Kompendium

Veröffentlichungen zur Anwendung der konfokalen Endomikroskopie (CLE) bei kranialen Eingriffen

2 Juli 2024 · 5 Min. Lesedauer
Zusammengestellt von ZEISS Medical Technology
Zusammenfassung

Auflistung wissenschaftlicher Veröffentlichungen zum Stellenwert der CLE für die intraoperativen Beurteilung der Gewebefeinstruktur

In dieser Übersicht stellt ZEISS klinische Fachbeiträge zur Anwendung von konfokaler Endomikroskopie (CLE) bei kranialen Eingriffen zur Verfügung, mit Fokus auf die Nutzung zur Visualisierung der Gewebefeinstruktur. Zu den weiteren themenrelevanten Aspekten, die darüber hinaus beleuchtet werden, zählen u. a. technologische Fragen, Möglichkeiten zur Workflow-Optimierung und wirtschaftliche Auswirkungen. Auf diese Weise möchten wir Ihnen den Zugang zu weiterführenden Informationen ermöglichen und Fachwissen mit Ihnen teilen.

Jede Veröffentlichung beruht auf der fachlichen Meinung oder den Studienergebnissen des jeweiligen Autors. Sie spiegelt nicht zwingend die Auffassung der Carl Zeiss Meditec AG wider und stimmt nicht unbedingt mit der klinischen Bewertung oder Zweckbestimmung unserer Medizinprodukte überein. Die klinische Anwendbarkeit der einzelnen Publikationen ist daher durch den ausführenden Arzt sorgfältig zu prüfen.

Neuro-Indikationen

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    2024 May

    Intraoperative in vivo confocal endomicroscopy of the glioma margin: performance assessment of image interpretation by neurosurgeon users

    Frontiers in Oncology

    Xu Y, On TJ, Abramov I, Restelli F, Belykh E, Mathis AM, Schlegel J, Hewer E, Pollo B, Maragkou T, Quint K, Porter RW, Smith KA, Preul MC

    2024 Jan

    Fluorescein-stained confocal laser endomicroscopy versus conventional frozen section for intraoperative histopathological assessment of intracranial tumors

    Neuro-Oncology

    Wagner A, Brielmaier MC, Kampf C, Baumgart L, Aftahy AK, Meyer HS, Kehl V, Höhne J, Schebesch KM, Schmidt NO, Zoubaa S, Riemenschneider MJ, Ratliff M, Enders F, von Deimling A, Liesche-Starnecker F, Delbridge C, Schlegel J, Meyer B, Gempt J

    2023 Sep

    Intraoperative confocal laser endomicroscopy for interpretation of a sellar hemangioblastoma: illustrative case

    Journal of Neurosurgery

    Abramov I, Furey CG, Xu Y, Eschbacher JM, Smith KA, Preul MC

    2023 Aug

    Intraoperative in vivo confocal laser endomicroscopy imaging at glioma margins: can we detect tumor infiltration?

    Journal of Neurosurgery

    Xu Y, Mathis AM, Pollo B, Schlegel J, Maragkou T, Seidel K, Schucht P, Smith KA, Porter RW, Raabe A, Little AS, Sanai N, Agbanyim DC, Martirosyan NL, Eschbacher JM, Quint K, Preul MC, Hewer E

    2022 Sep

    Introduction of In Vivo Confocal Laser Endomicroscopy and Real-Time Telepathology for Remote Intraoperative Neurosurgery-Pathology Consultation

    Operative Neurosurgery

    Park MT, Abramov I, Gooldy TC, Smith KA, Porter RW, Little AS, Lawton MT, Eschbacher JM, Preul MC

    2022 Jun

    Real-time intraoperative surgical telepathology using confocal laser endomicroscopy

    Neurosurgical Focus

    Abramov I, Park MT, Gooldy TC, Xu Y, Lawton MT, Little AS, Porter RW, Smith KA, Eschbacher JM, Preul MC

    2022

    A new study protocol for in vivo assessment of tumor diagnosis and microscopic tumor infiltration at the resection cavity in Central Nervous System tumors by a new miniature confocal endomicroscope (CONVIVO system)

    Journal of Neurosurgical Sciences

    Restelli F, Mazzapicchi E, Pollo B, Falco J, Bonomo G, La Corte E, Broggi M, Schiariti M, Di Meco F, Ferroli P, Tramacere I, Acerbi F

    2022

    Intraoperative confocal laser endomicroscopy: prospective in vivo feasibility study of a clinical-grade system for brain tumors

    Journal of Neurosurgery

    Abramov I, Park MT, Belykh E, Dru AB, Xu Y, Gooldy TC, Scherschinski L, Farber SH, Little AS, Porter RW, Smith KA, Lawton MT, Eschbacher JM, Preul MC

    2021

    Intraoperative imaging of brain tumors with fluorescein: confocal laser endomicroscopy in neurosurgery. Clinical and user experience

    Neurosurgical Focus FOC

    Höhne J, Schebesch KM, Zoubaa S, Proescholdt M, Riemenschneider MJ, Schmidt NO

    2020

    Ex Vivo Fluorescein-Assisted Confocal Laser Endomicroscopy (CONVIVO® System) in Patients With Glioblastoma: Results From a Prospective Study

    Frontiers in Oncology

    Acerbi F, Pollo B, De Laurentis C, Restelli F, Falco J, Vetrano IG, Broggi M, Schiariti M, Tramacere I, Ferroli P, DiMeco F

    2020

    Confocal laser endomicroscopy assessment of pituitary tumor microstructure: A feasibility study

    Journal of Clinical Medicine

    Belykh E, Ngo B, Farhadi DS, Zhao X, Mooney MA, White WL, Daniels JK, Little AS, Eschbacher JM, Preul MC

    2020

    Intraoperative Confocal Laser Endomicroscopy Ex Vivo Examination of Tissue Microstructure During Fluorescence-Guided Brain Tumor Surgery

    Frontiers in Oncology

    Belykh E, Zhao X, Ngo B, Farhadi DS, Byvaltsev VA, Eschbacher JM, Nakaji P, Preul MC

    2018

    Confocal scanning microscopy provides rapid, detailed intraoperative histological assessment of brain neoplasms: Experience with 106 cases

    Clinical Neurology and Neurosurgery

    Martirosyan NL, Georges J, Eschbacher JM, Belykh E, Carotenuto A, Spetzler RF, Nakaji P, Preul MC

    2017

    Confocal Laser Endomicroscopy in Neurosurgery—An Alternative to Instantaneous Sections?

    World Neurosurgery

    Breuskin D, Szczygielski J, Urbschat S, Kim YJ, Oertel J

    2016

    Prospective evaluation of the utility of intraoperative confocal laser endomicroscopy in patients with brain neoplasms using fluorescein sodium: Experience with 74 cases

    Neurosurgical Focus

    Martirosyan NL, Eschbacher JM, Yashar M, Turner JD, Belykh E, Spetzler RF, Nakaji P, Preul MC

    2016

    Intraoperative Probe-Based Confocal Laser Endomicroscopy in Surgery and Stereotactic Biopsy of Low-Grade and High-Grade Gliomas: A Feasibility Study in Humans

    Neurosurgery

    Pavlov V, Meyronet D, Meyer-Bisch V, Armoiry X, Pikul B, Dumot C, Beuriat PA, Signorelli F, Guyotat J

    2015

    Confocal laser endomicroscopy for real-time histomorphological diagnosis: Our clinical experience with 150 brain and spinal tumor cases

    Neurosurgery

    Charalampaki P, Javed M, Daali S, Heiroth HJ, Igressa A, Weber F

    2012

    In vivo intraoperative confocal microscopy for real-time histopathological imaging of brain tumors: Clinical article

    Journal of Neurosurgery

    Eschbacher J, Martirosyan NL, Nakaji P, Sanai N, Preul MC, Smith KA, Coons SW, Spetzler RF

    2011

    Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas: Clinical article

    Journal of Neurosurgery

    Sanai N, Snyder LA, Honea NJ, Coons SW, Eschbacher JM, Smith KA, Spetzler RF

    2010

    Confocal neurolasermicroscopy in human brain – perspectives for neurosurgery on a cellular level (including additional Comments to this article)

    Zentralblatt für Neurochirurgie

    Schlosser HG, Suess O, Vajkoczy P, Van Landeghem FK, Zeitz M, Bojarski C

  • Jahr

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    2021

    Visualization of brain microvasculature and blood flow in vivo: Feasibility study using confocal laser endomicroscopy

    Microcirculation

    Belykh E, Zhao X, Ngo B, Farhadi DS, Kindelin A, Ahmad S, Martirosyan NL, Lawton MT, Preul MC

    2018

    Diagnostic Accuracy of a Confocal Laser Endomicroscope for InVivo Differentiation Between Normal Injured And Tumor Tissue During Fluorescein-Guided Glioma Resection: Laboratory Investigation

    World Neurosurgery

    Belykh E, Miller EJ, Patel AA, Yazdanabadi MI, Martirosyan NL, Yağmurlu K, Bozkurt B, Byvaltsev VA, Eschbacher JM, Nakaji P, Preul MC

    2013

    Miniaturized handheld confocal microscopy identifies focal brain invasion in a mouse model of aggressive meningioma

    Brain Pathology

    Peyre M, Clermont-Taranchon E, Stemmer-Rachamimov A, Kalamarides M

    2012

    Confocal laser endomicroscopy for diagnosis and histomorphologic imaging of brain tumors in vivo

    PLOS ONE

    Foersch S, Heimann A, Ayyad A, Spoden GA, Florin L, Mpoukouvalas K, Kiesslich R, Kempski O, Goetz M, Charalampaki P

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    2022

    Characterization of ex vivo and in vivo intraoperative neurosurgical confocal laser endomicroscopy imaging

    Frontiers in Oncology

    Xu Y, Abramov I, Belykh E, Mignucci-Jiménez G, Park MT, Eschbacher JM, Preul MC

    2021

    Redosing of Fluorescein Sodium Improves Image Interpretation During Intraoperative Ex Vivo Confocal Laser Endomicroscopy of Brain Tumors

    Frontiers in Oncology

    Abramov I, Dru AB, Belykh E, Park MT, Bardonova L, Preul MC

    2021

    High-Dose Fluorescein Reveals Unusual Confocal Endomicroscope Imaging of Low-Grade Glioma

    Frontiers in Neurology

    Belykh E, Onaka NR, Zhao X, Abramov I, Eschbacher JM, Nakaji P, Preul MC

    2021

    Fluorescence-Guided Surgery: A Review on Timing and Use in Brain Tumor Surgery

    Frontiers in Neurology

    Schupper AJ, Rao M, Mohammadi N, Baron R, Lee JY, Acerbi F, Hadjipanayis CG

    2020

    Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors

    Frontiers in Oncology

    Belykh E, Shaffer KV, Lin C, Byvaltsev VA, Preul MC, Chen L

    2019

    Progress in Confocal Laser Endomicroscopy for Neurosurgery and Technical Nuances for Brain Tumor Imaging With Fluorescein

    Frontiers in Oncology

    Belykh E, Miller EJ, Carotenuto A, Patel AA, Cavallo C, Martirosyan NL, Healey DR, Byvaltsev VA, Scheck AC, Lawton MT, Eschbacher JM, Nakaji P, Preul MC

    2018

    Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: Technical note

    Journal of Neurosurgery

    Molina ES, Wölfer J, Ewelt C, Ehrhardt A, Brokinkel B, Stummer W

    2018

    Probe-based three-dimensional confocal laser endomicroscopy of brain tumors: Technical note

    Cancer Management and Research

    Belykh E, Patel AA, Miller EJ, Bozkurt B, Yağmurlu K, Woolf EC, Scheck AC, Eschbacher JM, Nakaji P, Preul MC

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    2022 Oct

    Confocal laser imaging in neurosurgery: A comprehensive review of sodium fluorescein-based CONVIVO preclinical and clinical applications

    Frontiers in Oncology

    Restelli F, Mathis AM, Höhne J, Mazzapicchi E, Acerbi F, Pollo B, Quint K

    2021

    Confocal laser microscopy in neurosurgery: State of the art of actual clinical applications

    Journal of Clinical Medicine

    Restelli F, Pollo B, Vetrano IG, Cabras S, Broggi M, Schiariti M, Falco J, de Laurentis C, Raccuia G, Ferroli P, Acerbi F

    2018

    Utilization of intraoperative confocal laser endomicroscopy in brain tumor surgery

    Journal of Neurosurgical Sciences

    Belykh E, Cavallo C, Gandhi S, Zhao X, Veljanoski D, Yazdanabadi MI, Martirosyan NL, Byvaltsev VA, Eschbacher J, Preul MC, Nakaji P

  • Jahr

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    2022 Nov

    Intraoperative confocal laser endomicroscopy for brain tumors - potential and challenges from a neuropathological perspective

    Free Neuropathology

    Maragkou T, Quint K, Pollo B, Hewer E

    2022

    Real-time intraoperative surgical telepathology using confocal laser endomicroscopy

    Journal of Neurosurgery

    Abramov I, Park MT, Gooldy TC, Xu Y, Lawton MT, Little AS, Porter RW, Smith KA, Eschbacher JM, Preul MC

    2021

    Socio-organizational impact of confocal laser endomicroscopy in neurosurgery and neuropathology: Results from a process analysis and expert survey

    Diagnostics

    Fotteler ML, Liesche-Starnecker F, Brielmaier MC, Schobel J, Gempt J, Schlegel J, Swoboda W

    2000

    Accuracy, Utility, and Cost of Frozen Section Margins in Head and Neck Cancer Surgery

    The Laryngoscope

    DiNardo LJ, Lin J, Karageorge LS, Powers CN

    2019

    In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice

    Archives of Pathology and Laboratory Medicine

    Wells WA, Thrall M, Sorokina A, Fine J, Krishnamurthy S, Haroon A, Rao B, Shevchuk MM, Wolfsen HC, Tearney GJ, Hariri LP

    2019

    Clinical Benefits of Combining Different Visualization Modalities in Neurosurgery

    Frontiers in Surgery

    Schebesch KM, Rosengarth K, Brawanski A, Proescholdt M, Wendl C, Höhne J, Ott C, Lamecker H, Doenitz C

    2019

    In vivo and ex vivo microscopy: A business plan to justify the introduction of similar emerging technologies into pathology practice

    Archives of Pathology and Laboratory Medicine

    Wells WA, Harhen MT, Thrall MJ, Shevchuk MM, Tearney GJ, Hariri LP

    2019

    Toward Quantitative Neurosurgical Guidance With High-Resolution Microscopy of 5-Aminolevulinic Acid-Induced Protoporphyrin IX

    Frontiers in Oncology

    Wei L, Fujita Y, Sanai N, Liu JT

Sonstige Indikationen

  • Jahr

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    2021

    Fluorescein-Guided Panendoscopy for Head and Neck Cancer Using Handheld Probe-Based Confocal Laser Endomicroscopy: A Pilot Study

    Frontiers in Oncology

    Dittberner A, Ziadat R, Hoffmann F, Pertzborn D, Gassler N, Guntinas-Lichius O

    2021

    Confocal laser endomicroscopy of head and neck squamous cell carcinoma: a systematic review

    Laryngo-Rhino-Otologie

    Sievert M, Auberville M, Oetter N, Stelzle F, Maier A, Mantsopoulos K, Iro H, Goncalves M

    2021

    Intraoperative free margins assessment of oropharyngeal squamous cell carcinoma with confocal laser endomicroscopy: a pilot study

    European Archives of Oto-Rhino-Laryngology

    Sievert M, Stelzle F, Aubreville M, Mueller SK, Eckstein M, Oetter N, Maier A, Mantsopoulos K, Iro H, Goncalves M

    2019

    Probe-based confocal laser endomicroscopy for diagnosis of nasopharyngeal carcinoma in vivo

    The Laryngoscope

    Wu L, Yu H, Zhou R, Luo J, Zhao J, Li Y, Wang K, Wang Y, Li H

    2019

    Probe-based confocal laser endomicroscopy in detecting malignant lesions of vocal folds

    Acta Otorhinolaryngologica Italica

    Goncalves M, Aubreville M, Mueller SK, Sievert M, Maier A, Iro H, Bohr C

    2017

    Value of confocal laser endomicroscopy in the diagnosis of vocal cord lesions

    European review for medical and pharmacological sciences

    Goncalves M, Iro H, Dittberner A, Agaimy A, Bohr C

    2016

    Evaluation of confocal laser endomicroscopy as an aid to differentiate primary flat lesions of the larynx: A prospective clinical study

    Head & Neck

    Volgger V, Girschick S, Ihrler S, Englhard AS, Stepp H, Betz CS

    2016

    Noninvasive histological imaging of head and neck squamous cell carcinomas using confocal laser endomicroscopy

    European Archives of Oto-Rhino-Laryngology

    Linxweiler M, Kadah BA, Bozzato A, Bozzato V, Hasenfus A, Kim YJ, Wagner M, Igressa A, Schick B, Charalampaki P

    2012

    Systematic intraoperative application of confocal endomicroscopy for early detection and resection of squamous cell carcinoma of the head and neck: A preliminary report

    Archives of Otolaryngology - Head and Neck Surgery

    Pogorzelski B, Hanenkamp U, Goetz M, Kiesslich R, Gosepath J

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    2015

    Confocal laser endomicroscopy in breast surgery: A pilot study

    BMC Cancer

    De Palma GD, Esposito D, Luglio G, Limite G, Accurso A, Sollazzo V, Maione F, Cassese G, Siciliano S, Gennarelli N, Ilardi G, Paternoster M, Giglio MC, Forestieri P

    2015

    Imaging breast cancer morphology using probe-based confocal laser endomicroscopy: towards a real-time intraoperative imaging tool for cavity scanning

    Breast Cancer Research and Treatment

    Chang TP, Leff DR, Shousha S, Hadjiminas DJ, Ramakrishnan R, Hughes MR, Yang GZ, Darzi A

    2014

    Fluorescence confocal microscopy for pathologists

    Modern Pathology

    Ragazzi M, Piana S, Longo C, Castagnetti F, Foroni M, Ferrari G, Gardini G, Pellacani G

Translationale Forschung und Technologie

  • Jahr

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    2021

    Deep Neural Network for Differentiation of Brain Tumor Tissue Displayed by Confocal Laser Endomicroscopy

    Frontiers in Oncology

    Ziebart A, Stadniczuk D, Roos V, Ratliff M, von Deimling A, Hänggi D, Enders F

    2018

    Context aware decision support in neurosurgical oncology based on an efficient classification of endomicroscopic data

    International Journal of Computer Assisted Radiology and Surgery

    Li Y, Charalampaki P, Liu Y, Yang GZ, Giannarou S

    2018

    Convolutional neural networks: Ensemble modeling, fine-tuning and unsupervised semantic localization for neurosurgical CLE images

    Journal of Visual Communication and Image Representation

    Izadyyazdanabadi M, Belykh E, Mooney M, Martirosyan N, Eschbacher J, Nakaji P, Preul MC, Yang Y

    2018

    Weakly-supervised learning-based feature localization for confocal laser endomicroscopy glioma images

    Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

    Izadyyazdanabadi M, Belykh E, Cavallo C, Zhao X, Gandhi S, Moreira LB, Eschbacher J, Nakaji P, Preul MC, Yang Y

    2018

    Prospects for theranostics in neurosurgical imaging: Empowering confocal laser endomicroscopy diagnostics via deep learning

    Frontiers in Oncology

    Izadyyazdanabadi M, Belykh E, Mooney MA, Eschbacher JM, Nakaji P, Yang Y, Preul MC

    2016

    Automatic Tissue Differentiation Based on Confocal Endomicroscopic Images for Intraoperative Guidance in Neurosurgery

    BioMed Research International

    Kamen A, Sun S, Wan S, Kluckner S, Chen T, Gigler AM, Simon E, Fleischer M, Javed M, Daali S, Igressa A, Charalampaki P


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