Pharma employee in the laboratory transferring liquid with a pipette
OEM Applications

Pharma & Healthcare

  • HPLC
  • Pharmaceutical production
  • Healthcare

Servicing the growing HPLC market HPLC

The market for high pressure liquid chromatography (HPLC) is driven by the need for effective drug development, clinical research, food safety and environmental analytics. HPLC enables the separation, identification, quantification and purification of compounds via UV-VIS absorption spectroscopy and high-performance detectors. High sensitivity and low noise must be balanced with affordable prices.

Striving for more efficiency Pharmaceutical production

Precise and reliable metrology tools are required at every stage of pharmaceutical manufacturing – from the inspection and identification of raw materials to development and formulation, where exact concentrations of ingredients are quantified. It is critical to ensure that both the manufacturing process and the end product meet regulatory specifications and governmental guidelines.

Fast and flexile diagnostic instrumentation Healthcare

Strict requirements must be met in healthcare, clinical and life sciences instrumentation. Growing demand for real-time, miniaturized, non-destructive and affordable solutions drives innovation in diagnostic tools. Effective fiber-optic UV-NIR spectroscopy is needed for various medical and biomedical applications – from co-oximetry, capillary electrophoresis, spectral flow cytometry to endoscopy.


Quality Control Laboratory medicine. High Pressure Liquid Chromatography operation. A woman makes an analysis on a gas chromatograph.

High pressure liquid chromatography

HPLC (high pressure liquid chromatography) is one of the standard analytical techniques used to separate mixed compounds in biochemistry, analytical chemistry, drug manufacturing and research. ZEISS offers plane gratings and mono- & polychromator gratings for all standard detection techniques and also provides rotating gratings (VWD) and spectrometers usable as multiple wavelength Diode-Array-Detectors (DAD). ZEISS gratings supporting HPLC applications with the lowest levels of stray light and high efficiency to enhance the dynamic range of the  instruments.
The UV/VIS DAD range includes cost-effective
MMS UV-VIS (190 - 720 nm), high-performance MCS PDA and CGS PDA (190 - 1015 nm) spectrometers. The optical design and integrated sensor arrays are optimized for the highest sensitivity (signal/noise), high wavelength accuracy, stable wavelength calibration and the lowest levels of stray light < 0.1 %.

Pharmaceutical production

Pharmaceutical researcher doing dissolution testing

Dissolution testing

Drug dissolution testing is used by the pharmaceutical industry to guide formulation and control product quality. A solution of the dosage form (tablet, capsule etc.) is made and the rate of in vitro drug release is monitored over time giving information about batch-to batch consistency of the manufacturing process and (in limited cases) in vivo drug release profiles. ZEISS spectrophotometers like the MMS UV-VIS series are an excellent choice to monitor dissolution baths. The design combines maximum throughput with good resolution as well as long-term stable wavelength calibration and minimum stray light in the sensor for precise analytical results.

Factory of the pharmaceutical industry, pills on the conveyor belt

Process analytical technology

US FDA process analytical technology (PAT) is guidance to optimize and control pharmaceutical & food manufacturing through standardized quality control and the documentation of critical variables during production (at-line, on-line and in-line). NIR spectroscopy provides an invaluable tool in achieving compliance with the PAT framework, especially for in-line processes and incoming goods inspection. NIR spectrometers like the PGS series deliver real-time data as probes can easily be mounted within process streams and NIR instruments measure through packaging such as glass vials and the blister packs of plastic bags.  MCS CCD  spectrometers can be used to control the cleaning process between production batches, whereas  MMS UV and MMS UV-VIS spectrophotometers cover PAT guidance for waste water treatment by the non-destructive monitoring of waste water constituents from ongoing production (see industrial waste water).


Technician holding blood tube test in the research laboratory / doctor hand taking a blood sample tube from a rack with machines of analysis in the lab background

Blood analysis

Optical spectroscopy is utilized for various ways of blood analysis. Via pulse oximetry, the arterial oxygen saturation is determined non-invasively and in real-time by measuring the light absorption around 660 and 940 nm during the transillumination of the fingertip skin. Spectrometers like the MMS 1 NIR enhanced are ideal suited for the qualification and validation of pulse oximeters. Pulse oximeters performing a more advanced blood gas analysis are known als co-oximeters. The latter can distinguish binding of carbon monoxide to hemoglobin from oxygen by analyzing absorption spectra at a series of wavelengths. ZEISS CGS (190 - 1015 nm) compact spectrometer with minimum temperature drift, low stray light and high throughput is the ideal product of choice  here.
Polychromator gratings support our customer's specific spectrometer designs with tailored wavelength ranges and the lowest levels of stray light combined with aberration correction.

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