Structures in the Eye in Health and Disease

Changes in the porosity and architecture of tissues in the eye can change due to age and disease restricting fluid flow and causing a build up of intraocular pressure that can result in vision loss. We have characterised these changes in the trabecular meshwork of donor human eyes with or without glaucoma using the Versa 620. We are evaluating a tissue engineering approach to treat this disease using electrospun fibrous scaffolds that aim to mimic the tissue structure.

Key Learnings:

• Non-destructive imaging of the eye using X-ray microscopy is a useful way to study disease conditions such as glaucoma.
• Tissue engineering is providing promising new approaches for the treatment of eye diseases
• Structure and efficacy of electrospun fibrous scaffolds for the treatment of diseases can be assessed using X-ray tomography