Pharma & Healthcare
High pressure liquid chromatography
HPLC (high pressure liquid chromatography) is one of the standard analytical techniques used to separate mixed compounds in biochemistry, analytical chemistry, drug manufacturing and research. ZEISS offers plane gratings and mono- & polychromator gratings for all standard detection techniques and also provides rotating gratings (VWD) and spectrometers usable as multiple wavelength Diode-Array-Detectors (DAD). ZEISS gratings supporting HPLC applications with the lowest levels of stray light and high efficiency to enhance the dynamic range of the instruments.
The UV/VIS DAD range includes cost-effective MMS UV-VIS (190 - 720 nm), high-performance MCS PDA and CGS PDA (190 - 1015 nm) spectrometers. The optical design and integrated sensor arrays are optimized for the highest sensitivity (signal/noise), high wavelength accuracy, stable wavelength calibration and the lowest levels of stray light < 0.1 %.
Drug dissolution testing is used by the pharmaceutical industry to guide formulation and control product quality. A solution of the dosage form (tablet, capsule etc.) is made and the rate of in vitro drug release is monitored over time giving information about batch-to batch consistency of the manufacturing process and (in limited cases) in vivo drug release profiles. ZEISS spectrophotometers like the MMS UV-VIS series are an excellent choice to monitor dissolution baths. The design combines maximum throughput with good resolution as well as long-term stable wavelength calibration and minimum stray light in the sensor for precise analytical results.
Process analytical technology
US FDA process analytical technology (PAT) is guidance to optimize and control pharmaceutical & food manufacturing through standardized quality control and the documentation of critical variables during production (at-line, on-line and in-line). NIR spectroscopy provides an invaluable tool in achieving compliance with the PAT framework, especially for in-line processes and incoming goods inspection. NIR spectrometers like the PGS series deliver real-time data as probes can easily be mounted within process streams and NIR instruments measure through packaging such as glass vials and the blister packs of plastic bags. MCS CCD spectrometers can be used to control the cleaning process between production batches, whereas MMS UV and MMS UV-VIS spectrophotometers cover PAT guidance for waste water treatment by the non-destructive monitoring of waste water constituents from ongoing production (see industrial waste water).
Optical spectroscopy is utilized for various ways of blood analysis. Via pulse oximetry, the arterial oxygen saturation is determined non-invasively and in real-time by measuring the light absorption around 660 and 940 nm during the transillumination of the fingertip skin. Spectrometers like the MMS 1 NIR enhanced are ideal suited for the qualification and validation of pulse oximeters. Pulse oximeters performing a more advanced blood gas analysis are known als co-oximeters. The latter can distinguish binding of carbon monoxide to hemoglobin from oxygen by analyzing absorption spectra at a series of wavelengths. ZEISS CGS (190 - 1015 nm) compact spectrometer with minimum temperature drift, low stray light and high throughput is the ideal product of choice here.
Polychromator gratings support our customer's specific spectrometer designs with tailored wavelength ranges and the lowest levels of stray light combined with aberration correction.