INTRAGO-I: Dosiseskalationsstudie für die intraoperative Strahlentherapie (IORT) bei Glioblastoma multiforme (GBM)
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Dieser kurze Überblick ersetzt nicht die Lektüre der gesamten Studie, sondern gewährt lediglich einen gekürzten Einblick, und spiegelt nicht zwingend die Meinung der benannten Stellen und/oder Zulassungsbehörden (z. B. DQS oder FDA) wider.
Kurzer Überblick über die INTRAGO-I Dosiseskalationsstudie von Dr. Frank A. Giordano im Auftrag von ZEISS, März 2019.
Originaltitel:
INTRAGO: intraoperative radiotherapy in glioblastoma multiforme – a Phase I/II dose escalation study
Autoren:
Frank A. Giordano, Stefanie Brehmer, Yasser Abo-Madyan, Grit Welzel, Elena Sperk, Anke Keller,
Frank Schneider, Sven Clausen, Carsten Herskind, Peter Schmiedek, Frederik Wenz
Quelle:
Giordano, F. A., Brehmer, S., Abo-Madyan, Y., Welzel, G., Sperk, E., Keller, A., … Wenz, F. (2014).
INTRAGO: intraoperative radiotherapy in glioblastoma multiforme – a Phase I/II dose escalation study.
BMC Cancer, 14(1), 992.
- Glioblastoma multiforme (GBM) ist der häufigste maligne Hirntumor bei Erwachsenen. Bei nahezu allen GBM ist das Rezidivrisiko direkt im Tumorbett am höchsten.
- Nach dem Standard-Behandlungsprotokoll für primäre GBM liegen das mediane lokale progressionsfreie Überleben bei 7 Monaten und das durchschnittliche Gesamtüberleben bei etwa 15 Monaten.
- In der Phase-I/II-Dosiseskalationsstudie INTRAGO für neu diagnostizierte GBM wird erstmals die Ergänzung der standardmäßigen Radiochemotherapie um die intraoperative Strahlentherapie (IORT) mit INTRABEAM® der Carl Zeiss Meditec AG untersucht.
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