Crystallographic Structure of Powder Beds from X-ray Microscopy
Researchers successfully use LabDCT to study 3D crystallographic information.
The vast majority of pharmaceutical formulations involve polycrystalline materials in some form. The interactions between different crystals can be important for the behavior of the formulation and necessary to assess manufacturability and performance. Surprisingly, there is an absence of methods and techniques for 3D crystallographic information for organic materials and a clear need for techniques that provide non-destructive granular information of organic materials in powders.
Dr. Parmesh Gajjar, a research associate at the University of Manchester, United Kingdom, recently published how he used the ZEISS Xradia Versa X-ray microscope with LabDCT to investigate crystalline powder bed structure.
These results have significance for the pharmaceutical industry and, more broadly, fine chemical industries, where a firm knowledge of the chemical basis behind powder bed structuring is of utmost importance for manufacturing and performance.