ZEISS Cell Observer SD

Fast and Gentle Confocal Imaging

Clearer Images. Clearly Faster.

Cell Observer SD by ZEISS Combines the Best Technologies
With Cell Observer SD, you have it all: The image quality of Axio Observer and Axio Examiner. Spinning disk technology from Yokogawa CSU-X1. The dual camera technology of ZEN software. This symbiosis of optics, hardware and software in one system makes your confocal live cell imaging uniquely accurate: you control your Cell Observer SD precisely in the millisecond range. By streaming image data, you will acquire your images in breathtakingly short times. You also document two fluorescence channels of your sensitive samples simultaneously and get even more valuable data.

Histone-2B-expressing HeLa cells
Histone-2B-expressing HeLa cells
Mitosis in LLC-PK1 cells
Mitosis in LLC-PK1 cells
Zebrafish embryo
Zebrafish embryo


  • Excellent Optics. Image quality without compromises.
    A tube lens developed by ZEISS especially for Cell Observer SD gives even better color correction and higher contrast.
    LCI objectives also work with a correction ring that makes the best image quality possible under your demanding conditions. Consequently, DirectFRAP – our solution for laser manipulation – is coupled into the illumination beam path. This leaves the imaging beam path free of additional components, delivering uncompromised image quality.
  • Two Channels simultaneously. A true Cell Observer.
    Document and quantify dynamic processes in living samples with the proven Cell Observer HS technology. Your system reads two hardware-triggered, highly sensitive cameras simultaneously to give you the benefit of the highest precision in timing. Observe dynamic cell processes with high frame rates, thanks to streaming technology.
  • A Universe of Options. Combine freely to Your Requirements.
    Combine Cell Observer SD according to your needs with motorized scanning stages, Z-Piezo inserts, stage-top incubation and DirectFRAP. All components are seamlessly integrated and managed with millisecond accuracy. You control environmental conditions when acquiring living cells with completely software-run incubation.

Applications Videos


Laser Manipulation for the Analysis of Cell Dynamics
With DirectFRAP from ZEISS you manipulate fluorescent proteins in living cells and organisms for the analysis of highly active processes. With an advanced system design, resolve highly dynamic events and physiological processes in cells. Experience the shortest manipulation times for FRAP, FLIP, photoactivation and photoconversion with simultaneous manipulation across the complete region of interest.

Benefit with DirectFRAP:
  • Image fast processes with a wide observation field and short acquisition times for extensive data for modeling of underlying processes
  • Use short manipulation times with simultaneous manipulation across the complete region of interest
  • Combine imaging techniques, such as TIRF or spinning disk confocal, for even more extensive analysis


ZEISS Cell Observer SD

Fast and Sensitive Confocal Imaging

19 Pages
Filesize: 5,857 kB

ZEISS Cell Observer SD (in Portuguese Language)

Imagem Confocal Rápida e Sensível

18 Pages
Filesize: 5,756 kB