Fluorescence in brain tumor treatment

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John Y. K. Lee, MD, MSCE

Professor, Neurosurgery & Otolaryngology, University of Pennsylvania, Philadelphia, PA, USA

Jeffrey N. Bruce, MD

Professor of Neurological Surgery, Columbia University, New York, NY, USA

Constantinos G. Hadjipanayis, MD, PhD

Professor of Neurosurgery & Oncological Sciences, Mount Sinai, New York, NY, USA


Summary

Use of fluorescence in treating brain tumors

In this recorded webinar, John Y. K. Lee, MD, MSCE (starting at minute 00:57), Jeffrey N. Bruce, MD (starting at minute 17:54), and Constantinos G. Hadjipanayis, MD, PhD (starting at minute 37:29) talk about the use of fluorescence in treating brain tumors.

Dr. Lee presents the technique of using near-infrared ICG fluorescent image-guided surgery for different neurosurgical cases such as gliomas, metastasis and meningiomas. Dr. Bruce shares his experience in fluorescein-guided resection of enhancing and non-enhancing glioblastomas. A short comparison of 5-ALA vs. fluorescein sodium is given, followed by the presentation of related study results about the usage of intraoperative fluorescein guidance in glioblastoma surgery. Dr. Hadjipanayis talks about 5-ALA fluorescence-guided surgery for brain tumors after FDA approval of Gleolan. He speaks about the association of maximal resection of non-contrast-enhanced tumors and overall survival as well as the advantages of 5-ALA fluorescence-guided surgery in this context. Furthermore, benefits of using digital hybrid visualization during glioma surgery are shared.


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