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ZEISS at Neuroscience 2022

Discover the Power of Possibilities

San Diego, CA | Booth #2228
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As researchers, you wield curiosity to create an ever-changing world. Your discoveries present a need for our society to adopt and adapt to that new understanding.  Throughout the past two years we have all been finding new ways to adapt to the changing times. We all jumped into a world of digital efficiencies. We have encountered new ways to work, new avenues for interpersonal connections, new approaches to previous hurdles.  As your partner, we have used that drastic change to recalibrate how we serve you.

This year at SfN Neuroscience 2022, we are bringing those digital efficiencies to our in-person booth with an eye on sustainability.  Come and interact with researcher discoveries on our interactive wall, see our products in a VR showroom, or remote into our ZEISS Microscopy Customer Center for a live product introduction. Register for our in-booth presentations to hear from researchers like you, who have surmounted the challenges of the last two years to find their discoveries.  We believe that you are the power behind what's possible, let us help you find efficiencies to achieve your discoveries, faster.

In-Booth Presentations

Attend daily presentations from researchers like you in the ZEISS booth.

  • Multicolor confocal imaging through implanted GRIN lenses

    Abstract:

    Head-mounted miniscopes have allowed researchers to observe and correlate neuronal activity and behavior in freely moving animals, even in deeper regions of the brain. The achievable image quality of these recordings is severely limited, however, falling far behind traditional confocal or multiphoton microscopy.
    We can overcome these limitations by supplementing imaging during behavior with subsequent confocal and Airyscan images taken in head-fixed animals. Initial epifluorescence imaging allows easy co-registration of head-fixed and freely moving imaging modalities. Fast functional imaging of GCaMP positive cells using multiplexed Airyscan detection enables the localization of previously observed signaling neurons with high resolution and sensitivity. Multicolor volumetric imaging allows us to map all labeled cells in the visible brain column and to determine, which of these neurons co-express secondary labels alongside GCaMP. Using the available excitation lasers and full spectral detection capabilities of the microscope, while compensating especially for chromatic aberrations induced by the GRIN lens, we can image a myriad of different fluorescent labels in any color of the visible spectrum without compromising the functional GCaMP recordings.
    The additional spatial and multicolor information gained using this method offers both valuable context and improved spatial information of the neurons previously observed during behavior.

    Presented by:  Nicolai T. Urban, Ph.D., Head of Light Microscopy, Max Planck Florida Institute for Neuroscience

    Nicolai T. Urban, Ph.D., Head of Light Microscopy,
    Max Planck Florida Institute for Neuroscience

    Nicolai Urban is a physicist by training who has gone on to build a career in neuroscience and technology. As Head of the Light Microscopy Core at the Max Planck Florida Institute for Neuroscience (MPFI) in Jupiter, Florida, he collaborates with researchers to answer cutting edge neuroscience questions using high- and super-resolution imaging techniques, and to develop new methodologies and imaging applications. Dr. Urban specializes in STED super-resolution microscopy, a technique developed by Nobel laureate Dr. Stefan W. Hell, under whom Dr. Urban studied as a doctoral student. Dr. Urban also works as an independent consultant for Abberior Instruments America, manufacturer and distributor of STED imaging technology, and played a major role in establishing Abberior Instruments’ first North American location at the Max Planck Florida Headquarters in 2017. Prior to working with MPFI, Dr. Urban was a postdoctoral researcher at the Department of NanoBiophotonics at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, where he also earned his PhD with the rank of “summa cum laude” and defended his thesis under two Nobel laureates. He has spoken about advances in imaging at events throughout the world such as the Society for Neuroscience Conferences, SPIE Photonics West, Optics Within Life Sciences (OWLS) in Genoa, Italy, Molekulare Bildgebung (MOBI) in Göttingen, Germany, and the Joint European Magnetic Symposia in Dublin Ireland. His work has been published in many notable journals, including Nature, Neuron, and Nature Communications.

  • Neuroscience Research Without Compromises: Faster Results From Better Images With the ZEISS LSM 9 Series and arivis's new Automatic Neuron Tracing

    Abstract:

    Learn how to overcome the typical imaging and analysis challenges in neuroscience research, with the ZEISS LSM 9 series and arivis. LSM Plus and Airyscan joint Deconvolution (jDCV) can enable you to reliably gather higher quality data from your confocal imaging, enhancing resolution and signal to noise (SNR). Explore how the automatic end-to-end pipelines and AI-driven image analysis by arivis allow you to push the boundaries of your research. Automatic Neuron Tracing allows you to adapt the methods and parameters to your specific microscopy modalities and datasets, thus helping you to get the most out of your valuable imaging data from every sample.

    Presented by:  Kalliopi Arkoudi, Ph.D., Applications Development Engineer, ZEISS Microscopy

    Kalliopi Arkoudi, Ph.D., Applications Development Engineer
    ZEISS Microscopy

    Dr. Kalliopi Arkoudi has a Master's degree in Neuroscience from King's College London (KCL), where she worked for three years on the characterization of interneurons in the zebrafish brain using confocal microscopy. She completed her Ph.D. in Inflammation and Regenerative Medicine in KCL, where she used various microscopy techniques including multiphoton imaging, FLIM, and FRET to study the importance of inflammatory pathways in the response of macrophages to injury. In 2020 Dr. Kalliopi Arkoudi joined ZEISS Microscopy as an Applications Development Engineer, where she is using her expertise in the development of high-end imaging applications for confocal microscopy.

  • Reaching the Brain: Developing Novel Genome Engineering Delivery Systems in vivo

    Abstract:
    Recent breakthroughs in the use of CRISPR/Cas9 and other genetic modifying domains have revolutionized the way we develop treatments for rare neurological disorders. However, prior to applying these breakthroughs clinically, several major hurdles exist that must be addressed in pre-clinical studies. For many neurodevelopmental disorders and neurodegenerative diseases, accessing the affected cells in the brain remains a significant obstacle. The Fink lab has undertaken multiple approaches to address this problem. Specifically, we developed a novel AAV vector system to deliver CRISPR/dCas9 epigenetic editors to the brain as well as stem cell-mediated delivery platforms to secrete DNA-binding domains such as Zinc Fingers, for regulating gene expression in vivo. To assess global distribution and efficacy across the mouse brain, we utilize the ZEISS Axioscan high throughput slide scanner; enabling screening and consequently research progression to happen much quicker than previously possible. Brains of particular interest are then examined in 3D at high resolution for colocalization and subcellular expression using the Apotome on a ZEISS Axio Observer. Taken together these studies and approaches are helping to move these promising interventions down the translational pipeline toward treatment.

    Presented by: Kyle Fink, Ph.D., Assistant Professor, University of California, Davis Medical Center

    Kyle Fink, Ph.D., Assistant Professor,
    University of California, Davis Medical Center

  • AT the Visual Cortex: Mapping Synapses with Correlative Array Tomography

    Abstract:  

    To visualize the wide array of synapses in the mouse primary visual cortex, sample preparation, imaging, and imaging tools used are key factors. Using correlative array tomography, we are able to visualize and map thousands of synapses. Starting from tissue preparation, through antibody optimization, imaging with both wide field, and scanning electron microscopy (SEM), and finally the tools utilized to visualize the data, we can most accurately describe various synapses and receptors. This talk will walk through sample preparation through data analysis, and how correlative array tomography has allowed us to learn about synaptic connectivity, paying special attention to the use of ATLAS and how it allows for exceptional array ROI reproducibility.

    Presented by:  Jenna Schardt, Research Associate III, Allen Institute for Brain Science

    Jenna Schardt, Research Associate III,
    Allen Institute for Brain Science

    Jenna completed her masters in Materials Science from Oregon State University and has been at the Allen Institute for Brain Science since 2017. While at the Allen institute, she has worked with Stephen J Smith using Array Tomography for various applications from antibody optimization, synapse detection, to neuropeptide research. She is now also on the EM Connectomics team which creates large datasets of mouse EM volumes. She has 11 years of experience working with sample preparation, sectioning and imaging of samples prepared for a variety of light and electron microscopy techniques, including array tomography IF and SEM, correlative PALM microscopy, and tilt TEM tomography.

  • Automatic Neuron Tracing for Faster Results, even from Large Datasets

    Abstract:

    Learn how the arivis Scientific Imaging Platform easily tackles your demands  in neuroscience research with a new module that integrates two scientifically  published methods. The module allows you to adapt the methods and parameters  to your specific microscopy modalities and datasets, thus helping you to get the most  out of your valuable imaging data from every sample.

    Presented by:  Christian Götze, CTO, arivis

    Christian Götze, CTO
    arivis

Register for our In-Booth Presentations

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Live Microscopy Workflow Sessions

As part of a commitment to sustainability, ZEISS has chosen not to ship instrumentation to Neuroscience this year. We are excited to offer you an engaging and interactive alternative by connecting you directly with our microscopes and applications experts in California, directly from the tradeshow floor.

  

Browse the microscopy workflows we're showcasing at the booth and stop by our reception desk at booth #2228 to request a session.  

  • Making High Powered FESEM Accessible to both the Experienced and Novice User

    Flexible and Efficient High Resolution Imaging and Analytics

    Putting the Synchrotron Beamline in Your Lab with Nondestructive 3D X-ray Microscopy

    Maximizing Your SEM Insights and 3D Resolution FIB-SEM Analysis

    Gain an introduction to the intuitive user interface of ZEISS Sigma 300 with SmartSEM touch and how it can help users of all skill levels arrive at excellent results quickly.

    Explore your sample in a variety of ways with ZEISS GeminiSEM 460 - see the power of Atlas large area and mosaic imaging or discover TEM-like imaging with your SEM using Sense BSD. Experience high-resolution, high contrast ultrastrucural imaging with a new degree of speed and image quality.

    Gain structural insights from your intact biological samples with the high resolution, nondestructive imaging power of ZEISS Xradia Versa 620. Target your regions of interest for subsequent imaging studies using the easy to follow workflow-guided user interface.  

    See how the ZEISS Crossbeam 550 FIB-SEM delivers ultrahigh resolution while performing fast, precise room temperature tomography of your biological samples with Atlas 3D.

  • Connect Your 2D and 3D Imaging Methodologies to Gain the Full Context - From Large Overviews to Detailed High Resolution Regions of Interest

    Keeping Your Cool: Evaluating the Quality of Your Cryo Samples and Localizing Promising Regions of Interest

    See how ZEN Connect allows you to utilize your larger scale 2D overviews acquired on the ZEISS Axioscan 7 to quickly hone in on your key regions of interest, and begin imaging at high resolution effortlessly.

    Learn how to screen your grids for ice contamination and acquire high resolution, sub-cellular fluorescence data with ZEISS Cryo LSM 900 with Airyscan.

  • Increase Your Spectral Palette and Number of Markers to Gain the Most Spatial Context From Your 3D Neuroscience Applications

    Automatic Detection, Seemless Tiling and Crisp Optical Sectioning of Multiplexed Mouse Brain  on the Axio Observer 7

    Save Time and Money with High Throughput Multiplex Tissue Imaging on the  Axioscan 7

    See how the latest improvements to our LSM 980 spectral capabilities enable the imaging of several markers in the same brain tissue section. New tools such as LSM Plus will further improve resolution, single to noise, and lead to faster acquisition times.

    Understand global expression and subcellular localization using AI Sample Finder to automatically detect, calibrate and define your ROI. Create seemless whole tissue images to followed by high magnification optical sections all on a widefield system.

    Even completely translucent tissue is automatically detected and the imaging area assigned with Custom Sample Detection. No longer waste time tracing sections or imaging a slide at a time. Axioscan 7 can do it all for you.

  • Automated Imaging of your Color Samples in High Resolution  on the Axio Observer 7

    One-click Detection, Imaging and Quantification  on the Celldsicoverer 7

    See how an Automated Confocal Handles Screening and Airyscan Imaging without User Interaction  with  Celldiscoverer 7

    AI Sample Finder Makes Imaging and Analysis of 96 Well Plates Easy  on the Axio Observer 7

    Capture your entire sample with perfect color rendition and high resolution without using oil.

    With a single click of a button on the system, your multi well plate is detected, calibrated, imaged and quatified. Screening has never been easier.

    The  Celldiscoverer 7 will image the entire multiwell plate then determine the positive cells of interest. With auto immersion, these neurons will then be imaged in super resolution using Airyscan.

    See how easily multiwell plates can be imaged, cells counted and heatmaps generated. Artificial Intelligence steps in to calibrate, focus, segment and count.

  • Go Beyond the Diffraction Limit with ZEISS Elyra 7 with Lattice SIM²

    ZEISS Airyscan jDCV and LSM Plus Imaging Combined with Neuron Tracing in arivis Vision 4D

    Explore your sample over different scales from high quality overview images to super-resolution of live samples with Lattice SIM² then quantify those results with image analysis tools.

    See how Airyscan with jDCV or the LSM 980 confocal with LSM Plus can image neurons in brain tissue with the best combined resolution and signal to noise to enable neuron tracing with the highest fidelity and accuracy.

  • Discover How Accessible Lattice Light Sheet Technology Really is with ZEISS Lattice Lightsheet 7

    Go Beyond the Diffraction Limit with ZEISS Elyra 7 with Lattice SIM²

    See how to perform rapid volume imaging of even your most sensitive samples with next to no phototoxicity and bleaching.

    Explore your sample over different scales from high quality overview images to super-resolution of live samples with Lattice SIM² then quantify those results with image analysis tools.

Request a workflow session

Thank you for your interest!  Pre-registration is no longer available.  To request a workflow session at Neuroscience, please stop by our reception desk at booth #2228!

You can also request an in-person or virtual demo with the ZEISS Microscopy Customer Center at your convenience: