Are You Missing the Bigger Picture? Don't Let Your Sample Size Limit Your Discoveries

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Courtney Akitake Ph.D. Product Marketing Manager Lightsheet,
ZEISS Microscopy

The demand for contextual data in larger specimens, both live and fixed, has led to a significant increase in the use of samples such as zebrafish, Drosophila, organoids and cleared tissue for probing cellular and subcellular structure and function. Capturing meaningful 3D datasets in such samples is challenging due to limitations in depth penetration, long acquisition times and significant phototoxic burden. Light sheet technology not only increases your image capture rate in larger living samples but also in fixed and cleared tissue and the resolution now made possible by advances in optics is generating impactful results. Making use of this powerful imaging modality for both live and fixed samples all in the same instrument really diversifies the applications and users that can benefit and ensures that the system is always used to full capacity.

Key Learnings:

  • Learn how light sheet technology is revolutionizing imaging of whole, living specimens such as zebrafish, Drosophila and organoids as well as cleared tissue such as brain and kidney
  • See ZEISS Lightsheet 7 in action and get a feel for how easy it is to get started​
  • Hear from the experts how the imaging demands of live and cleared specimens have driven the development of unique optics for ZEISS Lightsheet 7

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ZEISS Lightsheet 7
ZEISS Lightsheet 7 Your Light Sheet Microscope for Multiview Imaging of Living and Cleared Specimens

Light sheet fluorescence microscopy (LSFM) with its unique illumination principle allows fast and gentle imaging of whole living model organisms, tissues, and developing cells. The high stability of ZEISS Lightsheet 7 enables researchers to observe living samples over extended periods of time – even days – with less phototoxicity than ever before. The new light sheet microscope can also be used to image very large optically cleared specimens in toto, and with subcellular resolution. The dedicated optics, sample chambers, and sample holders of ZEISS Lightsheet 7 can be adjusted to the refractive index of the chosen clearing method to observe large samples, even whole mouse brains.