
ZEISS Celldiscoverer 7
Your Automated Microscope for Live Cell Imaging
Combine the ease of use of an automated microscope with the image quality and flexibility of a research microscope. Whether working with 2D or 3D cell cultures, tissue or small model organisms, you will acquire better data in shorter times with this automated live cell imaging platform. Add LSM 900 with Airyscan 2 to gently image dynamic processes with highest framerates in superresolution.

A Flexible Platform
For Demanding Applications
The fully integrated high-end imaging system comes with various incubation and detection options so you can tailor it to your applications. Go for fast, sensitive cameras when performing demanding live cell experiments and rapid time-lapse recordings. To get better data from your 3D samples, simply add LSM 900 with Airyscan 2 for confocal super-resolution imaging, or fast GPU-based deconvolution.
Top Quality Data
From Living Samples
For long-term, time-lapse imaging, Celldiscoverer 7 gives you the advantage of Autoimmersion and a focus that is kept automatically after detecting the thickness and optical properties of the sample carrier. Autocorr objectives correct spherical aberrations to deliver crisp contrast and high resolution. Integrated incubation options keep your cells happy to deliver unbiased data.

Reproducible Results
Made Easy
As soon as you start imaging, automatic calibration routines take over to ensure reproducible results. Check the current status and follow progress of your experiments on the touchscreen. With barcode recognition you can identify your sample, sample carrier and even the type of experiment. If you don’t work with barcodes, an automatic preview scan will identify the sample carrier and calibrate it.
ZEISS Celldiscoverer 7 Product Family
ZEISS Celldiscoverer 7 Technology Insights
A Wealth of Options to Automate Your Live Cell Imaging
Automatic Adaptation to Your Samples and Sample Carriers
Live cell imaging requires objectives with high numerical apertures. Those objectives will only deliver high contrast and sensitivity if their optics can adapt to variations in bottom thickness or to the material of different sample carriers. You are free to use Petri dishes, chamber slides, multi-well plates, plastic or glass, thin or thick vessel bottoms, low-skirt or high-skirt plates. Automatic sample recognition detects all relevant vessel features while loading your sample. Autocorr adjusts the correction ring of the objective to compensate for spherical aberrations.

ZEISS Celldiscoverer 7 water immersion objective
Autoimmersion: There Is No Life Without Water
In life sciences, cell biology or screening applications, your samples mostly consist of water and / or will be mounted in aqueous solutions. Celldiscoverer 7 combines an outstanding 50x water immersion objective with rapid automated immersion supply and removal. An elastic silicon membrane simultaneously seals the sample chamber to avoid unnecessary airflow while protecting the system from potential liquid spillage. You can perform unbiased live cell experiments at 37 °C over several days or carry out extensive scanning processes on multi-well plates.

Find Focus – Keep Focus
Use the hardware-based Find Focus function to automatically focus your sample and find your region of interest quickly with just a single click. Select Definite Focus to maintain the focal position throughout your live cell experiment, whether it takes a few seconds or several days. Or combine both methods: Celldiscoverer 7 can automatically create focus maps for multiple positions in long-term time-lapse experiments.

LED Technology for Live Cell Imaging
Use the advantages of LED-technology for efficient illumination with low phototoxicity, fast switching times and long-term stability. That’s what delivers gentle live cell imaging, increased throughput and reproducible results. The fluorescence excitation unit combines up to seven LEDs for maximum flexibility in the choice of dyes – from deep blue to far-red. Celldiscoverer 7 simply switches LEDs on / off – without moving any mechanical parts – so you get high-speed multi-channel imaging, even when combined with transmitted light.


SH-SY5Y cells cultured on a 384 micro-well plate; multichannel image at a single position. Hoechst – Chromatin (blue), anti-alpha-tubulin antibody FITC for alphas tubulin (green), Phalloidine for actin (red), MitoTracker Deep Red for mitochondria (purple).
SH-SY5Y cells cultured on a 384 micro-well plate; multichannel image at a single position. Hoechst – Chromatin (blue), anti-alpha-tubulin antibody FITC for alphas tubulin (green), Phalloidine for actin (red), MitoTracker Deep Red for mitochondria (purple). Sample courtesy of P. Denner, Core Research Facilities, German Center of Neuro-degenerative Diseases (DZNE), Bonn, Germany.
LSM 900 with Airyscan 2
Automated Confocal 3D Imaging
Life happens in 3D. Add LSM 900 with Airyscan 2 and get the best of both worlds: ease of use and automation from a fully integrated microscope platform and the superb confocal image quality and flexibility of LSM 9 family. Super-resolution 3D imaging with up to 1.9x resolution improvement becomes possible. Easily separate multiple labels with spectral imaging. Analyze dynamic processes in living samples with photomanipulation for FRAP, FRET or related techniques. Precisely connect widefield and confocal images. Fast mixed-mode acquisition simplifies and speeds up your workflow and gives you unique insights into your sample.