Histology Research

ZEISS provides a wide range of microscopy solutions tailored for histology, including:

• Light Microscopes: For routine histological analysis, such as ZEISS Axioscope and ZEISS Primostar.
• Digital Microscopes: For documentation and sharing, like ZEISS Smart Microscopy systems.
• Confocal Microscopes: For high-resolution imaging of tissue sections, such as ZEISS LSM 990.
• Slide Scanners: For digitizing histological slides, like the Axioscan 7.
  

Yes, ZEISS microscopes are compatible with all standard histological stains, including:

• Hematoxylin and eosin (H&E)
• Periodic acid-Schiff (PAS)
• Immunohistochemical (IHC) stains
• Fluorescent dyes for advanced imaging

ZEISS systems are optimized to provide accurate color reproduction and fluorescence imaging, ensuring reliable results.

Here are the main fluorescence-imaging options ZEISS offers for histology and histopathology, covering everything from routine IHC to advanced multiplex and 3-D tissue analysis:

• Upright Research Microscopes: ZEISS upright research microscopes, such as the Axio Imager series, deliver exceptional optical performance, modularity, and advanced imaging capabilities, making them ideal for demanding applications in life sciences, materials research, and histology.
• Inverted Microscopes: ZEISS inverted microscopes, like the Axio Observer series, are designed for advanced live-cell imaging and materials research, offering superior stability, flexibility, and high-resolution imaging for dynamic and long-term studies.
• Digital Slide Scanning: Systems like the Axioscan 7 provide automated fluorescence whole-slide imaging with multiple filter channels, autofocus, and high-throughput scanning—perfect for multiplex IHC and digital pathology workflows.
• Laser Scanning & Super-Resolution Microscopy: Use a focused laser beam to scan samples point by point. The ability of confocal microscopy to eliminate out-of-focus light by employing a pinhole aperture results in excellent optical sections with high contrast and enables the high-resolution reconstruction of three-dimensional structures.
• Lightsheet Microscopy: Systems like the Lightsheet 7 can enable fluorescence imaging of cleared whole organs or large tissue blocks with minimal photodamage, capturing intact 3D histological context.
• Correlative & Volume Electron Microscopy: Combine fluorescence (widefield or confocal) with ZEISS GeminiSEM or Volutome for precise correlation of fluorescent markers to ultrastructure.

Yes, ZEISS offers customizable solutions, including:

• Modular microscope configurations.
• Specialized objectives and filters for unique imaging needs.
• Tailored software workflows.
  
• Personalized microscopy application services where we do the research for you.

ZEISS provides a full suite of software designed to support every stage of histology and histopathology workflows—from image capture to analysis, data management, and cloud collaboration. Here are the key offerings and how they help:

• ZEISS arivis Software suite: Advanced image analysis and large-data management for 2D, 3D, and 4D datasets.
• ZEISS ZEN: Core acquisition and analysis platform that streamlines multi-channel tissue imaging and quantitative assessment of stains or biomarkers with reproducible workflows.