Compendium

Publications on the use of indocyanine green (ICG) in fluorescence-guided surgery

Focusing on neurosurgical indications

21 April 2026 · 10 min read

Compiled by ZEISS Medical Technology

SUMMARY

List of articles about ICG in fluorescence-guided surgery

This literature compendium presents an overview of peer-reviewed publications discussing the use of ICG videoangiography in fluorescence-guided neurosurgical procedures across various cerebrovascular and oncological indications. The objective is to compile and share evidence-based medical insights into the application of ICG videoangiography to support knowledge exchange within the neurosurgical community.

Each publication is based on the author´s own professional opinion or on their study results. It does not necessarily reflect the opinion of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or intended purpose of our medical devices. Therefore, suitability of clinical application for each publication should be carefully assessed by the concerned physician.

Year	Title	Publication type (study design)	Journal	Authors
2026 Jan	Efficacy of intraoperative indocyanine green videoangiography (ICG-VA) and FLOW 800 in the surgical management of intracranial aneurysms: a systematic review and meta-analysis Link to Publication	Sytematic review and meta-analysis	Acta Neurochirurgica	Turpo-Pequeña AG, Santos-Vargas SA, Loza-Chipa HR, Lamas FM, Espinoza-Laura GA, Núñez-Basurco CS, Medina-Neira DN, Benites-Bustamante VA, Osorio-Pacheco RR, Turpo-Peqqueña JR, Huanca-Quispe G, Vizcarra-Vizcarra CA, Gómez B, Rivillas JA, Hernández-Mayori R
2026 Jan	Application of intraoperative fluorescent imaging techniques in vascular neurosurgical procedures Link to Publication	Original article (retrospective, single-center, n=154)	Egyptian Journal of Neurosurgery	Nathal E, Serrano-Rubio A, Xochipa-Ruiz KE, Medina-Félix ZE, Riley-Moguel AE, Fernández-Rodríguez ER, Becerril-Mejía A
2024 Sep	Comparison of intraoperative sodium fluorescein and indocyanine green videoangiography during intracranial aneurysm and arteriovenous malformation surgery Link to Publication	Original article (prospective, n=49)	Clinical Neurology and Neurosurgery	Kırış T, Akçakaya MO
2024 Sep	Clipping of a persistent middle cerebral artery aneurysm after previous flow diverter placement: an illustrative case and review of the literature Link to Publication	Original article (n=1)	Journal of Cerebrovascular and Endovascular Neurosurgery	Veken JV, Keukeleire K
2024 Jun	Improved rates of postoperative ischemia, completeness of aneurysm occlusion and neurological deficits in elective clipping of anterior circulation aneurysms over the past 20 years - association with technical improvements Link to Publication	Original article (retrospective, single-center, n=1317)	Acta Neurochirurgica	Siller S, Briegel J, Kunz M, Liebig T, Forbrig R, Tonn JC, Schichor C, Thorsteinsdottir J
2023 Dec	Complementary role of indocyanine green video angiography, dual-image video angiography and flow-800 Link to Publication	Original article (single-center, n=35)	British Journal of Neurosurgery	Khasanov KA, Alikhodjayeva GA, Yamada Y, Kato Y, Yakubov JB, Yağmurlu K, Chaurasia B
2020 Oct	Indocyanine green angiography visualized by augmented reality in aneurysm surgery Link to Publication	Original article (prospective, single-center, n=20)	World Neurosurgery	Carl B, Bopp M, Benescu A, Saß B, Nimsky C
2020 Feb	Intraoperative use of microscope-integrated Flow 800 - a valuable tool in surgical management of anterior communicating artery aneurysm: our institutional experience Link to Publication	Original article (single-center, n=10)	Asian Journal of Neurosurgery	Chavan VS, Yamada Y, Chandratej K, Gowtham D, Riccardo S, Firuz S, Yoko K
2003 Jan	Near-infrared indocyanine green video angiography: a new method for intraoperative assessment of vascular flow Link to Publication	Original article (single-center, n=14)	Neurosurgery	Raabe A, Beck J, Gerlach R, Zimmermann M, Seifert V

2026 Feb	Intraoperative evaluation of dural arteriovenous fistula obliteration using FLOW 800 hemodynamic analysis Link to Publication	Original article (retrospective, single-center, n=8)	Operative Neurosurgery	Sangwon KL, Grin EA, Negash B, Wiggan DD, Lapierre C, Raz E, Shapiro M, Laufer I, Sharashidze V, Rutledge C, Riina HA, Oermann EK, Nossek E
2025 Aug	Intraoperative indocyanine green videoangiography with FLOW800 and multimodal fusion neuro-navigation for the resection of arteriovenous malformation with reduced blood loss Link to Publication	Original article (retrospective, single-center, n=90)	World Neurosurgery	Yang X, Tao X, Meng J, You W, Gu F, Li J, Tian Z, Wang Z
2023 Sep	Evaluation of serial intra-arterial indocyanine green videoangiography in the surgical treatment of cranial and craniocervical junction arteriovenous fistulae: a case series Link to Publication	Original article (retrospective, single-center, n=50)	Operative Neurosurgery	Yamaguchi I, Kanematsu Y, Shimada K, Yamamoto N, Korai M, Miyake K, Miyamoto T, Sogabe S, Shikata E, Ishihara M, Yamamoto Y, Kuroda K, Takagi Y
2023 Feb	Evaluation of the utility of indocyanine green video angiography in cerebral arteriovenous malformation surgery Link to Publication	Original article (retrospective, single-center, n=24)	World Neurosurgery	Erdogan K, Mammadkhanli O, Abbasoglu B, Bayatli E, Ozden M, Bozkurt M
2023 Jan	Efficacy of utilizing both 3-dimensional multimodal fusion image and intra-arterial indocyanine green videoangiography in cerebral arteriovenous malformation surgery Link to Publication	Original article (single-center, n=12)	World Neurosurgery	Shimada K, Miyake K, Yamaguchi I, Sogabe S, Korai M, Kanematsu Y, Takagi Y
2022 Aug	Role of indocyanine green with FLOW 800 in removal of hidden arteriovenous malformations Link to Publication	Systematic review and case series (retrospective, single-center, n=14)	World Neurosurgery	Grzyb CC, Church EW
2021 Jun	Multimodality management in bAVM surgery - recent experience from international cerebrovascular fellowship Link to Publication	Original article (retrospective, single-center, n=11)	Medical Archives	Ahmetspahic A, Burazerovic E, Hajdarpasic E, Dzurlic A, Omerhodzic I, Sefo H, Kato Y
2020 Sep	Preservation of coexisting normal superior petrosal vein in the microsurgical treatment of superior petrosal sinus dural arteriovenous fistulas assisted by indocyanine green video angiography Link to Publication	Original article (retrospective, single-center, n=12)	World Neurosurgery	Sun L, Ren J, Wang L, Li J, He C, Ye M, Li G, Zhang H
2020 Aug	Hemodynamic changes in superficial arteriovenous malformation surgery measured by intraoperative ICG fluorescence videoangiography with FLOW 800 software Link to Publication	Original article (retrospective, single-center, n=17)	Chinese Neurosurgical Journal	Ye X, Wang L, Li MT, Chen XL, Wang H, Ma L, Wang R, Zhang Y, Cao Y, Zhao YL, Zhang D, Wang S
2019 Dec	Application of indocyanine green during arteriovenous malformation surgery: evidence, techniques, and practical pearls Link to Publication	Review	Frontiers in Surgery	Foster CH, Morone PJ, Tomlinson SB, Cohen-Gadol AA

2025 Aug	Clinical and hemodynamic outcomes of side-to-side anastomosis in superficial temporal artery-middle cerebral artery bypass for adult patients with moyamoya disease: a prospective cohort study Link to Publication	Original article (prospective, single-center, n=50)	Frontiers in Neurology	Shi Z, Deng Z, Chen X, Wu L, Li W, Wang J, Liu Y, Zhang D, Wang Y, Hang C, Yang Y
2025 Jun	Diagnostic values of the “To and Fro” conflict sign on intraoperative indocyanine green video angiography as a warning sign of the focal cerebral hyperperfusion and watershed shift phenomenon after superficial temporal artery-middle cerebral artery bypass for adult patients with moyamoya disease Link to Publication	Original article (retrospective, single-center, n=97)	Cerebrovascular Diseases	Tashiro R, Fujimura M, Nishizawa T, Tominaga K, Kanoke A, Endo H
2024 Nov	The significance of postbypass blood flow model in side to side bypass for moyamoya disease in predicting postoperative cerebral hyperperfusion syndrome Link to Publication	Original article (retrospective, single-center, n=153)	Frontiers in Neurology	Wan G, Hu M, Yu J, Xin C, Tao T, Quan W, Chen J, Zhang J.
2024 Oct	Cerebral hemodynamic plasticity related to potential compensatory self-recirculation network in moyamoya disease: an observational study Link to Publication	Original article (prospective, single-center, n=63)	Scientific Reports	Cao, Lei; Yuan, Xiaoli; Dong, Yang; Wang, Zeming; Guo, Mengguo; Li, Dongpeng; Wang, Hao; Zhu, Lingyun; Yang, Bo; Li, Hongwei
2024 Aug	Assessing superficial temporal artery-middle cerebral artery anastomosis patency using FLOW 800 hemodynamics Link to Publication	Original article (retrospective, single-center, n=39)	Journal of Neurosurgery	Sangwon KL, Nguyen M, Wiggan DD, Negash B, Alber DA, Liu XC, Liu A, Rabbin-Birnbaum C, Sharashidze V, Baranoski J, Raz E, Shapiro M, Rutledge C, Nelson PK, Riina H, Russin J, Oermann EK, Nossek E
2024 Jun	Individualised evaluation based on pathophysiology for moyamoya vasculopathy: application in surgical revascularisation Link to Publication	Original article (prospective, multicenter, n=375)	Stroke and Vascular Neurology	Zhang X, Lei Y, Su J, Gao C, Li Y, Feng R, Xia D, Gao P, Gu Y, Mao Y
2023 Oct	Application of intraarterial superselective indocyanine green angiography in bypass surgery for adult moyamoya disease Link to Publication	Original article (single-center, n=20)	Frontiers in Neurology	Ni H, Wu Y, Zhou C, Li X, Zhou S, Lan W, Zhang Z, Huang Y, Wang H, Lin J
2023 Oct	The value of indocyanine green-FLOW800 in microvasculature for predicting cerebral hyperperfusion syndrome in moyamoya disease patients Link to Publication	Original article (retrospective, single-center, n=31)	Scientific Reports	Guo Z, Yan Z, Qu F, Cheng D, Wang C, Feng Y
2022 Jan	Application of FLOW 800 in extracranial-to-intracranial bypass surgery for moyamoya disease Link to Publication	Video article (single-center, n=3)	Neurosurgical Focus Video	Yim B, Gauden AJ, Steinberg GK
2020 Oct	Decreased cortical perfusion in areas with blood-brain barrier dysfunction in moyamoya disease Link to Publication	Original article (prospective, single-ceter, n=25)	Acta Neurochirurgica	Lu X, Huang Y, Zhou P, Hui P, Wang Z
2020 Aug	Evaluation of hemodynamic change by indocyanine green-FLOW 800 videoangiography mapping: prediction of hyperperfusion syndrome in patients with moyamoya disease Link to Publication	Original article (retrospective, single-center, n=62)	Oxidative Medicine and Cellular Longevity	Zhang X, Ni W, Feng R, Li Y, Lei Y, Xia D, Gao P, Yang S, Gu Y
2020 Aug	Indocyanine green videoangiography for recipient vessel stratification in superficial temporal artery-middle cerebral artery bypass surgery Link to Publication	Original article (retrospective, n=60)	Journal of Neurosurgery	Goldberg J, Vajkoczy P, Hecht N
2020 Jul	Matching selection of donor-recipient vessels in revascularization surgery effectively reduce the incidence of postoperative hyperperfusion syndrome in adult moyamoya disease: a retrospective comparison study Link to Publication	Original article (retrospective, single-center, n=216)	Cerebrovascular Diseases	Hu; Zeng X, Su K, Tian X, Chen J; Zhang

2025 Oct	NIR indocyanine-white light overlay visualization for neuro-oto-vascular preservation during anterior transpetrosal approaches: a technical note Link to Publication	Original article (prospective, single-center, n=1))	Journal of Clinical Medicine	Tariciotti L, Rodas A, De Andrade E Jr, Revuelta Barbero JM, Zohdy YM, Soriano R, Vuncannon JR, Maldonado J, Lohana S, DiMeco F, Garzon-Muvdi T, Reyes C, Solares CA, Pradilla G
2025 Apr	Microvascular cortical dynamics in minimal invasive deep-seated brain tumour surgery Link to Publication	Original article (prospective, single-center, n=35)	Cancers	Lavrador JP, Wroe-Wright O, Marchi F, Elhag A, O'Keeffe A, De La Fuente P, Soumpasis C, Cardia A, Mirallave-Pescador A, Díaz-Baamonde A, Mosquera JS, Coiteiro D, Jewell S, Strong A, Gullan R, Ashkan K, Vergani F, Vasan AK, Bhangoo R
2025 Feb	Tubular retractor-assisted minimally invasive parafascicular approach for dermoid cyst Link to Publication	Original article (single-center, n=1)	Journal of Surgical Case Reports	Lee KS, Kalyal N, Mthunzi E, Marchi F, Elhag A, Bodi I, Bhangoo R, Vergani F, Ashkan K, Gullan R, Lavrador JP
2025 Jan	Intraoperative indocyanine green (ICG) videoangiography in spinal hemangioblastoma surgery - helpful tool or unnecessary? Link to Publication	Original article (retrospective, single-center, n=39)	Clinical Neurology and Neurosurgery	Klingler JH, Gizaw C, Blaß BI, Hohenhaus R, Neidert N, Neumann-Haefelin E, Kotsis F, Grauvogel J, Scheiwe C, Beck J
2024 Dec	Intraoperative real-time near-infrared image-guided surgery to identify necrotic tissues Link to Publication	Original article (prospective, single-center, n=4)	Operative Neurosurgery	Fujiwara E, Muto J, Murayama K, Yamada S, Hirose Y
2022 Apr	Utility of indocyanine green videoangiography with FLOW 800 analysis in brain tumour resection as a venous protection technique Link to Publication	Original article (retrospective, n=23)	BMC Surgery	Sun Y, Wang Z, Jiang F, Yang X, Tan X, Chen Z, Liu Y, Zhu Y, Wang Z, Chen G

2025 Jun	Fluorescence guidance in glioma surgery: a narrative review of current evidence and the drive towards objective margin differentiation Link to Publication	Review	Cancers	Elliot M, Ségaud S, Lavrador JP, Vergani F, Bhangoo R, Ashkan K, Xie Y, Stasiuk GJ, Vercauteren T, Shapey J
2024 Oct	Enlightening the invisible: applications, limits and perspectives of intraoperative fluorescence in neurosurgery Link to Publication	Review	Brain and Spine	Cossu G, Le Van T, Kerherve L, Houidi SA, Morlaix E, Bonneville F, Chapon R, Baland O, Cao C, Lleu M, Farah W, El Cadhi A, Beaurain J, Picart T, Xu B, Berhouma M
2024 May	Advances in intraoperative imaging for vascular neurosurgery Link to Publication	Review	Neuroimaging Clinics of North America	Fritch C, Church E, Wilkinson DA
2019 Nov	Applications of microscope-integrated indocyanine green videoangiography in cerebral revascularization procedures Link to Publication	Review	Frontiers in Surgery	Cavallo C, Gandhi S, Zhao X, Belykh E, Valli D, Nakaji P, Preul MC, Lawton MT
2014 Sep	Indocyanine green video-angiography in neurosurgery: a glance beyond vascular applications Link to Publication	Systematic review	Clinical Neurology and Neurosurgery	Scerrati A, Della Pepa GM, Conforti G, Sabatino G, Puca A, Albanese A, Maira G, Marchese E, Esposito G