Upgrade Your Technology and Expand Your Research Possibilities

ZEISS Microscopy can help you acquire the newest imaging innovations

Do you have an aging microscope in your lab?

Whether you are a current ZEISS customer or not, we can help you acquire the newest ZEISS technology. This upgrade offer allows special pricing and access to our world-class labs to support data collection for your funding application. 

We will honor this offer through September 2023.

Research-Grade Light Microscopes

Do you currently work with an older research compound or stereo microscope? Use this offer to upgrade to a new ZEISS Axio Observer inverted microscope, ZEISS Axio Imager 2 upright microscope, ZEISS Axio Examiner fixed stage microscope, ZEISS Axio Zoom.V16 or ZEISS SteREO Discovery microscopes for large fields and 3D vision.

Here are a few features you might consider with your new research stand:

Conventional widefield image
Optical sectioning with Apotome 3
Optical sectioning of neurons through 25um brain section at 63x using Apotome 3 on widefield fluorescent microscope. Samples courtesy of Jim Trimmer Lab, University of California, Davis

Confocal-like Imaging on a Widefield Microscope

ZEISS Apotome 3 is a robust, easy-to-use optical sectioning tool providing crisp imaging for cells, tissues and small model organisms in 2D and 3D. No expertise or special sample preparation is required. It is economical compared to a confocal and other advanced fluorescence systems, making it an ideal choice for single labs.

AI Sample Finder Workflow. Expand the video to read captions. Samples courtesy of Jim Trimmer Lab, University of California, Davis.

Hands-free Detection, Calibration and Focusing

ZEISS AI Sample Finder on  ZEISS Axio Observer 7 will reduce your time to start imaging from minutes to seconds. AI Sample Finder automatically calibrates the sample carrier, focuses your sample, and finds your sample region, all without bleaching or damaging your cells. Increase your efficiency and enable novice microscopy users to collect large amounts of data accurately, remotely and without crashing objectives. Sample and carrier information is automatically fed into the experiment file and is ready to begin imaging.
244 tiles with four channels were acquired to generate this image of a 25 um thick adult mouse brain section. Image acquired with a Plan-Apochromat 20x/0.8 NA objective lens. Samples courtesy of Jim Trimmer Lab, University of California, Davis.

Seamless Tiling

ZEISS ZEN Tiles and Positions software module offers flexible focus strategies and the necessary hardware integration to produce seamless and beautiful large area images. Image hundreds of tiles across the slide and multiple tissue regions without losing focus.
ZEN Connect video of slide overview from AI Sample Finder, including darkfield composite contrast image, 20x whole tissue multiplex image and 63x 3D optical sectioning with Apotome. Samples courtesy of Jim Trimmer Lab, University of California, Davis.

Simplify Image Documentation and Sample Navigation

ZEISS ZEN Connect streamlines documentation and sample navigation by automatically recording and cataloging your image acquisition across your slide. Combine images from any camera or system allowing you to correlate photos from lab notebooks, cell phones and across the full scale of microscope images. An interactive map allows you to review your images and navigate to new areas with a simple double click; all while knowing exactly what you have already imaged.
 

Upgrade Your Laser-Based System

If you are using an older confocal microscope for 3D imaging, an older multiphoton microscope for deep tissue imaging, a spinning disk microscope for live cell imaging, or another laser-based system, leverage this offer for a new laser-based system from ZEISS and get access to these technologies:

Mouse intestine tissue section stained for Substance P (cyan, Alexa 488) labeling the presynaptic contacts in the enteric nervous system, HuC/D (yellow, Alexa 568) labeling the enteric neurons, and neuronal Nitric Oxide Synthase (nNOS, red, Alexa 750) labeling a sub-population of enteric neurons. Courtesy of P. Vanden Berghe, University of Leuven, Belgium.
Breast cancer tissue section with five labels including NIR dye Alexa 750. Courtesy of D. Schwartz, Cell IDx, San Diego, USA

Confocal Microscopy with Unlimited Fluorophores, Super-resolution and Higher Throughput

The revolutionary design of ZEISS LSM 980 and LSM 900 confocal microscopes breaks the barriers many scientists face with older confocals. In addition to high sensitivity for crisp imaging even with delicate samples, gain spectral flexibility and use any fluorophore with overlapping excitation and emission spectra into the NIR. The LSM Plus feature provides improved resolution and signal-to-noise for all your imaging data, enabling faster acquisition speeds and gentler imaging for your live cell applications and more accurate signal separation for your spectral data. The ZEISS Airyscan 2 detector adds more versatility to your confocal system, adding super-resolution capabilities, with jDCV, the resolution of the system can be pushed to ~90 nm. Add Multiplex mode for increased speeds and higher throughput.

Microtubules in Cos-7 cells color coded for depth.
 
Drosophila sample stained for muscle, nervous system synapses and synaptotagmin. Imaged using the Elyra 7 at different lengthscales. Courtesy: S. Sweeney, B. Rix, P. O'Toole and G. Calder, University of York, United Kingdom
 
Simultaneous imaging of the endoplasmic reticulum (ER) and microtubules in a Cos-7 cell.

Unprecedented Super-resolution for Live or Fixed Cells

ZEISS Elyra 7 with Lattice SIM² takes you far beyond the diffraction limit of conventional microscopy to super-resolution. You can now double the conventional SIM resolution and discriminate the finest sub-organelle structures, even those no more than 60 nm apart, in living cells using standard fluorophores. Or utilize single molecule localization microscopy (SMLM) for techniques such as PALM, dSTORM and PAINT to achieve lateral resolution of 20-30 nm, the highest level of super-resolution for light microscopy.

Two day old lamprey embryo showing segmentation of all green fluorescent objects including nuclei, micronuclei and debris. Courtesy of C. Saraceno and J. Smith, University of Kentucky, USA
 
Vasculatore of a mouse brain cleared with iDISCO+. Courtesy of E. Diel, Harvard University, USA
 
Zebrafish embryo development shown using GFP-labeled histones. Courtesy: J. Li, D. Sepich and L. Solnica-Krezel, Washington University School of Medicine, USA

Fast, High-Resolution Imaging of Large Samples including Cleared Tissues and Developing Embryos

Use light sheet fluorescence microscopy (LSFM) to collect amazingly high-resolution data throughout a large sample at extremely high speeds. ZEISS Lightsheet 7 equips you for fast imaging of your optically cleared organs or large tissue sections. Its gentle illumination and unique sample handling also enable long term acquisitions of developing model organisms from Drosophila to zebrafish, mouse embryos and plants.

Upgrade Your Electron Microscope

From compositional contrast to topographical imaging and 3D reconstruction of ultrastructure, both new and experienced electron microscopy users can benefit from the high resolution, low voltage, gentle imaging of electron microscopy. ZEISS Gemini technology minimizes your time-to-image with inlens secondary and/or backscattered electron detection while maximizing low voltage, high resolution imaging with beam booster technology. Leverage this offer for special discounts and sustained pricing on a new ZEISS field emission scanning electron microscope (FE-SEM).

Ease-of-Use High Quality Imaging

ZEISS Sigma field emission scanning electron microscope offers an excellent price-to-performance ratio. With its four-step workflow, experience fast time-to-image and save time on training - especially in a multi-user environment. Characterize all your biological samples with the latest detection technology. Produce high resolution transmission images with the aSTEM detector. With the C2D and VPSE detectors of Sigma in variable pressure mode, you can work at low vacuum and can expect crisp images with up to 85% more contrast.

SARS-CoV-2 virus grown in tissue culture. Courtesy: M. Hannah, Public Health England, United Kingdom
Mouse brain section. Courtesy: C. Genoud, Friedrich Miescher Institute for Biomedical Research, Switzerland

Effortless Imaging with Sub-nanometer Resolution

With its amazing resolution, ZEISS GeminiSEM field emission scanning electron microscope family is ideal for visualizing the ultrastructure of cells and tissues at high resolutions. Also use its large field of view to investigate substantial areas with array tomography and serial sectioning. Innovations in electron optics and a new, larger chamber design let you benefit from better image quality, usability, and flexibility.

  • ZEISS GeminiSEM 360 offers high resolution imaging over the widest range of application and sample types making it the ideal solution for your imaging core facility. Gather high resolution, surface, and compositional information, even on sensitive samples by using Inlens secondary and backscatter electron imaging simultaneously.
  • ZEISS GeminiSEM 460 performs high-resolution imaging and analytics rapidly, switching seamlessly from low current-low kV work to high current-high kV work, and back again utilizing the Gemini 2 column.
  • ZEISS GeminiSEM 560 easily images below 1 kV providing surface-sensitive, distortion free, high-resolution imaging.

Master Your Multi-Scale Challenge

Extend the capacity of your ZEISS FE-SEM with Atlas 5. Create comprehensive multi-scale, multi-modal images with the sample-centric correlative environment of Atlas 5. Seamlessly navigate and correlate your images from any source while taking advantage of high throughput and large area imaging. Acquire EM images faster and easier than ever before while gaining a comprehensive understanding of your sample.
Isolated immune cells from a zebrafish, embedded in epoxy resin and cut into ultrathin sections of 100 nm thickness. Elongated, electron-dense, cigar-shaped granules which are typical for neutrophils and other cellular components such as nuclei and mitochondria are clearly visible.
A. Seybold and H. Hausen, Sars Centre for Marine Molecular Biology, University of Bergen, Norway
 
Courtesy: M. Ellisman, University of California San Diego, USA

TEM-like Imaging with Your SEM

ZEISS Sense BSD is your backscatter electron detector for fast and gentle ultrastructural imaging of your most delicate biological samples. Combining high-resolution, ultrastructural imaging with a new degree of efficiency and image quality, this detector makes TEM-like imaging possible with your SEM. It is well suited for non-conductive, charge prone biological samples. With a new diode design and superior detector sensitivity, Sense BSD can detect very small numbers of electrons and convert low signals into high-contrast images, even at low kV, producing high-quality images in less time.
Ultrathin mouse brain section
Ultrathin mouse brain section
Ultrathin mouse brain section. (A) Overview image acquired with ZEISS Axio Observer 7 and ZEN Connect. Synapsin-1 was labeled with Alexa Fluor 647 (green) targeting the pre-synaptic vesicles and Alexa Fluor 594 labeled Gephyrin (red), targeting a part of the postsynaptic protein network. Nuclei were stained with DAPI (blue). The overview image was used for navigation and ROI relocation. The insets (1-3) were acquired with ZEISS GeminiSEM 300 and show the ultrastructure of the ROIs. (B) shows a zoomed image of inset (3).
Courtesy: M. Ocana, Harvard University, Boston, MA, USA.

Add Context with Easy Correlation of Overview Images to Minute Structures

Add context to your image data with ZEISS ZEN Connect. Seamlessly correlate large overview images to the smallest regions of interest – from widefield light microscope to ultra-resolution electron microscopy.

Find Out If You Qualify for This Upgrade Offer

If you are currently using outdated microscopy and are considering new technology for your lab, contact us and let us help you with special pricing and application support for a ZEISS solution. *Please note that this special offer is for specific models of microscope stands for customers in the United States. Contact us to confirm if you qualify.