Mikroskopieanwendungen für die Reproduktionsmedizin
Mikroskoplösungen für die Bewertung der Embryonenqualität
Kriterien für Embryonen „hoher Qualität“
Nach der Fertilisation der Eizelle wird das embryonale Wachstum bis zur Implantation des Embryos überwacht. Embryologen haben morphologische Kriterien entwickelt, die eine gute oder schlechte Prognose für den sich entwickelnden Embryo ermöglichen. Jedes Entwicklungsstadium wird sorgfältig überprüft.
Die Kriterien für Embryonen „hoher Qualität“ umfassen:
Anzahl der Zellen – Blastomere und Embryo am 3. Tag
Regelmäßigkeit der Zellen
Fragmentierung/Bleb-Bildung
Mehrkernbildung
Vakuolen, Granularität und Dicke der äußeren Membran (Zona pellucida)
Anwendungsbeispiele
Mit freundlicher Genehmigung von Dr. L.-M. Criado Rodríguez, Abteilung Transgenese, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spanien
Nukleus mit sichtbaren Nukleoli in der rechten Zelle, iHMC
![Mikroskoplösungen für die Bewertung der Embryonenqualität]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_human-embryo_axio-observer_1.jpg/_jcr_content/renditions/original.image_file.100.100.271,0,1300,1029.file/plasdic_human-embryo_axio-observer_1.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_human-embryo_axio-observer_1.jpg/_jcr_content/renditions/original.image_file.360.360.271,0,1300,1029.file/plasdic_human-embryo_axio-observer_1.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_human-embryo_axio-observer_1.jpg/_jcr_content/renditions/original.image_file.768.768.271,0,1300,1029.file/plasdic_human-embryo_axio-observer_1.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_human-embryo_axio-observer_1.jpg/_jcr_content/renditions/original.image_file.1024.1024.271,0,1300,1029.file/plasdic_human-embryo_axio-observer_1.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_human-embryo_axio-observer_1.jpg/_jcr_content/renditions/original.image_file.1029.1029.271,0,1300,1029.file/plasdic_human-embryo_axio-observer_1.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_human-embryo_axio-observer_1.jpg/_jcr_content/renditions/original.image_file.1029.1029.271,0,1300,1029.file/plasdic_human-embryo_axio-observer_1.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_human-embryo_axio-observer_1.jpg/_jcr_content/renditions/original.image_file.1029.1029.271,0,1300,1029.file/plasdic_human-embryo_axio-observer_1.jpg"} "Mikroskoplösungen für die Bewertung der Embryonenqualität")
![Embryos einer transgenen Maus, DIC; mit freundlicher Genehmigung von Dr. L.-M. Criado Rodríguez, Abteilung Transgenese, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spanien]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_mouseembryo_micromanipulation_2.jpg/_jcr_content/renditions/original.image_file.100.75.4,0,1388,1038.file/plasdic_mouseembryo_micromanipulation_2.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_mouseembryo_micromanipulation_2.jpg/_jcr_content/renditions/original.image_file.360.270.4,0,1388,1038.file/plasdic_mouseembryo_micromanipulation_2.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_mouseembryo_micromanipulation_2.jpg/_jcr_content/renditions/original.image_file.768.576.4,0,1388,1038.file/plasdic_mouseembryo_micromanipulation_2.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_mouseembryo_micromanipulation_2.jpg/_jcr_content/renditions/original.image_file.1024.768.4,0,1388,1038.file/plasdic_mouseembryo_micromanipulation_2.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_mouseembryo_micromanipulation_2.jpg/_jcr_content/renditions/original.image_file.1280.960.4,0,1388,1038.file/plasdic_mouseembryo_micromanipulation_2.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_mouseembryo_micromanipulation_2.jpg/_jcr_content/renditions/original.image_file.1384.1038.4,0,1388,1038.file/plasdic_mouseembryo_micromanipulation_2.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/plasdic_mouseembryo_micromanipulation_2.jpg/_jcr_content/renditions/original.image_file.1384.1038.4,0,1388,1038.file/plasdic_mouseembryo_micromanipulation_2.jpg"} "Embryos einer transgenen Maus, DIC; mit freundlicher Genehmigung von Dr. L.-M. Criado Rodríguez, Abteilung Transgenese, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spanien")
![Embryo: Nukleus mit sichtbaren Nukleoli in der rechten Zelle, iHMC]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/ihmc_embryo_axio-vert.jpg/_jcr_content/renditions/original.image_file.100.75.13,0,1908,1421.file/ihmc_embryo_axio-vert.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/ihmc_embryo_axio-vert.jpg/_jcr_content/renditions/original.image_file.360.270.13,0,1908,1421.file/ihmc_embryo_axio-vert.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/ihmc_embryo_axio-vert.jpg/_jcr_content/renditions/original.image_file.768.576.13,0,1908,1421.file/ihmc_embryo_axio-vert.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/ihmc_embryo_axio-vert.jpg/_jcr_content/renditions/original.image_file.1024.768.13,0,1908,1421.file/ihmc_embryo_axio-vert.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/ihmc_embryo_axio-vert.jpg/_jcr_content/renditions/original.image_file.1280.960.13,0,1908,1421.file/ihmc_embryo_axio-vert.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/ihmc_embryo_axio-vert.jpg/_jcr_content/renditions/original.image_file.1440.1080.13,0,1908,1421.file/ihmc_embryo_axio-vert.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/reproductive-medicine/ihmc_embryo_axio-vert.jpg/_jcr_content/renditions/original.image_file.1895.1421.13,0,1908,1421.file/ihmc_embryo_axio-vert.jpg"} "Embryo: Nukleus mit sichtbaren Nukleoli in der rechten Zelle, iHMC")
![ZEISS Axio Observer für biowissenschaftliche Forschung]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axio-observer-l/axio-observer-ls_product.jpg/_jcr_content/renditions/original.image_file.100.100.420,0,1500,1080.file/axio-observer-ls_product.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axio-observer-l/axio-observer-ls_product.jpg/_jcr_content/renditions/original.image_file.360.360.420,0,1500,1080.file/axio-observer-ls_product.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axio-observer-l/axio-observer-ls_product.jpg/_jcr_content/renditions/original.image_file.768.768.420,0,1500,1080.file/axio-observer-ls_product.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axio-observer-l/axio-observer-ls_product.jpg/_jcr_content/renditions/original.image_file.1024.1024.420,0,1500,1080.file/axio-observer-ls_product.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axio-observer-l/axio-observer-ls_product.jpg/_jcr_content/renditions/original.image_file.1080.1080.420,0,1500,1080.file/axio-observer-ls_product.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axio-observer-l/axio-observer-ls_product.jpg/_jcr_content/renditions/original.image_file.1080.1080.420,0,1500,1080.file/axio-observer-ls_product.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axio-observer-l/axio-observer-ls_product.jpg/_jcr_content/renditions/original.image_file.1080.1080.420,0,1500,1080.file/axio-observer-ls_product.jpg"} "ZEISS Axio Observer für biowissenschaftliche Forschung")
![ZEISS Axiovert 5 für die Biologie]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axiovert-5-bio/axiovert-5_product_side.jpg/_jcr_content/renditions/original.image_file.100.100.371,0,1432,1061.file/axiovert-5_product_side.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axiovert-5-bio/axiovert-5_product_side.jpg/_jcr_content/renditions/original.image_file.360.360.371,0,1432,1061.file/axiovert-5_product_side.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axiovert-5-bio/axiovert-5_product_side.jpg/_jcr_content/renditions/original.image_file.768.768.371,0,1432,1061.file/axiovert-5_product_side.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axiovert-5-bio/axiovert-5_product_side.jpg/_jcr_content/renditions/original.image_file.1024.1024.371,0,1432,1061.file/axiovert-5_product_side.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axiovert-5-bio/axiovert-5_product_side.jpg/_jcr_content/renditions/original.image_file.1061.1061.371,0,1432,1061.file/axiovert-5_product_side.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axiovert-5-bio/axiovert-5_product_side.jpg/_jcr_content/renditions/original.image_file.1061.1061.371,0,1432,1061.file/axiovert-5_product_side.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/widefield/axiovert-5-bio/axiovert-5_product_side.jpg/_jcr_content/renditions/original.image_file.1061.1061.371,0,1432,1061.file/axiovert-5_product_side.jpg"} "ZEISS Axiovert 5 für die Biologie")
![ZEISS SteREO Discovery.V12]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v12%E2%80%8B/stereo-discovery-v12-product.jpg/_jcr_content/renditions/original.image_file.100.100.420,0,1500,1080.file/stereo-discovery-v12-product.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v12%E2%80%8B/stereo-discovery-v12-product.jpg/_jcr_content/renditions/original.image_file.360.360.420,0,1500,1080.file/stereo-discovery-v12-product.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v12%E2%80%8B/stereo-discovery-v12-product.jpg/_jcr_content/renditions/original.image_file.768.768.420,0,1500,1080.file/stereo-discovery-v12-product.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v12%E2%80%8B/stereo-discovery-v12-product.jpg/_jcr_content/renditions/original.image_file.1024.1024.420,0,1500,1080.file/stereo-discovery-v12-product.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v12%E2%80%8B/stereo-discovery-v12-product.jpg/_jcr_content/renditions/original.image_file.1080.1080.420,0,1500,1080.file/stereo-discovery-v12-product.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v12%E2%80%8B/stereo-discovery-v12-product.jpg/_jcr_content/renditions/original.image_file.1080.1080.420,0,1500,1080.file/stereo-discovery-v12-product.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v12%E2%80%8B/stereo-discovery-v12-product.jpg/_jcr_content/renditions/original.image_file.1080.1080.420,0,1500,1080.file/stereo-discovery-v12-product.jpg"} "ZEISS SteREO Discovery.V12")
![ZEISS SteREO Discovery.V20]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v20/stereo-discovery_v20_product.jpg/_jcr_content/renditions/original.image_file.100.100.file/stereo-discovery_v20_product.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v20/stereo-discovery_v20_product.jpg/_jcr_content/renditions/original.image_file.360.360.file/stereo-discovery_v20_product.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v20/stereo-discovery_v20_product.jpg/_jcr_content/renditions/original.image_file.768.768.file/stereo-discovery_v20_product.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v20/stereo-discovery_v20_product.jpg/_jcr_content/renditions/original.image_file.1024.1024.file/stereo-discovery_v20_product.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v20/stereo-discovery_v20_product.jpg/_jcr_content/renditions/original.image_file.1280.1280.file/stereo-discovery_v20_product.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v20/stereo-discovery_v20_product.jpg/_jcr_content/renditions/original.image_file.1440.1440.file/stereo-discovery_v20_product.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v20/stereo-discovery_v20_product.jpg/_jcr_content/renditions/original./stereo-discovery_v20_product.jpg"} "ZEISS SteREO Discovery.V20")
![ZEISS SteREO Discovery.V8]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v8/stereo-discoveryv8-stage.jpg/_jcr_content/renditions/original.image_file.100.100.420,0,1500,1080.file/stereo-discoveryv8-stage.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v8/stereo-discoveryv8-stage.jpg/_jcr_content/renditions/original.image_file.360.360.420,0,1500,1080.file/stereo-discoveryv8-stage.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v8/stereo-discoveryv8-stage.jpg/_jcr_content/renditions/original.image_file.768.768.420,0,1500,1080.file/stereo-discoveryv8-stage.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v8/stereo-discoveryv8-stage.jpg/_jcr_content/renditions/original.image_file.1024.1024.420,0,1500,1080.file/stereo-discoveryv8-stage.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v8/stereo-discoveryv8-stage.jpg/_jcr_content/renditions/original.image_file.1080.1080.420,0,1500,1080.file/stereo-discoveryv8-stage.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v8/stereo-discoveryv8-stage.jpg/_jcr_content/renditions/original.image_file.1080.1080.420,0,1500,1080.file/stereo-discoveryv8-stage.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stereo-discovery-v8/stereo-discoveryv8-stage.jpg/_jcr_content/renditions/original.image_file.1080.1080.420,0,1500,1080.file/stereo-discoveryv8-stage.jpg"} "ZEISS SteREO Discovery.V8")
![8:1-Zoom und apochromatische Optik für alle Laborarbeiten und die industrielle Inspektion.]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stemi508/stemi-508-stage-axiocam208-color.jpg/_jcr_content/renditions/original.image_file.100.100.302,81,1604,1383.file/stemi-508-stage-axiocam208-color.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stemi508/stemi-508-stage-axiocam208-color.jpg/_jcr_content/renditions/original.image_file.360.360.302,81,1604,1383.file/stemi-508-stage-axiocam208-color.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stemi508/stemi-508-stage-axiocam208-color.jpg/_jcr_content/renditions/original.image_file.768.768.302,81,1604,1383.file/stemi-508-stage-axiocam208-color.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stemi508/stemi-508-stage-axiocam208-color.jpg/_jcr_content/renditions/original.image_file.1024.1024.302,81,1604,1383.file/stemi-508-stage-axiocam208-color.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stemi508/stemi-508-stage-axiocam208-color.jpg/_jcr_content/renditions/original.image_file.1280.1280.302,81,1604,1383.file/stemi-508-stage-axiocam208-color.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stemi508/stemi-508-stage-axiocam208-color.jpg/_jcr_content/renditions/original.image_file.1302.1302.302,81,1604,1383.file/stemi-508-stage-axiocam208-color.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/products/light/stereo-zoom/stemi508/stemi-508-stage-axiocam208-color.jpg/_jcr_content/renditions/original.image_file.1302.1302.302,81,1604,1383.file/stemi-508-stage-axiocam208-color.jpg"} "ZEISS Stemi 508")