Usted se encuentra en nuestro sitio web internacional en español. Este sitio contiene todo nuestro catálogo de productos a nivel mundial. Es posible que algunos de los productos presentados no estén disponibles en México. Si usted es residente de México, por favor, visite el sitio web de su país para obtener más información y los contactos locales.
Usted se encuentra en nuestro sitio web internacional en español. Este sitio contiene todo nuestro catálogo de productos a nivel mundial. Es posible que algunos de los productos presentados no estén disponibles en México. Si usted es residente de México, por favor, visite el sitio web de su país para obtener más información y los contactos locales.
Tecnologías de fluorescencia intraoperatoria de ZEISS
Descubrir lo nunca visto
La fluorescencia es la propiedad de los átomos y moléculas, llamados fluoróforos, de absorber la luz a una longitud de onda particular y de emitir posteriormente luz de una longitud de onda más larga. La microscopía de fluorescencia se puede basar en la autofluorescencia o en la adición de tinciones fluorescentes1,2. En condiciones de luz normal, las tinciones fluorescentes pueden ser invisibles. Pero un microscopio quirúrgico con tecnología de fluorescencia integrada ilumina el tinte para visualizar tejido tumoral o vasos sanguíneos durante la cirugía.
El primer uso de la captura de imágenes por fluorescencia intraoperatoria en una cirugía se remonta a 1948, cuando los cirujanos empleaban la fluoresceína intravenosa para realzar las neoplasias intracraneales durante una neurocirugía.2,9 Desde entonces, se han utilizado otros agentes fluorescentes para diversas aplicaciones quirúrgicas.4,5,6,9 La captura de imágenes por fluorescencia intraoperatoria ofrece las ventajas de un alto contraste y sensibilidad, ausencia de radiación ionizante, facilidad de uso, seguridad y alta especificidad.7,8,9 En comparación con la visión estándar sin medios auxiliares mediante la captura de imágenes por luz blanca, la captura de imágenes por fluorescencia en tiempo real es útil para visualizar el tejido canceroso y delinear los márgenes tumorales.8 Asimismo, una visualización mejorada del cáncer puede reducir el daño a estructuras normales importantes, como nervios, vasos sanguíneos, uréteres y conductos biliares.9
En el complejo ámbito de la microcirugía, los complementos de visualización quirúrgica son fundamentales para tomar las decisiones correctas en el momento adecuado. Las tecnologías de fluorescencia intraoperatoria1 de ZEISS le ofrecen las herramientas que necesita.
Visualización intraoperatoria de estructuras teñidas con fluorescencia en la cirugía de tumores
Visualización intraoperatoria de estructuras teñidas con fluorescencia en la cirugía de tumores
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BLUE 400 de ZEISS
BLUE 400 de ZEISS ayuda en la diferenciación intraoperatoria entre tejido enfermo y sano. Fue el único módulo de fluorescencia completamente integrado en un microscopio que demostró su eficacia en la fase III realizada con éxito de un estudio multicéntrico2.
Según un estudio de 2015 de Esteves et al., los gliomas de alto grado (grados III–IV) son los tumores cerebrales más comunes en Europa, con una incidencia de 3,13 por cada 100 000 habitantes. El alcance de la resección tumoral es un importante factor pronóstico de la supervivencia3. Los estudios demuestran que es necesaria una resección de al menos el 98 % del tejido tumoral para que la tasa de supervivencia sea significativa. Un ensayo controlado aleatorizado (RCT) de Stummer et al. en 2006 demostró que la probabilidad de una resección completa del tumor aumentaba significativamente al usar fluorescencia 5-ALA (ácido 5-aminolevulínico) (65 % frente a 37 %, p<0,0001)2.
Nosotros [...] publicamos un estudio económico médico [...] para demostrar que [mediante] el uso de BLUE 400, podemos mejorar el desenlace de los pacientes [...].
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Extirpación de glioblastoma de alto grado guiada por fluorescencia
Prof. Dr. Andreas Raabe
Director y Jefe del Departamento de neurocirugía, Inselspital Bern, Suiza
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ZEISS YELLOW 560
ZEISS YELLOW 560 es el primer módulo de fluorescencia intraoperatoria1 que destaca las estructuras teñidas con fluorescencia mientras se ve el tejido no teñido a color natural. Permite realizar actividades de investigación con tinciones de fluorescencia adecuadas1.
La ventaja es que el tumor se extirpa mejor, ya que el cerebro no afectado se visualiza de forma indirecta y se puede preservar.
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Extirpación de glioblastoma guiada por fluorescencia
Prof. Dr. Karl-Michael Schebesch y Dr. Julius Höhne
Clínica y Policlínica de neurocirugía, Hospital universitario de Regensburg, Alemania
Constantinos G Hadjipanayis,
Jeffrey N Bruce,
John YK Lee
1
Utilice el contraste de fluorescencia conforme al estado de aprobación de la aplicación en su país.
2
Stummer W, Pichlmeier U, Meinel T et al: Fluorescence-guided surgery for resection of malignant glioma: a randomized controlled multicentre phase III trial. En: Lancet Oncol 7: 392-401, 2006.
3
Esteves S, Alves M, Castel-Branco M, Stummer W: A Pilot Cost-Effectiveness Analysis of Treatments in Newly Diagnosed High-Grade Gliomas: The Example of 5-Aminoelvulinic Acid Compared With White-Light Surgery. En: Neurosurgery 76: 552–562, 2015.
4
Acerb Fi, Cavallo C, Schebesch KM, et al.: Fluorescein-Guided Resection of Intramedullary Spinal Cord Tumors: Results from a Preliminary, Multicentric, Retrospective Study. En: World Neurosurgery 108: 603-609, 2017.
5
Rey-Dios R, Cohen-Gadol AA: Technical principles and neurosurgical applications of fluorescein fluorescence using a microscope-integrated fluorescence module. En: Acta Neurochirurgica 155(4):701–706, 2013.
6
De Laurentis C, Höhne J, Cavallo C, et al.: The impact of fluorescein-guided technique in the surgical removal of CNS tumors in a pediatric population: results from a multicentric observational study. En: Journal of Neurosurgical Sciences 63(6): 679-687, 2019.
7
Acerbi F, Broggi M, Schebesch KM, et al. Fluorescein-guided surgery for resection of high-grade gliomas: A multicentric prospective phase II study (FLUOGLIO). En: Clinical Cancer Research 24(1): 52-61, 2018.
8
Schebesch KM, Proescholdt M, Höhne J, et al.: Sodium fluorescein-guided rescetion under the YELLOW 560 nm surgical microscope filter in malignant brain tumor surgery – a feasibility study. En: Acta Neurochirurgica 157(6): 899–904, 2015.
9
Höhne J, Hohenberger C, Proescholdt M, et al. Fluorescein sodium-guided resection of cerebral metastases-an update. En: Acta Neurochirurgica 159: 363-367, 2017.
10
Raabe A, Beck J, Gerlach R, Zimmermann M, Seifert V: Near-Infrared Indocyanine Green Video Angiography: A New Method For Intraoperative Assessment Of Vascular Flow. En: Neurosurgery 52(1):132-139, 2003.
11
Raabe A, Beck J, Seifert V: Technique and image quality of intraoperative indocyanine green angiography during aneurysm surgery using surgical microscope integrated near-infrared video technology. En: Zentralbl Neurochir 66(1):1–6, 2005.
12
Kamp MA, Slotty P, Turowski B, Etminan N, Steiger HJ, Hänggi D, Stummer W: Microscope-integrated quantitative analysis of intraoperative indocyanine green fluorescence angiography for blood flow assessment: first experience in 30 patients. En: Operative Neurosurgery 70(1 Suppl Operative): 65-73, 2012.
13
Mücke T, Reeps C, Wolff KD, et al.: Objective qualitative and quantitative assessment of blood flow with near-infrared angiography in microvascular anastomoses in the rat model. En: Microsurgery 33(4):287-96, 2013.
14
Ye X, Liu XJ, Ma L, et al.: Clinical values of intraoperative indocyanine green fluorescence video angiography with Flow 800 software in cerebrovascular surgery. En: Chinese Medical Journal 126(22): 4232-4237, 2013.
15
Holling M, Brokinkel B, Ewelt C, et al.: Dynamic ICG fluorescence provides better intraoperative understanding of arteriovenous fistulae. En: Operative Neurosurgery 73(Issue suool_1): 93-99, 2013.
16
Ng YP, King NK, Wan KR, et al.: Uses and limitations of indocyanine green videoangiography for flow analysis in arteriovenous malformation surgery. En: Journal of Clinical Neuroscience 20(2): 224-232, 2013.
17
Holzbach T, Artunian N, Spanholtz TA, et al.: Intraoperative Indocyaningrün-Fluoreszenzdiagnostik mittels Operationsmikroskop in der plastischen Chirurgie. En: Handchirurgie, Plastische Chirurgie, Ästhetische Chirurgie 44(2):84-8, 2012.
18
Mücke T, Fichter AM, Schmidt LH, et al.: Indocyanine green videoangiography-assisted prediction of flap necrosis in the rat epigastric flap using FLOW® 800 Tool. En: Microsurgery 37:235–242, 2017.
19
Mücke T, Wolff C, Fichter AM, et al.: Detection of thrombosis in microvessels with8 indocyanine green videoangiography. En: British Journal of Oral and Maxillofacial Surgery 56(8): 678-683, 2018.
20
Yamato T, Yamamoto N, Numahata T, et al.: Navigation Lymphatic Supermicrosurgery for the Treatment of Cancer-Related Peripheral Lymphedema. En: Vascular and Endovascular Surgery 48(2):139-143, 2014.
21
Höhne J, Schebesch KM, de Laurentis C, Akçakaya MO, Pedersen CB, Brawanski A, Poulsen FR, Kiris T, Cavallo C, Broggi M, Ferroli P, Acerbi F Fluorescein Sodium in the Surgical Treatment of Recurrent Glioblastoma Multiforme. World Neurosurg. 2019 May;125:E158-E164. Epub 2019 Jan 22.
22
Imagen: craneotomía temporal izquierda para resección tumoral utilizando YELLOW 560. Imagen por cortesía del Dr. Peter Nakaji, Barrow Neurological Institute, Phoenix, Arizona, EE. UU.
Imágenes intraoperatorias del flujo sanguíneo cerebral en la cirugía vascular
Imágenes intraoperatorias del flujo sanguíneo cerebral en la cirugía vascular
ZEISS INFRARED 800
ZEISS INFRARED 800 le permite visualizar los vasos sanguíneos submilimétricos. Las imágenes intraoperatorias del flujo sanguíneo cerebral son de especial interés en neurocirugía vascular. La angiografía asistida por fluorescencia con verde de indocianina (ICG) permite la evaluación cualitativa en tiempo real de la permeabilidad vascular o de estructuras vasculares patológicas durante la cirugía. Ya en 2003, los resultados de un estudio de viabilidad realizado por Raabe et al. revelaron que la angiografía por fluorescencia con ICG es útil en la evaluación de aneurismas, fístulas en la duramadre y en la cirugía de revascularización.10 Integrada en el microscopio quirúrgico, la angiografía con ICG es una técnica adecuada para la visualización y para asistir en la evaluación e interpretación del flujo sanguíneo intraoperatorio en vasos con un diámetro inferior a 1 mm. Ayuda en la detección temprana de complicaciones y en la reducción del riesgo de daño isquémico y la necesidad de otra intervención posoperatoria11.
INFRARED 800 ha cambiado la práctica de neurocirugía vascular en el quirófano. Nos ha permitido responder realmente a las preguntas críticas tras un clipaje o un bypass [...]. Ha facilitado nuestras operaciones, acortado nuestras intervenciones y casi ha eliminado la necesidad de angiografía intraoperatoria.
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ZEISS FLOW 800
Mediante el uso de secuencias de vídeo de ZEISS INFRARED 800, ZEISS FLOW 800 ofrece una aplicación de fluorescencia única para el análisis visual del flujo sanguíneo vascular. La información de las secuencias de vídeo se compila en mapas visuales, diagramas o imágenes en paralelo. Esto permite un análisis detallado de los vídeos de fluorescencia.
A menudo una captura de imágenes simple de las estructuras vasculares resulta insuficiente para la detección de hipoperfusión o hiperfusión; para ello, hace falta un análisis cuantitativo de los datos.12 Los resultados del estudio han revelado que el software de análisis FLOW 800 proporciona información adicional valiosa para los cirujanos en la evaluación intraoperatoria de la permeabilidad arterial y el flujo sanguíneo regional.13-16
FLOW 800 es una importante herramienta de análisis de visualización en cirugía de MAV, ya que nos ayuda a entender rápidamente la hemodinámica detrás de una MAV. Trabajo con FLOW 800 desde hace ya varios años [...] y para mí se ha vuelto imprescindible.
Maximice el uso de sus productos gracias a MyZEISS
Acceda a contenido de aprendizaje exclusivo, contenido de otros profesionales, material para los pacientes y herramientas para gestionar sus tareas cotidianas.
1
Utilice el contraste de fluorescencia conforme al estado de aprobación de la aplicación en su país.
2
Stummer W, Pichlmeier U, Meinel T et al: Fluorescence-guided surgery for resection of malignant glioma: a randomized controlled multicentre phase III trial. En: Lancet Oncol 7: 392-401, 2006.
3
Esteves S, Alves M, Castel-Branco M, Stummer W: A Pilot Cost-Effectiveness Analysis of Treatments in Newly Diagnosed High-Grade Gliomas: The Example of 5-Aminoelvulinic Acid Compared With White-Light Surgery. En: Neurosurgery 76: 552–562, 2015.
4
Acerb Fi, Cavallo C, Schebesch KM, et al.: Fluorescein-Guided Resection of Intramedullary Spinal Cord Tumors: Results from a Preliminary, Multicentric, Retrospective Study. En: World Neurosurgery 108: 603-609, 2017.
5
Rey-Dios R, Cohen-Gadol AA: Technical principles and neurosurgical applications of fluorescein fluorescence using a microscope-integrated fluorescence module. En: Acta Neurochirurgica 155(4):701–706, 2013.
6
De Laurentis C, Höhne J, Cavallo C, et al.: The impact of fluorescein-guided technique in the surgical removal of CNS tumors in a pediatric population: results from a multicentric observational study. En: Journal of Neurosurgical Sciences 63(6): 679-687, 2019.
7
Acerbi F, Broggi M, Schebesch KM, et al. Fluorescein-guided surgery for resection of high-grade gliomas: A multicentric prospective phase II study (FLUOGLIO). En: Clinical Cancer Research 24(1): 52-61, 2018.
8
Schebesch KM, Proescholdt M, Höhne J, et al.: Sodium fluorescein-guided rescetion under the YELLOW 560 nm surgical microscope filter in malignant brain tumor surgery – a feasibility study. En: Acta Neurochirurgica 157(6): 899–904, 2015.
9
Höhne J, Hohenberger C, Proescholdt M, et al. Fluorescein sodium-guided resection of cerebral metastases-an update. En: Acta Neurochirurgica 159: 363-367, 2017.
10
Raabe A, Beck J, Gerlach R, Zimmermann M, Seifert V: Near-Infrared Indocyanine Green Video Angiography: A New Method For Intraoperative Assessment Of Vascular Flow. En: Neurosurgery 52(1):132-139, 2003.
11
Raabe A, Beck J, Seifert V: Technique and image quality of intraoperative indocyanine green angiography during aneurysm surgery using surgical microscope integrated near-infrared video technology. En: Zentralbl Neurochir 66(1):1–6, 2005.
12
Kamp MA, Slotty P, Turowski B, Etminan N, Steiger HJ, Hänggi D, Stummer W: Microscope-integrated quantitative analysis of intraoperative indocyanine green fluorescence angiography for blood flow assessment: first experience in 30 patients. En: Operative Neurosurgery 70(1 Suppl Operative): 65-73, 2012.
13
Mücke T, Reeps C, Wolff KD, et al.: Objective qualitative and quantitative assessment of blood flow with near-infrared angiography in microvascular anastomoses in the rat model. En: Microsurgery 33(4):287-96, 2013.
14
Ye X, Liu XJ, Ma L, et al.: Clinical values of intraoperative indocyanine green fluorescence video angiography with Flow 800 software in cerebrovascular surgery. En: Chinese Medical Journal 126(22): 4232-4237, 2013.
15
Holling M, Brokinkel B, Ewelt C, et al.: Dynamic ICG fluorescence provides better intraoperative understanding of arteriovenous fistulae. En: Operative Neurosurgery 73(Issue suool_1): 93-99, 2013.
16
Ng YP, King NK, Wan KR, et al.: Uses and limitations of indocyanine green videoangiography for flow analysis in arteriovenous malformation surgery. En: Journal of Clinical Neuroscience 20(2): 224-232, 2013.
17
Holzbach T, Artunian N, Spanholtz TA, et al.: Intraoperative Indocyaningrün-Fluoreszenzdiagnostik mittels Operationsmikroskop in der plastischen Chirurgie. En: Handchirurgie, Plastische Chirurgie, Ästhetische Chirurgie 44(2):84-8, 2012.
18
Mücke T, Fichter AM, Schmidt LH, et al.: Indocyanine green videoangiography-assisted prediction of flap necrosis in the rat epigastric flap using FLOW® 800 Tool. En: Microsurgery 37:235–242, 2017.
19
Mücke T, Wolff C, Fichter AM, et al.: Detection of thrombosis in microvessels with8 indocyanine green videoangiography. En: British Journal of Oral and Maxillofacial Surgery 56(8): 678-683, 2018.
20
Yamato T, Yamamoto N, Numahata T, et al.: Navigation Lymphatic Supermicrosurgery for the Treatment of Cancer-Related Peripheral Lymphedema. En: Vascular and Endovascular Surgery 48(2):139-143, 2014.
21
Höhne J, Schebesch KM, de Laurentis C, Akçakaya MO, Pedersen CB, Brawanski A, Poulsen FR, Kiris T, Cavallo C, Broggi M, Ferroli P, Acerbi F Fluorescein Sodium in the Surgical Treatment of Recurrent Glioblastoma Multiforme. World Neurosurg. 2019 May;125:E158-E164. Epub 2019 Jan 22.
22
Imagen: craneotomía temporal izquierda para resección tumoral utilizando YELLOW 560. Imagen por cortesía del Dr. Peter Nakaji, Barrow Neurological Institute, Phoenix, Arizona, EE. UU.
Imágenes de fluorescencia intraoperatoria en cirugía reconstructiva
Imágenes de fluorescencia intraoperatoria en cirugía reconstructiva
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Vídeo de ejemplo que muestra el uso de INFRARED 800 al examinar anastomosis linfovenosas. Cortesía de PD Dr. Christian Taeger, médico líder y sénior del Departamento de cirugía plástica, reconstructiva y de manos, Hospital universitario de Regensburg, Alemania.
ZEISS INFRARED 800
INFRARED 800 de ZEISS normalmente se emplea en cirugía de flap libre y permite la evaluación asistida por fluorescencia del flujo sanguíneo tras haber creado una anastomosis y visualiza la permeabilidad vascular del tejido injertado.
Un estudio de 2012 de Holzbach et al.17 demostró que la angiografía por fluorescencia con ICG es un procedimiento útil, ágil y seguro en la cirugía de flap, sobre todo en el uso intraoperatorio. Los hallazgos de Mücke et al. demuestran que FLOW 800 es una herramienta de análisis fiable para la monitorización de la perfusión intraoperatoria del flap18, además de para la detección de una trombosis intraoperatoria19. En un estudio de 2014 realizado por Yamamoto et al.20, se observó que la linfografía intraoperatoria con ICG facilita la identificación de los vasos linfáticos y permite una evaluación precisa de las anastomosis.
La integración de la tecnología de fluorescencia en el microscopio quirúrgico ofrece al cirujano más seguridad y certeza en las situaciones clínicamente ambiguas mientras se realiza el procedimiento. Las anomalías en el flujo sanguíneo se pueden detectar rápidamente y se pueden iniciar de inmediato las intervenciones quirúrgicas necesarias. El método puede predecir con más éxito la cicatrización sin complicaciones de la piel y de injertos tisulares y proporcionar indicaciones iniciales de trombosis.
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Cortesía del Prof. Dr. Milomir Ninkovic, Jefe del departamento de cirugía plástica y reconstructiva, Cirugía de manos y quemaduras, Clínica universitaria, Bogenhausen.
Vídeo de ejemplo que muestra el uso de INFRARED 800 al examinar el flujo sanguíneo tras la anastomosis.
Maximice el uso de sus productos gracias a MyZEISS
Acceda a contenido de aprendizaje exclusivo, contenido de otros profesionales, material para los pacientes y herramientas para gestionar sus tareas cotidianas.
Utilice el contraste de fluorescencia conforme al estado de aprobación de la aplicación en su país.
2
Stummer W, Pichlmeier U, Meinel T et al: Fluorescence-guided surgery for resection of malignant glioma: a randomized controlled multicentre phase III trial. En: Lancet Oncol 7: 392-401, 2006.
3
Esteves S, Alves M, Castel-Branco M, Stummer W: A Pilot Cost-Effectiveness Analysis of Treatments in Newly Diagnosed High-Grade Gliomas: The Example of 5-Aminoelvulinic Acid Compared With White-Light Surgery. En: Neurosurgery 76: 552–562, 2015.
4
Acerb Fi, Cavallo C, Schebesch KM, et al.: Fluorescein-Guided Resection of Intramedullary Spinal Cord Tumors: Results from a Preliminary, Multicentric, Retrospective Study. En: World Neurosurgery 108: 603-609, 2017.
5
Rey-Dios R, Cohen-Gadol AA: Technical principles and neurosurgical applications of fluorescein fluorescence using a microscope-integrated fluorescence module. En: Acta Neurochirurgica 155(4):701–706, 2013.
6
De Laurentis C, Höhne J, Cavallo C, et al.: The impact of fluorescein-guided technique in the surgical removal of CNS tumors in a pediatric population: results from a multicentric observational study. En: Journal of Neurosurgical Sciences 63(6): 679-687, 2019.
7
Acerbi F, Broggi M, Schebesch KM, et al. Fluorescein-guided surgery for resection of high-grade gliomas: A multicentric prospective phase II study (FLUOGLIO). En: Clinical Cancer Research 24(1): 52-61, 2018.
8
Schebesch KM, Proescholdt M, Höhne J, et al.: Sodium fluorescein-guided rescetion under the YELLOW 560 nm surgical microscope filter in malignant brain tumor surgery – a feasibility study. En: Acta Neurochirurgica 157(6): 899–904, 2015.
9
Höhne J, Hohenberger C, Proescholdt M, et al. Fluorescein sodium-guided resection of cerebral metastases-an update. En: Acta Neurochirurgica 159: 363-367, 2017.
10
Raabe A, Beck J, Gerlach R, Zimmermann M, Seifert V: Near-Infrared Indocyanine Green Video Angiography: A New Method For Intraoperative Assessment Of Vascular Flow. En: Neurosurgery 52(1):132-139, 2003.
11
Raabe A, Beck J, Seifert V: Technique and image quality of intraoperative indocyanine green angiography during aneurysm surgery using surgical microscope integrated near-infrared video technology. En: Zentralbl Neurochir 66(1):1–6, 2005.
12
Kamp MA, Slotty P, Turowski B, Etminan N, Steiger HJ, Hänggi D, Stummer W: Microscope-integrated quantitative analysis of intraoperative indocyanine green fluorescence angiography for blood flow assessment: first experience in 30 patients. En: Operative Neurosurgery 70(1 Suppl Operative): 65-73, 2012.
13
Mücke T, Reeps C, Wolff KD, et al.: Objective qualitative and quantitative assessment of blood flow with near-infrared angiography in microvascular anastomoses in the rat model. En: Microsurgery 33(4):287-96, 2013.
14
Ye X, Liu XJ, Ma L, et al.: Clinical values of intraoperative indocyanine green fluorescence video angiography with Flow 800 software in cerebrovascular surgery. En: Chinese Medical Journal 126(22): 4232-4237, 2013.
15
Holling M, Brokinkel B, Ewelt C, et al.: Dynamic ICG fluorescence provides better intraoperative understanding of arteriovenous fistulae. En: Operative Neurosurgery 73(Issue suool_1): 93-99, 2013.
16
Ng YP, King NK, Wan KR, et al.: Uses and limitations of indocyanine green videoangiography for flow analysis in arteriovenous malformation surgery. En: Journal of Clinical Neuroscience 20(2): 224-232, 2013.
17
Holzbach T, Artunian N, Spanholtz TA, et al.: Intraoperative Indocyaningrün-Fluoreszenzdiagnostik mittels Operationsmikroskop in der plastischen Chirurgie. En: Handchirurgie, Plastische Chirurgie, Ästhetische Chirurgie 44(2):84-8, 2012.
18
Mücke T, Fichter AM, Schmidt LH, et al.: Indocyanine green videoangiography-assisted prediction of flap necrosis in the rat epigastric flap using FLOW® 800 Tool. En: Microsurgery 37:235–242, 2017.
19
Mücke T, Wolff C, Fichter AM, et al.: Detection of thrombosis in microvessels with8 indocyanine green videoangiography. En: British Journal of Oral and Maxillofacial Surgery 56(8): 678-683, 2018.
20
Yamato T, Yamamoto N, Numahata T, et al.: Navigation Lymphatic Supermicrosurgery for the Treatment of Cancer-Related Peripheral Lymphedema. En: Vascular and Endovascular Surgery 48(2):139-143, 2014.
21
Höhne J, Schebesch KM, de Laurentis C, Akçakaya MO, Pedersen CB, Brawanski A, Poulsen FR, Kiris T, Cavallo C, Broggi M, Ferroli P, Acerbi F Fluorescein Sodium in the Surgical Treatment of Recurrent Glioblastoma Multiforme. World Neurosurg. 2019 May;125:E158-E164. Epub 2019 Jan 22.
22
Imagen: craneotomía temporal izquierda para resección tumoral utilizando YELLOW 560. Imagen por cortesía del Dr. Peter Nakaji, Barrow Neurological Institute, Phoenix, Arizona, EE. UU.
Póngase en contacto con nosotros.
Reciba más información acerca del producto y su disponibilidad en su país.
Utilice el contraste de fluorescencia conforme al estado de aprobación de la aplicación en su país.
2
Stummer W, Pichlmeier U, Meinel T et al: Fluorescence-guided surgery for resection of malignant glioma: a randomized controlled multicentre phase III trial. En: Lancet Oncol 7: 392-401, 2006.
3
Esteves S, Alves M, Castel-Branco M, Stummer W: A Pilot Cost-Effectiveness Analysis of Treatments in Newly Diagnosed High-Grade Gliomas: The Example of 5-Aminoelvulinic Acid Compared With White-Light Surgery. En: Neurosurgery 76: 552–562, 2015.
4
Acerb Fi, Cavallo C, Schebesch KM, et al.: Fluorescein-Guided Resection of Intramedullary Spinal Cord Tumors: Results from a Preliminary, Multicentric, Retrospective Study. En: World Neurosurgery 108: 603-609, 2017.
5
Rey-Dios R, Cohen-Gadol AA: Technical principles and neurosurgical applications of fluorescein fluorescence using a microscope-integrated fluorescence module. En: Acta Neurochirurgica 155(4):701–706, 2013.
6
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Imagen: craneotomía temporal izquierda para resección tumoral utilizando YELLOW 560. Imagen por cortesía del Dr. Peter Nakaji, Barrow Neurological Institute, Phoenix, Arizona, EE. UU.
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