The moment radiotherapy can be ideally tailored to the needs of your patient.

This is the moment we work for.


TARGIT - Targeted Intraoperative Radiotherapy with INTRABEAM

The trend in oncological therapy is moving towards the targeted, risk-adapted and interdisciplinary treatment of tumors. INTRABEAM®, the innovative radiotherapy system from ZEISS is an ideal platform to fulfill these requirements. It provides:

  • Localized tumor treatment with lower toxicity to the breast1
  • Localized irradiation with a high radio-biological effectiveness2
  • Practical mobility and fast workflow integration
  • Versatility of the clinical application

2Liu, Q., Schneider, F., Ma, L., Wenz, F., & Herskind, C. (2013). Relative Biologic Effectiveness (RBE) of 50 kV X-rays Measured in a Phantom for Intraoperative Tumor-Bed Irradiation. International Journal of Radiation Oncology*Biology*Physics, 85(4), 1127-1133.


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Targeted Radiotherapy for a Wide Range of Applications


4 steps web

Breast Cancer Treatment with Targeted Intraoperative Radiotherapy

INTRABEAM has been studied for more than 13 years and over 8,000 patients have received treatment for early breast cancer. It has been exclusively used to develop the targeted intraoperative radiotherapy technique implemented in the TARGIT-A Trial - a highly reputable international consortium that studies the efficacy of IORT in the treatment of early breast cancer versus traditional external beam radiotherapy (EBRT).

Targeted IORT with INTRABEAM is a risk-adapted individualized therapy that delivers low-energy X-rays directly into the tumor bed at the time of surgery (after tumor excision). During this procedure, the radiation is applied using a spherical applicator in a way that ensures direct contact with the target tissue. Radiation is delivered precisely to the area with the highest risk of tumor recurrence while minimizing radiation to healthy tissue.

4 steps web a

A: Step 1 - The position of the tumor is determined.

4 steps web b

B: Step 2 - The tumor is surgically removed.

4 steps web c

C: Step 3 - The INTRABEAM applicator tip is positioned in the tumor cavity. The radiation is applied for about 30 minutes.

4 steps web d

D: Step 4 - The applicator is removed and the incision closed.

Intraoperative radiotherapy (IORT) with INTRABEAM can be adapted to the needs of the patient. In the TARGIT trial, a flexible risk adaptive approach was used  - such that, if the final pathology demonstrated adverse risk factors that were not predicted prior to the procedure, then EBRT can be added to the TARGIT treatment. The intraoperative radiation then serves as a boost dose to the EBRT treatment that is prescribed.


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More Applications


Radiotherapy for Spinal Metastases with INTRABEAM

INTRABEAM Needle Applicator

Example: Treatment of spinal metastases with Kypho-IORT

For many cancer patients who develop spinal metastases in the natural course of their disease, percutaneous kyphoplasty and vertebroplasty are valuable treatment options. By using intraoperative radiotherapy with INTRABEAM during kyphoplasty or vertrebroplasty, the metastasis can be sterilized and if necessary vertebra simultaneously stabilized, a solution that results in reduction of patient’s discomfort. It also restores mobility, significantly enhancing the patient’s quality of life. The first clinical trial experience of this approach has yielded very promising results.3


Kypho 6 Schritte Web

Step 1:
Vertebral body containing a bone metastasis


Kypho 6 Schritte Web

Step 4:
A balloon is inserted in the vertebral body with painfull lesions

Kypho 6 Schritte Web

Step 2:
A minimal invasive access is created

Kypho 6 Schritte Web

Step 5:
The balloon is carefuly inflated, returning the vertebral body to its normal position

Kypho 6 Schritte Web

Step 3:
Radiation (< 5 min) of the bone metastasis at its precise location

Kypho 6 Schritte Web

Step 6:
The cavity created by the balloon is filled with bone cement for stabilization

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1 Wenz F, Kraus-Tiefenbacher U: Intraoperative Radiotherapy for Breast Cancer, Uni-Med, 2011; 51

2 Vaidya JS, Tobias JS, Baum M, et al.: TARGeted Intraoperative radioTherapy (TARGIT): An Innovative Approach to Partial-Breast Irradition, Semin Radiat Oncol, 2005, 84-91

3 Wenz F, Schneider F, Neumaier C et al. Kypho-IORT – a novel approach of intraoperative radiotherapy during kyphoplasty for vertebral metastases. Radiat Oncol 2010; 5: 11

INTRABEAM Product information
INTRABEAM, the innovative radiotherapy system from Carl Zeiss, is an ideal system for these requirements.

The INTRABEAM® System is indicated for radiation therapy treatments. The INTRABEAM® Spherical Applicators used with the INTRABEAM System are able to deliver a prescribed dose of intraoperative radiation in conjunction with whole breast irradiation, based upon the medical judgment of the physician. The safety and effectiveness of the INTRABEAM System as a replacement for whole breast irradiation in the treatment of breast cancer has not been established.

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