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Advanced Microscopy Solutions

Biotech & Pharma Microscopy

Our microscopy solutions push the boundaries of biotech, pharma, and industrial research by enabling high-resolution microscopy for druggable target identification, automated high-content screening for hit-to-lead selection and AI-driven imaging workflows.

From 3D-cellular imaging to tissue analysis for pre-clinical studies, our devices deliver the precision, scalability, and automation needed to drive regulatory-compliant drug discovery workflows.

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Imaging innovations for drug discovery

See more, discover faster: advance your discovery with our excellence

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Target Identification
Lead Screening
Preclinical
AI in Imaging

Novel Approaches to Measure Receptor-Mediated Endocytosis of Herceptin

In this case study, we sought to develop a proof-of-concept assay that could quantify Herceptin plasma-membrane binding, internalization, and trafficking to late endosomes.
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3D Multiplexing Spatial Omics Workflows in Neuroscience

This case study provides a blueprint for the analysis of 3D spatial omics multiplexing datasets from a CODEX multiplex antibody panel imaged with a custom set-up using the Akoya Phenocycler and ZEISS LSM 980 confocal microscope to explore the expression of an extensive list of pre-synaptic markers in the mouse brain.
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From Image to Results | Organoid Analysis

This case study showcases a simple imaging experiment performed on intestinal organoids treated with and without a Wnt-inhibiting drug, with the experimental goal to study the role of Wnt signaling in organoid formation.​
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High Content Imaging for Genotoxicity

In this series "From Image to Results", explore various case studies explaining how to reach results from your demanding samples and acquired images in an efficient way. For each case study, we highlight different samples, imaging systems, and research questions.
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Analyzing Influenza A Virus Entry Through Lattice Light Sheet Microscopy

A research group led by Prof. Allen Liu at the University of Michigan, USA, used ZEISS Lattice Lightsheet 7 to study cellular entry mechanisms of this virus. They focused on the membrane-bending protein epsin. Their findings support the hypothesis that epsin plays a biomechanical role in IAV entry.
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Brain Tumor Microenvironment Spatial Biology with High-Throughput Hyperplexed Imaging

This article investigates how the brain tumor microenvironment responds to radiotherapy, not just in terms of changes in different cell populations, but also regarding how the cells spatially organize themselves. In order to do this, the team worked to create a new multiplex workflow, called Hyperplexed Immunofluorescence Imaging (HIFI), to study the spatial biology of tumors before and after treatment.
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AI-Driven Image Analysis for Organoid Research and Analysis

Our innovative algorithms support your organoid research. From visualization to automated analysis and subcellular segmentation, we’ve got you covered. AI models help take your organoid analysis to new levels.
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Image Analysis Made Easy with ZEISS arivis

Discover how AI-powered tools in ZEISS arivis simplify microscopy image analysis. Handle large multidimensional datasets with ease.

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Why pharma leaders choose ZEISS

ZEISS high-resolution imaging solutions drive innovation in drug discovery. By leveraging superior optics, intuitive software and automation capabilities, we can help keep your labs running smoothly. Scientists and technicians around the world have used our imaging solutions to explore protein targets, track antibody trafficking, measure intracellular dynamics, screen for lead compounds in multi-well plates in 2D cells and 3D complex invitro models, conduct toxicity studies, and secure spatial-omics data among others. With flexible financing options, expert application and service support, and robust microscopes, we ensure you'll meet your current and future research needs.

  • Empowering the top 30 pharma companies worldwide

  • Years of experience. Your trusted partner in scientific advancement & drug discovery

  • Publications in the past decade. Powering life science discoveries one research publication at a time

Featured imaging solutions for BioPharma

  • Your solution for advanced image analysis and visualization

    ZEISS arivis Software

    Create seamless analysis pipelines with just a few clicks. Effortlessly process massive datasets on compatible workstations. “Walk into your sample” using our VR toolkit for a new perspective.

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    Product features

    • Flexible, End-to-End Image Analysis Pipelines
    • Advanced 3D Analysis
    • Boost your research with AI with no coding
    Explore arivis Software

  • High-performance slide scanner for fluorescence, brightfield and polarization

    ZEISS Axioscan 7

    ZEISS Axioscan 7 combines qualities that you would not expect to get in a slide scanner: high speed digitization and outstanding image quality plus an unrivaled variety of imaging modes are all available in a fully automated and easy to operate system.

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    Product features

    • Multiple imaging modalities, including brightfield, fluorescence, and phase contrast imaging.
    • Can scan up to 1,000 slides in a single run, significantly enhancing throughput for large-scale studies.
    • Sophisticated filter concept for demanding fluorescence imaging.
    Explore the Axioscan 7

  • Your compact confocal microscope for innovative imaging and smart analysis

    ZEISS LSM 910

    ZEISS LSM 910 combines high-quality confocal imaging with innovative possibilities for your next research endeavors. Gain more information with gentle super-resolution imaging or study the dynamics of life in 3D at impressively high speed.

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    Product features

    • Integrate conventional confocal with super-resolution and high-speed 4D imaging
    • Interactively discover new approaches for your experiments
    • AI-assisted features simplify your experimental setup
    Explore the LSM 910

  • Top-class multimodal imaging combined in one confocal system

    ZEISS LSM 990

    ZEISS LSM 990 combines an unprecedented range of imaging options to help you explore new research dimensions. Delve into your biological research with 90 nm super-resolution, high-speed volumetric imaging, or the separation of 10 fluorescent labels simultaneously.

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    Product features

    • A wealth of possibilities for your research
    • Fluorescence imaging as colorful as life itself
    • Unique insights into molecular dynamics and protein interactions
    Explore the LSM 990

  • Your smart microscope for cell culture and research

    ZEISS Axiovert 5

    Axiovert 5 brings smart microscopy into your cell culture lab. All you need to do is focus on your samples and workflow. Use all standard contrasting techniques in transmitted light and combine them with multichannel fluorescence.

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    Product features

    • Be smart. Simply focus and snap to get excellent images.
    • Stay flexible. Use all standard contrasting techniques.
    • Relax. Clever features make your work easier.
    Explore the Axiovert 5

  • Expertise that maximizes your results

    Microscopy Applications Services

    From experiment design to workflow optimizaiton, ZEISS Applications Services empower you to get the most out of your solutions with tailored and expert guidance. 

    Microscopy applications services

    Product features

    • Experiment Design Support
    • Workflow Optimization
    • Training and Knowledge Transfer
    • Technical Troubleshooting
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  • NEW!

    ZEISS Spatial Biology Solutions

    Turn complexity into clarity and enhance your research capabilities. ZEISS solutions for spatial biology facilitate the seamless integration of spatial profiling into your workflows, ensuring efficient and consistent multiplexed spatial profiling at scale. We accelerate research to better insights and transform the understanding of cellular systems to revolutionize pathology.

  • From Complexity to Clarity: Workflow Automation at Scale

    With our ZEISS Spatial Biology offering, we simplify high-throughput multiplex IF imaging and analysis making it robust, scalable, and accessible. Our seamless tissue multiplexing workflow aims to empower routine histopathology labs, including those with no prior spatial biology expertise, to generate comprehensive, reproducible biomarker data across large sample cohorts.​ By combining automation, optimized imaging, and AI-powered analysis, we pave the way for the translational adoption of spatial proteomics and the transition to clinical practice.​

Configure your Axioscan 7 for Spatial Biology

Workflow automation for spatial biology at scale

The new Axioscan 7 Spatial Biology Configuration is designed to maximize efficiency, accuracy, and reproducibility for multiplex immunofluorescence (mIF) and high-throughput spatial biology workflows.

Configure your Axioscan 7 for Spatial Biology
ZEISS Microscopy Solutions Center - Grand Opening @ CIC Philadelphia

Incubators & start-up ecosystem

We are committed to empowering emerging biotech companies through our New Biotech Startup Program, partnering with leading incubators like Lab Central, BioLabs, JLabs, and CIC. We provide flexible imaging solutions, expert guidance, and scalable financing options to help startups drive innovation, generate high-quality data, and accelerate their path to discovery.

  • ZEISS arivis software has allowed us to extract crucial insights from our high-content imaging experiments, leading to better-informed decisions in drug discovery and development.

    Marta da Silva, PhD Senior Scientist, Charles River Laboratories

  • The applications and service team provides exceptional support, ensuring all my requests are handled promptly with a positive attitude. Their level of service makes me feel like I’m their only customer, which is truly outstanding.

    Customer Associate Manager, Asset Management @ Pharma Company

  • At Ultivue, we have successfully scanned thousands of tissue sections stained with our multiplex assays with the ZEISS Axioscan to serve our biopharma customers.

    Customer Ultivue, Inc.

  • A key bottleneck in any spatial biology project is whole-slide tissue scanning, which can lead to unplanned reviews and repeat imaging, making it difficult to predict delivery timelines and associated costs. ZEISS is addressing this challenge with an efficient and reproducible automated workflow that truly benefits CROs offering this service.

    Christopher Mills Senior Scientist, Concept Life Sciences (CRO in United Kingdom)

Drug discovery phases & microscopy

Focus your microscope for specific areas of research

Unlock disease biology

With high-resolution microscopy for drug target discovery

✔ Super-resolution imaging for identifying druggable targets & protein interactions

✔ Live-cell imaging for CRISPR screening & gene editing research


✔ AI-powered segmentation for predictive drug response modeling

Streamline lead optimization

With AI-powered microscopy workflows for drug efficacy testing and in vitro toxicity screening

✔ High-content screening (HCS) with automated AI-driven microscopy


✔ Live-cell imaging for pharmacokinetics (PK) & dose-response modeling

✔ Automated imaging workflows for drug screening scalability

Bridge the gap between discovery and clinical application

With GLP-compliant whole-slide imaging for histopathology, multi-modal imaging for drug safety pharmacology, and imaging for toxicology studies

✔ AI-driven image analysis for spatial-omics & immuno-oncology


✔ Reproducible and easy to use imaging solutions for CROs


✔ Go from samples to finished reports

Biopharma insights hub

Discover tailored applications

Explore applications and discover tailored solutions for you industry needs.

Explore applications & insights
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We look forward to your inquiry - please let us know what we can help you with and we'll get back to you as soon as possible.

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