Biochemical Pharmacology

Biochemical Pharmacology & Toxicology

Interdisciplinary Interactions

In biochemical pharmacology you study interactions between chemical substances and biochemical processes of a living organism. This discipline of medicine, biology and chemistry also encompasses chemical and pharmaceutical toxicology. For your multidisciplinary research you rely on technological advances in proteomics and metabolomics, computational and synthetic chemistry, drug discovery, bioinformatics, bioanalytical chemistry and, of course, digital imaging with various microscopic methods.

Understanding Cellular Metabolism

The fields of biochemical pharmacology and toxicology have changed substantially over the past few years, fueled by the rapid increase in cell biological and biochemical knowledge. You design chemicals and molecules that act on specific cellular signaling or metabolic pathways. With the ability to highlight processes in the cell by using fluorescence proteins, you analyze and better understand the dynamics of compound metabolism. The inverted Axio Observer with incubator option is your tool for advanced fluorescent imaging of living cells. Use Axio Observer as a platform for ZEISS confocal laser scanning systems, for example LSM 700 or LSM 780. With high resolution and sensitivity you study intracellular protein localization and monitor protein interactions and dynamics. To image your living cells rapidly, gently and in 3D you upgrade to Cell Observer SD with spinning disk technology. For single molecule imaging of cell membrane receptors and other molecules near the cell surface, integrate Laser TIRF 3 into your Axio Oberver system to achieve highest sensitivity and resolution in Z.

High-Throughput Screening

To evaluate high numbers of compounds with potential pharmaceutical use, you deploy high-content screening systems. Carl Zeiss software supports you in doing so with dedicated high-throughput software modules. Analyze your cells quickly and effectively for reporter expression, molecular localization, cell differentiation or cytotoxicity with ASSAYBuilder and ZEN. The sensitive high-throughput fluorescence slide scanner Axio Scan.Z1 perfectly supports your screening projects for identification and characterization of pharmaceutical targets. Create and save scanning profiles with a huge variety of settings that are easily assigned to a group of slides. The open and well documented user interface lets you access your data with your own programs for image analysis, or you use the integrated image analysis modules.

Correlative Light and Electron Microscopy

Combine the functional perspective from your fluorescence microscope with the high resolution and structural information of an electron microscope to examine the interaction of drug molecules on a molecular level. With Shuttle & Find you define your region of interest on the light microscope, transfer your sample to the electron microscope and relocate the specified region easily. With SIGMA scanning electron microscope research in biochemical pharmacology benefits from higher resolution as well as the ability to use extended analytical functions, such as EDX for element analysis.

Recommended Products for Biochemical Pharmacology & Toxicology

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