IORT Applications Overview

Armoogum, K., Parry, J., Mackay, C., Thompson, A., Vaidya, J., Ackland, C., … Eljamel, S. (2007). Implementation and Experiences of an Intraoperative Radiotherapy Service. Clinical Oncology, 19(3), S8–S9.

Brehmer, S., Guthier, C. V, Clausen, S., Schneider, F., Schulte, D. M., Benker, M., … Giordano, F. A. (2016). Combined stereotactic biopsy and stepping-source interstitial irradiation of unresectable glioblastoma multiforme. Journal of Neurosurgical Sciences.

Cosgrove, G. R., Hochberg, F. H., Zervas, N. T., Pardo, F. S., Valenzuela, R. F., & Chapman, P. (1997). Interstitial irradiation of brain tumors, using a miniature radiosurgery device: initial experience. Neurosurgery, 40(3), 518-23–5.

Dinsmore, M., Yanch, J. C., Sliski, A. P., & Harte, K. J. (1994). New X-ray generator for interstitial radiotherapy. Transact. Amer. Nuclear Soc., 70, 24–25.
 

Eljamel, M. S., Liaguart, I., Perry, J., Mowle, D., Ballantyne, E., Ackland, C., & Munro, A. (2008). Intraoperative radiotherapy using mobile miniture X-ray source in malignant brain tumors.

Giordano, F. A., Brehmer, S., Abo-Madyan, Y., Welzel, G., Sperk, E., Keller, A., … Wenz, F. (2014). INTRAGO: intraoperative radiotherapy in glioblastoma multiforme – a Phase I/II dose escalation study. BMC Cancer, 14(1), 992.

Giordano, F. A., Brehmer, S., Muerle, B., Welzel, G., Sperk, E., Schneider, F., … Wenz, F. (2016). Initial Results of a Phase 1/2 Trial on Intraoperative Radiation Therapy (IORT) in Newly Diagnosed Glioblastoma Multiforme (INTRAGO). International Journal of Radiation Oncology, Biology, Physics, 96(2S), E67–E68.

Giordano, F. A., Wenz, F., & Petrecca, K. (2016). Rationale for intraoperative radiotherapy in glioblastoma. Journal of Neurosurgical Sciences, 60(3), 350–6.

Gzell, C., Back, M., Wheeler, H., Bailey, D., & Foote, M. (2016). Radiotherapy in Glioblastoma: the Past, the Present and the Future. Clinical Oncology.

Han, X., Fu, B., Wu, M., Zhang, H., Li, D., Zhang, J., … Sun, S. (2014). Intraoperative Radiotherapy with INTRABEAM in primary brain tumors after resection: Preliminary reports of 26 cases. Neuro-Oncology, 16.

Haneder, S., Giordano, F. A., Konstandin, S., Brehmer, S., Buesing, K. A., Schmiedek, P., … Ong, M. M. (2015). ²³ Na-MRI of recurrent glioblastoma multiforme after intraoperative radiotherapy: technical note. Neuroradiology, 57(3), 321–326.

Kalapurakal, J. A., Goldman, S., Stellpflug, W., Curran, J., Sathiaseelan, V., Marymont, M. H., & Tomita, T. (2006). Phase I study of intraoperative radiotherapy with photon radiosurgery system in children with recurrent brain tumors: Preliminary report of first dose level (10 Gy). International Journal of Radiation Oncology Biology Physics, 65(3), 800–808.

Kawano, H., Hirano, H., Yonezawa, H., Yunoue, S., Yatsushiro, K., Ogita, M., … Arita, K. (2015). Improvement in treatment results of glioblastoma over the last three decades and beneficial factors. British Journal of Neurosurgery, 29(2), 206–212.

Louis, D. N., Perry, A., Reifenberger, G., von Deimling, A., Figarella-Branger, D., Cavenee, W. K., … Ellison, D. W. (2016). The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathologica, 131(6), 803–820.

Minafra, L., & Bravatà, V. (2014). Cell and molecular response to IORT treatment. Translational Cancer Research, 3(1), 32–47.

NCCN. (2015). NCCN Clinical Practice Guidelines in Oncology - Central Nervous System Cancers.

Niyazi, M., Brada, M., Chalmers, A. J., Combs, S. E., Erridge, S. C., Fiorentino, A., … Belka, C. (2016). ESTRO-ACROP guideline “target delineation of glioblastomas.” Radiotherapy and Oncology, 118(1), 35–42.

Seddighi, A., Akbari, M. E., Seddighi, A. S., Rakhsha, A., Vaezi, M., & Zohrevand, A. H. (2015). First experience of intraoperative radiation therapy in cerebral high grade glioma in Iran: A report of three cases and literature review. Iranian Journal of Cancer Prevention, 8(5).

Shcherbuk, I., Shcherbuk, Ai., Eroshenko, M., Tokarev, S., Ivanov, V., & Dovgopolaia, K. (2014). Intraoperative photon therapy in combination with mapping of motoric cerebral cortex in surgery of metastatic tumours of functionally significant zones of the large hemispheres of the brain. Vestn Khir Im I I Grek, 173(1), 47–50.

Sologuren, I., Rodríguez-Gallego, C., & Lara, P. C. (2014). Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects. Transl Cancer Res, 3(1), 18–31.

Takakura, K., & Kubo, O. (2000). Treatment of malignant brain tumors. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 27 Suppl 2, 449–53.

Weil, R. J., Mavinkurve, G. G., Chao, S. T., Vogelbaum, M. a, Suh, J. H., Kolar, M., & Toms, S. a. (2015). Intraoperative radiotherapy to treat newly diagnosed solitary brain metastasis: initial experience and long-term outcomes. Journal of Neurosurgery, 122(4), 825–832.

Wang, M., Maier, P., Wenz, F., Giordano, F. A., & Herskind, C. (2013). Mitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell line. Journal of Neuro-Oncology, 115(3), 323–331.

Zamzuri, I., Rahman, G. I., Muzaimi, M., Jafri, a M., Nik Ruzman, N. I., Lutfi, Y. a, … Mar, W. (2012). Polymodal therapy for high grade gliomas: a case report of favourable outcomes following intraoperative radiation therapy. The Medical Journal of Malaysia, 67(1), 121–2.

Alvarado, M. D., Mohan, A. J., Esserman, L. J., Park, C. C., Harrison, B. L., Howe, R. J., … Ozanne, E. M. (2013). Cost-effectiveness analysis of intraoperative radiation therapy for early-stage breast cancer. Annals of Surgical Oncology, 20(9), 2873–80.

Alvarado, M. D., Conolly, J., Park, C., Sakata, T., Mohan, A. J., Harrison, B. L., … Ozanne, E. M. (2014). Patient preferences regarding intraoperative versus external beam radiotherapy following breast-conserving surgery. Breast Cancer Research and Treatment, 143(1), 135–140.

Andersen, K. G., Gärtner, R., Kroman, N., Flyger, H., Kehlet, H. (2012). Persistent pain after targeted intraoperative radiotherapy (TARGIT) or external breast radiotherapy for breast cancer: A randomized trial. The Breast, 21(1), 46–49.

Armoogum, K., Parry, J., Mackay, C., Thompson, A., Vaidya, J., Ackland, C., … Munro, A. (2007). Measurement of Skin Dose from Very Low Energy X-rays during Partial Breast Irradiation. Clinical Oncology, 19(3), S23.

Darby, S. C., Ewertz, M., McGale, P., Bennet, A. M., Blom-Goldman, U., Brønnum, D., … Hall, P. (2013). Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer. New England Journal of Medicine, 368(11), 987–998

Elsberger, B., Romsauerova, A., Vinnicombe, S., Whelehan, P., Brown, D. C., Dewar, J. A., … Evans, A. (2014). Comparison of mammographic findings after intraoperative radiotherapy or external beam whole breast radiotherapy. European Journal of Surgical Oncology, 40(2), 163–167.

Esposito, E., Anninga, B., Harris, S., Capasso, I., D’Aiuto, M., Rinaldo, M., Douek, M. (2015). Intraoperative radiotherapy in early breast cancer. British Journal of Surgery, 102(6), 599–610.

Esposito, E., Anninga, B., Honey, I., Ross, G., Rainsbury, D., Laws, S., … Douek, M. (2015). Is IORT ready for roll-out? Ecancermedicalscience, 9, 516.

Esserman, L. J., Alvarado, M. D., Howe, R. J., Mohan, A. J., Harrison, B., Park, C., … Ozanne, E. M. (2014). Application of a decision analytic framework for adoption of clinical trial results: Are the data regarding TARGIT-A IORT ready for prime time? Breast Cancer Research and Treatment, 144(2), 371–378.

Grobmyer, S. R., Lightsey, J. L., Bryant, C. M., Shaw, C., Yeung, A., Bhandare, N., … Copeland, E. M. (2013). Low-kilovoltage, single-dose intraoperative radiation therapy for breast cancer: Results and impact on a multidisciplinary breast cancer program. Journal of the American College of Surgeons, 216(4), 617–624.

Holmes, D. R., Baum, M., Joseph, D. (2007). The TARGIT trial: targeted intraoperative radiation therapy versus conventional postoperative whole-breast radiotherapy after breast-conserving surgery for the management of early-stage invasive breast cancer (a trial update). American Journal of Surgery, 194(4), 507–510.

Holmes, D. R. (2014). Intraoperative radiotherapy in breast conserving surgery. Journal of Surgical Oncology, 110(1), 68–74.

Holmes, D. R. (2015). Intraoperative Radiotherapy of the Breast for Early-Stage Breast Cancer: Ready for Primetime. The Breast Journal, 21(2), 181–184.

Keshtgar, M. R. S., Vaidya, J. S., Tobias, J. S., Wenz, F., Joseph, D., Stacey, C., … Baum, M. (2011). Targeted Intraoperative Radiotherapy for Breast Cancer in Patients in Whom External Beam Radiation Is Not Possible. International Journal of Radiation Oncology*Biology*Physics, 80(1), 31–38.

Keshtgar, M. R. S., Williams, N. R., Bulsara, M., Saunders, C., Flyger, H., Cardoso, J. S., … Joseph, D. J. (2013). Objective assessment of cosmetic outcome after targeted intraoperative radiotherapy in breast cancer: results from a randomised controlled trial. Breast Cancer Research and Treatment, 140(3), 519–525.

Kraus-Tiefenbacher, U., Bauer, L., Kehrer, T., Hermann, B., Melchert, F., Wenz, F. (2006). Intraoperative Radiotherapy (IORT) as a Boost in Patients with Early-Stage Breast Cancer – Acute Toxicity. Oncology Research and Treatment, 29(3), 77–82.

Kraus-Tiefenbacher, U., Bauer, L., Scheda, A., Fleckenstein, K., Keller, A., Herskind, C., … Wenz, F. (2006). Long-term toxicity of an intraoperative radiotherapy boost using low energy X-rays during breast-conserving surgery. International Journal of Radiation Oncology*Biology*Physics, 66(2), 377–381.

Kraus-Tiefenbacher, U., Bauer, L., Scheda, A., Schoeber, C., Schaefer, J., Steil, V., Wenz, F. (2007). Intraoperative radiotherapy (IORT) is an option for patients with localized breast recurrences after previous external-beam radiotherapy. BMC Cancer, 7(1), 178.

Kraus-Tiefenbacher, U., Welzel, G., Brade, J., Hermann, B., Siebenlist, K., Wasser, K. S., … Wenz, F. (2010). Postoperative Seroma Formation After Intraoperative Radiotherapy Using Low-Kilovoltage X-Rays Given During Breast-Conserving Surgery. International Journal of Radiation Oncology*Biology*Physics, 77(4), 1140–1145 .

Lim, S. Z., Yong, W. S., Ho, G. H., Madhukumar, P., Wong, F. Y., Chua, E. T., … Ong, K. W. (2014). Early experience with INTRABEAM intra-operative radiotherapy in an Asian population. European Journal of Cancer, 50, S214–S215.

Malter, W., Kirn, V., Richters, L., Fridrich, C., Markiefka, B., Bongartz, R., … Kraemer, S. (2014). Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences. International Journal of Breast Cancer, 1–6.

Massa, M., Franchelli, S., Panizza, R., Massa, T. (2016). Is current clinical practice modified about intraoperative breast irradiation? Chinese Journal of Cancer Research, 28(2), 146–149.

Merdad, A. A., Bahadur, Y. A., Fawzy, E. E., Hassouna, A. H., Eltaher, M. M., Alghaithy, Z. K., … Constantinescu, C. T. (2013). Phase II study on the use of intraoperative radiotherapy in early breast cancer. Saudi Medical Journal, 34(11), 1133–8.

Mooney, H. (2014). NICE gives go ahead to intrabeam radiotherapy for breast cancer. BMJ, 349(jul28 6), g4863–g4863.

Pan, L., Zheng, W., Ye, X., Chen, L., Ke, Y., Wan, M., … Zhang, X. (2014). A novel approach of INTRABEAM intraoperative radiotherapy for nipple-sparing mastectomy with breast reconstruction. Clinical Breast Cancer, 14(6), 435–441.

Picot, J., Copley, V., Colquitt, J. L., Kalita, N., Hartwell, D., Bryant, J. (2015). The INTRABEAM^® photon radiotherapy system for the adjuvant treatment of early breast cancer: A systematic review and economic evaluation. Health Technology Assessment, 19(69), 1–190.

Preuss, J., Lester, L., Saunders, C. (2012). BCCT.core – Can a computer program be used for the assessment of aesthetic outcome after breast reconstructive surgery? The Breast, 21(4), 597–600.

Rivera, R., Banks, A., Casillas-Lopez, A., Rashtian, A., Lewinsky, B., Sheth, P., … Holmes, D. R. (2016). Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the Breast. The Breast Journal, 22(1), 63–74.

Ruano-Ravina, A., Cantero-Muñoz, P., Eraso Urién, A. (2011). Efficacy and safety of intraoperative radiotherapy in breast cancer: A systematic review. Cancer Letters, 313(1), 15–25.

Sedlmayer, F., Zehentmayr, F., Fastner, G. (2013). Partial breast re-irradiation for local recurrence of breast carcinoma: Benefit and long term side effects. The Breast, 22, S141–S146.

Sperk, E., Welzel, G., Keller, A., Kraus-Tiefenbacher, U., Gerhardt, A., Sütterlin, M., Wenz, F. (2012). Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT A. Breast Cancer Research and Treatment, 135(1), 253–260.

Sperk, E., Astor, D., Keller, A., Welzel, G., Gerhardt, A., Tuschy, B., … Wenz, F. (2014). A cohort analysis to identify eligible patients for intraoperative radiotherapy (IORT) of early breast cancer. Radiation Oncology, 9(1), 154.

Vaidya, J. S., Baum, M., Tobias, J. S., Massarut, S., Wenz, F., Murphy, O., … Joseph, D. (2006). Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost. International Journal of Radiation Oncology*Biology*Physics, 66(5), 1335–1338.

Vaidya, J. S., Joseph, D. J., Tobias, J. S., Bulsara, M., Wenz, F., Saunders, C., … Baum, M. (2010). Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. The Lancet, 376(9735), 91–102.

Vaidya, J. S., Baum, M., Tobias, J. S., Wenz, F., Massarut, S., Keshtgar, M., … Joseph, D. (2011). Long-Term Results of Targeted Intraoperative Radiotherapy (Targit) Boost During Breast-Conserving Surgery. International Journal of Radiation Oncology*Biology*Physics, 81(4), 1091–1097.

Vaidya, J. (2013). “1-stop” radiotherapy could offer an alternative to lengthy and inconvenient post-surgery procedures for breast cancer

Vaidya, J. S., Wenz, F., Bulsara, M., Tobias, J. S., Joseph, D. J., Keshtgar, M., … Baum, M. (2014). Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. The Lancet, 383(9917), 603–613.

Vaidya, J. S., Bulsara, M., Wenz, F., Joseph, D., Saunders, C., Massarut, S., … Baum, M. (2015). Pride, prejudice, or science: Attitudes towards the results of the TARGIT-A trial of targeted intraoperative radiation therapy for breast cancer. International Journal of Radiation Oncology Biology Physics, 92(3), 491–497.

Vaidya, J. S., Bulsara, M., Wenz, F., Coombs, N., Singer, J., Ebbs, S., … Baum, M. (2016). Reduced mortality with partial breast irradiation for early breast cancer – a meta-analysis of randomised trials. International Journal of Radiation Oncology*Biology*Physics, 1–7.

Valente, S. A., Tendulkar, R. D., Cherian, S., O’Rourke, C., Greif, J. M., Bailey, L., … Grobmyer, S. R. (2016). TARGIT-R (Retrospective): North American Experience with Intraoperative Radiation Using Low-Kilovoltage X-Rays for Breast Cancer. Annals of Surgical Oncology.

Wasser, K., Schoeber, C., Kraus-Tiefenbacher, U., Bauer, L., Brade, J., Teubner, J., … Neff, W. (2007). Early mammographic and sonographic findings after intraoperative radiotherapy (IORT) as a boost in patients with breast cancer. European Radiology, 17(7), 1865–74.

Welzel, G., Blank, E., Kraus-Tiefenbacher, U., Keller, A., Vorodi, F., Herskind, C., … Wenz, F. K. (2008). The influence of the interval between IORT during breast-conserving surgery and external beam radiotherapy (EBRT) on late toxicity. Journal of Clinical Oncology, 26, 630.

Welzel, G., Boch, A., Sperk, E., Hofmann, F., Kraus-Tiefenbacher, U., Gerhardt, A., … Wenz, F. (2013). Radiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from the randomized phase III trial TARGIT-A. Radiation Oncology, 8(1), 9.

Wenz, F., Welzel, G., Keller, A., Blank, E., Vorodi, F., Herskind, C., … Kraus-Tiefenbacher, U. (2008). Early initiation of external beam radiotherapy (EBRT) may increase the risk of long-term toxicity in patients undergoing intraoperative radiotherapy (IORT) as a boost for breast cancer. Breast, 17(6), 617–622.

Wenz, F., Welzel, G., Blank, E., Hermann, B., Steil, V., Sütterlin, M., Kraus-Tiefenbacher, U. (2010). Intraoperative Radiotherapy as a Boost During Breast-Conserving Surgery Using Low-Kilovoltage X-Rays: The First 5 Years of Experience With a Novel Approach. International Journal of Radiation Oncology*Biology*Physics, 77(5), 1309–1314.

Wenz, F., Blank, E., Welzel, G., Hofmann, F., Astor, D., Neumaier, C., … Kraus-Tiefenbacher, U. (2012). Intraoperative radiotherapy during breast-conserving surgery using a miniature x-ray generator (Intrabeam ® ): theoretical and experimental background and clinical experience. Women’s Health, 8(1), 39–47.

Wenz, F., Sedlmayer, F., Herskind, C., Welzel, G., Sperk, E., Neumaier, C., … Sütterlin, M. (2015). Accelerated Partial Breast Irradiation in Clinical Practice. Breast Care, 10(4), 247–252.

Williams, N. R., Pigott, K. H., Brew-Graves, C., Keshtgar, M. R. S. (2014). Intraoperative radiotherapy for breast cancer. Gland Surgery, 3(2), 109–119.

Berenson, J., Pflugmacher, R., ..., Jarzem, P. (2011) Cancer Patient Fracture Evaluation (CAFE) lnvestigators. Balloon kyphoplasty versus non-surgical fracture management for treatment of painful vertebral body compression fractures in patients with cancer: a multicentre, randomised controlled trial. Lancet Oncology, 12(3), 225-35.

Bludau, F., Obertacke, U., Schmidt, R. (2012). First middle-term results after Kypho-IORT. European Spine Journal, 21(11), 2332.

Bludau, F. (2014). Kypho-IORT: Intraoperative Radiotherapy in Spinal Metastases: Nine-Month Clinical Results. The Spine Journal, 14(11), S163

Bludau, F., Reis, T., Schneider, F., Clausen, S., Wenz, F., Obertacke, U. (2015). Kyphoplastie kombiniert mit intraoperativer Radiotherapie (Kypho-IORT). Der Radiologe, 55(10), 859–867.

Kayser, R., Ender, S. A., Asse, E., Wilhelm, E., Adler, F., Schmidt, R., … Bludau, F. (2013). Kyphoplastie in Kombination mit intraoperativer Radiotherapie. Der Orthopäde, 42(9), 765–771.

Miglierini, P., Dam-Hieu, P., Key, S. (2014). Kypho-IORT: the first French treatment. Translational Cancer Research, 3(1).

Reis, T., Schneider, F., Hermann, B., Bohrer, M., Schmitt, R., Obertacke, U., Wenz, F. (2010). Kypho-IORT: A novel treatment of spinal metastases with intraoperative radiotherapy during kyphoplasty. International Journal of Radiation Oncology Biology Physics, 78(3), S581–S582.

Reis, T., Schneider, F., Welzel, G., Schmidt, R., Bludau, F., Obertacke, U., Wenz, F. (2012). Intraoperative radiotherapy during kyphoplasty for vertebral metastases (Kypho-IORT): first clinical results. Tumori, 98(4), 434–40.

Reis, T., Sperk, E., Schneider, F., Schmidt, R., Obertacke, U., Wenz, F. (2012). Kypho-IORT for spinal metastasis: a case study. Hospital Oncology & Haematology Europe, Campden Publishing Ltd, Apr, 21-24.

Schmidt, R., Obertacke, U., Wenz, F., Reis, T., Schneider, F. (2010). Clinical feasibility of a new minimal invasive intraoperative radiation in combination with balloon kyphoplasty (Kypho-IORT) for spinal metastases. European Spine Journal, 19(11), 2049.

Schmidt, R., Wenz, F., Reis, T., Janik, K., Bludau, F., Obertacke, U. (2012). Kyphoplasty and intra-operative radiotheray, combination of kyphoplasty and intra-operative radiation for spinal metastases: technical feasibility of a novel approach. International Orthopaedics, 36(6), 1255–1260.

Schneider, F., Greineck, F., Clausen, S., Mai, S., Obertacke, U., Reis, T., Wenz, F. (2011). Development of a Novel Method for Intraoperative Radiotherapy During Kyphoplasty for Spinal Metastases (Kypho-IORT). International Journal of Radiation Oncology*Biology*Physics, 81(4), 1114–1119.

Wenz, F., Schneider, F., Neumaier, C., Kraus-Tiefenbacher, U., Reis, T., Schmidt, R., Obertacke, U. (2010). Kypho-IORT - a novel approach of intraoperative radiotherapy during kyphoplasty for vertebral metastases. Radiation Oncology, 5(1), 11.

Amini, S., Viera, M. H., Valins, W., Berman, B. (2010). Nonsurgical innovations in the treatment of nonmelanoma skin cancer. The Journal of Clinical and Aesthetic Dermatology, 3(6), 20–34.

Armoogum, K., Parry, J., Mackay, C., Thompson, A., Vaidya, J., Ackland, C., … Munro, A. (2007). Measurement of Skin Dose from Very Low Energy X-rays during Partial Breast Irradiation. Clinical Oncology, 19(3), S23.

Bhatnagar, A., Loper, A. (2010). The initial experience of electronic brachytherapy for the treatment of non-melanoma skin cancer. Radiation Oncology (London, England), 5, 87.

Chan, S., Dhadda, A.S. (2007) Swindell, R., Single fraction radiotherapy for small superficial carcinoma of the skin. Clin Oncol (R Coll Radiol), 19(4), 256-9.

Cognetta, A. B., Howard, B. M., Heaton, H. P., Stoddard, E. R., Hong, H. G., Green, W. H. (2012). Superficial x-ray in the treatment of basal and squamous cell carcinomas: a viable option in select patients. Journal of the American Academy of Dermatology, 67(6), 1235–41.

Bodner, W. R., Hilaris, B. S., Alagheband, M., Safai, B., Mastoras, C. A., Saraf, S. (2003). Use of low-energy X-rays in the treatment of superficial nonmelanomatous skin cancers. Cancer Investigation, 21(3), 355–362.

Ducassou, A. (2015). First experience of skin treatments with INTRABEAM at IUCT Oncopole Toulouse. In ESTRO proceeding.

Ermertcan, A. T., Hellings, P. W., Cingi, C. (2012). Nonmelanoma skin cancer of the head and neck: nonsurgical treatment. Facial Plastic Surgery Clinics of North America, 20(4), 445–54.

Goubert, M., Parent, L. (2015). Dosimetric characterization of INTRABEAM® miniature accelerator flat and surface applicators for dermatologic applications. Physica Medica, 31(3), 224–232.

Jankarashvili, N., Topeshashvili, M. (2015). Treatment of skin cancer with intrabeam. 9th ZEISS INTRABEAM User Meeting.

Levell, N. J., Igali, L., Wright, K. A., Greenberg, D. C. (2013). Basal cell carcinoma epidemiology in the UK: the elephant in the room. Clinical and Experimental Dermatology, 38(4), 367–9.

Nguyen, T. H., Ho, D. Q.-D. (2002). Nonmelanoma skin cancer. Current Treatment Options in Oncology, 3(3), 193–203.

Perkins, J. L., Liu, Y., Mitby, P. A., Neglia, J. P., Hammond, S., Stovall, M., … Mertens, A. C. (2005). Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: a report from the childhood cancer survivor study. Journal of Clinical Oncology, 23(16), 3733–41.

Tward, J.D., Anker, C, J,. Gaffney, D.K., Bowen, G. . (2012). Radiation Therapy and Skin Cancer. Modern Practices in Radiation Therapy, 207–246.  

Algur, E., Mahadevan, A., Deibel, C. (2005). Interstitial photon radiosurgery system for re-current and locally advanced rectal cancer: a retrospective review of 24 patients. ASCO Gastrointestinal Cancers Symposium, Jan 27–29, Hollywood, Florida, USA, Abstract No 208.

Guo, S., Reddy, C. A., Kolar, M., Woody, N., Mahadevan, A., Deibel, F., … Suh, J. H. (2012). Intraoperative radiation therapy with the photon radiosurgery system in locally advanced and recurrent rectal cancer: retrospective review of the Cleveland clinic experience. Radiation Oncology, 7(1), 110.

Haddock, M. G. (2016). Irradiation of Very Locally Advanced and Recurrent Rectal Cancer. Seminars in Radiation Oncology, 26(3), 226–235.

Lyadov, K., Krymskiy, V., Markin, A., Krymskiy, A. (2008). Evaluation of safety of intraoperative radiotherapy using the intra beam system in combined treatment of gastric cancer. Poster Abstract Presented at the ISIORT Meeting.

Lyadov, K., Yu, S., Krymskiy, V., Krymskiy, A. (2008). Improvement of Curativity of Video-Assisted Surgery for Colorectal Cancer Due to Intra-Operative Contact Radiotherapy Using the INTRA BEAM System. ISIORT.

Polkowski, W. P., Skórzewska, M. (2014). Intraoperative Radiotherapy with Low-Energy Photons in Rectal Cancer Recurrence. (M. Keshtgar, K. Pigott, & F. Wenz, Eds.), Targeted Intraoperative Radiotherapy in Oncology. Berlin, Heidelberg: Springer Berlin Heidelberg.

Potemin, S., Uvarov, I., Vasilenko, I. (2015). Intraoperative radiotherapy in locally-advanced and recurrent rectal cancer: retrospective review of 68 cases. Transl Cancer Res, 4(2), 189–195.

Skórzewska, M., Mielko, J., Kurylcio, A., Romanek, J., Polkowski, W. P. (2016). Intraoperative radiotherapy with low energy photons in recurrent colorectal cancer: a single centre retrospective study. Współczesna Onkologia, 20(1), 52–57.

Susko, M., Lee, J., Salama, J., Thomas, S., Uronis, H., Hsu, D., … Palta, M. (2016). The Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal Cancer. Annals of Surgical Oncology.  

Abo-Madyan, Y., Gößler, U., Vent, J., Nwankwo, C., Schneider, F., Hörmann, K., Wenz, F. (2013). Intraoperative Radiotherapie for recurrent Head & Neck Squamous Cell Carcinoma using a mobile 50kV mini accelerator. DEGRO 2013, Poster.

Chen, A. M., Bucci, M. K., Singer, M. I., Garcia, J., Kaplan, M. J., Chan, A. S., Phillips, T. L. (2007). Intraoperative radiation therapy for recurrent head-and-neck cancer: The UCSF experience. International Journal of Radiation Oncology*Biology*Physics, 67(1), 122–129.

De Felice, F., Musio, D., Tombolini, V. (2016). Intraoperative radiation therapy (IORT) in recurrent head and neck cancer. Oral Oncology, 55(March), e1.

Münter, M. W., Köppen, U., Ramuscak, A., Sittel, C., Wegner, N. (2015). Intraoperative radiotherapy (IORT) in the treatment of head and neck cancer. Transl Cancer Res, 4(2), 178–181.

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