neurosurgical SciencesGiordano FA, Wenz F, Petrecca K2015 AprIntraoperative radiotherapy to treat newly diagnosed solitary brain metastasis: initial experience and long-term outcomesJournal of NeurosurgeryWeil RJ, Mavinkurve GG, Chao ST, Vogelbaum MA, Suh JH, Kolar M, Toms SA2014 SepINTRAOPERATIVE RADIOTHERAPY WITH INTRABEAM IN PRIMARY BRAIN TUMORS AFTER RESECTION: PRELIMINARY REPORTS OF 26 CASESNeuro-OncologyHan X, Fu B, Wu M, Zhang H, Li D, Zhang J, Sun D, Sun S2014 FebIntraoperative radiotherapy (IORT)—a resurrected option for treating glioblastoma?Translational Cancer ResearchGiordano FA, Abo-Madyan Y, Brehmer S, Herskind C, Sperk E, Schneider F, Clausen S, Welzel G, Schmiedek P, Wenz F2006 AprPhase I study of intraoperative radiotherapy with photon radiosurgery system in children with recurrent brain tumors: Preliminary report of first dose level (10 Gy)International Journal of Radiation Oncology, Biology & PhysicsKalapurakal JA, Goldman S, Stellpflug W, Curran J, Sathiaseelan V, Marymont MH, Tomita T
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YearTitleLinkJournalAuthors2021 JanKyphoplasty and intra-operative radiotheray, combination of kyphoplasty and intra-operative radiation for spinal metastases: technical feasibility of a novel approachInternational OrthopaedicsSchmidt R, Wenz F, Reis T, Janik K, Bludau F, Obertacke U2019 MayCombined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful vertebral metastases - a randomized phase III studyBMC CancerBludau F, Welzel G, Reis T, Abo-Madyan Y, Sperk E, Schneider F, Clausen S, Ruder AM, Obertacke U, Ghaly MM, Wenz F, Giordano FA2018 MayPhase I/II trial of combined kyphoplasty and intraoperative radiotherapy in spinal metastasesThe Spine JournalBludau F, Welzel G, Reis T, Schneider F, Sperk E, Neumaier C, Ehmann M, Clausen S, Obertacke U, Wenz F, Giordano FA2017 AugCirculating Tumour Cell Release after Cement Augmentation of Vertebral MetastasesScientific ReportsMohme M, Riethdorf S, Dreimann M, Werner S, Maire CL, Joosse SA, Bludau F, Mueller V, Neves RPL, Stoecklein NH, Lamszus K, Westphal M, Pantel K, Wikman H, Eicker SO2015 SepKyphoplastie kombiniert mit intraoperativer Radiotherapie (Kypho-IORT)Der RadiologeBludau F, Reis T, Schneider F, Clausen S, Wenz F, Obertacke U2014 JanKypho-IORT: the first French treatmentTranslational Cancer ResearchMiglierini P, Dam-Hieu P, Key S2013 JulKyphoplastie in Kombination mit intraoperativer RadiotherapieDer OrthopädeKayser R, Ender SA, Asse E, Wilhelm E, Adler F, Schmidt R, Wenz F, Obertacke U, Bludau F
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YearTitleLinkJournalAuthors2022 JanIntraoperative Radiotherapy for Breast Cancer in Elderly WomenClinical Breast CancerGuillerm SO, Bourstyn E, Itti R, Cahen-Doidy L, Quéro L, Labidi M, Marchand E, Lorphelin H, Giacchetti S, Cuvier C, Espié M, Teixeira L, Hennequin C2021 JunHypofractionated whole breast irradiation after IORT treatment is safe in patients receiving adjuvant chemotherpyClinical and Translational OncologyBurgos-Burgos J, Vega V, Macias-Verde D, Gómez V, Travieso-Aja M, Travieso J, Vicente E, Murias C, Santana C, Ospina J, Lara PC2021 MayNew clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancerBritish Journal of CancerVaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Douek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams NR, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Corica T, Lundgren S, Holmes DR, Vinante L, Bozza F, Pazos M, Le Blanc-Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Joseph DJ, Tobias JS2021 AprIntraoperative radiotherapy booster as part of breast-conservation therpy for breast cancer: a single-institution retrospective analysisStrahlentherapie und OnkologieStoian R, Erbes T, Zamboglou C, Scholber J, Galney M, Sachpazidis I, Haehl E, Spohn SK, Verma V, Krug D, Rühle A, Juhasz-Böss I, Grosu AL, Nicolay NH, Sprave T2021 AprComparison of IORT (Radical and Boost Dose) and EBRT in Terms of Disease-Free Survival and Overall Survival according Demographic, Pathologic, and Biological Factors in Patients with Breast CancerInternational Journal of OncologyHashemi S, Javadi S, Akbari ME, Mirzaei H, Mahdavi SR2021 MarPatients Older 65 Years With Early Breast Cancer Prefer Intraoperative Radiation as a Locoregional Treatment ChoiceAnnals of Surgical OncologyTang A, Cohan CM, Beattie G, Cureton EL, Svahn JD, Lyon LL, Kelly JF, Shim VC2021 FebAssessment of Thyroid Lobe Dose in Breast Cancer Intraoperative RadiotherapyJournal of Biomedical Physics and EngineeringFarkhani RR, Gholamhosseinian H, Anvari K, Forghani MN2021 FebSingle-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatmentBritish Journal of CancerVaidya JS, Bulsara M, Baum M, Tobias JS on behalf of TARGIT-A trial authors2021 JanIntraoperative radiotherapy for breast cancer: powerful evidence to change practiceClinical OncologyVaidya JS, Bulsara M, Baum M, Alvarado M, Bernstein M, Massarut S, Saunders C, Sperk E, Wenz F, Tobias JS, TARGIT-A investigators2021 JulTARGIT-IORT during lumpectomy for breast cancer- better for patients than other PBI approachesFull TextInternational Journal of Radiation Oncology, Biology & PhysicsVaidya JS, Bulsara M, Sperk E, Massarut S, Douek M, Alvarado M, Pigorsch S, Holmes D, Bernstein M, Saunders C, Flyger H, Joseph D, Wenz F, Tobias JS, TARGIT-A investigators2021 FebIntraoperative radiotherapy in early breast cancer: observational comparison with whole breast radiotherapyCirugía EspanolaGuillén JRO, Almudi EH, Osorio GM, Carreras RI, Gómez JAF, Gómez IV, Mur CG, Franco MCC2020 AugLong term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trialThe BMJVaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Douek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams NR, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Corica T, Lundgren S, Holmes DR, Vinante L, Bozza F, Pazos M, Le Blanc-Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Joseph DJ, Tobias JS, TARGIT-A trial authors2020 MarThe actual benefit of intraoperative radiation therapy using 50 kV x-rays in early breast cancer: A retrospective study of 676 patientsThe Breast JournalTallet A, Racadot S, Boher J.-M, Cohen M, Barrou J, Houvenaeghel G, Gutowski M, Delmond L, Lemanski C2019 SepFirst per Protocol Analysis of the Prospective Phase II Study of Intraoperative Radiotherapy (IORT) in Elderly Patients with Small Breast Cancer: Targit E(lderly)International Journal of Radiation Oncology, Biology & PhysicsSperk E2017 DecIntraoperative Radiotherapy for Breast CancerFrontiers in OncologyHarris EER, Small W2017 SepTargeted Intraoperative Radiotherapy Tumour Bed Boost during Breast-Conserving Surgery after Neoadjuvant Chemotherapy - a Subgroup Analysis of Hormone Receptor-Positive HER2-Negative Breast CancerBreast CareKolberg H-C, Lövey G, Akpolat-Basci L, Stephanou M, Fasching P, Untch M, Hoffmann O, Bulsara M, Vaidya J, Liedtke C2017 AugKeynote Address at the American Society of Breast Surgeons 18th Annual MeetingAnnals of Surgical OncologyWenz F2017 FebEarly complications after intraoperative radiotherapy revisitedJournal of Surgical OncologyHolmes DR2017 JanIntraoperative radiotherapy (IORT) as boost in breast cancerRadiation OncologySedlmayer F, Reitsamer R, Wenz F, Sperk E, Fussl C, Kaiser J, Ziegler I, Zehentmayr F, Deutschmann H, Kopp P, Fastner G2016 NovTargeted intraoperative radiotherapy tumour bed boost during breast-conserving surgery after neoadjuvant chemotherapyStrahlentherapie und OnkologieKolberg H-C, Loevey G, Akpolat-Basci L, Stephanou M, Fasching PA, Untch M, Liedtke C, Bulsara M, Vaidya JS2016 OctReduced Mortality With Partial-Breast Irradiation for Early Breast Cancer: A Meta-Analysis of Randomized TrialsInternational Journal of Radiation Oncology, Biology & PhysicsVaidya JS, Bulsara M, Wenz F, Coombs N, Singer J, Ebbs S, Massarut S, Saunders C, Douek M, Williams NR, Joseph DJ, Tobias JS, Baum M2015 NovTargeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the BreastThe Breast JournalRivera R, Banks A, Casillas-Lopez A, Rashtian A, Lewinsky B, Sheth P, Hovannesian-Larsen L, Brousseau D, Holmes DR2015 JulPride, Prejudice, or Science: Attitudes Towards the Results of the TARGIT-A Trial of Targeted Intraoperative Radiation Therapy for Breast CancerInternational Journal of Radiation Oncology, Biology & PhysicsVaidya JS, Bulsara M, Wenz F, Joseph D, Saunders C, Massarut S, Flyger HL, Eiermann W, Alvarado M, Esserman L, Falzon M, Brew-Graves C, Potyka I, Tobias JS, Baum M2015 FebIntraoperative Radiotherapy of the Breast for Early-Stage Breast Cancer: Ready for PrimetimeThe Breast JournalHolmes DR2014 DecIntraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center ExperiencesInternational Journal of Breast CancerMalter W, Kirn V, Richters L, Fridrich C, Markiefka B, Bongartz R, Semrau R, Mallmann P, Kraemer S2014 JulA cohort analysis to identify eligible patients for intraoperative radiotherapy (IORT) of early breast cancerRadiation OncologySperk E, Astor D, Keller A, Welzel G, Gerhardt A, Tuschy B, Sütterlin M, Wenz F2014 FebRisk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trialThe LancetVaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M, Flyger HL, Massarut S, Alvarado M, Saunders C, Eiermann W, Metaxas M, Sperk E, Sütterlin M, Brown D, Esserman L, Roncadin M, Thompson A, Dewar JA, Holtveg HMR, Pigorsch S, Falzon M, Harris E, Matthews A, Brew-Graves C, Potyka I, Corica T, Williams NR, Baum M2013 JunCost-Effectiveness Analysis of Intraoperative Radiation Therapy for Early-Stage Breast CancerAnnals of Surgical OncologyAlvarado MD, Mohan AJ, Esserman LJ, Park CC, Harrison BL, Howe RJ, Thorsen C Ozanne EM2012 JulLate radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT ABreast Cancer Research and TreatmentSperk E, Welzel G, Keller A, Kraus-Tiefenbacher U, Gerhardt A, Sütterlin M, Wenz F2011 MayTargeted Intraoperative Radiotherapy for Breast Cancer in Patients in Whom External Beam Radiation Is Not PossibleInternational Journal of Radiation Oncology, Biology & PhysicsKeshtgar MRS, Vaidya JS, Tobias JS, Wenz F, Joseph D, Stacey C, Metaxas MG, Keller A, Corica T, Williams NR, Baum M
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TitleTitleLinkJournalAuthors2021 DecDosimetric Comparison of Intraoperative Radiotherapy and SRS for Liver MetastasesFrontiers in OncologyScafa D, Muedder T, Holz JA, Koch D, Nour Y, Garbe S, Gonzalez-Carmona MA, Feldmann G, Vilz TO, Köksal M, Giordano FA, Schmeel LC, Sarria GR2021 AprThe role of intraoperative radiotherapy in advanced rectal cancer: a meta- analysisColorectal DiseaseFahy MR, Kelly ME, Foley MP, Nugent TS, Shields CJ, Winter DC2020 AugINTRABEAM intraoperative radiotherapy combined with portal vein infusion chemotherapy for treating hepatocelular carcinoma with portal vein tumor thrombusBMC SurgerySong X, He Y, Liang H, Han M, Shao Z2020 JunLow-kilovolt x-ray intraoperative radiotherapy for pT3 locally advanced colon cancer: a single-institution retrospective analysisWorld Journal of Surgical OncologyMa L, Qiang J, Yin H, Lin L, Jiao Y, Ma C, Li X, Dong L, Cui J, Wei D, Sharma AM, Schwartz DL, Gu W, Chen H2020 AprIntraoperative Strahlentherapie in der Abdominalchirurgie- eigene ErfahrungenDer ChirurgJoechle K, Gkika E, Grosu AL, Hopt UT, Neeff HP, Fichtner-Feigl S, Lang SA2020 FebShort-term outcomes of laparoscopic intersphincteric resection with intraoperative radiotherapy using low-energy X-rays for primary locally advanced low rectal cancer: a single center experienceWorld Journal of Surgical OncologyXue W, Wang S, Zhao Z, Li Y, Shang A, Li D, Yang J, Wang T, Wang M2020 JanIntraoperative radiotherapy as an immediate adjuvant treatment of rectal cancer due to limited access to external-beam radiotherapyRadiation OncologyPotemin S, Kübler J, Uvarov I, Wenz F, Giordano F2019 MarA phase II study of intraoperative radiotherapy using a low-energy x-ray source for resectable pancreatic cancer: a study protocolBMC SurgeryKim JW, Cho Y, Kim HS, Choi WH, Park JS, Lee IJ2016 MayThe Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal CancerRadiation OncologySusko M, Lee J, Salama J, Thomas S, Uronis H, Hsu D, Migaly J, Willett C, Czito B, Palta M2016 MarIntraoperative radiotherapy with low energy photons in recurrent colorectal cancer: a single centre retrospective studyContemporary OncologySkórzewska M, Mielko J, Kurylcio A, Romanek J, Polkowski WP2015 AprIntraoperative radiotherapy in locally-advanced and recurrent rectal cancer: retrospective review of 68 casesTranslational Cancer ResearchPotemin S, Uvarov I, Vasilenko I2013 NovIntraoperative Radiotherapy with Low-Energy Photons in Rectal Cancer RecurrenceTargeted Intraoperative Radiotherapy in Oncology (Book)Polkowski WP, Skórzewska M2012 JulIntraoperative radiation therapy with the photon radiosurgery system in locally advanced and recurrent rectal cancer: retrospective review of the Cleveland clinic experienceRadiation OncologyGuo S, Reddy CA, Kolar M, Woody N, Mahadevan A, Deibel F, Dietz DW, Remzi FH, Suh JH
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YearTitleLinkJournalAuthors2016 DecIntraoperative radiation therapy (IORT) in head and neck cancer: A systematic reviewMedicineKyrgias G, Hajiioannou J, Tolia M, Kouloulias V, Lachanas V, Skoulakis C, Skarlatos I, Rapidis A, Bizakis I2016 AprIntra-operative radiation therapy (IORT) in recurrent head and neck cancerOral OncologyDe Felice F, Musio D, Tombolini V2015 AprIntraoperative radiotherapy (IORT) in the treatment of head and neck cancerTranslational Cancer ResearchMünter MW, Köppen U, Ramuscak A, Sittel C, Wegner N2013 DecCurrent advances in radiotherapy of head and neck malignanciesFull TextJournal of International Oral HealthRoopashri G, Baig M
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YearTitleLinkJournalAuthors2019 SepIntraoperative Radiotherapy with Low Energy x-Rays for Primary and Recurrent Soft-Tissue SarcomaInternational Journal of Radiation Oncology, Biology & PhysicsSarria, G. R., Petrova, V., Abo-Madyan, Y., Wenz, F., Hohenberger, P., Sperk, E., & Giordano, F. A.2012 DecSuperficial x-ray in the treatment of basal and squamous cell carcinomas: A viable option in select patientsJournal of the American Academy of DermatologyCognetta AB, Howard BM, Heaton HP, Stoddard ER, Hong HG, Green W H2012 MarRadiation Therapy and Skin CancerModern Practices in Radiation TherapyTward JD, Anker CJ. Gaffney DK, Bowen G2003 MayUse of Low-Energy X-Rays in the Treatment of Superficial Nonmelanomatous Skin CancersCancer InvestigationBodner WR, Hilaris BS, Alagheband M, Safai B, Mastoras CA, Saraf S
Medical Physics, Translational Research & Technology
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YearTitleLinkJournalAuthors2021 DecGold-nanoparticle-enriched breast tissue in breast cancer treatment using the INTRABEAM system: a Monte Carlo studyRadiation and Environmental BiophysicsTegaw EM, Geraily G, Gholami S, Shojaei M, Tadesse GF2021 NovMonte Carlo calculation of the TG-43 dosimetry parameters for the INTRABEAM source with spherical applicatorsPhysics in Medicine & BiologyAlvarez DSA, Watson P, Popovic M, Heng VJ, Evans M, Seuntjens J2021 MarPatient-Specific Quality Assurance Using a 3D-Printed Chest Phantom for Intraoperative Radiotherapy in Breast CancerFrontiers in OncologyChoi Y, Lee IJ, Park K, Park KR, Cho Y, Kim JW, Lee H2021 FebA Comparison between Electron Gamma Shower, National Research Council/Easy Particle Propagation (EgSnrc/Epp) and Monte Carlo N-Particle Transport Code (MCNP) in Simulation of the INTRABEAM System with Spherical ApplicatorsJournal of Biomedical Physics and EngineeringTegaw EM, Geraily GH, Etesami SM, Gholami S, Ghanbari H, Farzin M, Tadesse GF, Shojaei M2021 JanEffective energy assessment during breast cancer intraoperative radiotherapy by low-energy X-rays: A Monte Carlo studyRadiation and Environmental BiophysicsShamsabadi R, Baghani HR, Mowlavi AA, Azadegan B2020 AprDose-rate considerations for the INTRABEAM electronic brachytherapy system: Report from the American association of physicists in medicine task group no. 292Medical PhysicsCulberson WS, Davis SD, Gwe‐Ya Kim G, Lowenstein JR, Ouhib Z, Popovic M, Waldron TJ, Safigholi H, Simiele SJ, Rivard MJ2020 FebDosimetric evaluation of incorporating the revised V4.0 calibration protocol for breast intraoperative radiotherapy with the INTRABEAM systemJournal of Applied Clinical Medical PhysicsShaikh MY, Burmeister J, Scott R, Kumaraswamy LK, Nalichowski A, Joiner MC2018 MarIntraoperative Radiotherapy With INTRABEAM: Technical and Dosimetric ConsiderationsFrontiers in OncologySethi A, Emami B, Small W, Thomas TO2015 MayDosimetric characterization of INTRABEAM® miniature accelerator flat and surface applicators for dermatologic applicationsMedica PhysicaGoubert M, Parent L2014 SepRadiation protection for an intraoperative X-ray source compared to C-arm fluoroscopyStrahlenschutz einer Röntgenquelle zur intraoperativen Strahlentherapie im Vergleich mit C-Bogen-DurchleuchtungZeitschrift für Medizinische PhysikSchneider F, Clausen S, Jahnke A, Steil V, Bludau F, Sütterlin M, Obertacke U, Wenz F2014 JanRadiation protection for an intra-operative X-ray devicer an intra-operative X-ray deviceThe British Journal of RadiologyEaton DJ, Gonzalez R, Duck S, Keshtgar M2014 JanA novel approach for superficial intraoperative radiotherapy (IORT) using a 50 kV X-ray source: a technical and case reportJournal of Applied Clinical Medical PhysicsSchneider F, Clausen S, Thölking J, Wenz F, Abo-Madyan Y2012 OctQuality assurance and independent dosimetry for an intraoperative x-ray deviceMedical PhysicsEaton DJ2011 NovDevelopment of a Novel Method for Intraoperative Radiotherapy During Kyphoplasty for Spinal Metastases (Kypho-IORT)International Journal of Radiation Oncology, Biology & PhysicsSchneider F, Greineck F, Clausen S, Mai S, Obertacke U, Reis T, Wenz F
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YearTitleLinkJournalAuthors2021 JanChanges in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancerJournal of Radiation ResearchLinares-Galiana I, Berenguer-Frances MA, Cañas-Cortés R, Pujol-Canadell M,Comas-Antón S,Martínez E, Laplana M, Pérez-Montero H, Pla-Farnós MJ, Navarro-Martin A,Nuñez M ,Both B, Guedea F2021 AprWound Fluid from Breast Cancer Patients Undergoing Intraoperative Radiotherapy Exhibits an Altered Cytokine Profile and Impairs Mesenchymal Stromal Cell FunctionCancers (Basel)Wuhrer A , Uhlig S ,Tuschy B,Berlit S ,Sperk E , Bieback K, Sütterlin M2020 AugCardiac serum marker alterations after intraoperative radiotherapy with low-energy x-rays in early breast cancer as an indicator of possible cardiac toxicityStrahlentherapie und OnkologieStefanovic S, Berlit S, Sperk E, Wenz F, Weiß C, Trinkmann F, Sütterlin M, Tuschy B2020 FebIntraoperative radiotherapy for breast cancer treatment efficiently targets the tumor bed preventing breast adipose stromal cell outgrowthStrahlentherapie und OnkologieUhlig S, Wuhrer A, Berlit S, Tuschy B, Sütterlin M, Bieback K2020 FebSurgical Wound Fluids from Patients with Breast Cancer Reveal Similarities in the Biological Response Induced by Intraoperative Radiation Therapy and the Radiation-Induced Bystander Effect—Transcriptomic ApproachInternational Journal of Molecular SciencesKulcenty K, Piotrowski I, Rucinski M, Wroblewska JP, Jopek K, Murawa D, Suchorska WM2017 JanBiology of high single doses of IORT: RBE, 5 R’s, and other biological aspectsRadiation OncologyHerskind C, Ma L, Liu Q, Zhang B, Schneider F, Veldwijk MR, Wenz F2015 AprTissue inhomogeneity corrections in low-kV intra-operative radiotherapy (IORT)Translational Cancer ResearchSethi A, Chinsky B, Gros S, Diak A2015 AprBeyond the linear quadratic model: intraoperative radiotherapy and normal tissue toleranceTranslational Cancer ResearchEmami B, Woloschak G, Small W2014 FebRadiobiological aspects of intraoperative tumour-bed irradiation with low-energy X-rays (LEX-IORT)Translational Cancer ResearchHerskind C, Wenz F2014 FebCell and molecular response to IORT treatmentInternational Journal of Radiation Oncology, Biology & PhysicsMinafra L, Bravatà V2014 FebImmune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effectsTranslational Cancer ResearchSologuren I, Rodríguez-gallego C, Lara PC2013 SepMitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell lineJournal of Neuro-OncologyWang M, Maier P, Wenz F, Giordano FA, Herskind C2013 MarMitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell lineInternational Journal of Radiation Oncology, Biology & PhysicsLiu Q, Schneider F, Ma L, Wenz F, Herskind C2008 DecSphere of Equivalence - A Novel Target Volume Concept for Intraoperative Radiotherapy Using Low-Energy X RaysInternational Journal of Radiation Oncology, Biology & PhysicsHerskind C, Griebel J, Kraus-Tiefenbacher U, Wenz F2008 MarTargeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical WoundingClinical Cancer ResearchBelletti B, Vaidya JS, D’Andrea S, Entschladen F, Roncadin M, Lovat F, Berton S, Perin T, Candiani E, Reccanello S, Veronesi A, Canzonieri V, Trovò MG, Zaenker KS, Colombatti A, Baldassarre G, Massarut S
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YearTitleLinkJournalAuthors2015 AprElectronic brachytherapy—current status and future directionsThe British Journal of RadiologyEaton DJ
Quality of Life & Cosmesis
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YearTitleLinkJournalAuthors2019 JanPatient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignmentEuropean Journal of Cancer CareCorica T, Saunders CM, Bulsara MK, Taylor M, Joseph DJ, Nowak AK2017 JulIntraoperative radiotherapy: Patient selection, management, and follow-upJournal of Surgical OncologyHolmes DR, Zimmerman R2016 SepCosmesis and Breast-Related Quality of Life Outcomes After Intraoperative Radiation Therapy for Early Breast Cancer: A Substudy of the TARGIT-A TrialInternational Journal of Radiation Oncology, Biology & PhysicsCorica T, Nowak AK, Saunders CM, Bulsara M, Taylor M, Vaidya JS, Baum M, Joseph DJ2016 MayEnvironmental and social benefits of the targeted intraoperative radiotherapy for breast cancer: data from UK TARGIT-A trial centres and two UK NHS hospitals offering TARGIT IORTThe BMJCoombs NJ, Coombs JM, Vaidya UJ, Singer J, Bulsara M, Tobias JS, Wenz F, Joseph DJ, Brown DA, Rainsbury R, Davidson T, Adamson DJA, Massarut S, Morgan D, Potyka I, Corica T, Falzon M, Williams N, Baum M, Vaidya JS2014 FebComparison of mammographic findings after intraoperative radiotherapy or external beam whole breast radiotherapyEuropean Journal of Surgical OncologyElsberger B, Romsauerova A, Vinnicombe S, Whelehan P, Brown DC, Dewar JA, Thompson AM, Evans, A2013 NovPatient preferences regarding intraoperative versus external beam radiotherapy following breast-conserving surgeryBreast Cancer Research and TreatmentAlvarado MD, Conolly J, Park C, Sakata T, Mohan AJ, Harrison BL, Hayes M, Esserman LJ, Ozanne EM2013 MarRisk of Ischemic Heart Disease in Women after Radiotherapy for Breast CancerThe New England Journal of MedicineDarby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, Correa C, Cutter D, Gagliardi G, Gigante B, Jensen M-B, Nisbet A, Peto R, Rahimi K, Taylor C, Hall P2013 JanRadiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from the randomized phase III trial TARGIT-ARadiation OncologyWelzel G, Boch A, Sperk E, Hofmann F, Kraus-Tiefenbacher U, Gerhardt A, Wenz F2012 FebPersistent pain after targeted intraoperative radiotherapy (TARGIT) or external breast radiotherapy for breast cancer: A randomized trialThe BreastAndersen KG, Gärtner R, Kroman N, Flyger H, Kehlet H
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YearTitleLinkJournalAuthors2018 AprCosmetic outcome as rated by patients, doctors, nurses and BCCT.core software assessed over 5 years in a subset of patients in the TARGIT-A TrialRadiation OncologyCorica T, Nowak AK, Saunders CM, Bulsara MK, Taylor M, Williams NR, Keshtgar M, Joseph DJ, Vaidya JS2017 DecAesthetic outcome after breast conserving surgery and either intraoperative radiotherapy or whole breast external beam radiotherapy for early breast cancer: objective assessment of patients in a randomized controlled trial in Lublin, PolandFull TextEuropean Journal of Gynaecological OncologyWilliams N, Kurylcio A, Jankiewicz M, Romanek J, Polkowski W, Michalopoulos N, Keshtgar M2014 FebOncoplastic breast reconstruction after IORTTranslational Cancer ResearchMalter W, Kirn V, Mallmann P, Kraemer S2013 JulObjective assessment of cosmetic outcome after targeted intraoperative radiotherapy in breast cancer: results from a randomised controlled trialBreast Cancer Research and TreatmentKeshtgar MRS, Williams NR, Bulsara M, Saunders C, Flyger H, Cardoso JS, Corica T, Bentzon N, Michalopoulos NV, Joseph DJ
Guidelines, Recommendations & HTAs
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YearTitleLinkJournalAuthors2021 SepIntraoperative Radiation Therapy (IORT)AETNAAETNA2020NCCN GuidelinesNCCNNCCN2020Leitlinienprogramm Onkologie: S3-Leitlinie Früherkennung, Diagnose, Therapie und Nachsorge des MammakarzinomsLeitlinienprogramm OnkologieLeitlinienprogramm Onkologie2019 AugEarly breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upAnnals of OncologyCardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S, Senkus E2018 JunRadiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guidelinePractical Radiation OncologySmith BD, Bellon JR, Blitzblau R, Freedman G, Haffty B, Hahn C, Halberg F, Hoffman K, Horst K, Moran J, Patton C, Perlmutter J, Warren L, Whelan T, Wright JL, Jagsi R2018 JanIntrabeam radiotherapy system for adjuvant treatment of early breast cancer Technology appraisal guidance [TA501]NICENICE2016 JanESTRO-ACROP guideline “target delineation of glioblastomas”Radiotherapy and OncologyNiyazi M, Brada M, Chalmers AJ, Combs SE, Erridge SC, Fiorentino A, Grosu AL, Lagerwaard FJ, Minniti G, Mirimanoff R-O, Ricardi U, Short SC, Weber DC, Belka C2012 SepRadiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guidelinePractical Radiation OncologyTsao MN, Rades D, Wirth A, Lo SS, Danielson BL, Gaspar LE, Sperduto PW, Vogelbaum MA, Radawski JD, Wang JZ, Gillin MT, Mohideen N, Hahn CA, Chang EL
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YearTitleLinkJournalAuthors2010 MarPatient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: Recommendations of the Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group based on clinical evidence (2009)Radiotherapy and OncologyPolgár C, Van Limbergen E, Pötter R, Kovács G, Polo A, Lyczek J, Hildebrandt G, Niehoff P, Guinot JL, Guedea F, Johansson B, Ott OJ, Major T, Strnad V
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YearTitleLinkJournalAuthors2016 SepAn international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial)Health Technology AssessmentVaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Saunders C, Brew-Graves C, Potyka I, Morris S, Vaidya HJ, Williams NR, Baum M2015 SepThe INTRABEAM® Photon Radiotherapy System for the adjuvant treatment of early breast cancer: a systematic review and economic evaluationHealth Technology AssessmentPicot J, Copley V, Colquitt JL, Kalita N, Hartwell D, Bryant J
Miscellaneous
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YearTitleLink TextJournalAuthors2020 SepAdjuvant electronic brachytherapy for endometrical carcinoma: A 4-year outcomes reportBrachytherapySarria GR, Sperk E, Wenz F, Schneider F, Abo-Madyan Y, Giordano FA, Ehmann M2020 JulSafety and efficacy of INTRABEAM intraoperative radiotherapy for invasive thymomaMedicineCui T, Dai J, Li J, Qian J, Li G, Sun J
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