Besides the immediate effect IORT has on the tumor bed environment, clinical results also prove that a one-shot IORT treatment can replace up to 15-30 fractions of conventional EBRT treatments for 80% of patients1 if given as a boost, speeding up the overall radiotherapy treatment for care-givers and patients. This is not only greatly reducing the number of necessary hospital visits during the treatment course but also more convenient for patients. IORT results in less radiation scattering to organs at risk and causes less radiation-induced side effects the patient can feel compared to EBRT, e.g. less moderate to severe pain and better cosmetic outcomes, as proven by objective assessments over time and patient self-reported data.1,5,8,9,10 Thus, for most patients and especially for risk populations, e.g. patients with cardiac diseases or smokers, IORT is a safer breast cancer treatment option compared to the standard of care.6,7,9,16