Focus on Lattice Light-Sheet Microscopy: Past, Present and Future

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Prof. Marco Fritzsche

Scientific Director, Oxford-Zeiss Centre of Excellence

Dr. Huw Colin-York

Postdoctoral Research Fellow, BPI Lab

Dr. Helena Coker

Advanced Microscopy Specialist, BPI Lab, Kennedy and Oxford-Zeiss Centre of Excellence

Dr. Niall Geoghegan

Senior Postdoctoral Researcher, CDI at WEHI

Dr. Kirstin Elgass

Application Development Engineer, ZEISS Microscopy


This webinar focuses on the development of Lattice Light-Sheet Microscopy through time. Leading researchers present their experiences with long-term volumetric imaging of living cells using this technology. Listen to first-hand experience reports how Lattice Lightsheet evolved from initial prototypes to established instruments in core facilities and research labs. Learn about the next generation of ZEISS Lattice Lightsheet 7 and how it advances live cell research projects.

Key Learnings:

  • Experiences with home-built lattice light-sheet systems
  • ZEISS Lattice Lightsheet 7 in multi-user environments
  • Quantifying diffusion dynamics of biomolecules in activating T cells
  • Malaria invasion of red blood cells in 4D
  • ZEISS Lattice Lightsheet 7 improvements:
    • Imaging just above the noise level
    • Faster imaging
    • Crosstalk-free imaging
    • Truly simultaneous two-color imaging

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ZEISS Lattice Lightsheet 7 makes light sheet fluorescence microscopy available for live cell imaging at subcellular resolution – while also allowing you to use your standard sample carriers. With this automated, easy-to-use system, volumetric imaging of subcellular structures and dynamics over hours and days with best protection from photo damage becomes available to everyone. Discover the dynamics of life in unprecedented depth of detail – with the ease you never imagined possible!