Molecular Cell Biology Products and Microscope Accessories

Cell Biology

It's All About Cells

Cell biology encompasses the study of cell anatomy and structure, organelles, life cycle and communication with other cells and their environments. Cell biologists study many types of samples including bacteria, yeast, plant or animal and human cells. Depending on the research interest, you focus on structures that are tens of microns or even only nanometers in size.

Cell Culture Microscopes

To observe cell growth and maintain a stable cell culture you need a microscope, which facilitates daily routine checks of your living cells. With Primovert from  ZEISS you inspect your cultures quickly and easily. In Primovert HDcam the camera is already integrated into the stand. You control your camera and acquisition settings directly at the stand. In combination with your iPad and the imaging app Labscope you share, discuss and explain your observations with colleagues. Due to the compact design, Primovert fits perfectly under your hood. For your demanding routine tasks in molecular cell biology Axio Vert offers LED illumination and all standard contrasting technics. Observe fluorescently labeled cells, check transfection rates and visualize fine structures with PlasDIC to gain additional insight into the state of your cell culture.

Gentle Imaging to Keep Your Cells Alive

To study dynamic processes, you need to use living cells in multidimensional fluorescence experiments. Thus, fast and gentle imaging techniques are required to minimize photodamage on one hand, while incubating options maintain cell health over periods of extended imaging.
With Cell Observer you monitor your living cells with high frame rates and smart illumination schemes, applying gentle LEDs as an excitation light source. You control all key incubation parameters to provide the perfect environment for your cells. Deconvolution can be used to improve image signal-to-noise ratio helping to resolve more details or upgrade with VivaTome for optical sectioning. Perform confocal imaging at high frame rates with Cell Observer SD featuring the spinning disc technology of Yokogawa CSU-X1. Illumination time and phototoxicity are reduced to a minimum. As a cell biologist interested in plasma membrane-associated phenomena you benefit greatly from total internal reflection fluorescence microscopy, abbreviated TIRF-M. This method even allows single molecule imaging experiments at the cell surface. Laser TIRF 3 is easy to use and addresses advanced applications such as synchronous observation of differently labeled molecules at high temporal resolution.

Confocals, Your Workhorses for 3D Imaging

Most 3D imaging experiments in molecular cell biology are performed on confocal laser scanning microscopes. With excellent sectioning capability in Z and a perfect low noise image quality these systems have become indispensable in most research facilities. Additionally, these systems offer you the option for photobleaching experiments, such as FRAP or photoactivation. For example, photo-activatable dyes and fluorescence proteins allow you to measure the dynamics and localization of protein populations over time. Similarly, fluorescence correlation studies within cells provide you with valuable information on protein clustering and dynamics.
LSM 800 is ideally suited for cell biological applications. You obtain high sensitivity with low noise level. Amongst other improvements, this is achieved by oversampling with 30 percent longer sampling time, optimized laser suppression and a new spectral grating. Your live cell experiments especially benefit from faster scan rates and consistent image conditions, guaranteed by ultra-stable laser excitation and Definite Focus. Quickly adjust your settings with the Smart Setup function of ZEN digital imaging software suite. Your FRAP and photoactivation experiments profit from tools for manipulating freely definable ROIs with individual settings.

Beyond the Diffraction Limit – Superresolution and Electron Microscopy

Many structures within a cell fall below the light microscopy resolution limit of approximately 200 nm. New microscope techniques in molecular cell biology, such as superresolution structured illumination (SR-SIM) and photoactivated localization microscopy (PAL-M), enable you to use fluorescence to examine sub-cellular structures, such as the nuclear pore complex and actin cytoskeleton. You configure your ELYRA superresolution system to either SR-SIM or PAL-M or even both technologies simultaneously in one turn-key platform. When you need even more resolving power, SIGMA and MERLIN scanning electron microscopes are powerful tools for your research. Understand and visualize cell ultrastructure and intracellular organization. With Crossbeam FIB-SEM you investigate even three-dimensional morphology. To link functional investigations using fluorescent markers with structural information from electron microscopes, Shuttle & Find provides a unique workflow to improve your efficiency. You profit from fast relocation and precise image overlays with this unique solution for correlative light and electron microscopy.

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