In this recorded panel discussion, Jürgen Schlegel, MD, Jens Gempt, MD, and Mark C. Preul, MD exchange on the current role of confocal laser endomicroscopy in brain tumor surgery. Based on actual clinical experiences with this technology, the speakers cover topics such as  in vivo CLE and ex vivo CLE study results, confocal image acquisition, and the role of different benefits for the multidisciplinary collaboration.