
ZEISS LSM 980 Workshop
Microscopy Solutions for 3D Spatial Omics
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Microscopy Solutions for 3D Spatial Omics
- How to apply our 3D spectral multiplexing confocal technology to a wide range of spatial omics applications
- How the new NIR technology on the LSM 980 allows you to expand your spectral palette
- New tools such as LSM Plus to further increase resolution and sensitivity and acquire the signature of even up to 10 or more markers in a single scan
- About a number of our ZEISS analysis software solutions relevant to this application space
To register for the presentation and/or sign up for a demonstration, fill out the form below. We look forward to your participation.
LSM 980 Product Demonstrations
We will be hosting 2-hour demo time slots, available at the Ragon Institute Immunology (Imaging) Core, Room 910. We can accommodate up to 2 people per demo session. If you have more than 2, please sign up for a separate session.
January 30 – February 3, 2023:10am-12pm (W, Th, F), 1-3pm (M-Th), 3-5pm (M-Th)
Presentation
There will be a presentation during this workshop taking place in the Auditorium at the Ragon Institute Immunology (Imaging) Core.
Coffee and refreshments will be provided.
Save the date

Geoff Guimaraes
Your Local Account Manager

Tanay Desai, Ph.D.
Product Application Sales Specialist

Kevin O'Keefe, Ph.D.
Senior Software Sales Biotech Pharma
Abstract
In the past 5 years, the life sciences community has witnessed the progression of the genomics and proteomics world into the spatial domain. This was in large part due to a strong desire to not only know which genes were being turned on and which proteins were being expressed, but also precisely where in a much larger context. This contextual data is leading to discoveries about not just how the biology is acting but rather where it is acting, leading to the terminology of “actionable biology.” This concept of actionable biology is leading to a much deeper understanding of diseases and genetic disorders and is transforming the developments of treatments, cures, and drug discoveries. Certainly, the spatial concept easily lends itself to microscopy methods, and we have seen the release of many powerful instruments on the market dedicated to spatial omics applications. Initially, this work was almost exclusively being done on thin tissue sections or monolayers of cells, and therefore, 2D imaging using widefield microscopy was sufficient. However, biology is inherently 3D, and the desire to resolve information in the z-dimension, even in relatively thin sections, is increasing. Furthermore, we see researchers pushing these methods into even thicker tissue samples, and therefore, this obviates the need for an optical sectioning microscopy method to accomplish the imaging goals. In addition to being able to optically section thick samples, the ideal system should also possess spectral flexibility to meet the demands of the growing number of biomarkers needed to be interrogated in a single imaging cycle, as well as RNAScope and smFISH probes pushing out into the NIR wavelength range. The LSM 980 with NIR detection provides the most flexible spectral acquisition of any confocal on the market. With new tools such as LSM Plus to further increase resolution and sensitivity, we can now acquire the signature of even up to 10 or more markers in a single scan; therefore, increasing throughput and productivity.