Targeted Intraoperative Radiotherapy (TARGIT) with INTRABEAM

Delivery of targeted, intraoperative radiation therapy (TARGIT) with INTRABEAM® is a treatment option for early stage breast cancer care.This risk-adapted therapeutic solution expands treatment options for a select patient cohort. 

Study verifies effectiveness of the TARGIT

The results of a multinational, randomized clinical study (TARGIT-A) of 3,451 patients at 33 centers in 10 countries confirms the intraoperative targeted radiotherapy (TARGIT) with INTRABEAM is non-inferior to traditional external beam radiotherapy (EBRT) for early stage breast cancer.1 A subject group with a favorable risk profile (median age 63 years, median tumor size 13 mm, 83% pN0, 91% estrogen receptor positive) was treated.2

TARGIT-A Immediate IORT Delivery Cohort

Both study groups in the TARGIT-A study showed good tolerance of the radiotherapy. The percent within each study group in the TARGIT-A study that have not had a recurrence after 5 years of treatment is shown in the group below. 

1 Vaidya JS, Wenz F, Bulsara M, et al. Targeted intraoperative radiotherapy for early breast cancer: TARGIT-A trial-updated analysis of local recurrence and first analysis of survival Abstract S 4-2, published in: CancerRes; 72 (24 Suppl.) December 15, 2012

2 Vaidya JS, Joseph DJ, Tobias JS et al. Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet 2010; 376: 91-102


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