MICROSCOPY APPLICATIONS FOR YOUR LABORATORY

Microscopy Solutions for Urinalysis

Observing Urine, Detecting Abnormalities

As clinical laboratory professional, you understand the critical role microscopic examination plays in analyzing urine samples for abnormalities. Microscopes can provide invaluable insights into the physical and chemical composition of urine, enabling you to come up with accurate diagnosis and treatment plans. Utilizing brightfield, phase and polarization contrast techniques, you examine urine sediment to detect cells, crystals, and other substances. This thorough examination allows to identify indications of various conditions, including diabetes mellitus, glomerulonephritis, and chronic urinary tract infections.

High-resolution imaging for accurate analysis

ZEISS microscopes deliver unparalleled optical quality and resolution, enabling researchers to identify and analyze urinary sediments, crystals, and microorganisms with exceptional clarity. This ensures accurate diagnostic insights and supports high-confidence decision-making in clinical and research settings.
Automation and workflow efficiency

With advanced imaging software and automated features, ZEISS solutions streamline urinalysis workflows. Automated image acquisition, analysis, and reporting reduce manual effort, improve reproducibility, and save valuable time, allowing researchers to focus on critical findings.
Customizable solutions for diverse research needs

ZEISS offers a wide range of microscopy platforms, from light and fluorescence microscopy to advanced imaging techniques like confocal and electron microscopy. This flexibility allows researchers to tailor their approach to specific urinalysis challenges, such as studying rare biomarkers or visualizing subcellular structures in urinary samples.

Microscopy precision for reliable urinalysis

Application examples for urinalysis

Courtesy of J. Poloni

Crystals in urine, polarization contrast, acquired with ZEISS Axiolab 5

Andrea Michelsen | Laborleitung, Klinikum Ortenau

Calcium-Oxalate in urine, crystals acquired with ZEISS Axiolab 5

Courtesy of A. Michelsen

Erythrocyte, red blood cells showing thorn apple shape due to non-physiological pH-value of urine, acquired with ZEISS Axiolab 5

Uric acid crystals in urine sediment under polarized light microscopy with ZEISS Primostar 3

Phase contrast image of urine sediment, acquired with ZEISS Primostar 3

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Recommended products for urinalysis

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Microscopy Solutions for Urinalysis

Microscope Requirements

Urine is traditionally examined with upright light microscopes. In general, brightfield microscopes are the instrument of choice. However, urinalysis guidelines also recommend the use of microscopes equipped with phase contrast and polarized light filters to identify urine particles like dysmorphic erythrocytes and casts (phase contrast) as well as lipids and crystals (polarized light). LED illumination increases the quality of sample visualization. Standard objectives for routine urinary sediment are a 10x for casts and a 40x for cells and other smaller structures, resulting in a 100x or 400x magnification (when used with 10x eyepieces). 400x is also fine to visualize bacteria. In order to get a more detailed observation of bacterial morphology, such as shape, size, and cellular structures, 1000x magnification can be helpful. However, at a higher magnification, it can be increasingly difficult to keep them in focus as they move.