Radioterapia intraoperatoria (RIO) durante la resección quirúrgica de metástasis cerebrales
Un análisis conjunto internacional de 54 pacientes
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La lectura de este breve resumen no sustituye la lectura del estudio original, sino que solo aporta información sintetizada y que no necesariamente refleja la opinión de los organismos notificados ni de las autoridades reguladoras, como DQS o la FDA.
Un breve resumen del análisis conjunto sobre pacientes con metástasis cerebral, creado por Christopher P. Cifarelli, MD, doctorado, FAANS, FACS en nombre de ZEISS, abril de 2020.
Título original:
Intraoperative radiotherapy (IORT) for surgically resected brain metastases: outcome analysis of a international cooperative study.
Autores:
Christopher P. Cifarelli, Stefanie Brehmer, John A. Vargo, Joshua D. Hack, Klaus H. Kahl, Gustavo Sarria-Vargas, Frank A. Giordano
Fuente:
Cifarelli, C. P., Brehmer, S., Vargo, J. A. et al. Intraoperative radiotherapy (IORT) for surgically resected brain metastases: outcome analysis of an international cooperative study. J Neurooncol 145,391 397 (2019) doi: 10.1007/s11060-019-03309-6
- Dar una dosis inmediata y suficiente para esterilizar el lecho tumoral después de la resección de las metástasis cerebrales es un debate importante que se discute constantemente.
- Los elementos clave de las terapias para las metástasis cerebrales son el control local, el tratamiento de la necrosis por radiación y un período corto de tiempo hasta que se inicie una terapia sistémica, potencialmente esto se puede lograr con una RIO inmediata.
- En este estudio retrospectivo participaron 54 pacientes con una media de edad de 64 años procedentes de tres centros diferentes de EE. UU. y Alemania. Tras la resección quirúrgica, todos los pacientes recibieron radioterapia intraoperatoria con una media de dosis en la superficie de 30 Gy.
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