Multicentric assessment of safety and efficacy of combinatorial adjuvant brain metastasis treatment by intraoperative radiotherapy and immunotherapy

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International Journal of Radiation Oncology, Biology & Physics

Layer JP, Shiban E, Brehmer S, Diehl CD, de Castro DG, Hamed M, Dejonckheere CS, Cifarelli DT, Friker LL, Herrlinger U, Hölzel M, Vatter H, Schneider M, Combs SE, Schmeel LC, Cifarelli CP, Giordano FA, Sarria GR, Kahl KH

Intraoperative radiotherapy in recurrent IDH-wildtype glioblastoma with gross total resection: A single-center retrospective study

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Clinical Neurology and Neurosurgery

Bao H, Ai S, Wang G, Yi L, Lai J, Wang S, Lv Z, Li C, Liu Q, Zhao X, Wu C, Liu C, Mi S, Sun X, Hao C, Liang P

Intraoperative or postoperative stereotactic radiotherapy for brain metastases: time to systemic treatment onset and other patient-relevant outcomes

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Journal of Neuro-Oncology

Dejonckheere CS, Layer JP, Hamed M, Layer K, Glasmacher A, Friker LL, Potthoff A, Zeyen T, Scafa D, Koch D, Garbe S, Holz JA, Kugel F, Grimmer M, Schmeel FC, Gielen GH, Forstbauer H, Vatter H, Herrlinger U, Giordano FA, Schneider M, Schmeel LC, Sarria GR

Intracranial intraoperative radiotherapy (IORT): evaluation of electrocorticography and peri-operative seizure risk

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Journal of Neuro-Oncology

Cifarelli CP, Vargo JA, Sener U, Cifarelli DT, Scoville D, Dabir A

Opportunities and Alternatives of Modern Radiation Oncology and Surgery for the Management of Resectable Brain Metastases

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Cancers

Diehl CD, Giordano FA, Grosu AL, Ille S, Kahl KH, Onken J, Rieken S, Sarria GR, Shiban E, Wagner A, Beck J, Brehmer S, Ganslandt O, Hamed M, Meyer B, Münter M, Raabe A, Rohde V, Schaller K, Schilling D, Schneider M, Sperk E, Thomé C, Vajkoczy P, Vatter H, Combs SE

Outcome assessment of intraoperative radiotherapy for brain metastases: results of a prospective observational study with comparative matched-pair analysis

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Journal of Neuro-Oncology

Layer JP, Hamed M, Potthoff AL, Dejonckheere CS, Layer K, Sarria GR, Scafa D, Koch D, Köksal M, Kugel F, Grimmer M, Holz JA, Zeyen T, Friker LL, Borger V, Schmeel FC, Weller J, Hölzel M, Schäfer N, Garbe S, Forstbauer H, Giordano FA, Herrlinger U, Vatter H, Schneider M, Schmeel LC

Intraoperative radiotherapy for brain metastases: first-stage results of a single-arm, open-label, phase 2 trial

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National Library of Medicine

De Castro DG, Sanematsu Jr PI, Pellizzon ACA, Suzuki SH, Fogaroli RC, Dias Jr JES, Gondim GRM, Estrada DA, Silva MLG, Rassi MS, Chen MJ, Giacomelli R, Ramos H, Neto ES, Abrahão CH, Coelho TM, Yu LS, Tannous CQ, Calsavara VF, Giordano FA, Oliveira JG

Resection of supratentorial brain metastases with intraoperative radiotherapy. Is it safe? Analysis and experiences of a single center cohort

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Frontiers in Oncology

Krauss P, Steininger K, Motov S, Sommer B, Bonk MN, Cortes A, Wolfert C, Stueben G, Shiban E, Henning K

Low-Energy X-Ray Intraoperative Radiation Therapy (Lex-IORT) for Resected Brain Metastases: A Single-Institution Experience

Resumo

National Library of Medicine

Diehl CD, Pigorsch SU, Gempt J, Krieg SM, Reitz S, Waltenberger M, Barz M, Meyer HS, Wagner A, Wilkens J, Wiestler B, Zimmer C, Meyer B, Combs SE

Intraoperative radiotherapy during awake craniotomies: preliminary results of a single-center case series

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Neurosurgical Review

Steininger K, Kahl KH, Konietzko I, Wolfert C, Motov S, Krauß PE, Bröcheler T, Hadrawa M, Sommer B, Stüben G, Shiban E

Benchmarking Safety Indicators of Surgical Treatment of Brain Metastases Combined with Intraoperative Radiotherapy: Results of Prospective Observational Study with Comparative Matched-Pair Analysis

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Cancers (Basel)

Hamed M, Potthoff AL, Layer JP, Koch D, Borger V, Heimann M, Scafa D, Sarria GR, Holz JA, Schmeel FC, Radbruch A, Güresir E,
Schäfer N, Schuss P, Garbe S, Giordano FA, Herrlinger U, Vatter H, Schmeel LC, Schneider M

Intraoperative Radiotherapy in Brain Malignancies: Indications and Outcomes in Primary and Metastatic Brain Tumors

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Frontiers in Oncology

Cifarelli CP, Jacobson GM

Dosimetric Comparison of Upfront Boosting With Stereotactic Radiosurgery Versus Intraoperative Radiotherapy for Glioblastoma

Frontiers in Oncology

Sarria GR, Smalec Z, Muedder T, Holz JA, Scafa D, Koch D, Garbe S, Schneider M, Hamed M, Vatter H, Herrlinger U, Giordano FA, Schmeel LC

Intraoperative radiotherapy with low-energy x-rays after neurosurgical resection of brain metastases- an Augsburg University Medical Center experience

Strahlentherapie und Onkologie

Kahl KH, Balagiannis N, Höck M, Schill S, Roushan Z, Shiban E, Müller H, Grossert U, Konietzko I, Sommer B, Maurer CJ, Berlis A, Heidecke V, Janzen T, Stüben G

Dose homogeneity analysis of adjuvant radiation treatment in surgically resected brain metastases: Comparison of IORT, SRS and IMRT indices

Brachytherapy

Dahshan BA, Weir JS, Bice RP, Renz P, Cifarelli DT, Poplawski L, Hack J, Vargo JA, Cifarelli CP

Current approaches to the management of brain metastases

Clinical Oncology

Suh JH, Kotecha R, Chao ST, Ahluwalia MS, Sahgal A, Chang EL

Intraoperative radiotherapy (IORT) for surgically resected brain metastases: outcome analysis of an international cooperative study

Journal of Neuro-Oncology

Cifarelli CP, Brehmer S, Vargo JA, Hack JD, Kahl KH, Sarria-Vargas G, Giordano FA

Intraoperative Radiotherapy for Glioblastoma: An International Pooled Analysis

International Journal of Radiation Oncology, Biology & Physics

Sarria GR, Sperk E, Xiaodi H, Sarria G, Wenz F, Brehmer S, Fu B, Min S, Zhang H, Qin S, Qiu X, Abo-Madyan Y, Hänggi D, Martinez DA, Cabrera C, Giordano FA

Intraoperative radiotherapy (IORT) for surgically resected brain metastases: Local control and dosimetric analysis.

Journal of Global Oncology

Cifarelli CP, Vargo JA, Hack JD, Renz PB, Poplawski L, Jacobson GM, Kahl KH, Brehmer S, Sarria G, Giordano FA

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Treatment of Adults With Metastatic Brain Tumors: Executive Summary

Neurosurgery

Olson JJ, Kalkanis SN, Ryken TC

Feasibility of dose escalation using intraoperative radiotherapy following resection of large brain metastases compared to post-operative stereotactic radiosurgery

Journal of Neuro-Oncology

Vargo JA, Sparks KM, Singh R, Jacobson GM, Hack JD, Cifarelli CP

Combined stereotactic biopsy and stepping-source interstitial irradiation of glioblastoma multiforme

Journal of Neurosurgical Sciences

Brehmer S, Guthier CV, Clausen S, Schneider F, Schulte DM, Benker M, Bludau F, Glatting G, Marx A, Schmiedek P, Hesser J, Wenz F, Giordano FA

Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma (INTRAGO): An Open-Label, Dose-Escalation Phase I/II Trial

Neurosurgery

Giordano FA, Brehmer S, Mürle B, Welzel G, Sperk E, Keller A, Abo-Madyan Y, Scherzinger E, Clausen S, Schneider F, Herskind C, Glas M, Seiz-Rosenhagen M, Groden C, Hänggi D, Schmiedek P, Emami B, Souhami L, Petrecca K, Wenz F

Initial Results of a Phase 1/2 Trial on Intraoperative Radiation Therapy (IORT) in Newly Diagnosed Glioblastoma Multiforme (INTRAGO)

International Journal of Radiation Oncology, Biology & Physics

Giordano FA, Brehmer S, Muerle B, Welzel G, Sperk E, Schneider F, Clausen S, Schmiedek P, Groden C, Hänggi D, Abo-Madyan Y, Wenz F

Rationale for intraoperative radiotherapy in glioblastoma

Journal of Neurosurgical Sciences

Giordano FA, Wenz F, Petrecca K

Intraoperative radiotherapy to treat newly diagnosed solitary brain metastasis: initial experience and long-term outcomes

Journal of Neurosurgery

Weil RJ, Mavinkurve GG, Chao ST, Vogelbaum MA, Suh JH, Kolar M, Toms SA

INTRAOPERATIVE RADIOTHERAPY WITH INTRABEAM IN PRIMARY BRAIN TUMORS AFTER RESECTION: PRELIMINARY REPORTS OF 26 CASES

Neuro-Oncology

Han X, Fu B, Wu M, Zhang H, Li D, Zhang J, Sun D, Sun S

Intraoperative radiotherapy (IORT)—a resurrected option for treating glioblastoma?

Translational Cancer Research

Giordano FA, Abo-Madyan Y, Brehmer S, Herskind C, Sperk E, Schneider F, Clausen S, Welzel G, Schmiedek P, Wenz F

Phase I study of intraoperative radiotherapy with photon radiosurgery system in children with recurrent brain tumors: Preliminary report of first dose level (10 Gy)

International Journal of Radiation Oncology, Biology & Physics

Kalapurakal JA, Goldman S, Stellpflug W, Curran J, Sathiaseelan V, Marymont MH, Tomita T 

Intraoperative radiotherapy combined with spinal stabilization surgery-a novel treatment strategy for spinal metastases based on a first single-center experiences

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Journal of Neuro-Oncology

Krauss P, Wolfert CL, Sommer B, Stemmer B, Stueben G, Kahl KH, Shiban E

First Experience of Intra-Operative Radiation Therapy (IORT) during Kyphoplasty in Patients Diagnosed with Spinal Metastasis in Iran

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Austin Journal of Clinical Case Reports 

Seddighi AS, Nikouei A, Seddighi A, Akbari ME, Arjmand Y, Ommi D, Zali A, Hosseini M

Long-term outcome after combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) for vertebral tumors

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BioMed Central

Bludau F, Winter L, Welzel G, Obtertacke U, Schneider F, Wenz F, Ruder AM, Giordano FA

Combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful vertebral metastases - a randomized phase III study

BMC Cancer

Bludau F, Welzel G, Reis T, Abo-Madyan Y, Sperk E, Schneider F, Clausen S, Ruder AM, Obertacke U, Ghaly MM, Wenz F, Giordano FA

Phase I/II trial of combined kyphoplasty and intraoperative radiotherapy in spinal metastases

The Spine Journal

Bludau F, Welzel G, Reis T, Schneider F, Sperk E, Neumaier C, Ehmann M, Clausen S, Obertacke U, Wenz F, Giordano FA

Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases

Scientific Reports

Mohme M, Riethdorf S, Dreimann M, Werner S, Maire CL, Joosse SA, Bludau F, Mueller V, Neves RPL, Stoecklein NH, Lamszus K, Westphal M, Pantel K, Wikman H, Eicker SO

Kyphoplastie kombiniert mit intraoperativer Radiotherapie (Kypho-IORT)

Der Radiologe

Bludau F, Reis T, Schneider F, Clausen S, Wenz F, Obertacke U

Kypho-IORT: the first French treatment

Translational Cancer Research

Miglierini P, Dam-Hieu P, Key S

Kyphoplastie in Kombination mit intraoperativer Radiotherapie

Der Orthopäde

Kayser R, Ender SA, Asse E, Wilhelm E, Adler F, Schmidt R, Wenz F, Obertacke U, Bludau F

Kyphoplasty and intra-operative radiotherapy, combination of kyphoplasty and intra-operative radiation for spinal metastases: technical feasibility of a novel approach

International Orthopaedics

Schmidt R, Wenz F, Reis T, Janik K, Bludau F, Obertacke U

Acute and Long-Term Toxicity after Planned Intraoperative Boost and Whole Breast Irradiation in High-Risk Patients with Breast Cancer—Results from the Targeted Intraoperative Radiotherapy Boost Quality Registry (TARGIT BQR)

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Cancers

Goerdt L, Schnaubelt R, Kraus-Tiefenbacher U, Brück V, Bauer L, Dinges S, von der Assen A, Meye H, Kaiser C, Weiss C, Clausen S, Schneider F, Abo-Madyan Y, Fleckenstein K, Berlit S, Tuschy B, Sütterlin M, Wenz F, Sperk E

Intraoperative radiotherapy (IORT) of early breast cancer with low-energy x-rays in breast-conserving surgery: Prospective identification of pre- and intraoperative factors influencing the feasibility of IORT

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Strahlenther Onkol

Grimm A, Wollmann E, Sperk E, Weiß C, Sütterlin M, Berlit S, Tuschy B

Combined Ultrahypofractionated Whole-Breast Irradiation and IORT-Boost: A Safety and Feasibility Analysis

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Cancers (Basel)

Burgos-Burgos J, Vega V, Macias-Verde D, Gómez V, Vicente E, Murias C, Santana C, Lara PC

Case Report: Bilateral targeted intraoperative radiotherapy: a safe and effective alternative for synchronous bilateral breast cancer

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Frontiers in Oncology

Bhimani F, McEvoy M, Gupta A, Pastoriza J, Shihabi A, Basavatia A, Tomé WA, Fox J, Mehta K, Feldman S.

Experience with intraoperative radiation therapy in an urban cancer center

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Radiation Oncology

Andraos TY, Skalina KA, Feldman S, Mehta K, Tome WA, McEvoy MP, Gupta AM, Fox JL

Case Report: Intraoperative radiotherapy as the new standard of care for breast cancer patients with disabling health conditions or impairments

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Frontiers in Oncology

Omosule M, De Silva-Minor S, Coombs N

Breast Conserving Surgery in Combination With Targeted Intraoperative Radiotherapy Compared to Mastectomy for In-breast-tumor-recurrence

Resumo

National Library of Medicine

Kolberg HC, Niesing H, Vaidya JS, Akpolat-Basci L, Maguz A, Hoffmann O, Loevey G, Stephanou M, Kolberg-Liedtke C

A single-institution retrospective analysis of intraoperative radiation boost during breast-conservation treatment for breast cancer

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Journal of Cancer Research and Clinical Oncology

Hochhertz F, Hass P, Röllich B, Ochel HJ, Gawish A

The case for risk-stratified IORT for early breast cancer

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BRACHYTHERAPY An International Multidisciplinary Journal

Refaat T, Gros SE, Small Jr W

Intraoperative radiation therapy for early-stage breast cancer: a single-institution experience

Resumo

National Library of Medicine

Giap F, O'stehen L, Liu I, Spiguel LE, Shaw CM, Morris CG, Vega RBM, Lightsey J, Bradley JA, Mendenhall NP, Okuniedd P, Lockney NA

Global adoption of single-shot targeted intraoperative radiotherapy (TARGIT-IORT) for breast cancer—better for patients, better for healthcare systems

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Frontiers in Oncology

Vaidya JS, Vaidya UJ, Baum M, Bulsara MK, Joseph D, Tobias JS

Prognosis comparison between intraoperative radiotherapy and whole-breast external beam radiotherapy for T1–2 stage breast cancer without lymph node metastasis treated with breast-conserving surgery: A case–control study after propensity score matching

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Frontiers in Oncology

Chen Q, Qu L, He Y, Xu J, Deng Y, Zhou Q, Yi W

Risk-Stratified Intraoperative Radiation Therapy as a Definitive Adjuvant Radiation Therapy Modality for Women With Early Breast Cancer

Resumo

Scientific Reports

Small Jr W, Refaat T, Feldman SM, Holmes D

Accelerated Partial Breast Irradiation with Intraoperative Radiotherapy Is Effective in Luminal Breast Cancer Patients Aged 60 Years and Older

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Journal of Personalized Medicine

Falco M, Masojć B, Rolla M, Czekała A, Milchert-Leszczyńska M, Pietruszewska J

Case Report: Can Targeted Intraoperative Radiotherapy in Patients With Breast Cancer and Pacemakers be the New Standard of Care?

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Frontiers in Oncology

Bhimani F, Johnson K, Brodin NP, Tomé WA, Fox J, Mehta K, McEvoy M, Feldman S

Breast preservation after local recurrence of breast cancer: Comparison of length and quality of life (QoL) between breast conserving surgery with intraoperative radiotherapy (TARGIT-IORT) versus mastectomy.

Resumo

Journal of Clinical Oncology

Kolberg HC, Niesing H, Vaidya JS, Akpolat-Basci L, Maguz A, Hoffmann O, Loevey G

Targeted Intraoperative Radiotherapy (TARGIT-IORT) for Early-Stage Invasive Breast Cancer: A Single Institution Experience

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Frontiers in Oncology

Brown A, Buss EJ, Chin C, Liu G, Lee S, Rao R, Taback B, Wiechmann L, Horowitz D, Choi JC, Katz LM, Connolly EP

Long-Term Outcomes of an International Cooperative Study of Intraoperative Radiotherapy Upfront Boost With Low Energy X-Rays in Breast Cancer

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National Library of Medicine

Sarria GR, Ramos ML, Palacios A, Del Castillo R, Castro R, Calvo A, Cotrina JM, Heredia A, Galarreta JA, Fuentes-Rivera P, Avalos A, Martinez DA, Colqui K, Ziegler G, Schmeel LC, Pinillos LV, Wenz F, Giordano FA, Sarria GJ, Sperk E

Effectiveness and safety of intraoperative radiotherapy (IORT) with low-energy X-rays (INTRABEAM®) for accelerated partial breast irradiation (APBI)

Resumo

Clinical and Translational Oncology

Laplana M, García‑Marqueta M, Sánchez‑Fernández JJ, Martínez‑Pérez E, Pérez‑Montero H, Martínez‑Montesinos I, Eraso A, Saldaña P, Martín R, Martín MI, Pla MJ, García‑Tejedor A, Guedea F

Impact of targeted intraoperative (TARGIT-IORT) tumor bed boost during breast conserving surgery for early breast cancer on breast cancer associated and non-breast cancer associated mortality and morbidity

Resumo

American Association for Cancer Research

Kolberg HC, Gutberlet S, Vaidya JS, Krajewska M, Lövey G, Hoffmann O, Stephanou M, Kolberg-Liedtke C

Intraoperative radiation therapy for early stage breast cancer

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BMC Surgery

Zangouri V, Nasrollahi H, Taheri A, Akrami M, Arasteh P, Hamedi SH, Johari MG, Karimaghaee N, Ranjbar A, Karami MY, Tahmasebi S, Mosalaei A, Talei A

Intraoperative Radiotherapy for Breast Cancer in Elderly Women 

Resumo

Clinical Breast Cancer 

Guillerm SO, Bourstyn E, Itti R, Cahen-Doidy L, Quéro L, Labidi M, Marchand E, Lorphelin H, Giacchetti S, Cuvier C, Espié M, Teixeira L, Hennequin C

Single institute experience of intraoperative radiation therapy in early-stage breast cancer

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Medicine (Baltimore)

Chi MS, Ko HL, Chen CC, Hsu CH, Chen LK, Cheng FT

Intraoperative irradiation in breast cancer: preliminary results in 80 patients as partial breast irradiation or anticipated boost prior to hypo-fractionated whole breast irradiation

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Clinical and Translational Oncology

Li X, Sanz J, Argudo N, Vernet‑Tomas M, Rodríguez N, Torrent L, Fernández‑Velilla E, Pera O, Huang Y, Nicolau P, Jiménez M, Segura M, Algara M

Surgical and Oncologic Outcomes With Intraoperative Radiation Therapy for Early Breast Cancer

Resumo

The American Surgeon

Friedman-Eldar O , Layton C, De Castro Silva I, Moller MG, Allen A, Franceschi D, Isrow D, Samuels S, Takita C, Avisar E

TARGIT-IORT during lumpectomy for breast cancer- better for patients than other PBI approaches 

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International Journal of Radiation Oncology, Biology & Physics

Vaidya JS, Bulsara M, Sperk E, Massarut S, Douek M, Alvarado M, Pigorsch S, Holmes D, Bernstein M, Saunders C, Flyger H, Joseph D, Wenz F, Tobias JS, TARGIT-A investigators

Hypofractionated whole breast irradiation after IORT treatment is safe in patients receiving adjuvant chemotherapy

Resumo

Clinical and Translational Oncology

Burgos-Burgos J, Vega V, Macias-Verde D, Gómez V, Travieso-Aja M, Travieso J, Vicente E, Murias C, Santana C, Ospina J, Lara PC 

New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer

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British Journal of Cancer

Vaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Douek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams NR, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Corica T, Lundgren S, Holmes DR, Vinante L, Bozza F, Pazos M, Le Blanc-Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Joseph DJ, Tobias JS

Intraoperative radiotherapy booster as part of breast-conservation therpy for breast cancer: a single-institution retrospective analysis 

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Strahlentherapie und Onkologie

Stoian R, Erbes T, Zamboglou C, Scholber J, Galney M, Sachpazidis I, Haehl E, Spohn SK, Verma V, Krug D, Rühle A, Juhasz-Böss I, Grosu AL, Nicolay NH, Sprave T 

Comparison of IORT (Radical and Boost Dose) and EBRT in Terms of Disease-Free Survival and Overall Survival according Demographic, Pathologic, and Biological Factors in Patients with Breast Cancer 

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International Journal of Oncology 

Hashemi S, Javadi S, Akbari ME, Mirzaei H, Mahdavi SR

Patients Older 65 Years With Early Breast Cancer Prefer Intraoperative Radiation as a Locoregional Treatment Choice

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Annals of Surgical Oncology

Tang A, Cohan CM, Beattie G, Cureton EL, Svahn JD, Lyon LL, Kelly JF, Shim VC

Assessment of Thyroid Lobe Dose in Breast Cancer Intraoperative Radiotherapy 

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Journal of Biomedical Physics and Engineering 

Farkhani RR, Gholamhosseinian H, Anvari K, Forghani MN

Preoperative selection of patients with early-stage invasive breast cancer for intraoperative radiation therapy (IORT): A single-institution experience

Resumo

Cancer Research

Brown AM, Chin C, Connolly E, Rao R, Taback B, Wiechmann L

Intraoperative radiotherapy in early breast cancer: observational comparison with whole breast radiotherapy 

Resumo

Cirugía Espanola 

Guillén JRO, Almudi EH, Osorio GM, Carreras RI, Gómez JAF, Gómez IV, Mur CG, Franco MCC 

Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment

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British Journal of Cancer

Vaidya JS, Bulsara M, Baum M, Tobias JS on behalf of TARGIT-A trial authors

TARGIT-R (Retrospective): 5-Year Follow-Up Evaluation of Intraoperative Radiation Therapy (IORT) for Breast Cancer Performed in North America

Resumo

Annals of Surgical Oncology

Valente SA, Tendulkar RD, Cherian S, Shah C, Ross DL, Lottich SC, Laronga C, Broman KK, Donnelly ED, Bethke KP, Shaw C, Lockney NA, Pederson A, Rudolph R, Hasselle M, Kelemen P, Hermanto U, Ashikari A, Kang S, Hoefer RA, McCready D, Fyles A, Escallon J, Rohatgi N, Graves J, Graves G, Willey SC, Tousimis E, Riley L, Deb N, Tu C, Small Jr. W, Grobmyer SR

Intraoperative radiotherapy for breast cancer: powerful evidence to change practice

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Clinical Oncology 

Vaidya JS, Bulsara M, Baum M, Alvarado M, Bernstein M, Massarut S, Saunders C, Sperk E, Wenz F, Tobias JS, TARGIT-A investigators 

Results of intraoperative radiotherapy given as a boost after breast conserving-surgery

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Gland Surgery

Onthong K, Chakkabat C, Nantavithya C, Shotelersuk K, Denariyakoon S, Vongsaisuwon M, Chulakadabbav A, Chatamra K, Saksornchai K

Cardiac serum marker alterations after intraoperative radiotherapy with low-energy x-rays in early breast cancer as an indicator of possible cardiac toxicity

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Strahlentherapie und Onkologie

Stefanovic S, Berlit S, Sperk E, Wenz F, Weiß C, Trinkmann F, Sütterlin M, Tuschy B

Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial

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The BMJ

Vaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Douek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams NR, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Corica T, Lundgren S, Holmes DR, Vinante L, Bozza F, Pazos M, Le Blanc-Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Joseph DJ, Tobias JS, TARGIT-A trial authors

Breast-conserving surgery with intraoperative radiotherapy in recurrent breast cancer: the patient’s perspective

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Breast Cancer Research and Treatment

Elfgen C, Gürth U, Gruber G, Birrer S, Bjelic-Radisic V, Fleisch M, Tausch CJ 

Effect of Delayed Targeted Intraoperative Radiotherapy vs Whole-Breast Radiotherapy on Local Recurrence and Survival Long-term Results From the TARGIT-A Randomized Clinical Trial in Early Breast Cancer

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JAMA Oncology

Vaidya JS, Bulsara M, Saunders C, Flyger H, Tobias JS, Corica T, Massarut S, Wenz F, Pigorsch S, Alvarado M, Douek M, Eiermann W, Brew-Graves C, Williams N, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Lundgren S, Holmes D, Vinante L, Bozza F, Pazos M, Le Blanc-Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Baum M, Joseph D

The actual benefit of intraoperative radiation therapy using 50 kV x-rays in early breast cancer: A retrospective study of 676 patients

Resumo

The Breast Journal

Tallet A, Racadot S, Boher J.-M, Cohen M, Barrou J, Houvenaeghel G, Gutowski M, Delmond L, Lemanski C

Intraoperative partial irradiation for highly selected patients with breast cancer: Results of the INTRAOBS prospective study

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Cancer/Radiothérapie

Lemanski C, Bourgier C, Draghici R, Thezenas S, Morel A, Rouanet P, Colomboe PE, Mourregot A, Delmond L, Fenoglietto P, Ailleres N, Azriaa D, Gutowski M

Intraoperative radiation therapy for breast cancer—Immediate and 30-month oncological outcomes

Resumo

The Breast Journal

Melnik I, Yerushalmi R, Sobol Y, Magen A, Givon-Madhala O, Birinbaum Y, Fenig E, Sharon E

Outcomes of selective whole breast irradiation following lumpectomy with intraoperative radiation therapy for hormone receptor positive breast cancer

Resumo

American Journal of Surgeons

Broman K, Sun W, Zhou JM, Fridley B, Diaz R, Laronga C

First per Protocol Analysis of the Prospective Phase II Study of Intraoperative Radiotherapy (IORT) in Elderly Patients with Small Breast Cancer: Targit E(lderly)

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International Journal of Radiation Oncology, Biology & Physics

Sperk E

Targeted Intraoperative Radiotherapy During Breast-conserving Surgery for Breast Cancer in Patients After Implant Augmentation

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International Institute of Anticancer Research

Kolberg HC, Uhl V, Massarut S, Holmes D, Kolberg-Liedtke C, Kelly EW, Lövey G, Vaidya JS

Patient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignment

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European Journal of Cancer Care

Corica T, Saunders CM, Bulsara MK, Taylor M, Joseph DJ, Nowak AK 

A Prospective Analysis of Quality of Life and Toxicity Outcomes in Treating Early Breast Cancer With Breast Conservation Therapy and Intraoperative Radiation Therapy

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Frontiers in Oncology

Sosin M, Gupta SS, Wang JS, Costellic CD, Gulla A, Bartholomew AJ, O'Neill SC, Hechenbleikner EM, Collins BT, Rudra S, Collins SP, Chaldekas KM, Seevaratnam S, Langan RC, Willey SC, Tousimis EA

Breast conserving surgery with targeted intraoperative radiotherapy for the management of ductal carcinoma in situ

Resumo

Journal of Surgical Oncology

Banks A, Coronado G, Zimmerman R, Iyengar G, Holmes DR

A Single-Institution Experience in the Preoperative Selection of DCIS Patients for IORT using the ASTRO Consensus Guidelines

Texto completo

Advance Radiation Oncology

Chin C, Hirji S, Onishi M, Ha R, Taback B, Horowitz DP, Connolly EP

A phase II study investigating the acute toxicity of targeted intraoperative radiotherapy as tumor-bed boost plus whole breast irradiation after breast-conserving surgery in Korean patients

Resumo

Breast Cancer Research and Treatment

Ahn SG, Bae SJ, Lee HW, Yoon CI, Kim JW, Lee IJ, Jeong J

Skin dose assessment with treatment planning system (TPS) and skin reaction evaluation of early breast cancer patients treated via an intraoperative radiation therapy (IORT) device

Resumo

Cambridge University Press

Baziar O, Gholamhosseinian H, Forghani MN

Cosmetic outcome as rated by patients, doctors, nurses and BCCT.core software assessed over 5 years in a subset of patients in the TARGIT-A Trial

Texto completo

BMC Cancer

Corica T, Nowak AK, Saunders CM, Bulsara MK, Taylor M, Williams NR, Keshtgar M, Joseph DJ, Vaidya JS

Clinical analysis of early results of the implementation of intraoperative radiotherapy with the Intrabeam device during breast-conserving surgery of early breast cancer in a private hospital

Resumo

The Americal Society of Breast Surgeons

Papa M, Keller O, Tova Y

Targeted Intraoperative Radiotherapy Tumour Bed Boost During Breast Conserving Surgery after Neoadjuvant Chemotherapy in HER2 Positive and Triple Negative Breast Cancer

Resumo

Reviews on Recent Clinical Trials

Kolberg HC, Loevey G, Akpolat-Basci L, Stephanou M, Fasching PA, Untch M, Bulsara M, Vaidya JS, Liedtke C

Intraoperative Radiotherapy for Breast Cancer

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Frontiers in Oncology

Harris EER, Small W

Intraoperative Radiation for Breast Cancer with Intrabeam™: Factors Associated with Decreased Operative Times in Patients Having IORT for Breast Cancer

Texto completo

Frontiers in Oncology

Valente SA, Fanning A, Stewart RA, Grundfest S, Tendulkar RD, Cherian S, Shah C, Tu C, Yanda C, Radford D, Al-Hilli Z, Grobmyer SR

Long-Term Cosmetic Outcome after Hypofractionated, Normofractionated, and Intraoperative Breast Radiation Therapy: A Photographic Evaluation Study

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International Journal of Radiation Oncology, Biology & Physics

Ellethy T, Welzel G, Sperk E, Neumaier C, Ehmann M, Wenz F, Abo-Madyan Y

Targeted Intraoperative Radiotherapy Tumour Bed Boost during Breast-Conserving Surgery after Neoadjuvant Chemotherapy - a Subgroup Analysis of Hormone Receptor-Positive HER2-Negative Breast Cancer

Texto completo

KARGER/Breast Care

Kolberg HC, Loevey G, Akpolat-Basci L, Stephanou M, Fasching PA, Untch M, Hoffmann O, Bulsara M, Vaidya JS, Liedtke C

Keynote Address at the American Society of Breast Surgeons 18th Annual Meeting

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Annals of Surgical Oncology

Wenz F

A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter

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The American Journal of Surgery

Abbott AM, Valente SA, Loftus L, Tendulkar RD, Greif JM, Bethke KP, Donnelly ED, Lottich C, Ross DL, Friedman NB, Bedi CG, Joh JE,
Kelemen P, Hoefer RA, Kang SK, Ruffer J, Police A, Fyles A, Graves GM, Willey SC, Tousimis EA, Small W, Lyons J, Grobmyer S, Laronga C

Hypofractionated, normofractionated and intraoperative breast irradiation: Long term cosmetic outcome based on photographic evaluation.

Resumo

Journal of Clinical Oncology

Ellethy T, Welzel G, Sperk E, Neumaier C, Tuschy B, Berlit S, Ehmann M, Sütterlin M, Wenz FK, Abo-Madyan Y

TARGIT E(lderly): Prospective phase II study of intraoperative radiotherapy (IORT) in elderly patients with small breast cancer--3 year local control and overall survival

Resumo

Journal of Clinical Oncology

Wenz FK

Early complications after intraoperative radiotherapy revisited

Resumo

Journal of Surgical Oncology

Holmes DR

Intraoperative radiotherapy (IORT) as boost in breast cancer

Texto completo

Radiation Oncology

Sedlmayer F, Reitsamer R, Wenz F, Sperk E, Fussl C, Kaiser J, Ziegler I, Zehentmayr F, Deutschmann H, Kopp P, Fastner G

Targeted intraoperative radiotherapy tumour bed boost during breast-conserving surgery after neoadjuvant chemotherapy

Resumo

Strahlentherapie und Onkologie

Kolberg HC, Loevey G, Akpolat-Basci L, Stephanou M, Fasching PA, Untch M, Liedtke C, Bulsara M, Vaidya JS

Reduced Mortality With Partial-Breast Irradiation for Early Breast Cancer: A Meta-Analysis of Randomized Trials

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International Journal of Radiation Oncology, Biology & Physics

Vaidya JS, Bulsara M, Wenz F, Coombs N, Singer J, Ebbs S, Massarut S, Saunders C, Douek M, Williams NR, Joseph DJ, Tobias JS, Baum M

Cosmesis and Breast-Related Quality of Life Outcomes After Intraoperative Radiation Therapy for Early Breast Cancer: A Substudy of the TARGIT-A Trial

Texto completo

International Journal of Radiation Oncology, Biology & Physics

Corica T, Nowak AK, Saunders CM, Bulsara M, Taylor M, Vaidya JS, Baum M, Joseph DJ

Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the Breast

Resumo

The Breast Journal

Rivera R, Banks A, Casillas-Lopez A, Rashtian A, Lewinsky B, Sheth P, Hovannesian-Larsen L, Brousseau D, Iyengar G, Holmes DR

Late Toxicity and Cosmetic Outcome Following Intraoperative Radiation Therapy As a Boost or As Accelerated Partial-Breast Irradiation: A Monocenter Experience

Resumo

International Journal of Radiation Oncology, Biology & Physics

Key S, Miglinieri P, Vourch S, Miranda O, Mahlaire JP, Dupré PF, Pradier O, Schick U

Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the Breast

Resumo

The Breast Journal

Rivera R, Banks A, Casillas-Lopez A, Rashtian A, Lewinsky B, Sheth P, Hovannesian-Larsen L, Brousseau D, Holmes DR

Intraoperative Radiation Therapy (INTRABEAM) Experience at the Mastology Unit Leopoldo Aguerrevere Clinic

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Journal of Cancer Therapy

Muñoz G, Hany R, Cosson A, Gonzalez C, Rasquií J, Rodriguez I, Ghaleb J, Gonzalez E, Benitez M, Hurtado W, Sanchez N, Figuera C

Pride, Prejudice, or Science: Attitudes Towards the Results of the TARGIT-A Trial of Targeted Intraoperative Radiation Therapy for Breast Cancer

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International Journal of Radiation Oncology, Biology & Physics

Vaidya JS, Bulsara M, Wenz F, Joseph D, Saunders C, Massarut S, Flyger HL, Eiermann W, Alvarado M, Esserman L, Falzon M, Brew-Graves C, Potyka I, Tobias JS, Baum M

Targeted intraoperative radiotherapy in elderly patients (TARGIT-E) with early breast cancer; First safety analysis after 80 treated patients

Resumo

Strahlentherapie und Onkologie

Neumaier C, Welzel G, Keller A, Abo-Madyan Y, Sperk E, Gerhardt A, Sütterlin M, Wenz F

Cosmetic outcome after breast conserving surgery and either external beam or intraoperative radiotherapy for early breast cancer: Objective assessment of patients from a randomized controlled trial in Lublin, Poland.

Resumo

Journal of Clinical Oncology

Williams NR, Kurylcio A, Jankiewicz M, Romanek J, Polkowski W, Michalopoulos N, Keshtgar MR

Short term toxicity of intra-operative radiotherapy for patients with breast cancer treated at a single center

Resumo

Cancer Research

Shai A, Zur M, Leviov M, Bitterman M, Eitan S, Steiner M

Low-kilovoltage single dose intraoperative radiation therapy for breast cancer

Resumo

Radiotherapy and Oncology

Flores-Balcazar C, Santiago-Concha G, Sánchez-Castro R, Rosales-Pérez S, Bargalló-Rocha E, Rivera-Corona J

Whole breast radiotherapy does not affect growth of cancer foci in other quadrants: results from the TARGIT A trial

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Radiotherapy and Oncology

Vaidya J, Bulsara M, Wenz F, Tobias JS, Joseph DJ, Massarut S, Flyger H, Eiermann W, Saunders C, Alvarado M, Brew-Graves C, Potyka I, Williams MR, Baum M

Intraoperative Radiotherapy of the Breast for Early-Stage Breast Cancer: Ready for Primetime

Resumo

The Breast Journal

Holmes DR

Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences

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International Journal of Breast Cancer

Malter W, Kirn V, Richters L, Fridrich C, Markiefka B, Bongartz R, Semrau R, Mallmann P, Kraemer S

A cohort analysis to identify eligible patients for intraoperative radiotherapy (IORT) of early breast cancer

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Radiation Oncology

Sperk E, Astor D, Keller A, Welzel G, Gerhardt A, Tuschy B, Sütterlin M, Wenz F

Cosmetic outcome within one year of breast-conserving surgery, after external beam or intraoperative radiotherapy for early breast cancer: Objective assessment of patients from a randomized controlled trial.

Resumo

Journal of Clinical Oncology

Williams NR, Wenz F, Welzel G, Michalopoulos N, Keshtgar MR

Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial

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The Lancet

Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M, Flyger HL, Massarut S, Alvarado M, Saunders C, Eiermann W, Metaxas M, Sperk E, Sütterlin M, Brown D, Esserman L, Roncadin M, Thompson A, Dewar JA, Holtveg HMR, Pigorsch S, Falzon M, Harris E, Matthews A, Brew-Graves C, Potyka I, Corica T, Williams NR, Baum M

Cost-Effectiveness Analysis of Intraoperative Radiation Therapy for Early-Stage Breast Cancer

Resumo

Annals of Surgical Oncology

Alvarado MD, Mohan AJ, Esserman LJ, Park CC, Harrison BL, Howe RJ, Thorsen C Ozanne EM

Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT A

Resumo

Breast Cancer Research and Treatment

Sperk E, Welzel G, Keller A, Kraus-Tiefenbacher U, Gerhardt A, Sütterlin M, Wenz F

TARGIT-E(lderly)--Prospective phase II study of intraoperative radiotherapy (IORT) in elderly patients with small breast cancer

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BMC Cancer

Neumaier C, Sperk E, Welzel G, Xasser A, Kraus-Tiefenbacher U, Keller A, Gerhardt A, Sütterlin M,
Wenz F

Targeted Intraoperative Radiotherapy for Breast Cancer in Patients in Whom External Beam Radiation Is Not Possible

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International Journal of Radiation Oncology, Biology & Physics

Keshtgar MRS, Vaidya JS, Tobias JS, Wenz F, Joseph D, Stacey C, Metaxas MG, Keller A, Corica T, Williams NR, Baum M

A safety study of intraoperative radiation therapy following stereotactic body radiation therapy and multi-agent chemotherapy in the treatment of localized pancreatic adenocarcinoma: study protocol of a phase I trial

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Radiation Oncology

Reddy AV, Hill CS, Zheng L, He J, Narang AK

Intraoperative Radiotherapy for Resectable Pancreatic Cancer Using a Low-Energy X-Ray Source: Postoperative Complications and Early Outcomes

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Yonsei Med Journal

Cho Y, Kim JW, Kim HS, Park JS, Lee IJ

Dosimetric Comparison of Intraoperative Radiotherapy and SRS for Liver Metastases

Frontiers in Oncology

Scafa D, Muedder T, Holz JA, Koch D, Nour Y, Garbe S, Gonzalez-Carmona MA, Feldmann G, Vilz TO, Köksal M, Giordano FA, Schmeel LC, Sarria GR

Intraoperative radiation therapy induces immune response activity after pancreatic surgery

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BMC Cancer

Lee YS, Kim HS, Cho Y, Lee IJ, Kim HJ, Lee DE, Kang HW, Park JS

The role of intraoperative radiotherapy in advanced rectal cancer: a meta- analysis

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Colorectal Disease

Fahy MR, Kelly ME, Foley MP, Nugent TS, Shields CJ, Winter DC

INTRABEAM intraoperative radiotherapy combined with portal vein infusion chemotherapy for treating hepatocelular carcinoma with portal vein tumor thrombus

BMC Surgery

Song X, He Y, Liang H, Han M, Shao Z

Low-kilovolt x-ray intraoperative radiotherapy for pT3 locally advanced colon cancer: a single-institution retrospective analysis

World Journal of Surgical Oncology

Ma L, Qiang J, Yin H, Lin L, Jiao Y, Ma C, Li X, Dong L, Cui J, Wei D, Sharma AM, Schwartz DL, Gu W, Chen H

Intraoperative Strahlentherapie in der Abdominalchirurgie- eigene Erfahrungen

Der Chirurg

Joechle K, Gkika E, Grosu AL, Hopt UT, Neeff HP, Fichtner-Feigl S, Lang SA

Short-term outcomes of laparoscopic intersphincteric resection with intraoperative radiotherapy using low-energy X-rays for primary locally advanced low rectal cancer: a single center experience

World Journal of Surgical Oncology

Xue W, Wang S, Zhao Z, Li Y, Shang A, Li D, Yang J, Wang T, Wang M

Intraoperative radiotherapy as an immediate adjuvant treatment of rectal cancer due to limited access to external-beam radiotherapy

Radiation Oncology

Potemin S, Kübler J, Uvarov I, Wenz F, Giordano F

A phase II study of intraoperative radiotherapy using a low-energy x-ray source for resectable pancreatic cancer: a study protocol

BMC Surgery

Kim JW, Cho Y, Kim HS, Choi WH, Park JS, Lee IJ

The Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal Cancer

Radiation Oncology

Susko M, Lee J, Salama J, Thomas S, Uronis H, Hsu D, Migaly J, Willett C, Czito B, Palta M

Intraoperative radiotherapy with low energy photons in recurrent colorectal cancer: a single centre retrospective study

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Contemporary Oncology

Skórzewska M, Mielko J, Kurylcio A, Romanek J, Polkowski WP

Intraoperative radiotherapy in locally-advanced and recurrent rectal cancer: retrospective review of 68 cases

Translational Cancer Research

Potemin S, Uvarov I, Vasilenko I

Intraoperative Radiotherapy with Low-Energy Photons in Rectal Cancer Recurrence

Targeted Intraoperative Radiotherapy in Oncology (Book)

Polkowski WP, Skórzewska M

Intraoperative radiation therapy with the photon radiosurgery system in locally advanced and recurrent rectal cancer: retrospective review of the Cleveland clinic experience

Radiation Oncology

Guo S, Reddy CA, Kolar M, Woody N, Mahadevan A, Deibel F, Dietz DW, Remzi FH, Suh JH

Intraoperative radiation therapy for locally advanced and recurrent head and neck cancer

Resumo

Journal of Clinical Oncology

Chiodo C, Gros S, Lee B,  Block AM, Emami B, Small W, Abdelrhman TR

Intraoperative radiation therapy (IORT) in head and neck cancer: A systematic review

Medicine

Kyrgias G, Hajiioannou J, Tolia M, Kouloulias V, Lachanas V, Skoulakis C, Skarlatos I, Rapidis A, Bizakis I

Intra-operative radiation therapy (IORT) in recurrent head and neck cancer

Oral Oncology

De Felice F, Musio D, Tombolini V

Intraoperative radiotherapy (IORT) in the treatment of head and neck cancer

Translational Cancer Research

Münter MW, Köppen U, Ramuscak A, Sittel C, Wegner N

Current advances in radiotherapy of head and neck malignancies

Journal of International Oral Health

Roopashri G, Baig M

A case report on a novel use of intraoperative Intrabeam™ radiation therapy for a recurrent malignant peripheral nerve sheath tumor with sciatic nerve involvement

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Radiation Oncology

Chaharbakhshi E, Hardham J, Siochi RA, Tenenholz TC, Lindsey BA

Electronic brachytherapy for treatment of non-melanoma skin cancers: clinical results and toxicities

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Journal of Contemporary Brachytherapy

Goyal U, Cheung MK, Suszko J, Laughlin B, Kim Y, Askam J, Arif-Tiwari H, Slane B, Gordon J, Stea B

Intraoperative Radiotherapy with Low Energy x-Rays for Primary and Recurrent Soft-Tissue Sarcoma

International Journal of Radiation Oncology, Biology & Physics

Sarria GR, Petrova V, Abo-Madyan Y, Wenz F, Hohenberger P, Sperk E, Giordano FA

 

 

Superficial x-ray in the treatment of basal and squamous cell carcinomas: A viable option in select patients

Journal of the American Academy of Dermatology

Cognetta AB, Howard BM, Heaton HP, Stoddard ER, Hong HG, Green W H

Radiation Therapy and Skin Cancer

Modern Practices in Radiation Therapy

Tward JD, Anker CJ. Gaffney DK, Bowen G

Use of Low-Energy X-Rays in the Treatment of Superficial Nonmelanomatous Skin Cancers

Cancer Investigation

Bodner WR, Hilaris BS, Alagheband M, Safai B, Mastoras CA, Saraf S

Intraoperative radiation therapy with 50 kV x-rays: A multi-institutional review

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Journal of Applied Clinical Medical Physics

Sethi A, Gros S, Brodin P, Ghavidel B, Chai X, Popovic M, Tomé WA, Trichter S, Yang X, Zhang H, Uhl V

Dosimetric evaluation of an intraoperative radiotherapy system: a measurement-based and Monte-Carlo modelling investigation

Resumo

National Library of Medicine

Chin M, Rowshanfarzad P, Neveri G, Ebert MA, Pfefferlé D

Gold-nanoparticle-enriched breast tissue in breast cancer treatment using the INTRABEAM system: a Monte Carlo study

Radiation and Environmental Biophysics

Tegaw EM, Geraily G, Gholami S, Shojaei M, Tadesse GF

Monte Carlo calculation of the TG-43 dosimetry parameters for the INTRABEAM source with spherical applicators

Physics in Medicine & Biology

Alvarez DSA, Watson P, Popovic M, Heng VJ, Evans M, Seuntjens J

Patient-Specific Quality Assurance Using a 3D-Printed Chest Phantom for Intraoperative Radiotherapy in Breast Cancer

Frontiers in Oncology

Choi Y, Lee IJ, Park K, Park KR, Cho Y, Kim JW, Lee H

A Comparison between Electron Gamma Shower, National Research Council/Easy Particle Propagation (EgSnrc/Epp) and Monte Carlo N-Particle Transport Code (MCNP) in Simulation of the INTRABEAM System with Spherical Applicators

Journal of Biomedical Physics and Engineering

Tegaw EM, Geraily GH, Etesami SM, Gholami S, Ghanbari H, Farzin M, Tadesse GF, Shojaei M

Effective energy assessment during breast cancer intraoperative radiotherapy by low-energy X-rays: A Monte Carlo study

Radiation and Environmental Biophysics

Shamsabadi R, Baghani HR, Mowlavi AA, Azadegan B

Dose-rate considerations for the INTRABEAM electronic brachytherapy system: Report from the American association of physicists in medicine task group no. 292

Medical Physics

Culberson WS, Davis SD, Gwe‐Ya Kim G, Lowenstein JR, Ouhib Z, Popovic M, Waldron TJ, Safigholi H, Simiele SJ, Rivard MJ

Dosimetric evaluation of incorporating the revised V4.0 calibration protocol for breast intraoperative radiotherapy with the INTRABEAM system

Journal of Applied Clinical Medical Physics

Shaikh MY, Burmeister J, Scott R, Kumaraswamy LK, Nalichowski A, Joiner MC

Intraoperative Radiotherapy With INTRABEAM: Technical and Dosimetric Considerations

Frontiers in Oncology

Sethi A, Emami B, Small W, Thomas TO

Dosimetric characterization of INTRABEAM® miniature accelerator flat and surface applicators for dermatologic applications

Medica Physica

Goubert M, Parent L

Radiation protection for an intraoperative X-ray source compared to C-arm fluoroscopyStrahlenschutz einer Röntgenquelle zur intraoperativen Strahlentherapie im Vergleich mit C-Bogen-Durchleuchtung

Zeitschrift für Medizinische Physik

Schneider F, Clausen S, Jahnke A, Steil V, Bludau F, Sütterlin M, Obertacke U, Wenz F

Radiation protection for an intra-operative X-ray devicer an intra-operative X-ray device

The British Journal of Radiology

Eaton DJ, Gonzalez R, Duck S, Keshtgar M

A novel approach for superficial intraoperative radiotherapy (IORT) using a 50 kV X-ray source: a technical and case report

Journal of Applied Clinical Medical Physics

Schneider F, Clausen S, Thölking J, Wenz F, Abo-Madyan Y

Quality assurance and independent dosimetry for an intraoperative x-ray device

Medical Physics

Eaton DJ

Development of a Novel Method for Intraoperative Radiotherapy During Kyphoplasty for Spinal Metastases (Kypho-IORT)

International Journal of Radiation Oncology, Biology & Physics

Schneider F, Greineck F, Clausen S, Mai S, Obertacke U, Reis T, Wenz F

Biological and clinical review of IORT-induced wound fluid in breast cancer patients

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Front Oncol.

Jeibouei S, Shams F, Mohebichamkhorami F, Sanooghi D, Faal B, Akbari ME, Zali H

The impact of intraoperative radiotherapy on breast cancer: focus on the levels of angiogenic factors

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World Journal of Surgical Oncology

Nafissi N, Mohammadlou M, Akbari ME, Mahdavi SR, Sheikh M, Borji M, Babaee E, Baharlou R

Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer

Journal of Radiation Research

Linares-Galiana I, Berenguer-Frances MA, Cañas-Cortés R, Pujol-Canadell M,Comas-Antón S,Martínez E, Laplana M, Pérez-Montero H, Pla-Farnós MJ, Navarro-Martin A,Nuñez M ,Both B, Guedea F 

Wound Fluid from Breast Cancer Patients Undergoing Intraoperative Radiotherapy Exhibits an Altered Cytokine Profile and Impairs Mesenchymal Stromal Cell Function

Cancers (Basel)

Wuhrer A , Uhlig S ,Tuschy B,Berlit S ,Sperk E , Bieback K, Sütterlin M

Cardiac serum marker alterations after intraoperative radiotherapy with low-energy x-rays in early breast cancer as an indicator of possible cardiac toxicity

Strahlentherapie und Onkologie

Stefanovic S, Berlit S, Sperk E, Wenz F, Weiß C, Trinkmann F, Sütterlin M, Tuschy B

Intraoperative radiotherapy for breast cancer treatment efficiently targets the tumor bed preventing breast adipose stromal cell outgrowth

Strahlentherapie und Onkologie

Uhlig S, Wuhrer A, Berlit S, Tuschy B, Sütterlin M, Bieback K

Surgical Wound Fluids from Patients with Breast Cancer Reveal Similarities in the Biological Response Induced by Intraoperative Radiation Therapy and the Radiation-Induced Bystander Effect—Transcriptomic Approach

International Journal of Molecular Sciences

Kulcenty K, Piotrowski I, Rucinski M, Wroblewska JP, Jopek K, Murawa D, Suchorska WM

Biology of high single doses of IORT: RBE, 5 R’s, and other biological aspects

Radiation Oncology

Herskind C, Ma L, Liu Q, Zhang B, Schneider F, Veldwijk MR, Wenz F

Tissue inhomogeneity corrections in low-kV intra-operative radiotherapy (IORT)

Translational Cancer Research

Sethi A, Chinsky B, Gros S, Diak A

Beyond the linear quadratic model: intraoperative radiotherapy and normal tissue tolerance

Translational Cancer Research

Emami B, Woloschak G, Small W

Radiobiological aspects of intraoperative tumour-bed irradiation with low-energy X-rays (LEX-IORT)

Translational Cancer Research

Herskind C, Wenz F

Cell and molecular response to IORT treatment

International Journal of Radiation Oncology, Biology & Physics

Minafra L, Bravatà V

Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects

Translational Cancer Research

Sologuren I, Rodríguez-gallego C, Lara PC

Mitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell line

Journal of Neuro-Oncology

Wang M, Maier P, Wenz F, Giordano FA, Herskind C

Mitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell line

International Journal of Radiation Oncology, Biology & Physics

Liu Q, Schneider F, Ma L, Wenz F, Herskind C

Sphere of Equivalence - A Novel Target Volume Concept for Intraoperative Radiotherapy Using Low-Energy X Rays

International Journal of Radiation Oncology, Biology & Physics

Herskind C, Griebel J, Kraus-Tiefenbacher U, Wenz F

Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding

Clinical Cancer Research

Belletti B, Vaidya JS, D’Andrea S, Entschladen F, Roncadin M, Lovat F, Berton S, Perin T, Candiani E, Reccanello S, Veronesi A, Canzonieri V, Trovò MG, Zaenker KS, Colombatti A, Baldassarre G, Massarut S

Electronic brachytherapy—current status and future directions

The British Journal of Radiology

Eaton DJ

Patient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignment

European Journal of Cancer Care

Corica T, Saunders CM, Bulsara MK, Taylor M, Joseph DJ, Nowak AK

A Prospective Analysis of Quality of Life and Toxicity Outcomes in Treating Early Breast Cancer With Breast Conservation Therapy and Intraoperative Radiation Therapy

Texto completo

Frontiers in Oncology

Sosin M, Gupta SS, Wang JS, Costellic CD, Gulla A, Bartholomew AJ, O'Neill SC, Hechenbleikner EM, Collins BT, Rudra S, Collins SP, Chaldekas KM, Seevaratnam S, Langan RC, Willey SC, Tousimis EA

Intraoperative radiotherapy: Patient selection, management, and follow-up

Journal of Surgical Oncology

Holmes DR, Zimmerman R

Cosmesis and Breast-Related Quality of Life Outcomes After Intraoperative Radiation Therapy for Early Breast Cancer: A Substudy of the TARGIT-A Trial

International Journal of Radiation Oncology, Biology & Physics

Corica T, Nowak AK, Saunders CM, Bulsara M, Taylor M, Vaidya JS, Baum M, Joseph DJ

Environmental and social benefits of the targeted intraoperative radiotherapy for breast cancer: data from UK TARGIT-A trial centres and two UK NHS hospitals offering TARGIT IORT

The BMJ

Coombs NJ, Coombs JM, Vaidya UJ, Singer J, Bulsara M, Tobias JS, Wenz F, Joseph DJ, Brown DA, Rainsbury R, Davidson T, Adamson DJA, Massarut S, Morgan D, Potyka I, Corica T, Falzon M, Williams N, Baum M, Vaidya JS

Comparison of mammographic findings after intraoperative radiotherapy or external beam whole breast radiotherapy

European Journal of Surgical Oncology

Elsberger B, Romsauerova A, Vinnicombe S, Whelehan P, Brown DC, Dewar JA, Thompson AM, Evans, A

Patient preferences regarding intraoperative versus external beam radiotherapy following breast-conserving surgery

Breast Cancer Research and Treatment

Alvarado MD, Conolly J, Park C, Sakata T, Mohan AJ, Harrison BL, Hayes M, Esserman LJ, Ozanne EM

Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer

The New England Journal of Medicine

Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, Correa C, Cutter D, Gagliardi G, Gigante B, Jensen M-B, Nisbet A, Peto R, Rahimi K, Taylor C, Hall P

Radiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from the randomized phase III trial TARGIT-A

Radiation Oncology

Welzel G, Boch A, Sperk E, Hofmann F, Kraus-Tiefenbacher U, Gerhardt A, Wenz F

Persistent pain after targeted intraoperative radiotherapy (TARGIT) or external breast radiotherapy for breast cancer: A randomized trial

The Breast

Andersen KG, Gärtner R, Kroman N, Flyger H, Kehlet H

Clinical Outcomes of Breast-Conserving Surgery with Synchronous 50-kV X-ray Intraoperative Partial Breast Irradiation in Patients Aged 64 Years or Older with Low-Risk Breast Cancer

Texto completo

Breast Cancer (Auckl)

Salari K, Glaza A, Lee JS, Sarvepalli N, Dekhne N, Kiran SH, Chen PY, Dilworth JT

Longitudinal cosmetic outcome after planned IORT boost with low kV X-rays-monocentric results from the TARGIT BQR registry

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National Library of Medicine

Goerdt L, Poemsl J, Spaich S, Welzel G, Abo-Madyan Y, Ehmann M, Berlit S, Tuschy B, Sütterlin M, Wenz F, Sperk E

Surgical and Oncologic Outcomes With Intraoperative Radiation Therapy for Early Breast Cancer

Resumo

The American Surgeon

Friedman-Eldar O, Layton C, De Castro Silva I, Moller MG, Allen A, Franceschi D, Isrow D, Samuels S, Takita C, Avisar E

Hypofractionated whole breast irradiation after IORT treatment is safe in patients receiving adjuvant chemotherpy

Resumo

Clinical and Translational Oncology

Burgos-Burgos J, Vega V, Macias-Verde D, Gómez V, Travieso-Aja M, Travieso J, Vicente E, Murias C, Santana C, Ospina J, Lara PC

Cosmetic outcome as rated by patients, doctors, nurses and BCCT.core software assessed over 5 years in a subset of patients in the TARGIT-A Trial

Radiation Oncology

Corica T, Nowak AK, Saunders CM, Bulsara MK, Taylor M, Williams NR, Keshtgar M, Joseph DJ, Vaidya JS

Aesthetic outcome after breast conserving surgery and either intraoperative radiotherapy or whole breast external beam radiotherapy for early breast cancer: objective assessment of patients in a randomized controlled trial in Lublin, Poland

European Journal of Gynaecological Oncology

Williams N, Kurylcio A, Jankiewicz M, Romanek J, Polkowski W, Michalopoulos N, Keshtgar M

Oncoplastic breast reconstruction after IORT

Translational Cancer Research

Malter W, Kirn V, Mallmann P, Kraemer S

Objective assessment of cosmetic outcome after targeted intraoperative radiotherapy in breast cancer: results from a randomised controlled trial

Breast Cancer Research and Treatment

Keshtgar MRS, Williams NR, Bulsara M, Saunders C, Flyger H, Cardoso JS, Corica T, Bentzon N, Michalopoulos NV, Joseph DJ

Partial Breast Irradiation for Patients With Early-Stage Invasive Breast Cancer or Ductal Carcinoma In Situ: An ASTRO Clinical Practice Guideline

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Practical Radiation Oncology

ASTRO

Diagnosis and Treatment of Patients with early and advanced Breast Cancer - Adjuvant Radiotherapy

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AGO

AGO

Traitements locorégionaux des cancers du sein infiltrants non métastatiques - Synthèse

Resumo

INCa

INCa

Intraoperative Radiation Therapy (IORT)

AETNA

AETNA

NCCN Guidelines

NCCN

NCCN

Leitlinienprogramm Onkologie: S3-Leitlinie Früherkennung, Diagnose, Therapie und Nachsorge des Mammakarzinoms

Leitlinienprogramm Onkologie

Leitlinienprogramm Onkologie

Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Annals of Oncology

Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S, Senkus E

Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline

Practical Radiation Oncology

Smith BD, Bellon JR, Blitzblau R, Freedman G, Haffty B, Hahn C, Halberg F, Hoffman K, Horst K, Moran J, Patton C, Perlmutter J, Warren L, Whelan T, Wright JL, Jagsi R

Intrabeam radiotherapy system for adjuvant treatment of early breast cancer Technology appraisal guidance [TA501]

NICE

NICE

ESTRO-ACROP guideline «target delineation of glioblastomas»

Radiotherapy and Oncology

Niyazi M, Brada M, Chalmers AJ, Combs SE, Erridge SC, Fiorentino A, Grosu AL, Lagerwaard FJ, Minniti G, Mirimanoff R-O, Ricardi U, Short SC, Weber DC, Belka C

Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline

Practical Radiation Oncology

Tsao MN, Rades D, Wirth A, Lo SS, Danielson BL, Gaspar LE, Sperduto PW, Vogelbaum MA, Radawski JD, Wang JZ, Gillin MT, Mohideen N, Hahn CA, Chang EL

Primer consenso español sobre el uso de la radioterapia intraoperatoria en el cáncer de mama. Conclusiones del panel de expertos

Resumo

Revista de Senología y Patología Mamaria

SESPM - SEOR

Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: Recommendations of the Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group based on clinical evidence (2009)

Radiotherapy and Oncology

Polgár C, Van Limbergen E, Pötter R, Kovács G, Polo A, Lyczek J, Hildebrandt G, Niehoff P, Guinot JL, Guedea F, Johansson B, Ott OJ, Major T, Strnad V

An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial)

Health Technology Assessment 

Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Saunders C, Brew-Graves C, Potyka I, Morris S, Vaidya HJ, Williams NR, Baum M

The INTRABEAM® Photon Radiotherapy System for the adjuvant treatment of early breast cancer: a systematic review and economic evaluation

Health Technology Assessment 

Picot J, Copley V, Colquitt JL, Kalita N, Hartwell D, Bryant J