Labs at Location - Polish Academy of Sciences - Institute of Immunology and Experimental Therapy

labs@location Partner

Polish Academy of Sciences

Polish Academy of Sciences

Institute of Immunology and Experimental Therapy

Decide on your ideal ZEISS microscope in the facilities of our labs@location partner the Polish Academy of Sciences, and especially at the Institute of Immunology and Experimental Therapy in Wroclaw.

The Polish Academy of Sciences is a state scientific institution founded in 1952. From the very beginning, it has functioned as a learned society acting through an elected corporation of top scholars and research organizations, via its numerous scientific establishments. It has also become a major scientific advisory body through its scientific committees.

Institute of Immunology and Experimental Therapy was founded in 1952 by the Polish Academy of Sciences. The main founder and the first director of the Institute was Professor Ludwik Hirszfeld, famous Polish immunologist and microbiologist.

 

Major Reseach Programs

  • Antiviral immunity
  • Bacterial antigens
  • Bacteriophage research and therapy
  • Cellular signalling
  • Clinical immunology
  • Experimental cancer therapy
  • Glycoimmunobiology
  • Immunology of bacterial infections
  • Immunomodulation
  • Immunopharmacology
  • Molecular microbiology
  • Transplantation immunology
  • Tumor immunology

Main Projects

Molecular Microbiology

  • Streptomyces

    Streptomyces are harmless soil bacteria producing many valuable antibiotics and other secondary metabolites. Compartments of Streptomyces hyphae contain multiple copies of a linear chromosome, while E. coli and other studied rod-shaped bacteria possess single circular chromosome. This may imply unique features of Streptomyces chromosome replication. Our projects focus on the initiation of chromosome replication and the regulation of this process.

  • Segregation of Streptomyces

    During Streptomyces sporulation, multiple chromosomes in spore-forming aerial hyphae must be segregated so that each spore contains a single chromosome. This mode of growth and development provokes questions about how the mechanisms of chromosome segregation differ from those studied in unicellular bacteria.

  • Helicobacter pylorii

    Helicobacter pylori is a Gram-negative, microaerophilic pathogenic bacterium. It colonizes the human gastric mucosa of about half of the world's population and is a causative agent of peptic ulcer, gastric adenocarcinoma, and gastric lymphoma. The initiation of chromosome replication is the first and a tightly controlled step in DNA synthesis. In our laboratory we are studying the initiation and regulation of H. pylori chromosome replication. Using different in vivo and in vitro methods, we aim to discover and characterize the factors participating in this process: DNA sequences and proteins and their reciprocal interactions.

     

  • Mycobacteria

    Pathogenic Mycobacteria, including the agent of tuberculosis, are slow-growing elongated (sometimes branched) rods. Little is known about their cell division and DNA segregation. The aim of our project is to compare chromosome segregation machinery in Mycobacteria and Streptomyces.

     

Bacteriophage Research and Therapy

THERAPEUTIC USE OF BACTERIOPHAGES IN BACTERIAL INFECTIONS

Common use of antibiotics in the developed world has resulted in the emergence of bacterial strains, which are highly resistant to virtually all available antimicrobial agents. As a result, in most infections induced by such bacteria even intensive antibiotic therapy is ineffective. This creates a serious therapeutic problem. Therefore, we observe a growing interest in the use of bacteriophages in medical practice. Since 1980 the specific bacteriophages have been used in our Laboratory for the treatment of over 1500 patients with suppurative bacterial infections, in which a routine antibiotic therapy failed. The results obtained so far showed that phage therapy is safe and highly effective (the majority of patients were cured).


We offer:

  • isolation and identification of bacterial strains from the specimens of patients,
  • determination of sensitivity of the isolated strains to specific bacteriophages,
  • preparation of phage lysates for a therapeutic treatment.

 

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