![細胞診・細胞病理学向け顕微鏡ソリューション 細胞診・細胞病理学向け顕微鏡ソリューション]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/brightfield_cytological-smear_axio-imager.jpg/_jcr_content/renditions/original.image_file.100.100.0,0,1031,1031.file/brightfield_cytological-smear_axio-imager.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/brightfield_cytological-smear_axio-imager.jpg/_jcr_content/renditions/original.image_file.360.360.0,0,1031,1031.file/brightfield_cytological-smear_axio-imager.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/brightfield_cytological-smear_axio-imager.jpg/_jcr_content/renditions/original.image_file.768.768.0,0,1031,1031.file/brightfield_cytological-smear_axio-imager.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/brightfield_cytological-smear_axio-imager.jpg/_jcr_content/renditions/original.image_file.1024.1024.0,0,1031,1031.file/brightfield_cytological-smear_axio-imager.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/brightfield_cytological-smear_axio-imager.jpg/_jcr_content/renditions/original.image_file.1031.1031.0,0,1031,1031.file/brightfield_cytological-smear_axio-imager.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/brightfield_cytological-smear_axio-imager.jpg/_jcr_content/renditions/original.image_file.1031.1031.0,0,1031,1031.file/brightfield_cytological-smear_axio-imager.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/brightfield_cytological-smear_axio-imager.jpg/_jcr_content/renditions/original.image_file.1031.1031.0,0,1031,1031.file/brightfield_cytological-smear_axio-imager.jpg"})
ラボの顕微鏡アプリケーション
細胞診・細胞病理学向け顕微鏡ソリューション
細胞レベルで疾患を発見
細胞病理学や細胞診では、単一細胞や細胞構造を調べることで、細胞レベルで疾患を発見します。これは、「パップテスト」の開発者でもあるギリシャの医師ジョージ・パパニコロウによって1928年に確立された病理学の一分野です。現在の細胞病理学では塗抹検査が広く用いられています。体の様々な箇所から採取した臨床検体をスライドグラスの上に広げ、薄層になった細胞を染色して光学顕微鏡で観察します。
よく知られている剥離細胞診として、子宮頸部の細胞をへらでこすり取る前述のパップテストや、血液、尿、胸水、心膜液、腹水などの体液から細胞を集める検査などがあります。侵襲的な穿刺吸引細胞診(FNAC)では、病理学者は細い針を使って様々な臓器から細胞を集め、婦人科領域、リンパ節、甲状腺、乳腺、肝臓、肺、腎臓、膵臓の細胞診を行います。このような細胞診によるスクリーニングの多くは、過形成や異形成と呼ばれ、がん細胞に変化する可能性のある細胞を見つけるために用いられます。
細胞診・細胞病理学向け顕微鏡ソリューション
顕微鏡の要件
細胞診によるがんやがん細胞の診断では、細胞を明確に区別し、核の詳細を明瞭に観察することが必須です。そのため、細胞学者は、明視野、位相差、DIC、蛍光で優れた色再現性を持って試料を観察するための、鮮明な画像を必要とします。パパニコロウ染色、ギムザ染色、ロマノフスキー染色は試料の透明度が高くなり、細胞の特徴を具体的に染色できる一方で、患者検体のスクリーニングに多大な影響を与えるのは、顕微鏡の光学的品質、付属カメラによるデジタルドキュメンテーションの正確さ、人間工学に基づく機器の設計です。
アプリケーション例
![肺 肺]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm.jpg/_jcr_content/renditions/original.image_file.100.75.0,12,712,546.file/lung_lcm.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm.jpg/_jcr_content/renditions/original.image_file.360.270.0,12,712,546.file/lung_lcm.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm.jpg/_jcr_content/renditions/original.image_file.712.534.0,12,712,546.file/lung_lcm.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm.jpg/_jcr_content/renditions/original.image_file.712.534.0,12,712,546.file/lung_lcm.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm.jpg/_jcr_content/renditions/original.image_file.712.534.0,12,712,546.file/lung_lcm.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm.jpg/_jcr_content/renditions/original.image_file.712.534.0,12,712,546.file/lung_lcm.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm.jpg/_jcr_content/renditions/original.image_file.712.534.0,12,712,546.file/lung_lcm.jpg"})
関心領域がマークされています。
![肺、明視野 肺、明視野]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm_1.jpg/_jcr_content/renditions/original.image_file.100.75.61,0,868,605.file/lung_lcm_1.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm_1.jpg/_jcr_content/renditions/original.image_file.360.270.61,0,868,605.file/lung_lcm_1.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm_1.jpg/_jcr_content/renditions/original.image_file.768.576.61,0,868,605.file/lung_lcm_1.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm_1.jpg/_jcr_content/renditions/original.image_file.807.605.61,0,868,605.file/lung_lcm_1.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm_1.jpg/_jcr_content/renditions/original.image_file.807.605.61,0,868,605.file/lung_lcm_1.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm_1.jpg/_jcr_content/renditions/original.image_file.807.605.61,0,868,605.file/lung_lcm_1.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/lung_lcm_1.jpg/_jcr_content/renditions/original.image_file.807.605.61,0,868,605.file/lung_lcm_1.jpg"})
ご提供:Brockhoff working group, Institute of Pathology, University of Regensburg, Germany
![HER2セントロメア、蛍光 HER2セントロメア、蛍光]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/fluorescence_her2-centromere_axiocam-mrm_2.jpg/_jcr_content/renditions/original.image_file.100.75.0,54,406,359.file/fluorescence_her2-centromere_axiocam-mrm_2.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/fluorescence_her2-centromere_axiocam-mrm_2.jpg/_jcr_content/renditions/original.image_file.360.270.0,54,406,359.file/fluorescence_her2-centromere_axiocam-mrm_2.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/fluorescence_her2-centromere_axiocam-mrm_2.jpg/_jcr_content/renditions/original.image_file.406.305.0,54,406,359.file/fluorescence_her2-centromere_axiocam-mrm_2.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/fluorescence_her2-centromere_axiocam-mrm_2.jpg/_jcr_content/renditions/original.image_file.406.305.0,54,406,359.file/fluorescence_her2-centromere_axiocam-mrm_2.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/fluorescence_her2-centromere_axiocam-mrm_2.jpg/_jcr_content/renditions/original.image_file.406.305.0,54,406,359.file/fluorescence_her2-centromere_axiocam-mrm_2.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/fluorescence_her2-centromere_axiocam-mrm_2.jpg/_jcr_content/renditions/original.image_file.406.305.0,54,406,359.file/fluorescence_her2-centromere_axiocam-mrm_2.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/fluorescence_her2-centromere_axiocam-mrm_2.jpg/_jcr_content/renditions/original.image_file.406.305.0,54,406,359.file/fluorescence_her2-centromere_axiocam-mrm_2.jpg"})
![肺の細胞診 肺の細胞診]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/histology-lung_lcm.jpg/_jcr_content/renditions/original.image_file.100.75.31,0,516,364.file/histology-lung_lcm.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/histology-lung_lcm.jpg/_jcr_content/renditions/original.image_file.360.270.31,0,516,364.file/histology-lung_lcm.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/histology-lung_lcm.jpg/_jcr_content/renditions/original.image_file.485.364.31,0,516,364.file/histology-lung_lcm.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/histology-lung_lcm.jpg/_jcr_content/renditions/original.image_file.485.364.31,0,516,364.file/histology-lung_lcm.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/histology-lung_lcm.jpg/_jcr_content/renditions/original.image_file.485.364.31,0,516,364.file/histology-lung_lcm.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/histology-lung_lcm.jpg/_jcr_content/renditions/original.image_file.485.364.31,0,516,364.file/histology-lung_lcm.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/laboratory-and-routine/clinical-laboratory/cytology/histology-lung_lcm.jpg/_jcr_content/renditions/original.image_file.485.364.31,0,516,364.file/histology-lung_lcm.jpg"})