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Veröffentlichungen zur Anwendung der intraoperativen Strahlen- und Radiotherapie (IORT) bei onkologischen Behandlungen

Mit den Schwerpunkten Indikationen, medizinische Physik, Radiobiologie, technologische Aspekte, Lebensqualität sowie Leitlinien und Empfehlungen

7 Dezember 2023 · 10 Min. Lesedauer
Zusammengestellt von ZEISS Medical Technology
ZUSAMMENFASSUNG

Liste der Artikel zur IORT als Bestandteil radioonkologischer Behandlungsmöglichkeiten

In dieser Literaturübersicht stellt ZEISS verschiedene klinische Artikel in englischer und deutscher Sprache zur IORT für verschiedene onkologische Indikationen vor, mit Schwerpunkt auf bestimmten relevanten Aspekten wie medizinische Physik, Radiobiologie, technologische Aspekte, kosmetische Ergebnisse, Leitlinien, Empfehlungen oder die Bewertung von Gesundheitstechnologien (HTA). Auf diese Weise möchten wir Ihnen den Zugang zu weiterführenden Informationen ermöglichen und Fachwissen mit Ihnen teilen.

Jede Veröffentlichung beruht auf der fachlichen Meinung oder den Studienergebnissen des jeweiligen Autors. Sie spiegelt nicht zwingend die Auffassung der Carl Zeiss Meditec AG wider und stimmt nicht unbedingt mit der klinischen Bewertung oder Zweckbestimmung unserer Medizinprodukte überein. Die klinische Anwendbarkeit der einzelnen Publikationen ist daher durch den ausführenden Arzt sorgfältig zu prüfen.

Onkologische Indikationen

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    2023 Oct

    Intraoperative or postoperative stereotactic radiotherapy for brain metastases: time to systemic treatment onset and other patient-relevant outcomes

    Journal of Neuro-Oncology

    Dejonckheere CS, Layer JP, Hamed M, Layer K, Glasmacher A, Friker LL, Potthoff A, Zeyen T, Scafa D, Koch D, Garbe S, Holz JA, Kugel F, Grimmer M, Schmeel FC, Gielen GH, Forstbauer H, Vatter H, Herrlinger U, Giordano FA, Schneider M, Schmeel LC, Sarria GR

    2023 Sep

    Intracranial intraoperative radiotherapy (IORT): evaluation of electrocorticography and peri-operative seizure risk

    Journal of Neuro-Oncology

    Cifarelli CP, Vargo JA, Sener U, Cifarelli DT, Scoville D, Dabir A

    2023 Jul

    Opportunities and Alternatives of Modern Radiation Oncology and Surgery for the Management of Resectable Brain Metastases

    Cancers

    Diehl CD, Giordano FA, Grosu AL, Ille S, Kahl KH, Onken J, Rieken S, Sarria GR, Shiban E, Wagner A, Beck J, Brehmer S, Ganslandt O, Hamed M, Meyer B, Münter M, Raabe A, Rohde V, Schaller K, Schilling D, Schneider M, Sperk E, Thomé C, Vajkoczy P, Vatter H, Combs SE

    2023 Jul

    Outcome assessment of intraoperative radiotherapy for brain metastases: results of a prospective observational study with comparative matched-pair analysis

    Journal of Neuro-Oncology

    Layer JP, Hamed M, Potthoff AL, Dejonckheere CS, Layer K, Sarria GR, Scafa D, Koch D, Köksal M, Kugel F, Grimmer M, Holz JA, Zeyen T, Friker LL, Borger V, Schmeel FC, Weller J, Hölzel M, Schäfer N, Garbe S, Forstbauer H, Giordano FA, Herrlinger U, Vatter H, Schneider M, Schmeel LC

    2023 Feb

    Intraoperative radiotherapy for brain metastases: first-stage results of a single-arm, open-label, phase 2 trial

    National Library of Medicine

    De Castro DG, Sanematsu Jr PI, Pellizzon ACA, Suzuki SH, Fogaroli RC, Dias Jr JES, Gondim GRM, Estrada DA, Silva MLG, Rassi MS, Chen MJ, Giacomelli R, Ramos H, Neto ES, Abrahão CH, Coelho TM, Yu LS, Tannous CQ, Calsavara VF, Giordano FA, Oliveira JG

    2022 Dec

    Resection of supratentorial brain metastases with intraoperative radiotherapy. Is it safe? Analysis and experiences of a single center cohort

    Frontiers in Oncology

    Krauss P, Steininger K, Motov S, Sommer B, Bonk MN, Cortes A, Wolfert C, Stueben G, Shiban E, Henning K

    2022 Dec

    Low-Energy X-Ray Intraoperative Radiation Therapy (Lex-IORT) for Resected Brain Metastases: A Single-Institution Experience

    National Library of Medicine

    Diehl CD, Pigorsch SU, Gempt J, Krieg SM, Reitz S, Waltenberger M, Barz M, Meyer HS, Wagner A, Wilkens J, Wiestler B, Zimmer C, Meyer B, Combs SE

    2022 Jul

    Intraoperative radiotherapy during awake craniotomies: preliminary results of a single-center case series

    Neurosurgical Review

    Steininger K, Kahl KH, Konietzko I, Wolfert C, Motov S, Krauß PE, Bröcheler T, Hadrawa M, Sommer B, Stüben G, Shiban E

    2022 Mar

    Benchmarking Safety Indicators of Surgical Treatment of Brain Metastases Combined with Intraoperative Radiotherapy: Results of Prospective Observational Study with Comparative Matched-Pair Analysis

    Cancers (Basel)

    Hamed M, Potthoff AL, Layer JP, Koch D, Borger V, Heimann M, Scafa D, Sarria GR, Holz JA, Schmeel FC, Radbruch A, Güresir E,
    Schäfer N, Schuss P, Garbe S, Giordano FA, Herrlinger U, Vatter H, Schmeel LC, Schneider M

    2021 Nov
    Intraoperative Radiotherapy in Brain Malignancies: Indications and Outcomes in Primary and Metastatic Brain Tumors

    Frontiers in Oncology

    Cifarelli CP, Jacobson GM
    2021 Oct
    Dosimetric Comparison of Upfront Boosting With Stereotactic Radiosurgery Versus Intraoperative Radiotherapy for Glioblastoma

    Frontiers in Oncology

    Sarria GR, Smalec Z, Muedder T, Holz JA, Scafa D, Koch D, Garbe S, Schneider M, Hamed M, Vatter H, Herrlinger U, Giordano FA, Schmeel LC
    2021 Aug
    Intraoperative radiotherapy with low-energy x-rays after neurosurgical resection of brain metastases- an Augsburg University Medical Center experience
    Strahlentherapie und Onkologie
    Kahl KH, Balagiannis N, Höck M, Schill S, Roushan Z, Shiban E, Müller H, Grossert U, Konietzko I, Sommer B, Maurer CJ, Berlis A, Heidecke V, Janzen T, Stüben G
    2021 Mar
    Dose homogeneity analysis of adjuvant radiation treatment in surgically resected brain metastases: Comparison of IORT, SRS and IMRT indices
    Brachytherapy
    Dahshan BA, Weir JS, Bice RP, Renz P, Cifarelli DT, Poplawski L, Hack J, Vargo JA, Cifarelli CP
    2020 Feb
    Current approaches to the management of brain metastases
    Clinical Oncology
    Suh JH, Kotecha R, Chao ST, Ahluwalia MS, Sahgal A, Chang EL
    2019 Oct
    Intraoperative radiotherapy (IORT) for surgically resected brain metastases: outcome analysis of an international cooperative study
    Journal of Neuro-Oncology
    Cifarelli CP, Brehmer S, Vargo JA, Hack JD, Kahl KH, Sarria-Vargas G, Giordano FA
    2019 Sep
    Intraoperative Radiotherapy for Glioblastoma: An International Pooled Analysis
    International Journal of Radiation Oncology, Biology & Physics

    Sarria GR, Sperk E, Xiaodi H, Sarria G, Wenz F, Brehmer S, Fu B, Min S, Zhang H, Qin S, Qiu X, Abou Madian Y, Hänggi D, Martinez DA, Cabrera C, Giordano FA

    2019 May
    Intraoperative radiotherapy (IORT) for surgically resected brain metastases: Local control and dosimetric analysis.
    Journal of Global Oncology
    Cifarelli CP, Vargo JA, Hack JD, Renz PB, Poplawski L, Jacobson GM, Kahl KH, Brehmer S, Sarria G, Giordano FA
    2019 Jan
    Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Treatment of Adults With Metastatic Brain Tumors: Executive Summary
    Neurosurgery
    Olson JJ, Kalkanis SN, Ryken TC
    2018 Aug
    Feasibility of dose escalation using intraoperative radiotherapy following resection of large brain metastases compared to post-operative stereotactic radiosurgery
    Journal of Neuro-Oncology
    Vargo JA, Sparks KM, Singh R, Jacobson GM, Hack JD, Cifarelli CP
    2018 Apr
    Combined stereotactic biopsy and stepping-source interstitial irradiation of glioblastoma multiforme
    Journal of Neurosurgical Sciences
    Brehmer S, Guthier CV, Clausen S, Schneider F, Schulte DM, Benker M, Bludau F, Glatting G, Marx A, Schmiedek P, Hesser J, Wenz F, Giordano FA
    2018 Mar
    Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma (INTRAGO): An Open-Label, Dose-Escalation Phase I/II Trial
    Neurosurgery
    Giordano FA, Brehmer S, Mürle B, Welzel G, Sperk E, Keller A, Abou Madian Y, Scherzinger E, Clausen S, Schneider F, Herskind C, Glas M, Seiz-Rosenhagen M, Groden C, Hänggi D, Schmiedek P, Emami B, Souhami L, Petrecca K, Wenz F
    2016 Oct
    Initial Results of a Phase 1/2 Trial on Intraoperative Radiation Therapy (IORT) in Newly Diagnosed Glioblastoma Multiforme (INTRAGO)
    International Journal of Radiation Oncology, Biology & Physics
    Giordano FA, Brehmer S, Mürle B, Welzel G, Sperk E, Schneider F, Clausen S, Schmiedek P, Groden C, Hänggi D, Abou Madian Y, Wenz F
    2016 Jan
    Rationale for intraoperative radiotherapy in glioblastoma
    Journal of Neurosurgical Sciences
    Giordano FA, Wenz F, Petrecca K
    2015 Apr
    Intraoperative radiotherapy to treat newly diagnosed solitary brain metastasis: initial experience and long-term outcomes
    Journal of Neurosurgery
    Weil RJ, Mavinkurve GG, Chao ST, Vogelbaum MA, Suh JH, Kolar M, Toms SA
    2014 Sep
    INTRAOPERATIVE RADIOTHERAPY WITH INTRABEAM IN PRIMARY BRAIN TUMORS AFTER RESECTION: PRELIMINARY REPORTS OF 26 CASES
    Neuro-Oncology
    Han X, Fu B, Wu M, Zhang H, Li D, Zhang J, Sun D, Sun S
    2014 Feb
    Intraoperative radiotherapy (IORT)—a resurrected option for treating glioblastoma?
    Translational Cancer Research
    Giordano FA, Abou Madian Y, Brehmer S, Herskind C, Sperk E, Schneider F, Clausen S, Welzel G, Schmiedek P, Wenz F
    2006 Apr
    Phase I study of intraoperative radiotherapy with photon radiosurgery system in children with recurrent brain tumors: Preliminary report of first dose level (10 Gy)
    International Journal of Radiation Oncology, Biology & Physics
    Kalapurakal JA, Goldman S, Stellpflug W, Curran J, Sathiaseelan V, Marymont MH, Tomita T 
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    2021 Aug

    First Experience of Intra-Operative Radiation Therapy (IORT) during Kyphoplasty in Patients Diagnosed with Spinal Metastasis in Iran

    Austin Journal of Clinical Case Reports 

    Seddighi AS, Nikouei A, Seddighi A, Akbari ME, Arjmand Y, Ommi D, Zali A, Hosseini M

    2020 Nov

    Long-term outcome after combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) for vertebral tumors

    BioMed Central

    Bludau F, Winter L, Welzel G, Obtertacke U, Schneider F, Wenz F, Ruder AM, Giordano FA

    2019 May
    Combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful vertebral metastases - a randomized phase III study
    BMC Cancer
    Bludau F, Welzel G, Reis T, Abou Madian Y, Sperk E, Schneider F, Clausen S, Ruder AM, Obertacke U, Ghaly MM, Wenz F, Giordano FA
    2018 May
    Phase I/II trial of combined kyphoplasty and intraoperative radiotherapy in spinal metastases
    The Spine Journal
    Bludau F, Welzel G, Reis T, Schneider F, Sperk E, Neumaier C, Ehmann M, Clausen S, Obertacke U, Wenz F, Giordano FA
    2017 Aug
    Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases
    Scientific Reports
    Mohme M, Riethdorf S, Dreimann M, Werner S, Maire CL, Joosse SA, Bludau F, Mueller V, Neves RPL, Stoecklein NH, Lamszus K, Westphal M, Pantel K, Wikman H, Eicker SO
    2015 Sep
    Kyphoplastie kombiniert mit intraoperativer Radiotherapie (Kypho-IORT)
    Der Radiologe
    Bludau F, Reis T, Schneider F, Clausen S, Wenz F, Obertacke U
    2014 Jan
    Kypho-IORT: the first French treatment
    Translational Cancer Research
    Miglierini P, Dam-Hieu P, Key S
    2013 Jul
    Kyphoplastie in Kombination mit intraoperativer Radiotherapie
    Der Orthopäde
    Kayser R, Ender SA, Asse E, Wilhelm E, Adler F, Schmidt R, Wenz F, Obertacke U, Bludau F

    2012 Jan

    Kyphoplasty and intra-operative radiotherapy, combination of kyphoplasty and intra-operative radiation for spinal metastases: technical feasibility of a novel approach

    International Orthopaedics
    Schmidt R, Wenz F, Reis T, Janik K, Bludau F, Obertacke U
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    2023 Oct

    Case Report: Bilateral targeted intraoperative radiotherapy: a safe and effective alternative for synchronous bilateral breast cancer

    Frontiers in Oncology

    Bhimani F, McEvoy M, Gupta A, Pastoriza J, Shihabi A, Basavatia A, Tomé WA, Fox J, Mehta K, Feldman S.

    2023 Jul

    Experience with intraoperative radiation therapy in an urban cancer center

    Radiation Oncology

    Andraos TY, Skalina KA, Feldman S, Mehta K, Tome WA, McEvoy MP, Gupta AM, Fox JL

    2023 May

    Case Report: Intraoperative radiotherapy as the new standard of care for breast cancer patients with disabling health conditions or impairments

    Frontiers in Oncology

    Omosule M, De Silva-Minor S, Coombs N

    2023 Feb

    Breast Conserving Surgery in Combination With Targeted Intraoperative Radiotherapy Compared to Mastectomy for In-breast-tumor-recurrence

    National Library of Medicine

    Kolberg HC, Niesing H, Vaidya JS, Akpolat-Basci L, Maguz A, Hoffmann O, Loevey G, Stephanou M, Kolberg-Liedtke C

    2022 Dec

    A single-institution retrospective analysis of intraoperative radiation boost during breast-conservation treatment for breast cancer

    Journal of Cancer Research and Clinical Oncology

    Hochhertz F, Hass P, Röllich B, Ochel HJ, Gawish A

    2022 Sep

    The case for risk-stratified IORT for early breast cancer

    BRACHYTHERAPY An International Multidisciplinary Journal

    Refaat T, Gros SE, Small Jr W

    2022 Sep

    Intraoperative radiation therapy for early-stage breast cancer: a single-institution experience

    National Library of Medicine

    Giap F, O'stehen L, Liu I, Spiguel LE, Shaw CM, Morris CG, Vega RBM, Lightsey J, Bradley JA, Mendenhall NP, Okuniedd P, Lockney NA

    2022 Aug

    Global adoption of single-shot targeted intraoperative radiotherapy (TARGIT-IORT) for breast cancer—better for patients, better for healthcare systems

    Frontiers in Oncology

    Vaidya JS, Vaidya UJ, Baum M, Bulsara MK, Joseph D, Tobias JS

    2022 Aug

    Prognosis comparison between intraoperative radiotherapy and whole-breast external beam radiotherapy for T1–2 stage breast cancer without lymph node metastasis treated with breast-conserving surgery: A case-control study after propensity score matching

    Frontiers in Oncology

    Chen Q, Qu L, He Y, Xu J, Deng Y, Zhou Q, Yi W

    2022 Jul

    Risk-Stratified Intraoperative Radiation Therapy as a Definitive Adjuvant Radiation Therapy Modality for Women With Early Breast Cancer

    Scientific Reports

    Small Jr W, Refaat T, Feldman SM, Holmes D

    2022 Jul

    Accelerated Partial Breast Irradiation with Intraoperative Radiotherapy Is Effective in Luminal Breast Cancer Patients Aged 60 Years and Older

    Journal of Personalized Medicine

    Falco M, Masojć B, Rolla M, Czekała A, Milchert‑Leszczyńska M, Pietruszewska J

    2022 Jul

    Case Report: Can Targeted Intraoperative Radiotherapy in Patients With Breast Cancer and Pacemakers be the New Standard of Care?

    Frontiers in Oncology

    Bhimani F, Johnson K, Brodin NP, Tomé WA, Fox J, Mehta K, McEvoy M, Feldman S

    2022 June

    Breast preservation after local recurrence of breast cancer: Comparison of length and quality of life (QoL) between breast conserving surgery with intraoperative radiotherapy (TARGIT-IORT) versus mastectomy.

    Journal of Clinical Oncology

    Kolberg HC, Niesing H, Vaidya JS, Akpolat‑Basci L, Maguz A, Hoffmann O, Loevey G

    2022 June

    Targeted Intraoperative Radiotherapy (TARGIT-IORT) for Early-Stage Invasive Breast Cancer: A Single Institution Experience

    Frontiers in Oncology

    Brown A, Buss EJ, Chin C, Liu G, Lee S, Rao R, Taback B, Wiechmann L, Horowitz D, Choi JC, Katz LM, Connolly EP

    2022 Mar

    Long-Term Outcomes of an International Cooperative Study of Intraoperative Radiotherapy Upfront Boost With Low Energy X-Rays in Breast Cancer

    National Library of Medicine

    Sarria GR, Ramos ML, Palacios A, Del Castillo R, Castro R, Calvo A, Cotrina JM, Heredia A, Galarreta JA, Fuentes-Rivera P, Avalos A, Martinez DA, Colqui K, Ziegler G, Schmeel LC, Pinillos LV, Wenz F, Giordano FA, Sarria GJ, Sperk E

    2022 Mar

    Effectiveness and safety of intraoperative radiotherapy (IORT) with low-energy X-rays (INTRABEAM®) for accelerated partial breast irradiation (APBI)

    Clinical and Translational Oncology

    Laplana M, García‑Marqueta M, Sánchez‑Fernández JJ, Martínez‑Pérez E, Pérez‑Montero H, Martínez‑Montesinos I, Eraso A, Saldaña P, Martín R, Martín MI, Pla MJ, García‑Tejedor A, Guedea F

    2022 Feb

    Impact of targeted intraoperative (TARGIT-IORT) tumor bed boost during breast conserving surgery for early breast cancer on breast cancer associated and non-breast cancer associated mortality and morbidity

    American Association for Cancer Research

    Kolberg HC, Gutberlet S, Vaidya JS, Krajewska M, Lövey G, Hoffmann O, Stephanou M, Kolberg‑Liedtke C

    2022 Jan

    Intraoperative radiation therapy for early stage breast cancer

    BMC Surgery

    Zangouri V, Nasrollahi H, Taheri A, Akrami M, Arasteh P, Hamedi SH, Johari MG, Karimaghaee N, Ranjbar A, Karami MY, Tahmasebi S, Mosalaei A, Talei A

    2022 Jan

    Intraoperative Radiotherapy for Breast Cancer in Elderly Women 

    Clinical Breast Cancer 

    Guillerm SO, Bourstyn E, Itti R, Cahen-Doidy L, Quéro L, Labidi M, Marchand E, Lorphelin H, Giacchetti S, Cuvier C, Espié M, Teixeira L, Hennequin C

    2021 Nov

    Single institute experience of intraoperative radiaiton therapy in early-stage breast cancer

    Medicine (Baltimore)

    Chi MS, Ko HL, Chen CC, Hsu CH, Chen LK, Cheng FT

    2021 Nov

    Intraoperative irradiation in breast cancer: preliminary results in 80 patients as partial breast irradiation or anticipated boost prior to hypo-fractionated whole breast irradiation

    Clinical and Translational Oncology

    Li X, Sanz J, Argudo N, Vernet‑Tomas M, Rodríguez N, Torrent L, Fernández‑Velilla E, Pera O, Huang Y, Nicolau P, Jiménez M, Segura M, Algara M

    2021 Nov

    Surgical and Oncologic Outcomes With Intraoperative Radiation Therapy for Early Breast Cancer

    The American Surgeon

    Friedman‑Eldar O , Layton C, De Castro Silva I, Moller MG, Allen A, Franceschi D, Isrow D, Samuels S, Takita C, Avisar E

    2021 Jul

    TARGIT-IORT during lumpectomy for breast cancer- better for patients than other PBI approaches 

    International Journal of Radiation Oncology, Biology & Physics

    Vaidya JS, Bulsara M, Sperk E, Massarut S, Douek M, Alvarado M, Pigorsch S, Holmes D, Bernstein M, Saunders C, Flyger H, Joseph D, Wenz F, Tobias JS, TARGIT-A investigators

    2021 Jun

    Hypofractionated whole breast irradiation after IORT treatment is safe in patients receiving adjuvant chemotherapy

    Clinical and Translational Oncology

    Burgos‑Burgos J, Vega V, Macias‑Verde D, Gómez V, Travieso‑Aja M, Travieso J, Vicente E, Murias C, Santana C, Ospina J, Lara PC 

    2021 May

    New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer

    British Journal of Cancer

    Vaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Douek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams NR, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Corica T, Lundgren S, Holmes DR, Vinante L, Bozza F, Pazos M, Le Blanc-Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Joseph DJ, Tobias JS

    2021 Apr

    Intraoperative radiotherapy booster as part of breast-conservation therpy for breast cancer: a single-institution retrospective analysis 

    Strahlentherapie und Onkologie

    Stoian R, Erbes T, Zamboglou C, Scholber J, Galney M, Sachpazidis I, Haehl E, Spohn SK, Verma V, Krug D, Rühle A, Juhasz‑Böss I, Grosu AL, Nicolay NH, Sprave T 

    2021 Apr

    Comparison of IORT (Radical and Boost Dose) and EBRT in Terms of Disease-Free Survival and Overall Survival according Demographic, Pathologic, and Biological Factors in Patients with Breast Cancer 

    International Journal of Oncology 

    Hashemi S, Javadi S, Akbari ME, Mirzaei H, Mahdavi SR

    2021 Mar

    Patients Older 65 Years With Early Breast Cancer Prefer Intraoperative Radiation as a Locoregional Treatment Choice

    Annals of Surgical Oncology

    Tang A, Cohan CM, Beattie G, Cureton EL, Svahn JD, Lyon LL, Kelly JF, Shim VC

    2021 Feb 

    Assessment of Thyroid Lobe Dose in Breast Cancer Intraoperative Radiotherapy 

    Journal of Biomedical Physics and Engineering 

    Farkhani RR, Gholamhosseinian H, Anvari K, Forghani MN

    2021 Feb

    Preoperative selection of patients with early-stage invasive breast cancer for intraoperative radiation therapy (IORT): A single-institution experience

    Cancer Research

    Brown AM, Chin C, Connolly E, Rao R, Taback B, Wiechmann L

    2021 Feb 

    Intraoperative radiotherapy in early breast cancer: observational comparison with whole breast radiotherapy 

    Cirugía Espanola 

    Guillén JRO, Almudi EH, Osorio GM, Carreras RI, Gómez JAF, Gómez IV, Mur CG, Franco MCC 

    2021 Feb

    Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment

    British Journal of Cancer

    Vaidya JS, Bulsara M, Baum M, Tobias JS on behalf of TARGIT-A trial authors

    2021 Jan

    TARGIT-R (Retrospective): 5-Year Follow-Up Evaluation of Intraoperative Radiation Therapy (IORT) for Breast Cancer Performed in North America

    Annals of Surgical Oncology

    Valente SA, Tendulkar RD, Cherian S, Shah C, Ross DL, Lottich SC, Laronga C, Broman KK, Donnelly ED, Bethke KP, Shaw C, Lockney NA, Pederson A, Rudolph R, Hasselle M, Kelemen P, Hermanto U, Ashikari A, Kang S, Hoefer RA, McCready D, Fyles A, Escallon J, Rohatgi N, Graves J, Graves G, Willey SC, Tousimis E, Riley L, Deb N, Tu C, Small Jr. W, Grobmyer SR

    2021 Jan

    Intraoperative radiotherapy for breast cancer: powerful evidence to change practice

    Clinical Oncology 

    Vaidya JS, Bulsara M, Baum M, Alvarado M, Bernstein M, Massarut S, Saunders C, Sperk E, Wenz F, Tobias JS, TARGIT‑A investigators 

    2020 Oct

    Results of intraoperative radiotherapy given as a boost after breast conserving-surgery

    Gland Surgery

    Onthong K, Chakkabat C, Nantavithya C, Shotelersuk K, Denariyakoon S, Vongsaisuwon M, Chulakadabbav A, Chatamra K, Saksornchai K

    2020 Aug

    Cardiac serum marker alterations after intraoperative radiotherapy with low-energy x-rays in early breast cancer as an indicator of possible cardiac toxicity

    Strahlentherapie und Onkologie

    Stefanovic S, Berlit S, Sperk E, Wenz F, Weiß C, Trinkmann F, Sütterlin M, Tuschy B

    2020 Aug

    Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial

    The BMJ

    Vaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Douek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams NR, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Corica T, Lundgren S, Holmes DR, Vinante L, Bozza F, Pazos M, Le Blanc-Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Joseph DJ, Tobias JS, TARGIT-A trial authors

    2020 June

    Breast-conserving surgery with intraoperative radiotherapy in recurrent breast cancer: the patient’s perspective

    Breast Cancer Research and Treatment

    Elfgen C, Gürth U, Gruber G, Birrer S, Bjelic‑Radisic V, Fleisch M, Tausch CJ  

    2020 Apr

    Effect of Delayed Targeted Intraoperative Radiotherapy vs Whole-Breast Radiotherapy on Local Recurrence and Survival Long-term Results From the TARGIT-A Randomized Clinical Trial in Early Breast Cancer

    JAMA Oncology

    Vaidya JS, Bulsara M, Saunders C, Flyger H, Tobias JS, Corica T, Massarut S, Wenz F, Pigorsch S, Alvarado M, Douek M, Eiermann W, Brew‑Graves C, Williams N, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Lundgren S, Holmes D, Vinante L, Bozza F, Pazos M, Le Blanc‑Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Baum M, Joseph D

    2020 Mar

    The actual benefit of intraoperative radiation therapy using 50 kV x-rays in early breast cancer: A retrospective study of 676 patients

    The Breast Journal

    Tallet A, Racadot S, Boher J.-M, Cohen M, Barrou J, Houvenaeghel G, Gutowski M, Delmond L, Lemanski C

    2020 Jan

    Intraoperative partial irradiation for highly selected patients with breast cancer: Results of the INTRAOBS prospective study

    Cancer/Radiothérapie

    Lemanski C, Bourgier C, Draghici R, Thezenas S, Morel A, Rouanet P, Colomboe PE, Mourregot A, Delmond L, Fenoglietto P, Ailleres N, Azriaa D, Gutowski M

    Dez. 2019

    Intraoperative radiation therapy for breast cancer—Immediate and 30-month oncological outcomes

    The Breast Journal

    Melnik I, Yerushalmi R, Sobol Y, Magen A, Givon-Madhala O, Birinbaum Y, Fenig E, Sharon E

    2019 Oct

    Outcomes of selective whole breast irradiation following lumpectomy with intraoperative radiation therapy for hormone receptor positive breast cancer

    American Journal of Surgeons

    Broman K, Sun W, Zhou JM, Fridley B, Diaz R, Laronga C

    2019 Sep

    First per Protocol Analysis of the Prospective Phase II Study of Intraoperative Radiotherapy (IORT) in Elderly Patients with Small Breast Cancer: Targit E(lderly)

    International Journal of Radiation Oncology, Biology & Physics

    Sperk E

    Jul. 2019

    Targeted Intraoperative Radiotherapy During Breast-conserving Surgery for Breast Cancer in Patients After Implant Augmentation

    International Institute of Anticancer Research

    Kolberg HC, Uhl V, Massarut S, Holmes D, Kolberg‑Liedtke C, Kelly EW, Lövey G, Vaidya JS

    2019 Jan

    Patient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignment

    European Journal of Cancer Care

    Corica T, Saunders CM, Bulsara MK, Taylor M, Joseph DJ, Nowak AK 

    Dez. 2018

    A Prospective Analysis of Quality of Life and Toxicity Outcomes in Treating Early Breast Cancer With Breast Conservation Therapy and Intraoperative Radiation Therapy

    Frontiers in Oncology

    Sosin M, Gupta SS, Wang JS, Costellic CD, Gulla A, Bartholomew AJ, O'Neill SC, Hechenbleikner EM, Collins BT, Rudra S, Collins SP, Chaldekas KM, Seevaratnam S, Langan RC, Willey SC, Tousimis EA

    Dez. 2018

    Breast conserving surgery with targeted intraoperative radiotherapy for the management of ductal carcinoma in situ

    Journal of Surgical Oncology

    Banks A, Coronado G, Zimmerman R, Iyengar G, Holmes DR

    Nov. 2018

    A Single-Institution Experience in the Preoperative Selection of DCIS Patients for IORT using the ASTRO Consensus Guidelines

    Advance Radiation Oncology

    Chin C, Hirji S, Onishi M, Ha R, Taback B, Horowitz DP, Connolly EP

    Nov. 2018

    A phase II study investigating the acute toxicity of targeted intraoperative radiotherapy as tumor-bed boost plus whole breast irradiation after breast-conserving surgery in Korean patients

    Breast Cancer Research and Treatment

    Ahn SG, Bae SJ, Lee HW, Yoon CI, Kim JW, Lee IJ, Jeong J

    2018 Aug

    Skin dose assessment with treatment planning system (TPS) and skin reaction evaluation of early breast cancer patients treated via an intraoperative radiation therapy (IORT) device

    Cambridge University Press

    Baziar O, Gholamhosseinian H, Forghani MN

    2018 Apr

    Cosmetic outcome as rated by patients, doctors, nurses and BCCT.core software assessed over 5 years in a subset of patients in the TARGIT-A Trial

    BMC Cancer

    Corica T, Nowak AK, Saunders CM, Bulsara MK, Taylor M, Williams NR, Keshtgar M, Joseph DJ, Vaidya JS

    2018 Apr

    Clinical analysis of early results of the implementation of intraoperative radiotherapy with the Intrabeam device during breast-conserving surgery of early breast cancer in a private hospital

    The Americal Society of Breast Surgeons

    Papa M, Keller O, Tova Y

    2017 Dec

    Targeted Intraoperative Radiotherapy Tumour Bed Boost During Breast Conserving Surgery after Neoadjuvant Chemotherapy in HER2 Positive and Triple Negative Breast Cancer

    Reviews on Recent Clinical Trials

    Kolberg HC, Loevey G, Akpolat‑Basci L, Stephanou M, Fasching PA, Untch M, Bulsara M, Vaidya JS, Liedtke C

    2017 Dec

    Intraoperative Radiotherapy for Breast Cancer

    Frontiers in Oncology

    Harris EER, Small W

    2017 Oct

    Intraoperative Radiation for Breast Cancer with Intrabeam™: Factors Associated with Decreased Operative Times in Patients Having IORT for Breast Cancer

    Frontiers in Oncology

    Valente SA, Fanning A, Stewart RA, Grundfest S, Tendulkar RD, Cherian S, Shah C, Tu C, Yanda C, Radford D, Al‑Hilli Z, Grobmyer SR

    2017 Oct

    Long-Term Cosmetic Outcome after Hypofractionated, Normofractionated, and Intraoperative Breast Radiation Therapy: A Photographic Evaluation Study

    International Journal of Radiation Oncology, Biology & Physics

    Ellethy T, Welzel G, Sperk E, Neumaier C, Ehmann M, Wenz F, Abou Madian Y

    2017 Sep

    Targeted Intraoperative Radiotherapy Tumour Bed Boost during Breast-Conserving Surgery after Neoadjuvant Chemotherapy - a Subgroup Analysis of Hormone Receptor-Positive HER2-Negative Breast Cancer

    KARGER/Breast Care

    Kolberg HC, Loevey G, Akpolat‑Basci L, Stephanou M, Fasching PA, Untch M, Hoffmann O, Bulsara M, Vaidya JS, Liedtke C

    2017 Sep

    Targeted Intraoperative Radiotherapy Tumour Bed Boost during Breast-Conserving Surgery after Neoadjuvant Chemotherapy - a Subgroup Analysis of Hormone Receptor-Positive HER2-Negative Breast Cancer

    Breast Care

    Kolberg H-C, Lövey G, Akpolat-Basci L, Stephanou M, Fasching P, Untch M, Hoffmann O, Bulsara M, Vaidya J, Liedtke C

    2017 Aug

    Keynote Address at the American Society of Breast Surgeons 18th Annual Meeting

    Annals of Surgical Oncology

    Wenz F

    Jun. 2017

    A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter

    The American Journal of Surgery

    Abbott AM, Valente SA, Loftus L, Tendulkar RD, Greif JM, Bethke KP, Donnelly ED, Lottich C, Ross DL, Friedman NB, Bedi CG, Joh JE,
    Kelemen P, Hoefer RA, Kang SK, Ruffer J, Police A, Fyles A, Graves GM, Willey SC, Tousimis EA, Small W, Lyons J, Grobmyer S, Laronga C

    Mai 2017

    Hypofractionated, normofractionated and intraoperative breast irradiation: Long term cosmetic outcome based on photographic evaluation.

    Journal of Clinical Oncology

    Ellethy T, Welzel G, Sperk E, Neumaier C, Tuschy B, Berlit S, Ehmann M, Sütterlin M, Wenz FK, Abou Madian Y

    Mai 2017

    TARGIT E(lderly): Prospective phase II study of intraoperative radiotherapy (IORT) in elderly patients with small breast cancer–3 year local control and overall survival

    Journal of Clinical Oncology

    Wenz FK

    2017 Feb

    Early complications after intraoperative radiotherapy revisited

    Journal of Surgical Oncology

    Holmes DR

    2017 Jan

    Intraoperative radiotherapy (IORT) as boost in breast cancer

    Radiation Oncology

    Sedlmayer F, Reitsamer R, Wenz F, Sperk E, Fussl C, Kaiser J, Ziegler I, Zehentmayr F, Deutschmann H, Kopp P, Fastner G

    2016 Nov

    Targeted intraoperative radiotherapy tumour bed boost during breast-conserving surgery after neoadjuvant chemotherapy

    Strahlentherapie und Onkologie

    Kolberg HC, Loevey G, Akpolat‑Basci L, Stephanou M, Fasching PA, Untch M, Liedtke C, Bulsara M, Vaidya JS

    2016 Oct

    Reduced Mortality With Partial-Breast Irradiation for Early Breast Cancer: A Meta-Analysis of Randomized Trials

    International Journal of Radiation Oncology, Biology & Physics

    Vaidya JS, Bulsara M, Wenz F, Coombs N, Singer J, Ebbs S, Massarut S, Saunders C, Douek M, Williams NR, Joseph DJ, Tobias JS, Baum M

    2016 Sep

    Cosmesis and Breast-Related Quality of Life Outcomes After Intraoperative Radiation Therapy for Early Breast Cancer: A Substudy of the TARGIT-A Trial

    International Journal of Radiation Oncology, Biology & Physics

    Corica T, Nowak AK, Saunders CM, Bulsara M, Taylor M, Vaidya JS, Baum M, Joseph DJ

    2016 Jan

    Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the Breast

    The Breast Journal

    Rivera R, Banks A, Casillas‑Lopez A, Rashtian A, Lewinsky B, Sheth P, Hovannesian‑Larsen L, Brousseau D, Iyenger G, Holmes DR

    2015 Nov

    Late Toxicity and Cosmetic Outcome Following Intraoperative Radiation Therapy As a Boost or As Accelerated Partial-Breast Irradiation: A Monocenter Experience

    International Journal of Radiation Oncology, Biology & Physics

    Key S, Miglinieri P, Vourch S, Miranda O, Mahlaire JP, Dupré PF, Pradier O, Schick U

    2015 Nov

    Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the Breast

    The Breast Journal

    Rivera R, Banks A, Casillas-Lopez A, Rashtian A, Lewinsky B, Sheth P, Hovannesian-Larsen L, Brousseau D, Holmes DR

    2015 Sep

    Intraoperative Radiation Therapy (INTRABEAM) Experience at the Mastology Unit Leopoldo Aguerrevere Clinic

    Journal of Cancer Therapy

    Muñoz G, Hany R, Cosson A, Gonzalez C, Rasquií J, Rodriguez I, Ghaleb J, Gonzalez E, Benitez M, Hurtado W, Sanchez N, Figuera C

    2015 Jul

    Pride, Prejudice, or Science: Attitudes Towards the Results of the TARGIT-A Trial of Targeted Intraoperative Radiation Therapy for Breast Cancer

    International Journal of Radiation Oncology, Biology & Physics

    Vaidya JS, Bulsara M, Wenz F, Joseph D, Saunders C, Massarut S, Flyger HL, Eiermann W, Alvarado M, Esserman L, Falzon M, Brew-Graves C, Potyka I, Tobias JS, Baum M

    2015 June

    Targeted intraoperative radiotherapy in elderly patients (TARGIT-E) with early breast cancer; First safety analysis after 80 treated patients

    Strahlentherapie und Onkologie

    Neumaier C, Welzel G, Keller A, Abou Madian Y, Sperk E, Gerhardt A, Sütterlin M, Wenz F

    2015 May

    Cosmetic outcome after breast conserving surgery and either external beam or intraoperative radiotherapy for early breast cancer: Objective assessment of patients from a randomized controlled trial in Lublin, Poland.

    Journal of Clinical Oncology

    Williams NR, Kurylcio A, Jankiewicz M, Romanek J, Polkowski W, Michalopoulos N, Keshtgar MR

    2015 May

    Short term toxicity of intra-operative radiotherapy for patients with breast cancer treated at a single center

    Cancer Research

    Shai A, Zur M, Leviov M, Bitterman M, Eitan S, Steiner M

    2015 Apr

    Low-kilovoltage single dose intraoperative radiation therapy for breast cancer

    Radiotherapy and Oncology

    Flores‑Balcazar C, Santiago‑Concha G, Sánchez‑Castro R, Rosales‑Pérez S, Bargalló‑Rocha E, Rivera‑Corona J

    2015 Apr

    Whole breast radiotherapy does not affect growth of cancer foci in other quadrants: results from the TARGIT A trial

    Radiotherapy and Oncology

    Vaidya J, Bulsara M, Wenz F, Tobias JS, Joseph DJ, Massarut S, Flyger H, Eiermann W, Saunders C, Alvarado M, Brew‑Graves C, Potyka I, Williams MR, Baum M

    2015 Feb

    Intraoperative Radiotherapy of the Breast for Early-Stage Breast Cancer: Ready for Primetime

    The Breast Journal

    Holmes DR

    2014 Dec

    Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences

    International Journal of Breast Cancer

    Malter W, Kirn V, Richters L, Fridrich C, Markiefka B, Bongartz R, Semrau R, Mallmann P, Kraemer S

    2014 Jul

    A cohort analysis to identify eligible patients for intraoperative radiotherapy (IORT) of early breast cancer

    Radiation Oncology

    Sperk E, Astor D, Keller A, Welzel G, Gerhardt A, Tuschy B, Sütterlin M, Wenz F

    2014 May

    Cosmetic outcome within one year of breast-conserving surgery, after external beam or intraoperative radiotherapy for early breast cancer: Objective assessment of patients from a randomized controlled trial.

    Journal of Clinical Oncology

    Williams NR, Wenz F, Welzel G, Michalopoulos N, Keshtgar MR

    2014 Feb

    Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial

    The Lancet

    Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M, Flyger HL, Massarut S, Alvarado M, Saunders C, Eiermann W, Metaxas M, Sperk E, Sütterlin M, Brown D, Esserman L, Roncadin M, Thompson A, Dewar JA, Holtveg HMR, Pigorsch S, Falzon M, Harris E, Matthews A, Brew-Graves C, Potyka I, Corica T, Williams NR, Baum M

    2013 Jun

    Cost-Effectiveness Analysis of Intraoperative Radiation Therapy for Early-Stage Breast Cancer

    Annals of Surgical Oncology

    Alvarado MD, Mohan AJ, Esserman LJ, Park CC, Harrison BL, Howe RJ, Thorsen C, Ozanne EM

    2012 Jul

    Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT A

    Breast Cancer Research and Treatment

    Sperk E, Welzel G, Keller A, Kraus-Tiefenbacher U, Gerhardt A, Sütterlin M, Wenz F

    2012 May

    TARGIT-E(lderly)–Prospective phase II study of intraoperative radiotherapy (IORT) in elderly patients with small breast cancer

    BMC Cancer

    Neumaier C, Sperk E, Welzel G, Xasser A, Kraus‑Tiefenbacher U, Keller A, Gerhardt A, Sütterlin M,
    Wenz F

    2011 May

    Targeted Intraoperative Radiotherapy for Breast Cancer in Patients in Whom External Beam Radiation Is Not Possible

    International Journal of Radiation Oncology, Biology & Physics

    Keshtgar MRS, Vaidya JS, Tobias JS, Wenz F, Joseph D, Stacey C, Metaxas MG, Keller A, Corica T, Williams NR, Baum M

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    2022 Oct

    A safety study of intraoperative radiation therapy following stereotactic body radiation therapy and multi-agent chemotherapy in the treatment of localized pancreatic adenocarcinoma: study protocol of a phase I trial

    Radiation Oncology

    Reddy AV, Hill CS, Zheng L, He J, Narang AK

    2022 May

    Intraoperative Radiotherapy for Resectable Pancreatic Cancer Using a Low-Energy X-Ray Source: Postoperative Complications and Early Outcomes

    Yonsei Med Journal

    Cho Y, Kim JW, Kim HS, Park JS, Lee IJ

    2021 Dec
    Dosimetric Comparison of Intraoperative Radiotherapy and SRS for Liver Metastases
    Frontiers in Oncology
    Scafa D, Muedder T, Holz JA, Koch D, Nour Y, Garbe S, Gonzalez-Carmona MA, Feldmann G, Vilz TO, Köksal M, Giordano FA, Schmeel LC, Sarria GR

    2021 Oct 

    Intraoperative radiation therapy induces immune repsonse activity after pancreatic surgery

    BMC Cancer

    Lee YS, Kim HS, Cho Y, Lee IJ, Kim HJ, Lee DE, Kang HW, Park JS

    2021 Apr
    The role of intraoperative radiotherapy in advanced rectal cancer: a meta- analysis
    Colorectal Disease
    Fahy MR, Kelly ME, Foley MP, Nugent TS, Shields CJ, Winter DC
    2020 Aug
    INTRABEAM intraoperative radiotherapy combined with portal vein infusion chemotherapy for treating hepatocelular carcinoma with portal vein tumor thrombus
    BMC Surgery
    Song X, He Y, Liang H, Han M, Shao Z
    2020 Jun
    Low-kilovolt x-ray intraoperative radiotherapy for pT3 locally advanced colon cancer: a single-institution retrospective analysis
    World Journal of Surgical Oncology
    Ma L, Qiang J, Yin H, Lin L, Jiao Y, Ma C, Li X, Dong L, Cui J, Wei D, Sharma AM, Schwartz DL, Gu W, Chen H
    2020 Apr
    Intraoperative Strahlentherapie in der Abdominalchirurgie- eigene Erfahrungen
    Der Chirurg
    Joechle K, Gkika E, Grosu AL, Hopt UT, Neeff HP, Fichtner-Feigl S, Lang SA
    2020 Feb
    Short-term outcomes of laparoscopic intersphincteric resection with intraoperative radiotherapy using low-energy X-rays for primary locally advanced low rectal cancer: a single center experience
    World Journal of Surgical Oncology
    Xue W, Wang S, Zhao Z, Li Y, Shang A, Li D, Yang J, Wang T, Wang M
    2020 Jan
    Intraoperative radiotherapy as an immediate adjuvant treatment of rectal cancer due to limited access to external-beam radiotherapy
    Radiation Oncology
    Potemin S, Kübler J, Uvarov I, Wenz F, Giordano F
    2019 Mar
    A phase II study of intraoperative radiotherapy using a low-energy x-ray source for resectable pancreatic cancer: a study protocol
    BMC Surgery
    Kim JW, Cho Y, Kim HS, Choi WH, Park JS, Lee IJ
    2016 May
    The Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal Cancer
    Radiation Oncology
    Susko M, Lee J, Salama J, Thomas S, Uronis H, Hsu D, Migaly J, Willett C, Czito B, Palta M
    2016 Mar
    Intraoperative radiotherapy with low energy photons in recurrent colorectal cancer: a single centre retrospective study
    Volltext
    Contemporary Oncology
    Skórzewska M, Mielko J, Kurylcio A, Romanek J, Polkowski WP
    2015 Apr
    Intraoperative radiotherapy in locally-advanced and recurrent rectal cancer: retrospective review of 68 cases
    Translational Cancer Research
    Potemin S, Uvarov I, Vasilenko I
    2013 Nov
    Intraoperative Radiotherapy with Low-Energy Photons in Rectal Cancer Recurrence
    Targeted Intraoperative Radiotherapy in Oncology (Book)
    Polkowski WP, Skórzewska M
    2012 Jul
    Intraoperative radiation therapy with the photon radiosurgery system in locally advanced and recurrent rectal cancer: retrospective review of the Cleveland clinic experience
    Radiation Oncology
    Guo S, Reddy CA, Kolar M, Woody N, Mahadevan A, Deibel F, Dietz DW, Remzi FH, Suh JH
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    2022 June

    Intraoperative radiation therapy for locally advanced and recurrent head and neck cancer

    Journal of Clinical Oncology

    Chiodo C, Gros S, Lee B, Block AM, Emami B, Small W, Abdelrhman TR

    2016 Dec
    Intraoperative radiation therapy (IORT) in head and neck cancer: A systematic review
    Medicine
    Kyrgias G, Hajiioannou J, Tolia M, Kouloulias V, Lachanas V, Skoulakis C, Skarlatos I, Rapidis A, Bizakis I
    2016 Apr
    Intra-operative radiation therapy (IORT) in recurrent head and neck cancer
    Oral Oncology
    De Felice F, Musio D, Tombolini V
    2015 Apr
    Intraoperative radiotherapy (IORT) in the treatment of head and neck cancer
    Translational Cancer Research
    Münter MW, Köppen U, Ramuscak A, Sittel C, Wegner N
    2013 Dec
    Current advances in radiotherapy of head and neck malignancies
    Journal of International Oral Health
    Roopashri G, Baig M
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    2022 Nov

    A case report on a novel use of intraoperative Intrabeam™ radiation therapy for a recurrent malignant peripheral nerve sheath tumor with sciatic nerve involvement

    Radiation Oncology

    Chaharbakhshi E, Hardham J, Siochi RA, Tenenholz TC, Lindsey BA

    2021 Oct 

    Electronic brachytherapy for treatment of non-melanoma skin cancers: clinical results and toxicities

    Journal of Contemporary Brachytherapy

    Goyal U, Cheung MK, Suszko J, Laughlin B, Kim Y, Askam J, Arif‑Tiwari H, Slane B, Gordon J, Stea B

    2019 Sep
    Intraoperative Radiotherapy with Low Energy x-Rays for Primary and Recurrent Soft-Tissue Sarcoma
    International Journal of Radiation Oncology, Biology & Physics

    Sarria GR, Petrova V, Abou Madian Y, Wenz F, Hohenberger P, Sperk E, Giordano FA

     

     

    2012 Dec
    Superficial x-ray in the treatment of basal and squamous cell carcinomas: A viable option in select patients
    Journal of the American Academy of Dermatology
    Cognetta AB, Howard BM, Heaton HP, Stoddard ER, Hong HG, Green WH
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    Radiation Therapy and Skin Cancer
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    Tward JD, Anker CJ, Gaffney DK, Bowen G
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    Use of Low-Energy X-Rays in the Treatment of Superficial Nonmelanomatous Skin Cancers
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Medizinische Physik, Translationale Forschung und Technologie

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    2023 Mar

    Dosimetric evaluation of an intraoperative radiotherapy system: a measurement-based and Monte-Carlo modelling investigation

    National Library of Medicine

    Chin M, Rowshanfarzad P, Neveri G, Ebert MA, Pfefferlé D

    2021 Dec
    Gold-nanoparticle-enriched breast tissue in breast cancer treatment using the INTRABEAM system: a Monte Carlo study
    Radiation and Environmental Biophysics
    Tegaw EM, Geraily G, Gholami S, Shojaei M, Tadesse GF
    2021 Nov
    Monte Carlo calculation of the TG-43 dosimetry parameters for the INTRABEAM source with spherical applicators
    Physics in Medicine & Biology
    Alvarez DSA, Watson P, Popovic M, Heng VJ, Evans M, Seuntjens J
    2021 Mar
    Patient-Specific Quality Assurance Using a 3D-Printed Chest Phantom for Intraoperative Radiotherapy in Breast Cancer
    Frontiers in Oncology
    Choi Y, Lee IJ, Park K, Park KR, Cho Y, Kim JW, Lee H
    2021 Feb
    A Comparison between Electron Gamma Shower, National Research Council/Easy Particle Propagation (EgSnrc/Epp) and Monte Carlo N-Particle Transport Code (MCNP) in Simulation of the INTRABEAM System with Spherical Applicators
    Journal of Biomedical Physics and Engineering
    Tegaw EM, Geraily GH, Etesami SM, Gholami S, Ghanbari H, Farzin M, Tadesse GF, Shojaei M
    2021 Jan
    Effective energy assessment during breast cancer intraoperative radiotherapy by low-energy X-rays: A Monte Carlo study
    Radiation and Environmental Biophysics
    Shamsabadi R, Baghani HR, Mowlavi AA, Azadegan B
    2020 Apr
    Dose-rate considerations for the INTRABEAM electronic brachytherapy system: Report from the American association of physicists in medicine task group no. 292
    Medical Physics
    Culberson WS, Davis SD, Gwe‐Ya Kim G, Lowenstein JR, Ouhib Z, Popovic M, Waldron TJ, Safigholi H, Simiele SJ, Rivard MJ
    2020 Feb
    Dosimetric evaluation of incorporating the revised V4.0 calibration protocol for breast intraoperative radiotherapy with the INTRABEAM system
    Journal of Applied Clinical Medical Physics
    Shaikh MY, Burmeister J, Scott R, Kumaraswamy LK, Nalichowski A, Joiner MC
    2018 Mar
    Intraoperative Radiotherapy With INTRABEAM: Technical and Dosimetric Considerations
    Frontiers in Oncology
    Sethi A, Emami B, Small W, Thomas TO
    2015 May
    Dosimetric characterization of INTRABEAM® miniature accelerator flat and surface applicators for dermatologic applications
    Medica Physica
    Goubert M, Parent L
    2014 Sep
    Radiation protection for an intraoperative X-ray source compared to C-arm fluoroscopy / Strahlenschutz einer Röntgenquelle zur intraoperativen Strahlentherapie im Vergleich mit C-Bogen-Durchleuchtung
    Zeitschrift für Medizinische Physik
    Schneider F, Clausen S, Jahnke A, Steil V, Bludau F, Sütterlin M, Obertacke U, Wenz F
    2014 Jan
    Radiation protection for an intra-operative X-ray devicer an intra-operative X-ray device
    The British Journal of Radiology
    Eaton DJ, Gonzalez R, Duck S, Keshtgar M
    2014 Jan
    A novel approach for superficial intraoperative radiotherapy (IORT) using a 50 kV X-ray source: a technical and case report
    Journal of Applied Clinical Medical Physics
    Schneider F, Clausen S, Thölking J, Wenz F, Abou Madian Y
    2012 Oct
    Quality assurance and independent dosimetry for an intraoperative x-ray device
    Medical Physics
    Eaton DJ
    2011 Nov
    Development of a Novel Method for Intraoperative Radiotherapy During Kyphoplasty for Spinal Metastases (Kypho-IORT)
    International Journal of Radiation Oncology, Biology & Physics
    Schneider F, Greineck F, Clausen S, Mai S, Obertacke U, Reis T, Wenz F
  • Jahr
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    2022 Jun

    The impact of intraoperative radiotherapy on breast cancer: focus on the levels of angiogenic factors

    World Journal of Surgical Oncology

    Nafissi N, Mohammadlou M, Akbari ME, Mahdavi SR, Sheikh M, Borji M, Babaee E, Baharlou R

    2021 Jan
    Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer
    Journal of Radiation Research
    Linares-Galiana I, Berenguer-Frances MA, Cañas-Cortés R, Pujol-Canadell M, Comas-Antón S, Martínez E, Laplana M, Pérez-Montero H, Pla-Farnós MJ, Navarro-Martin A, Nuñez M, Both B, Guedea F 
    2021 Apr
    Wound Fluid from Breast Cancer Patients Undergoing Intraoperative Radiotherapy Exhibits an Altered Cytokine Profile and Impairs Mesenchymal Stromal Cell Function
    Cancers (Basel)
    Wuhrer A, Uhlig S, Tuschy B, Berlit S, Sperk E, Bieback K, Sütterlin M
    2020 Aug
    Cardiac serum marker alterations after intraoperative radiotherapy with low-energy x-rays in early breast cancer as an indicator of possible cardiac toxicity
    Strahlentherapie und Onkologie
    Stefanovic S, Berlit S, Sperk E, Wenz F, Weiß C, Trinkmann F, Sütterlin M, Tuschy B
    2020 Feb
    Intraoperative radiotherapy for breast cancer treatment efficiently targets the tumor bed preventing breast adipose stromal cell outgrowth
    Strahlentherapie und Onkologie
    Uhlig S, Wuhrer A, Berlit S, Tuschy B, Sütterlin M, Bieback K
    2020 Feb
    Surgical Wound Fluids from Patients with Breast Cancer Reveal Similarities in the Biological Response Induced by Intraoperative Radiation Therapy and the Radiation-Induced Bystander Effect—Transcriptomic Approach
    International Journal of Molecular Sciences
    Kulcenty K, Piotrowski I, Rucinski M, Wroblewska JP, Jopek K, Murawa D, Suchorska WM
    2017 Jan
    Biology of high single doses of IORT: RBE, 5 R's, and other biological aspects
    Radiation Oncology
    Herskind C, Ma L, Liu Q, Zhang B, Schneider F, Veldwijk MR, Wenz F
    2015 Apr
    Tissue inhomogeneity corrections in low-kV intra-operative radiotherapy (IORT)
    Translational Cancer Research
    Sethi A, Chinsky B, Gros S, Diak A
    2015 Apr
    Beyond the linear quadratic model: intraoperative radiotherapy and normal tissue tolerance
    Translational Cancer Research
    Emami B, Woloschak G, Small W
    2014 Feb
    Radiobiological aspects of intraoperative tumour-bed irradiation with low-energy X-rays (LEX-IORT)
    Translational Cancer Research
    Herskind C, Wenz F
    2014 Feb
    Cell and molecular response to IORT treatment
    International Journal of Radiation Oncology, Biology & Physics
    Minafra L, Bravatà V
    2014 Feb
    Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects
    Translational Cancer Research
    Sologuren I, Rodríguez-Gallego C, Lara PC
    2013 Sep
    Mitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell line
    Journal of Neuro-Oncology
    Wang M, Maier P, Wenz F, Giordano FA, Herskind C
    2013 Mar
    Mitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell line
    International Journal of Radiation Oncology, Biology & Physics
    Liu Q, Schneider F, Ma L, Wenz F, Herskind C
    2008 Dec
    Sphere of Equivalence - A Novel Target Volume Concept for Intraoperative Radiotherapy Using Low-Energy X Rays
    International Journal of Radiation Oncology, Biology & Physics
    Herskind C, Griebel J, Kraus-Tiefenbacher U, Wenz F
    2008 Mar
    Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding
    Clinical Cancer Research
    Belletti B, Vaidya JS, D'Andrea S, Entschladen F, Roncadin M, Lovat F, Berton S, Perin T, Candiani E, Reccanello S, Veronesi A, Canzonieri V, Trovò MG, Zaenker KS, Colombatti A, Baldassarre G, Massarut S
  • Jahr
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    2015 Apr
    Electronic brachytherapy—current status and future directions
    The British Journal of Radiology
    Eaton DJ

Lebensqualität und kosmetische Ergebnisse

  • Jahr
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    2019 Jan
    Patient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignment
    European Journal of Cancer Care
    Corica T, Saunders CM, Bulsara MK, Taylor M, Joseph DJ, Nowak AK

    Dez. 2018

    A Prospective Analysis of Quality of Life and Toxicity Outcomes in Treating Early Breast Cancer With Breast Conservation Therapy and Intraoperative Radiation Therapy

    Frontiers in Oncology

    Sosin M, Gupta SS, Wang JS, Costellic CD, Gulla A, Bartholomew AJ, O'Neill SC, Hechenbleikner EM, Collins BT, Rudra S, Collins SP, Chaldekas KM, Seevaratnam S, Langan RC, Willey SC, Tousimis EA

    2017 Jul
    Intraoperative radiotherapy: Patient selection, management, and follow-up
    Journal of Surgical Oncology
    Holmes DR, Zimmerman R
    2016 Sep
    Cosmesis and Breast-Related Quality of Life Outcomes After Intraoperative Radiation Therapy for Early Breast Cancer: A Substudy of the TARGIT-A Trial
    International Journal of Radiation Oncology, Biology & Physics
    Corica T, Nowak AK, Saunders CM, Bulsara M, Taylor M, Vaidya JS, Baum M, Joseph DJ
    2016 May
    Environmental and social benefits of the targeted intraoperative radiotherapy for breast cancer: data from UK TARGIT-A trial centres and two UK NHS hospitals offering TARGIT IORT
    The BMJ
    Coombs NJ, Coombs JM, Vaidya UJ, Singer J, Bulsara M, Tobias JS, Wenz F, Joseph DJ, Brown DA, Rainsbury R, Davidson T, Adamson DJA, Massarut S, Morgan D, Potyka I, Corica T, Falzon M, Williams N, Baum M, Vaidya JS
    2014 Feb
    Comparison of mammographic findings after intraoperative radiotherapy or external beam whole breast radiotherapy
    European Journal of Surgical Oncology
    Elsberger B, Romsauerova A, Vinnicombe S, Whelehan P, Brown DC, Dewar JA, Thompson AM, Evans A
    2013 Nov
    Patient preferences regarding intraoperative versus external beam radiotherapy following breast-conserving surgery
    Breast Cancer Research and Treatment
    Alvarado MD, Conolly J, Park C, Sakata T, Mohan AJ, Harrison BL, Hayes M, Esserman LJ, Ozanne EM
    2013 Mar
    Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer
    The New England Journal of Medicine
    Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, Correa C, Cutter D, Gagliardi G, Gigante B, Jensen M-B, Nisbet A, Peto R, Rahimi K, Taylor C, Hall P
    2013 Jan
    Radiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from the randomized phase III trial TARGIT-A
    Radiation Oncology
    Welzel G, Boch A, Sperk E, Hofmann F, Kraus-Tiefenbacher U, Gerhardt A, Wenz F
    2012 Feb
    Persistent pain after targeted intraoperative radiotherapy (TARGIT) or external breast radiotherapy for breast cancer: A randomized trial
    The Breast
    Andersen KG, Gärtner R, Kroman N, Flyger H, Kehlet H
  • Jahr
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    2023 Jul

    Longitudinal cosmetic outcome after planned IORT boost with low kV X-rays-monocentric results from the TARGIT BQR registry

    National Library of Medicine

    Goerdt L, Poemsl J, Spaich S, Welzel G, Abo-Madyan Y, Ehmann M, Berlit S, Tuschy B, Sütterlin M, Wenz F, Sperk E

    2021 Nov

    Surgical and Oncologic Outcomes With Intraoperative Radiation Therapy for Early Breast Cancer

    The American Surgeon

    Friedman-Eldar O, Layton C, De Castro Silva I, Moller MG, Allen A, Franceschi D, Isrow D, Samuels S, Takita C, Avisar E

    2021 Jun

    Hypofractionated whole breast irradiation after IORT treatment is safe in patients receiving adjuvant chemotherpy

    Clinical and Translational Oncology

    Burgos-Burgos J, Vega V, Macias-Verde D, Gómez V, Travieso-Aja M, Travieso J, Vicente E, Murias C, Santana C, Ospina J, Lara PC

    2018 Apr
    Cosmetic outcome as rated by patients, doctors, nurses and BCCT.core software assessed over 5 years in a subset of patients in the TARGIT-A Trial
    Radiation Oncology
    Corica T, Nowak AK, Saunders CM, Bulsara MK, Taylor M, Williams NR, Keshtgar M, Joseph DJ, Vaidya JS
    2017 Dec
    Aesthetic outcome after breast conserving surgery and either intraoperative radiotherapy or whole breast external beam radiotherapy for early breast cancer: objective assessment of patients in a randomized controlled trial in Lublin, Poland
    European Journal of Gynaecological Oncology
    Williams N, Kurylcio A, Jankiewicz M, Romanek J, Polkowski W, Michalopoulos N, Keshtgar M
    2014 Feb
    Oncoplastic breast reconstruction after IORT
    Translational Cancer Research
    Malter W, Kirn V, Mallmann P, Kraemer S
    2013 Jul
    Objective assessment of cosmetic outcome after targeted intraoperative radiotherapy in breast cancer: results from a randomised controlled trial
    Breast Cancer Research and Treatment
    Keshtgar MRS, Williams NR, Bulsara M, Saunders C, Flyger H, Cardoso JS, Corica T, Bentzon N, Michalopoulos NV, Joseph DJ

Leitlinien, Empfehlungen und HTAs

  • Jahr
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    2023 Nov

    Partial Breast Irradiation for Patients With Early-Stage Invasive Breast Cancer or Ductal Carcinoma In Situ: An ASTRO Clinical Practice Guideline

    Practical Radiation Oncology

    ASTRO

    2023 Apr

    Diagnosis and Treatment of Patients with early and advanced Breast Cancer – Adjuvant Radiotherapy

    AGO

    AGO

    2021 Oct

    Traitements locorégionaux des cancers du sein infiltrants non métastatiques – Synthèse

    INCa

    INCa

    2021 Sep
    Intraoperative Radiation Therapy (IORT)
    AETNA
    AETNA
    2020
    NCCN Guidelines
    NCCN
    NCCN
    2020
    Leitlinienprogramm Onkologie: S3-Leitlinie Früherkennung, Diagnose, Therapie und Nachsorge des Mammakarzinoms
    Leitlinienprogramm Onkologie
    Leitlinienprogramm Onkologie
    2019 Aug
    Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    Annals of Oncology
    Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S, Senkus E
    2018 Jun
    Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline
    Practical Radiation Oncology
    Smith BD, Bellon JR, Blitzblau R, Freedman G, Haffty B, Hahn C, Halberg F, Hoffman K, Horst K, Moran J, Patton C, Perlmutter J, Warren L, Whelan T, Wright JL, Jagsi R
    2018 Jan
    Intrabeam radiotherapy system for adjuvant treatment of early breast cancer Technology appraisal guidance [TA501]
    NICE
    NICE
    2016 Jan
    ESTRO-ACROP guideline “target delineation of glioblastomas”
    Radiotherapy and Oncology
    Niyazi M, Brada M, Chalmers AJ, Combs SE, Erridge SC, Fiorentino A, Grosu AL, Lagerwaard FJ, Minniti G, Mirimanoff R-O, Ricardi U, Short SC, Weber DC, Belka C
    2012 Sep
    Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline
    Practical Radiation Oncology
    Tsao MN, Rades D, Wirth A, Lo SS, Danielson BL, Gaspar LE, Sperduto PW, Vogelbaum MA, Radawski JD, Wang JZ, Gillin MT, Mohideen N, Hahn CA, Chang EL
  • Jahr
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    2023 Jul

    First Spanish consensus on the use of intraoperative radiotherapy in breast cancer. Conclusions of the expert panel

    Revista de Senología y Patología Mamaria

    SESPM – SEOR

    2010 Mar
    Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: Recommendations of the Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group based on clinical evidence (2009)
    Radiotherapy and Oncology
    Polgár C, Van Limbergen E, Pötter R, Kovács G, Polo A, Lyczek J, Hildebrandt G, Niehoff P, Guinot JL, Guedea F, Johansson B, Ott OJ, Major T, Strnad V
  • Jahr
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    Zeitschrift
    Verfasser
    2016 Sep
    An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial)
    Health Technology Assessment 
    Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Saunders C, Brew-Graves C, Potyka I, Morris S, Vaidya HJ, Williams NR, Baum M
    2015 Sep
    The INTRABEAM® Photon Radiotherapy System for the adjuvant treatment of early breast cancer: a systematic review and economic evaluation
    Health Technology Assessment 
    Picot J, Copley V, Colquitt JL, Kalita N, Hartwell D, Bryant J

Sonstiges

  • Titelzeile für Spalte
    Titelzeile für Spalte
    Jahr
    Titel
    Linktext
    Zeitschrift
    Verfasser

    2021 Jan

    Single-Fraction Adjuvant Electronic Brachytherapy after Resection of Conjunctival Carcinoma

    Cancers (Basel)

    Sarria GR, Serpa S, Buitrago M, Fuentes Rivera P, Ramirez D, Giordano FA, Sarria GJ

    2020 Sep
    Adjuvant electronic brachytherapy for endometrical carcinoma: A 4-year outcomes report
    Brachytherapy
    Sarria GR, Sperk E, Wenz F, Schneider F, Abou Madian Y, Giordano FA, Ehmann M
    2020 Jul
    Safety and efficacy of INTRABEAM intraoperative radiotherapy for invasive thymoma
    Medicine
    Cui T, Dai J, Li J, Qian J, Li G, Sun J

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