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MICROSCOPY FOR THE CLINICAL LAB

Microscopy solutions for Microbiology

From Gram stain to fluorescence.

From routine specimen examination and digital documentation to fluorescence imaging, collaboration, and teaching, ZEISS microscopy solutions are designed around the needs of today's clinical microbiology laboratory.

THE Microbiology CHALLENGE

Every organism needs the right contrast method

Stained smears, motile organisms, and fluorescent markers each call for different microscopy techniques. Across two platforms, ZEISS Axiolab 5 and Axioscope 5 offer flexible contrast options to support a range of routine clinical microbiology workflows.

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    Brightfield & high color fidelity

    Brightfield microscopy and compatible ZEISS color cameras support high color fidelity for Gram stains and other stained preparations.

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    Contrast without staining

    Phase contrast and DIC provide contrast for unstained specimens and wet preparations without requiring staining.

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    LED fluorescence

    LED fluorescence supports visualization of Auramine-stained and other fluorescently labeled specimens.

FIND YOUR FIT

Choose the microscope that fits your microbiology workflow

Choose from three Axiolab 5 configurations designed for different microbiology workflows: from routine microscopy to ergonomic viewing and fluorescence applications. Each configuration combines ZEISS optics with application-specific imaging and documentation capabilities.

MATCHED TO YOUR DISCIPLINE

One optical platform, diverse microbiology specimens

Whatever your lab reviews, both platforms deliver the same trusted ZEISS optics — configured for the specimen in front of you.

YOUR WORKFLOW, YOUR SETUP

Built for the way clinical microbiology labs actually work

Find the need that sounds like yours — each points to the platform and setup that fits.

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Routine Gram-stain examination

Ergonomic operation and high-color-fidelity digital documentation support routine examination of stained preparations.

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Fluorescence imaging

LED fluorescence supports observation of appropriately fluorescently labeled specimens and routine fluorescence microscopy workflows.

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Observe unstained specimens

Phase contrast provides enhanced contrast for unstained specimens and supports observation of microorganism morphology without staining.

Teach, consult, and review together

Co-observation allows multiple users to view the same specimen simultaneously for teaching, consultation, and collaborative review.

Explore the science behind microscopy in microbiology

Download the white paper to learn more.
Cover page preview of the white paper

This application note, developed with Hannover Medical School, covers both the science and the technique: bacterial morphology and cell structure, the full staining sequence from crystal violet through the safranin counterstain, how to time the decolorization step for consistent staining, and a reference table of common pathogens grouped by their staining behavior. It closes with the microscopy setup needed to capture the stain clearly — brightfield imaging at high magnification, with the color correction required to render violet and red-orange as distinct, accurate colors. A practical reference for anyone preparing, imaging, and reviewing Gram-stained samples in the lab.

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STILL DECIDING?

Clinical microbiology — frequently asked questions

Quick answers to help you choose between the Axiolab 5 and Axioscope 5 and configure the right setup for your organisms and workflow.

  • Which microscope should I choose for routine bacteriology?

    For routine microbiology workflows, Axiolab 5 configurations offer brightfield, phase contrast, and darkfield microscopy with digital imaging compatibility. Choose an Advanced Ergo configuration when additional ergonomic features are needed, or an Advanced Fluorescence configuration when fluorescence microscopy is part of your workflow.

  • What contrast methods are available for unstained specimens?

    Phase contrast and darkfield provide contrast for unstained specimens and wet preparations without requiring staining. Available contrast techniques depend on the selected configuration.

  • Do these microscopes support digital documentation?

    Yes. Compatible ZEISS cameras support digital image capture and documentation, including high-color-fidelity imaging. Smart Microscopy configurations can capture properly scaled images with metadata directly at the microscope.

  • How does documentation work?

    With Smart Microscopy and a compatible ZEISS camera, users can focus the specimen and capture a properly scaled, color-accurate image directly at the microscope with a single press of the Snap button—no separate PC required for routine documentation. Images can include metadata for documentation and sharing.

  • Why does image quality matter in microbiology microscopy?

    Microbiology specimens can contain fine structural detail and may require different contrast techniques depending on the preparation. ZEISS optics and configurable brightfield, phase contrast, darkfield, and fluorescence options support clear specimen observation across a range of routine microbiology workflows.

  • How do I configure a system and request a quote?

    Start with your primary workflow, then use Configure your solution to explore available configurations—or speak with a ZEISS specialist to match objectives, contrast methods, imaging, ergonomics, and documentation options to your laboratory needs and request a quote.