Reading this brief overview does not substitute the reading of the original study, but is just giving an abridged insight and is not necessarily reflecting the opinion of notified bodies and/or regulatory authorities, such as the DQS or FDA.

A brief overview about long-term outcomes of spinal metastases patients treated with Kypho-IORT created by Frederic Bludau, MD, on behalf of ZEISS, January 2021.

Long-term outcome after combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) for vertebral tumors.

Frederic Bludau, Laura Winter, Grit Welzel, Udo Obertacke, Frank Schneider, Frederik Wenz, Arne Mathias Ruder and Frank A. Giordano

Bludau, F., et al. (2020). Long-term outcome after combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) for vertebral tumors. Radiat Oncol 15, 263. https://doi.org/10.1186/s13014-020-01715-z

• Bone metastases in patients with systemic cancer frequently manifest in the spine. The median overall survival of patients with bone metastases is only 7-9 months¹ while some of these patients (with primary entities responsive to systemic treatment) can survive more than a decade.
• In order to instantly stabilize and sterilize the affected vertebral bodies, combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) provides a promising local treatment option as alternative to the external beam radiotherapy (EBRT) as standard-of-care.
• In this long-term outcome assessment, the currently largest existing patient cohort of 104 patients treated with Kypho-IORT between 2009 and 2019 are evaluated. The patients received Kypho-IORT using a needle applicator directly within the affected vertebral bodies of the thoracic, lumbar or sacral spine either as part of [...]

¹ ClinicalTrials.gov Identifier: NCT01280032