Manipulate Microscope Samples like Stem-Cells or Transgenic Structures


On the Trail of Life Itself

You manipulate living cells or genetic material and want maximum sample protection? You want to make even the very finest structures visible?

Irrespective of size or price – the performance features of our micromanipulation systems speak for themselves:

  • Maximum precision
  • Brilliant optics
  • Versatile contrasting techniques: PlasDIC, DIC, HMC, phase contrast – all on just one stand, depending on the configuration
  • Reliable reproducibility
  • Vibration-free
  • Ergonomic operating concept


Flexibility: well-considered modularity and complete integration

ZEISS is able to provide at least one solution for every application – with exactly the configuration that suits your requirements – and also leaves plenty of upgrade options open for future tasks.

With ZEISS micromanipulation systems you can choose from a wide variety of manual and motorized stereomicroscopes and inverted microscope systems with or without fluorescence.
From routine IVF applications and highly complex cell research experiments to high-throughput applications in developmental biology – the latest generation of instruments provides you with all the possibilities of micromanipulation.

System software and a variety of components

An economic advantage is full integration into AxioVision. With the possibility of adding a wide range of modules, right through to an analysis platform, even the functions of the basic version are perfectly sufficient for all relevant applications. AxioVision LE can be downloaded free of charge for simple image acquisition.

Applications under physiological conditions can substantially increase success rates. For this reason, ZEISS has developed a complete portfolio of incubation components which simulate in-vivo conditions of cells almost perfectly in the system.

For simple documentation using AxioVision LE you can connect digital cameras of your choice. Besides the tried-and-tested cameras of the AxioCam family, consumer and video cameras made by other manufacturers are also compatible – for simple image acquisition, image processing and measuring.


Besides conventional, routine IVF (in-vitro fertilization) applications, the systems from ZEISS also enable you to perform additional applications such as ICSI (intracytoplasmic sperm injection) and IMSI (intracytoplasmic morphologically selected sperm injection).

Specifically developed equipment helps you to considerably streamline and optimize your workflow - to reduce costs and operating procedures. Each system can be expanded to include cameras and incubation devices, and it is possible to attach all standard manipulators.

All contrasts available

For successful ICSI, clearly visible structures such as zona pellucida and polar body of the egg cell are essential. With IMSI, you can also assess the shape and vacuole count of the sperm cells. In borderline cases, several contrasting techniques have to be possible that can deliver scientifically unambiguous, high-contrast images.

Unique in the Axio Observer research microscope:

All relevant contrast techniques are available on one single stand: Hoffmann modulation contrast, PlasDIC and DIC. In addition, phase contrast can be combined with all methods.

The majority of ICSI experiments take place in plastic dishes for which DIC is not suitable. With the patented PlasDIC contrasting technique from ZEISS, egg and sperm cells can be observed in the same plane. PlasDIC produces a relief that is similar to DIC and delivers an impressive three-dimensional display. Your benefit: a total solution precisely tailored to your needs. Plus a completely vibration-free stand and high-resolution, needle-sharp DIC-like images.

Transgenic Techniques

Technology of the Future for the Tasks of the Future

Understanding and curing diseases – a considerable challenge in a field that is unsurpassed in terms of its complexity and demands. Virtually all areas of research come together here. At present we only have a vague notion of the potential of transgenic techniques and stem cell research.


No other research area offers so many positive opportunities and possibilities for medicine and for us as humans. It also represents a significant challenge as far as technology is concerned: manipulating genetic material or stem cells calls for microscopes that can be adapted quickly and fully to ever-increasing requirements.


In the case of applications such as PN injections, nuclear transfer and reporter gene analysis, which become visible using fluorescence illumination and the appropriate HE filter sets or using DIC or PlasDIC as contrasting technique, numerous configurations are available to you – ranging from routine high-throughput workflows to those requiring high-end technology involving incubation, documentation and analysis software. Here, it is also possible to work with various manipulators.


Embryonic development, cancer research, neurobiology – it is in the field of developmental biology that the most diverse range of micromanipulation applications is encountered. Versatility is therefore a key factor for your stereomicroscopes. From brilliant 3D images through to extremely fast systems, all-round performance is required.

You can find the perfect configuration for all applications in developmental biology. From samples such as small organelles, embryos and egg cells, or whole organisms such as Drosophila, C. elegans and zebra fish through to genetic manipulation and knockouts.

Stereomicroscopes of all classes deliver precisely the brilliant 3D display that such applications demand.