Tecnologias de fluorescência intraoperatória ZEISS
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A fluorescência é a propriedade de átomos e moléculas, os chamados fluoróforos, de absorver luz com um comprimento de onda específico e, subsequentemente, emitir luz com um comprimento de onda maior. A microscopia por fluorescência pode ser baseada em autofluorescência ou na adição de corantes fluorescentes.1,2 Em condições normais de luz, os corantes fluorescentes poderão ser invisíveis. Mas um microscópio operatório com tecnologia de fluorescência integrada destaca o corante para visualizar o tecido tumoral ou os vasos sanguíneos durante a cirurgia.
A primeira utilização da aquisição de imagens de fluorescência intraoperatória em cirurgia foi feita em 1948, quando cirurgiões utilizaram fluoresceína por via intravenosa para ver melhor neoplasias intracranianas durante a cirurgia.2,9 Desde aí, têm sido utilizados agentes fluorescentes adicionais em várias aplicações cirúrgicas.4,5,6,9 A aquisição de imagens de fluorescência intraoperatória tem várias vantagens: proporciona alto contraste e sensibilidade sem a utilização de radiação ionizante, é segura e tem alta especificidade.7,8,9 Em comparação com a visão geral sem auxiliares utilizando a aquisição de imagens com luz branca, a aquisição de imagens de fluorescência em tempo real ajuda a visualizar melhor o tecido cancerígeno e a delinear margens tumorais.8 Além disso, a melhor visualização do cancro pode reduzir os danos em estruturas sem patologia, como nervos, vasos sanguíneos, ureteres e vias biliares.9
Na microcirurgia, um contexto desafiante, os auxiliares de visualização cirúrgica são fundamentais para tomar as decisões corretas no momento certo. As tecnologias de fluorescência intraoperatória1 da ZEISS dão-lhe as ferramentas de que precisa.
Visualização intraoperatória de estruturas coradas por fluorescência em cirurgia tumoral
Visualização intraoperatória de estruturas coradas por fluorescência em cirurgia tumoral
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BLUE 400 da ZEISS
O BLUE 400 da ZEISS apoia a diferenciação intraoperatória dos tecidos entre o tecido patológico e saudável. Foi o único módulo de fluorescência integrado no microscópio a ter eficiência comprovada num estudo multicêntrico de Fase III realizado com sucesso.2
De acordo com um estudo de 2015 realizado por Esteves et al., os gliomas de alto grau (graus III–IV) são os tumores cerebrais mais frequentes na Europa, com uma incidência de 3,13 em cada 100.000 residentes. A extensão da ressecção tumoral é um fatores de prognóstico de sobrevida preponderante.3 Os estudos demonstram que é necessária a ressecção de pelo menos 98% do tecido tumoral para esta ter impacto significativo na taxa de sobrevida. Um ensaio clínico aleatorizado realizado por Stummer et al. em 2006 demonstrou que a probabilidade de ressecção completa do tumor aumentava significativamente quando era utilizada fluorescência com 5-ALA (ácido 5-aminolevulínico) (65% vs. 37%, p < 0,0001).2
Nós [...] publicámos um estudo de economia clínica [...] para demonstrar que, ao utilizar o BLUE 400, podemos melhorar os resultados dos pacientes [...].
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Ressecção de glioblastoma de alto grau guiada por fluorescência
Prof. Dr. Andreas Raabe
Diretor e chefe do departamento de neurocirurgia, Inselspital Bern, Suíça
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ZEISS YELLOW 560
O ZEISS YELLOW 560 é o primeiro módulo de fluorescência intraoperatória1 a destacar as estruturas coradas por fluorescência permitindo simultaneamente a visualização de tecidos não corados com a respetiva cor natural. Permite fazer atividades de investigação com corantes de fluorescência adequados.1
A vantagem é que a ressecção do tumor é mais perfeita, porque o tecido cerebral não afetado é visualizado diretamente, sendo possível preservá-lo.
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Ressecção de glioblastoma guiada por fluorescência
Prof. Dr. Karl-Michael Schebesch e Dr. Julius Höhne
Clínica de neurocirurgia, University Hospital Regensburg, Alemanha
Constantinos G Hadjipanayis,
Jeffrey N Bruce,
John YK Lee
1
Utilize o agente fluorescente em conformidade com o estado de aprovação para a aplicação no seu país.
2
Stummer W, Pichlmeier U, Meinel T et al: Fluorescence-guided surgery for resection of malignant glioma: a randomized controlled multicentre phase III trial. Publicado em: Lancet Oncol 7: 392-401, 2006.
3
Esteves S, Alves M, Castel-Branco M, Stummer W: A Pilot Cost-Effectiveness Analysis of Treatments in Newly Diagnosed High-Grade Gliomas: The Example of 5-Aminoelvulinic Acid Compared With White-Light Surgery. Publicado em: Neurosurgery 76: 552–562, 2015.
4
Acerb Fi, Cavallo C, Schebesch KM, et al.: Fluorescein-Guided Resection of Intramedullary Spinal Cord Tumors: Results from a Preliminary, Multicentric, Retrospective Study. Publicado em: World Neurosurgery 108: 603-609, 2017.
5
Rey-Dios R, Cohen-Gadol AA: Technical principles and neurosurgical applications of fluorescein fluorescence using a microscope-integrated fluorescence module. Publicado em: Acta Neurochirurgica 155(4):701–706, 2013.
6
De Laurentis C, Höhne J, Cavallo C, et al.: The impact of fluorescein-guided technique in the surgical removal of CNS tumors in a pediatric population: results from a multicentric observational study. Publicado em: Journal of Neurosurgical Sciences 63(6): 679-687, 2019.
7
Acerbi F, Broggi M, Schebesch KM, et al. Fluorescein-guided surgery for resection of high-grade gliomas: A multicentric prospective phase II study (FLUOGLIO). Publicado em: Clinical Cancer Research 24(1): 52-61, 2018.
8
Schebesch KM, Proescholdt M, Höhne J, et al.: Sodium fluorescein-guided resection under the YELLOW 560 nm surgical microscope filter in malignant brain tumor surgery – a feasibility study. Publicado em: Acta Neurochirurgica 157(6): 899–904, 2015.
9
Höhne J, Hohenberger C, Proescholdt M, et al. Fluorescein sodium-guided resection of cerebral metastases-an update. Publicado em: Acta Neurochirurgica 159: 363-367, 2017.
10
Raabe A, Beck J, Gerlach R, Zimmermann M, Seifert V: Near-Infrared Indocyanine Green Video Angiography: A New Method For Intraoperative Assessment Of Vascular Flow. Publicado em: Neurosurgery 52(1):132-139, 2003.
11
Raabe A, Beck J, Seifert V: Technique and image quality of intraoperative indocyanine green angiography during aneurysm surgery using surgical microscope integrated near-infrared video technology. Publicado em: Zentralbl Neurochir 66(1):1–6, 2005.
12
Kamp MA, Slotty P, Turowski B, Etminan N, Steiger HJ, Hänggi D, Stummer W: Microscope-integrated quantitative analysis of intraoperative indocyanine green fluorescence angiography for blood flow assessment: first experience in 30 patients. Publicado em: Operative Neurosurgery 70(1 Suppl Operative): 65-73, 2012.
13
Mücke T, Reeps C, Wolff KD, et al.: Objective qualitative and quantitative assessment of blood flow with near-infrared angiography in microvascular anastomoses in the rat model. Publicado em: Microsurgery 33(4):287-96, 2013.
14
Ye X, Liu XJ, Ma L, et al.: Clinical values of intraoperative indocyanine green fluorescence video angiography with Flow 800 software in cerebrovascular surgery. Publicado em: Chinese Medical Journal 126(22): 4232-4237, 2013.
15
Holling M, Brokinkel B, Ewelt C, et al.: Dynamic ICG fluorescence provides better intraoperative understanding of arteriovenous fistulae. Publicado em: Operative Neurosurgery 73(Issue suool_1): 93-99, 2013.
16
Ng YP, King NK, Wan KR, et al.: Uses and limitations of indocyanine green videoangiography for flow analysis in arteriovenous malformation surgery. Publicado em: Journal of Clinical Neuroscience 20(2): 224-232, 2013.
17
Holzbach T, Artunian N, Spanholtz TA, et al.: Intraoperative Indocyaningrün-Fluoreszenzdiagnostik mittels Operationsmikroskop in der plastischen Chirurgie. Publicado em: Handchirurgie, Plastische Chirurgie, Ästhetische Chirurgie 44(2):84-8, 2012.
18
Mücke T, Fichter AM, Schmidt LH, et al.: Indocyanine green videoangiography-assisted prediction of flap necrosis in the rat epigastric flap using FLOW® 800 Tool. Publicado em: Microsurgery 37:235–242, 2017.
19
Mücke T, Wolff C, Fichter AM, et al.: Detection of thrombosis in microvessels with8 indocyanine green videoangiography. Publicado em: British Journal of Oral and Maxillofacial Surgery 56(8): 678-683, 2018.
20
Yamato T, Yamamoto N, Numahata T, et al.: Navigation Lymphatic Supermicrosurgery for the Treatment of Cancer-Related Peripheral Lymphedema. Publicado em: Vascular and Endovascular Surgery 48(2):139-143, 2014.
21
Höhne J, Schebesch KM, de Laurentis C, Akçakaya MO, Pedersen CB, Brawanski A, Poulsen FR, Kiris T, Cavallo C, Broggi M, Ferroli P, Acerbi F Fluorescein Sodium in the Surgical Treatment of Recurrent Glioblastoma Multiforme. World Neurosurg. 2019 May;125:E158-E164. Epub 22 de janeiro de 2019.
22
Imagem: craniotomia temporal esquerda para ressecção tumoral com YELLOW 560. Imagem cortesia de Dr. Peter Nakaji, Barrow Neurological Institute, Phoenix Arizona, EUA
Aquisição de imagens intraoperatórias do fluxo sanguíneo cerebral na cirurgia vascular
Aquisição de imagens intraoperatórias do fluxo sanguíneo cerebral na cirurgia vascular
ZEISS INFRARED 800
Com o ZEISS INFRARED 800 é possível visualizar vasos sanguíneos com menos de um milímetro. A aquisição de imagens intraoperatórias do fluxo sanguíneo cerebral na cirurgia vascular é de particular interesse na neurocirurgia vascular. A angiografia assistida por fluorescência utilizando verde de indocianina (ICG) permite a avaliação qualitativa em tempo real da permeabilidade vascular ou de estruturas vasculares com patologia durante a cirurgia. Já em 2003, os resultados de um estudo de viabilidade de Raabe et al. revelaram que a angiografia de fluorescência com ICG é útil na avaliação de aneurismas, fístulas na dura e na cirurgia de revascularização.10 Integrada no microscópio operatório, a angiografia com ICG é uma técnica adequada para visualização e apoio na avaliação e interpretação do fluxo sanguíneo intraoperatório de vasos com menos de 1 mm de diâmetro. Ajuda na deteção precoce de complicações, bem como na redução do risco de danos por isquemia e na necessidade de intervenção adicional pós-operatória.11
O INFRARED 800 mudou a prática clínica da neurocirurgia vascular no bloco operatório. Permitiu-nos realmente responder às questões críticas após a colocação de clipes ou de um bypass [...]. Facilitou as cirurgias, encurtou-as e quase eliminou a necessidade de angiografia intraoperatória.
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ZEISS FLOW 800
Utilizando as sequências de vídeo do ZEISS INFRARED 800, o ZEISS FLOW 800 possibilita uma aplicação de fluorescência única para a análise virtual do fluxo sanguíneo vascular. As informações das sequências de vídeo são compiladas em mapas visuais, diagramas ou imagens apresentadas lado a lado. Isto permite uma análise detalhada dos vídeos de fluorescência.
A aquisição de imagens simples de estruturas vasculares é frequentemente insuficiente para a deteção de hipo ou hiperperfusão; para isso, é necessária uma análise quantitativa dos dados.12 Os resultados de estudos demonstraram que o software de análise FLOW 800 fornece informações adicionais valiosas aos cirurgiões na avaliação intraoperatória da obstrução arterial e do fluxo sanguíneo regional.13-16
O FLOW 800 é uma ferramenta de análise de visualização importante na cirurgia da malformação arteriovenosa porque nos ajuda muito rapidamente a compreender a hemodinâmica envolvida numa malformação arteriovenosa. Trabalho com o FLOW 800 há já alguns anos [...], creio que se tornou indispensável.
Maximize a utilização do seu produto com o MyZEISS
Obtenha conteúdos de formação exclusivos, conteúdos feitos por colegas, materiais para os pacientes e acesso a ferramentas para gerir as suas tarefas diárias.
1
Utilize o agente fluorescente em conformidade com o estado de aprovação para a aplicação no seu país.
2
Stummer W, Pichlmeier U, Meinel T et al: Fluorescence-guided surgery for resection of malignant glioma: a randomized controlled multicentre phase III trial. Publicado em: Lancet Oncol 7: 392-401, 2006.
3
Esteves S, Alves M, Castel-Branco M, Stummer W: A Pilot Cost-Effectiveness Analysis of Treatments in Newly Diagnosed High-Grade Gliomas: The Example of 5-Aminoelvulinic Acid Compared With White-Light Surgery. Publicado em: Neurosurgery 76: 552–562, 2015.
4
Acerb Fi, Cavallo C, Schebesch KM, et al.: Fluorescein-Guided Resection of Intramedullary Spinal Cord Tumors: Results from a Preliminary, Multicentric, Retrospective Study. Publicado em: World Neurosurgery 108: 603-609, 2017.
5
Rey-Dios R, Cohen-Gadol AA: Technical principles and neurosurgical applications of fluorescein fluorescence using a microscope-integrated fluorescence module. Publicado em: Acta Neurochirurgica 155(4):701–706, 2013.
6
De Laurentis C, Höhne J, Cavallo C, et al.: The impact of fluorescein-guided technique in the surgical removal of CNS tumors in a pediatric population: results from a multicentric observational study. Publicado em: Journal of Neurosurgical Sciences 63(6): 679-687, 2019.
7
Acerbi F, Broggi M, Schebesch KM, et al. Fluorescein-guided surgery for resection of high-grade gliomas: A multicentric prospective phase II study (FLUOGLIO). Publicado em: Clinical Cancer Research 24(1): 52-61, 2018.
8
Schebesch KM, Proescholdt M, Höhne J, et al.: Sodium fluorescein-guided resection under the YELLOW 560 nm surgical microscope filter in malignant brain tumor surgery – a feasibility study. Publicado em: Acta Neurochirurgica 157(6): 899–904, 2015.
9
Höhne J, Hohenberger C, Proescholdt M, et al. Fluorescein sodium-guided resection of cerebral metastases-an update. Publicado em: Acta Neurochirurgica 159: 363-367, 2017.
10
Raabe A, Beck J, Gerlach R, Zimmermann M, Seifert V: Near-Infrared Indocyanine Green Video Angiography: A New Method For Intraoperative Assessment Of Vascular Flow. Publicado em: Neurosurgery 52(1):132-139, 2003.
11
Raabe A, Beck J, Seifert V: Technique and image quality of intraoperative indocyanine green angiography during aneurysm surgery using surgical microscope integrated near-infrared video technology. Publicado em: Zentralbl Neurochir 66(1):1–6, 2005.
12
Kamp MA, Slotty P, Turowski B, Etminan N, Steiger HJ, Hänggi D, Stummer W: Microscope-integrated quantitative analysis of intraoperative indocyanine green fluorescence angiography for blood flow assessment: first experience in 30 patients. Publicado em: Operative Neurosurgery 70(1 Suppl Operative): 65-73, 2012.
13
Mücke T, Reeps C, Wolff KD, et al.: Objective qualitative and quantitative assessment of blood flow with near-infrared angiography in microvascular anastomoses in the rat model. Publicado em: Microsurgery 33(4):287-96, 2013.
14
Ye X, Liu XJ, Ma L, et al.: Clinical values of intraoperative indocyanine green fluorescence video angiography with Flow 800 software in cerebrovascular surgery. Publicado em: Chinese Medical Journal 126(22): 4232-4237, 2013.
15
Holling M, Brokinkel B, Ewelt C, et al.: Dynamic ICG fluorescence provides better intraoperative understanding of arteriovenous fistulae. Publicado em: Operative Neurosurgery 73(Issue suool_1): 93-99, 2013.
16
Ng YP, King NK, Wan KR, et al.: Uses and limitations of indocyanine green videoangiography for flow analysis in arteriovenous malformation surgery. Publicado em: Journal of Clinical Neuroscience 20(2): 224-232, 2013.
17
Holzbach T, Artunian N, Spanholtz TA, et al.: Intraoperative Indocyaningrün-Fluoreszenzdiagnostik mittels Operationsmikroskop in der plastischen Chirurgie. Publicado em: Handchirurgie, Plastische Chirurgie, Ästhetische Chirurgie 44(2):84-8, 2012.
18
Mücke T, Fichter AM, Schmidt LH, et al.: Indocyanine green videoangiography-assisted prediction of flap necrosis in the rat epigastric flap using FLOW® 800 Tool. Publicado em: Microsurgery 37:235–242, 2017.
19
Mücke T, Wolff C, Fichter AM, et al.: Detection of thrombosis in microvessels with8 indocyanine green videoangiography. Publicado em: British Journal of Oral and Maxillofacial Surgery 56(8): 678-683, 2018.
20
Yamato T, Yamamoto N, Numahata T, et al.: Navigation Lymphatic Supermicrosurgery for the Treatment of Cancer-Related Peripheral Lymphedema. Publicado em: Vascular and Endovascular Surgery 48(2):139-143, 2014.
21
Höhne J, Schebesch KM, de Laurentis C, Akçakaya MO, Pedersen CB, Brawanski A, Poulsen FR, Kiris T, Cavallo C, Broggi M, Ferroli P, Acerbi F Fluorescein Sodium in the Surgical Treatment of Recurrent Glioblastoma Multiforme. World Neurosurg. 2019 May;125:E158-E164. Epub 22 de janeiro de 2019.
22
Imagem: craniotomia temporal esquerda para ressecção tumoral com YELLOW 560. Imagem cortesia de Dr. Peter Nakaji, Barrow Neurological Institute, Phoenix Arizona, EUA
Aquisição de imagens de fluorescência intraoperatória na cirurgia reconstrutiva
Aquisição de imagens de fluorescência intraoperatória na cirurgia reconstrutiva
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Vídeo de exemplo que mostra a utilização do INFRARED 800 no exame a uma anastomose linfovenosa. Cortesia do PD Dr. Christian Taeger, Responsável e médico sénior do departamento de cirurgia plástica, da mão e reconstrutiva, University Hospital Regensburg, Alemanha.
ZEISS INFRARED 800
Tipicamente utilizado na cirurgia de transplante de tecido autólogo, o INFRARED 800 da ZEISS permite a avaliação assistida por fluorescência do fluxo sanguíneo após ter sido criada uma anastomose e visualiza a obstrução vascular do enxerto.
Um estudo de 2012 realizado por Holzbach et al.17 demonstra que a angiografia de fluorescência com ICG é uma intervenção útil, rápida e segura na cirurgia de transplante de tecido autólogo, especialmente com utilização intraoperatória. Os resultados de Mücke et al. demonstram que o FLOW 800 constitui uma ferramenta de análise fiável para a monitorização intraoperatória da perfusão do tecido autólogo,18 bem como para a deteção de trombose intraoperatória.19 Um estudo de 2014 realizado por Yamamoto et al.20 concluiu que a linfografia com ICG intraoperatória facilita a identificação dos vasos linfáticos e permite uma avaliação exata das anastomoses.
A integração de tecnologia de fluorescência no microscópio operatório dá ao cirurgião mais segurança e certezas em situações clinicamente ambíguas, enquanto realiza a intervenção. Podem ser detetadas rapidamente anomalias no fluxo sanguíneo e as intervenções cirúrgicas necessárias podem ser iniciadas de imediato. O método pode prever com mais sucesso a cicatrização sem problemas da pele e do enxerto e identificar indicações precoces de trombose.
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Cortesia do Prof. Dr. Milomir Ninkovic, Chefe do departamento de cirurgia plástica e reconstrutiva, da mão e unidade de queimados, University Clinic Bogenhausen.
Vídeo de exemplo que mostra a utilização do INFRARED 800 na verificação do fluxo sanguíneo após anastomose.
Maximize a utilização do seu produto com o MyZEISS
Obtenha conteúdos de formação exclusivos, conteúdos feitos por colegas, materiais para os pacientes e acesso a ferramentas para gerir as suas tarefas diárias.
Utilize o agente fluorescente em conformidade com o estado de aprovação para a aplicação no seu país.
2
Stummer W, Pichlmeier U, Meinel T et al: Fluorescence-guided surgery for resection of malignant glioma: a randomized controlled multicentre phase III trial. Publicado em: Lancet Oncol 7: 392-401, 2006.
3
Esteves S, Alves M, Castel-Branco M, Stummer W: A Pilot Cost-Effectiveness Analysis of Treatments in Newly Diagnosed High-Grade Gliomas: The Example of 5-Aminoelvulinic Acid Compared With White-Light Surgery. Publicado em: Neurosurgery 76: 552–562, 2015.
4
Acerb Fi, Cavallo C, Schebesch KM, et al.: Fluorescein-Guided Resection of Intramedullary Spinal Cord Tumors: Results from a Preliminary, Multicentric, Retrospective Study. Publicado em: World Neurosurgery 108: 603-609, 2017.
5
Rey-Dios R, Cohen-Gadol AA: Technical principles and neurosurgical applications of fluorescein fluorescence using a microscope-integrated fluorescence module. Publicado em: Acta Neurochirurgica 155(4):701–706, 2013.
6
De Laurentis C, Höhne J, Cavallo C, et al.: The impact of fluorescein-guided technique in the surgical removal of CNS tumors in a pediatric population: results from a multicentric observational study. Publicado em: Journal of Neurosurgical Sciences 63(6): 679-687, 2019.
7
Acerbi F, Broggi M, Schebesch KM, et al. Fluorescein-guided surgery for resection of high-grade gliomas: A multicentric prospective phase II study (FLUOGLIO). Publicado em: Clinical Cancer Research 24(1): 52-61, 2018.
8
Schebesch KM, Proescholdt M, Höhne J, et al.: Sodium fluorescein-guided resection under the YELLOW 560 nm surgical microscope filter in malignant brain tumor surgery – a feasibility study. Publicado em: Acta Neurochirurgica 157(6): 899–904, 2015.
9
Höhne J, Hohenberger C, Proescholdt M, et al. Fluorescein sodium-guided resection of cerebral metastases-an update. Publicado em: Acta Neurochirurgica 159: 363-367, 2017.
10
Raabe A, Beck J, Gerlach R, Zimmermann M, Seifert V: Near-Infrared Indocyanine Green Video Angiography: A New Method For Intraoperative Assessment Of Vascular Flow. Publicado em: Neurosurgery 52(1):132-139, 2003.
11
Raabe A, Beck J, Seifert V: Technique and image quality of intraoperative indocyanine green angiography during aneurysm surgery using surgical microscope integrated near-infrared video technology. Publicado em: Zentralbl Neurochir 66(1):1–6, 2005.
12
Kamp MA, Slotty P, Turowski B, Etminan N, Steiger HJ, Hänggi D, Stummer W: Microscope-integrated quantitative analysis of intraoperative indocyanine green fluorescence angiography for blood flow assessment: first experience in 30 patients. Publicado em: Operative Neurosurgery 70(1 Suppl Operative): 65-73, 2012.
13
Mücke T, Reeps C, Wolff KD, et al.: Objective qualitative and quantitative assessment of blood flow with near-infrared angiography in microvascular anastomoses in the rat model. Publicado em: Microsurgery 33(4):287-96, 2013.
14
Ye X, Liu XJ, Ma L, et al.: Clinical values of intraoperative indocyanine green fluorescence video angiography with Flow 800 software in cerebrovascular surgery. Publicado em: Chinese Medical Journal 126(22): 4232-4237, 2013.
15
Holling M, Brokinkel B, Ewelt C, et al.: Dynamic ICG fluorescence provides better intraoperative understanding of arteriovenous fistulae. Publicado em: Operative Neurosurgery 73(Issue suool_1): 93-99, 2013.
16
Ng YP, King NK, Wan KR, et al.: Uses and limitations of indocyanine green videoangiography for flow analysis in arteriovenous malformation surgery. Publicado em: Journal of Clinical Neuroscience 20(2): 224-232, 2013.
17
Holzbach T, Artunian N, Spanholtz TA, et al.: Intraoperative Indocyaningrün-Fluoreszenzdiagnostik mittels Operationsmikroskop in der plastischen Chirurgie. Publicado em: Handchirurgie, Plastische Chirurgie, Ästhetische Chirurgie 44(2):84-8, 2012.
18
Mücke T, Fichter AM, Schmidt LH, et al.: Indocyanine green videoangiography-assisted prediction of flap necrosis in the rat epigastric flap using FLOW® 800 Tool. Publicado em: Microsurgery 37:235–242, 2017.
19
Mücke T, Wolff C, Fichter AM, et al.: Detection of thrombosis in microvessels with8 indocyanine green videoangiography. Publicado em: British Journal of Oral and Maxillofacial Surgery 56(8): 678-683, 2018.
20
Yamato T, Yamamoto N, Numahata T, et al.: Navigation Lymphatic Supermicrosurgery for the Treatment of Cancer-Related Peripheral Lymphedema. Publicado em: Vascular and Endovascular Surgery 48(2):139-143, 2014.
21
Höhne J, Schebesch KM, de Laurentis C, Akçakaya MO, Pedersen CB, Brawanski A, Poulsen FR, Kiris T, Cavallo C, Broggi M, Ferroli P, Acerbi F Fluorescein Sodium in the Surgical Treatment of Recurrent Glioblastoma Multiforme. World Neurosurg. 2019 May;125:E158-E164. Epub 22 de janeiro de 2019.
22
Imagem: craniotomia temporal esquerda para ressecção tumoral com YELLOW 560. Imagem cortesia de Dr. Peter Nakaji, Barrow Neurological Institute, Phoenix Arizona, EUA
Entre em contacto connosco!
Receba mais informações sobre o produto e a disponibilidade no seu país!
Utilize o agente fluorescente em conformidade com o estado de aprovação para a aplicação no seu país.
2
Stummer W, Pichlmeier U, Meinel T et al: Fluorescence-guided surgery for resection of malignant glioma: a randomized controlled multicentre phase III trial. Publicado em: Lancet Oncol 7: 392-401, 2006.
3
Esteves S, Alves M, Castel-Branco M, Stummer W: A Pilot Cost-Effectiveness Analysis of Treatments in Newly Diagnosed High-Grade Gliomas: The Example of 5-Aminoelvulinic Acid Compared With White-Light Surgery. Publicado em: Neurosurgery 76: 552–562, 2015.
4
Acerb Fi, Cavallo C, Schebesch KM, et al.: Fluorescein-Guided Resection of Intramedullary Spinal Cord Tumors: Results from a Preliminary, Multicentric, Retrospective Study. Publicado em: World Neurosurgery 108: 603-609, 2017.
5
Rey-Dios R, Cohen-Gadol AA: Technical principles and neurosurgical applications of fluorescein fluorescence using a microscope-integrated fluorescence module. Publicado em: Acta Neurochirurgica 155(4):701–706, 2013.
6
De Laurentis C, Höhne J, Cavallo C, et al.: The impact of fluorescein-guided technique in the surgical removal of CNS tumors in a pediatric population: results from a multicentric observational study. Publicado em: Journal of Neurosurgical Sciences 63(6): 679-687, 2019.
7
Acerbi F, Broggi M, Schebesch KM, et al. Fluorescein-guided surgery for resection of high-grade gliomas: A multicentric prospective phase II study (FLUOGLIO). Publicado em: Clinical Cancer Research 24(1): 52-61, 2018.
8
Schebesch KM, Proescholdt M, Höhne J, et al.: Sodium fluorescein-guided resection under the YELLOW 560 nm surgical microscope filter in malignant brain tumor surgery – a feasibility study. Publicado em: Acta Neurochirurgica 157(6): 899–904, 2015.
9
Höhne J, Hohenberger C, Proescholdt M, et al. Fluorescein sodium-guided resection of cerebral metastases-an update. Publicado em: Acta Neurochirurgica 159: 363-367, 2017.
10
Raabe A, Beck J, Gerlach R, Zimmermann M, Seifert V: Near-Infrared Indocyanine Green Video Angiography: A New Method For Intraoperative Assessment Of Vascular Flow. Publicado em: Neurosurgery 52(1):132-139, 2003.
11
Raabe A, Beck J, Seifert V: Technique and image quality of intraoperative indocyanine green angiography during aneurysm surgery using surgical microscope integrated near-infrared video technology. Publicado em: Zentralbl Neurochir 66(1):1–6, 2005.
12
Kamp MA, Slotty P, Turowski B, Etminan N, Steiger HJ, Hänggi D, Stummer W: Microscope-integrated quantitative analysis of intraoperative indocyanine green fluorescence angiography for blood flow assessment: first experience in 30 patients. Publicado em: Operative Neurosurgery 70(1 Suppl Operative): 65-73, 2012.
13
Mücke T, Reeps C, Wolff KD, et al.: Objective qualitative and quantitative assessment of blood flow with near-infrared angiography in microvascular anastomoses in the rat model. Publicado em: Microsurgery 33(4):287-96, 2013.
14
Ye X, Liu XJ, Ma L, et al.: Clinical values of intraoperative indocyanine green fluorescence video angiography with Flow 800 software in cerebrovascular surgery. Publicado em: Chinese Medical Journal 126(22): 4232-4237, 2013.
15
Holling M, Brokinkel B, Ewelt C, et al.: Dynamic ICG fluorescence provides better intraoperative understanding of arteriovenous fistulae. Publicado em: Operative Neurosurgery 73(Issue suool_1): 93-99, 2013.
16
Ng YP, King NK, Wan KR, et al.: Uses and limitations of indocyanine green videoangiography for flow analysis in arteriovenous malformation surgery. Publicado em: Journal of Clinical Neuroscience 20(2): 224-232, 2013.
17
Holzbach T, Artunian N, Spanholtz TA, et al.: Intraoperative Indocyaningrün-Fluoreszenzdiagnostik mittels Operationsmikroskop in der plastischen Chirurgie. Publicado em: Handchirurgie, Plastische Chirurgie, Ästhetische Chirurgie 44(2):84-8, 2012.
18
Mücke T, Fichter AM, Schmidt LH, et al.: Indocyanine green videoangiography-assisted prediction of flap necrosis in the rat epigastric flap using FLOW® 800 Tool. Publicado em: Microsurgery 37:235–242, 2017.
19
Mücke T, Wolff C, Fichter AM, et al.: Detection of thrombosis in microvessels with8 indocyanine green videoangiography. Publicado em: British Journal of Oral and Maxillofacial Surgery 56(8): 678-683, 2018.
20
Yamato T, Yamamoto N, Numahata T, et al.: Navigation Lymphatic Supermicrosurgery for the Treatment of Cancer-Related Peripheral Lymphedema. Publicado em: Vascular and Endovascular Surgery 48(2):139-143, 2014.
21
Höhne J, Schebesch KM, de Laurentis C, Akçakaya MO, Pedersen CB, Brawanski A, Poulsen FR, Kiris T, Cavallo C, Broggi M, Ferroli P, Acerbi F Fluorescein Sodium in the Surgical Treatment of Recurrent Glioblastoma Multiforme. World Neurosurg. 2019 May;125:E158-E164. Epub 22 de janeiro de 2019.
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Imagem: craniotomia temporal esquerda para ressecção tumoral com YELLOW 560. Imagem cortesia de Dr. Peter Nakaji, Barrow Neurological Institute, Phoenix Arizona, EUA
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