Radioterapia intraoperatória (IORT) durante a ressecção cirúrgica de metástases cerebrais
Uma análise conjunta internacional de 54 pacientes
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A leitura desta breve síntese não substitui a leitura do estudo original, dá apenas uma visão resumida e não reflete necessariamente a opinião dos organismos notificados e/ou das autoridades reguladoras, tais como a DQS ou a FDA.
Breve apresentação geral de uma análise conjunta de pacientes com metástases cerebrais criada por Christopher P. Cifarelli, MD, PhD, FAANS, FACS em nome da ZEISS, abril de 2020.
Título original:
Intraoperative radiotherapy (IORT) for surgically resected brain metastases: outcome analysis of a international cooperative study.
Autores:
Christopher P. Cifarelli, Stefanie Brehmer, John A. Vargo, Joshua D. Hack, Klaus H. Kahl, Gustavo Sarria-Vargas, Frank A. Giordano
Fonte:
Cifarelli, C.P., Brehmer, S., Vargo, J.A. et al. Intraoperative radiotherapy (IORT) for surgically resected brain metastases: outcome analysis of an international cooperative study. J Neurooncol 145,391 397 (2019) doi: 10.1007/s11060-019-03309-6
- A administração de uma dose imediata e suficiente para esterilizar o leito tumoral após a ressecção de metástases cerebrais é uma discussão importante e constante.
- Os elementos-chave das terapêuticas de metástases cerebrais são o controlo local, o tratamento da necrose devido a radiação e um curto período de tempo até ao início da terapêutica sistémica, o que pode ser potencialmente alcançado com a IORT imediata.
- Neste estudo retrospetivo foram incluídos 54 pacientes com uma idade média de 64 anos de três centros diferentes nos EUA e na Alemanha. Após a ressecção cirúrgica, todos os pacientes receberam radioterapia intraoperatória com uma dose superficial média de 30 Gy.
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